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Page 1
Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk.
Kojima S, Koyama S, Ka M, Saito Y, Parrish EH, Endo M, Takata S, Mizukoshi M, Hikino K, Takeda A, Gelinas AF, Heaton SM, Koide R, Kamada AJ, Noguchi M, Hamada M; Biobank Japan Project Consortium; Kamatani Y, Murakawa Y, Ishigaki K, Nakamura Y, Ito K, Terao C, Momozawa Y, Parrish NF. Kojima S, et al. Nat Genet. 2023 Jun;55(6):939-951. doi: 10.1038/s41588-023-01390-2. Epub 2023 May 11. Nat Genet. 2023. PMID: 37169872
ME variants (MEVs) are difficult to genotype and integrate in statistical genetics, obscuring their impact on genome diversification and traits. We developed a tool that accurately genotypes MEVs using short-read whole-genome sequencing (WGS) and applied it t …
ME variants (MEVs) are difficult to genotype and integrate in statistical genetics, obscuring their impact on genome diversification …
The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2.
Dong R, Li M, Gu XF, Gao H, Wei Z, Qi H, Zhang J, Feng Q. Dong R, et al. J Transl Med. 2025 May 14;23(1):540. doi: 10.1186/s12967-025-06569-1. J Transl Med. 2025. PMID: 40369630 Free PMC article.
BACKGROUND: Periodontitis is a chronic inflammatory disease that significantly impacts periodontal bone regeneration, yet the distinct biological features of osteoblasts in this condition remain poorly understood. ...An experimental periodontitis model in mice and primary …
BACKGROUND: Periodontitis is a chronic inflammatory disease that significantly impacts periodontal bone regeneration, yet the distinc …
MR Fingerprinting with b-Tensor Encoding for Simultaneous Quantification of Relaxation and Diffusion in a Single Scan.
Afzali M, Mueller L, Sakaie K, Hu S, Chen Y, Szczepankiewicz F, Griswold MA, Jones DK, Ma D. Afzali M, et al. Magn Reson Med. 2022 Nov;88(5):2043-2057. doi: 10.1002/mrm.29352. Epub 2022 Jun 17. Magn Reson Med. 2022. PMID: 35713357 Free PMC article.
Here, we aim to simultaneously quantify relaxation and diffusion using MR fingerprinting (MRF) and b-tensor encoding in a clinically feasible time. METHODS: We developed multidimensional MRF scans (mdMRF) with linear and spherical b-tensor encoding (LTE and STE) to …
Here, we aim to simultaneously quantify relaxation and diffusion using MR fingerprinting (MRF) and b-tensor encoding in a clinically
Plasma proteins and osteosarcoma: Mendelian randomization analysis and targeted therapeutic discovery.
Zhao L, Shen J, Zheng X, Yuan Q, Ye J. Zhao L, et al. Medicine (Baltimore). 2025 Dec 5;104(49):e45704. doi: 10.1097/MD.0000000000045704. Medicine (Baltimore). 2025. PMID: 41366971 Free article.
However, no conclusive evidence has been presented to firmly establish a direct connection between particular plasma proteins and OS. To fill this research void, our study utilizes Mendelian randomization (MR) analysis to meticulously assess the causal impact
However, no conclusive evidence has been presented to firmly establish a direct connection between particular plasma proteins and OS. To fil …
Navigator-gated free-breathing joint T(1)-T(2) mapping of the kidney.
Calarnou P, Ogier AC, Roy CW, Ledoux JB, Rocca A, Rapacchi S, Pruijm M, Hullin R, Vallée JP, Yerly J, van Heeswijk RB. Calarnou P, et al. MAGMA. 2026 Mar 5. doi: 10.1007/s10334-026-01337-8. Online ahead of print. MAGMA. 2026. PMID: 41784853
OBJECTIVE: To develop and evaluate a free-breathing 2D radial joint T1-T2 mapping technique for the kidneys at 3T, and to assess the impact of navigator gating parameters on mapping accuracy in a phantom and precision in healthy volunteers. ...No T(1) or T(2) …
OBJECTIVE: To develop and evaluate a free-breathing 2D radial joint T1-T2 mapping technique for the kidneys at 3T, and to asse …
3D Whole-Heart Joint T(1)/T(1rho) Mapping and Water-Fat Imaging on a Clinical 0.55-T Low-Field Scanner.
Crabb MG, Kunze KP, Castillo-Passi C, Si D, Littlewood SJ, Prieto C, Botnar RM. Crabb MG, et al. NMR Biomed. 2026 Feb;39(2):e70195. doi: 10.1002/nbm.70195. NMR Biomed. 2026. PMID: 41431231 Free PMC article.
To overcome limitations associated with 2D breath-hold mapping sequences, we develop a novel free-breathing 3D joint T1 / T1rho mapping sequence with Dixon encoding to provide co-registered 3D T1 and T1rho maps and water-fat volumes with isotrop …
To overcome limitations associated with 2D breath-hold mapping sequences, we develop a novel free-breathing 3D joint T1 …
Features Constituting Actionable COVID-19 Dashboards: Descriptive Assessment and Expert Appraisal of 158 Public Web-Based COVID-19 Dashboards.
Ivanković D, Barbazza E, Bos V, Brito Fernandes Ó, Jamieson Gilmore K, Jansen T, Kara P, Larrain N, Lu S, Meza-Torres B, Mulyanto J, Poldrugovac M, Rotar A, Wang S, Willmington C, Yang Y, Yelgezekova Z, Allin S, Klazinga N, Kringos D. Ivanković D, et al. J Med Internet Res. 2021 Feb 24;23(2):e25682. doi: 10.2196/25682. J Med Internet Res. 2021. PMID: 33577467 Free PMC article.
METHODS: We conducted a descriptive assessment and scoring using nominal group technique with an international panel of experts (n=17) on a global sample of COVID-19 dashboards in July 2020. The sequence of steps included multimethod sampling of dashboards; development
METHODS: We conducted a descriptive assessment and scoring using nominal group technique with an international panel of experts (n=17) on a …
Plantar plate pathology is associated with erosive disease in the painful forefoot of patients with rheumatoid arthritis.
Siddle HJ, Hodgson RJ, Hensor EMA, Grainger AJ, Redmond AC, Wakefield RJ, Helliwell PS. Siddle HJ, et al. BMC Musculoskelet Disord. 2017 Jul 18;18(1):308. doi: 10.1186/s12891-017-1668-0. BMC Musculoskelet Disord. 2017. PMID: 28720138 Free PMC article.
The aims of this study were to investigate the relationship between plantar plate pathology and clinical, biomechanical and plain radiography findings in the painful forefoot of patients with RA. ...Intermediate weighted fat-suppressed sagittal and short axis seq
The aims of this study were to investigate the relationship between plantar plate pathology and clinical, biomechanical and pl …
Comprehensive in silico analysis of genetic landscape and pathways involved in Stickler syndrome.
Sharma R, Yadav K, Gupta V, Arora A, Yadav V. Sharma R, et al. PLoS One. 2026 Feb 20;21(2):e0343405. doi: 10.1371/journal.pone.0343405. eCollection 2026. PLoS One. 2026. PMID: 41719287 Free PMC article.
Stickler syndrome is a collection of hereditary conditions that impact connective tissue, mainly collagen, and can cause a variety of symptoms, such as joint and bone abnormalities, hearing loss, and visual impairments. ...Furthermore, drug-gene interaction analy
Stickler syndrome is a collection of hereditary conditions that impact connective tissue, mainly