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Page 1
High-titer production of 13R-manoyl oxide in metabolically engineered Saccharomyces cerevisiae.
Zhang C, Ju H, Lu CZ, Zhao F, Liu J, Guo X, Wu Y, Zhao GR, Lu W. Zhang C, et al. Microb Cell Fact. 2019 Apr 24;18(1):73. doi: 10.1186/s12934-019-1123-z. Microb Cell Fact. 2019. PMID: 31018856 Free PMC article.
Therefore, it is important to create an efficient diterpenoid-producing yeast cell factory of the production of various high-value diterpenoid compounds in a cost-effective manner RESULTS: In this study, 13R-manoyl oxide (13R-MO; 2.31 mg/L) was produced by expressin …
Therefore, it is important to create an efficient diterpenoid-producing yeast cell factory of the production of various high-value diterpeno …
Acylated manoyl oxide diterpenes of Stemodia trifoliata.
da Silva WM, Silveira ER, Pessoa OD. da Silva WM, et al. Magn Reson Chem. 2010 Jun;48(6):486-9. doi: 10.1002/mrc.2597. Magn Reson Chem. 2010. PMID: 20474028
Two new labdane diterpenes, 6alpha-malonyloxy-ethyl ester manoyl oxide and bis-6alpha-dioxymanoylmalonate, together with the known 6alpha-hydroxymanoyl oxide, 6alpha-malonyloxymaloyl oxide and betulinic acid were isolated from leaves of Stemodia trifoliata. ...
Two new labdane diterpenes, 6alpha-malonyloxy-ethyl ester manoyl oxide and bis-6alpha-dioxymanoylmalonate, together with the k …
Manoyl oxide (13R), the biosynthetic precursor of forskolin, is synthesized in specialized root cork cells in Coleus forskohlii.
Pateraki I, Andersen-Ranberg J, Hamberger B, Heskes AM, Martens HJ, Zerbe P, Bach SS, Møller BL, Bohlmann J, Hamberger B. Pateraki I, et al. Plant Physiol. 2014 Mar;164(3):1222-36. doi: 10.1104/pp.113.228429. Epub 2014 Jan 30. Plant Physiol. 2014. PMID: 24481136 Free PMC article.
Organelle purification and chemical analysis confirmed the localization of forskolin and of its simplest diterpene precursor backbone, (13R) manoyl oxide, to the oil bodies. The labdane diterpene backbone is typically synthesized by two successive reactions catalyze …
Organelle purification and chemical analysis confirmed the localization of forskolin and of its simplest diterpene precursor backbone, (13R) …
Manoyl oxide diterpenoids from Grindelia scorzonerifolia.
Ybarra MI, Popich S, Borkosky SA, Asakawa Y, Bardón A. Ybarra MI, et al. J Nat Prod. 2005 Apr;68(4):554-8. doi: 10.1021/np040174k. J Nat Prod. 2005. PMID: 15844947
Two new norditerpenoids, 4beta-hydroxy-19-normanoyl oxide (1) and 4alpha-hydroxy-18-normanoyl oxide (2), the new 18-O-alpha-l-arabinopyranosylmanoyl oxide (3a), and the known diterpenoids jhanol (4) and 18-hydroxy-13-epi-manoyl oxide (5) were isolated, together with …
Two new norditerpenoids, 4beta-hydroxy-19-normanoyl oxide (1) and 4alpha-hydroxy-18-normanoyl oxide (2), the new 18-O-alpha-l-arabinopyranos …
Manoyl oxide alpha-arabinopyranoside and grindelic acid diterpenoids from Grindelia integrifolia.
Ahmed AA, Mahmoud AA, Ahmed UM, El-Bassuony AA, Abd El-Razk MH, Pare PW, Karchesy J. Ahmed AA, et al. J Nat Prod. 2001 Oct;64(10):1365-7. doi: 10.1021/np010273n. J Nat Prod. 2001. PMID: 11678671
Two new manoyl oxide-alpha-arabinopyranoside diterpenoids, 15-hydroxy-13-epi-manoyl oxide-14-O-alpha-L-arabinopyranoside (tarapacol-14-O-alpha-L-arabinopyranoside) (1) and 15-acetoxy-13-epi-manoyl oxide-14-O-alpha-L-arabinopyranoside (tar …
Two new manoyl oxide-alpha-arabinopyranoside diterpenoids, 15-hydroxy-13-epi-manoyl oxide-14-O-alpha-L-arabinopy …
Production of the forskolin precursor 11beta-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities.
Ignea C, Ioannou E, Georgantea P, Trikka FA, Athanasakoglou A, Loupassaki S, Roussis V, Makris AM, Kampranis SC. Ignea C, et al. Microb Cell Fact. 2016 Feb 26;15:46. doi: 10.1186/s12934-016-0440-8. Microb Cell Fact. 2016. PMID: 26920948 Free PMC article.
Using CYP76AH24, a Salvia pomifera cytochrome P450 responsible for the oxidation of C-12 and C-11 of the abietane skeleton en route to carnosic acid, we were able to produce the forskolin precursor 11beta-hydroxy-manoyl oxide in yeast. To improve 11beta-hydroxy-m …
Using CYP76AH24, a Salvia pomifera cytochrome P450 responsible for the oxidation of C-12 and C-11 of the abietane skeleton en route to carno …
Microbial Synthesis of the Forskolin Precursor Manoyl Oxide in an Enantiomerically Pure Form.
Nielsen MT, Ranberg JA, Christensen U, Christensen HB, Harrison SJ, Olsen CE, Hamberger B, Møller BL, Nørholm MH. Nielsen MT, et al. Appl Environ Microbiol. 2014 Dec;80(23):7258-65. doi: 10.1128/AEM.02301-14. Epub 2014 Sep 19. Appl Environ Microbiol. 2014. PMID: 25239892 Free PMC article.
Hence, substantial efforts and resources have been invested in developing sustainable and reliable supply routes based on microbial cell factories. Here, we report microbial synthesis of (13R)-manoyl oxide, a proposed intermediate in the biosynthesis of forskolin an …
Hence, substantial efforts and resources have been invested in developing sustainable and reliable supply routes based on microbial cell fac …
Progress in heterologous biosynthesis of forskolin.
Ju H, Zhang C, Lu W. Ju H, et al. J Ind Microbiol Biotechnol. 2021 Apr 30;48(1-2):kuab009. doi: 10.1093/jimb/kuab009. J Ind Microbiol Biotechnol. 2021. PMID: 33928347 Free PMC article. Review.
Hemisynthesis and cytotoxic evaluation of manoyl oxide analogs from sclareol: effect of two tertiary hydroxyls & Heck coupling on cytotoxicity.
Gani I, Sofi ZI, Kaur G, Goswami A, Bhat KA. Gani I, et al. Nat Prod Res. 2024 Apr 18:1-10. doi: 10.1080/14786419.2024.2342558. Online ahead of print. Nat Prod Res. 2024. PMID: 38635350
In the first step manoyl oxide was prepared from sclareol using cerium (IV) ammonium nitrate. Further the structural modification of manoyl oxide via Palladium (II) catalysed Boron-Heck coupling reaction produced a new series of compounds. ...
In the first step manoyl oxide was prepared from sclareol using cerium (IV) ammonium nitrate. Further the structural modificat …
Metabolic Engineering of Synechocystis sp. PCC 6803 for Production of the Plant Diterpenoid Manoyl Oxide.
Englund E, Andersen-Ranberg J, Miao R, Hamberger B, Lindberg P. Englund E, et al. ACS Synth Biol. 2015 Dec 18;4(12):1270-8. doi: 10.1021/acssynbio.5b00070. Epub 2015 Jul 13. ACS Synth Biol. 2015. PMID: 26133196 Free PMC article.
We have engineered the unicellular cyanobacterium Synechocystis sp. PCC 6803 to produce the forskolin precursor 13R-manoyl oxide (13R-MO), paving the way for light driven biotechnological production of this high value compound. ...
We have engineered the unicellular cyanobacterium Synechocystis sp. PCC 6803 to produce the forskolin precursor 13R-manoyl oxide …
85 results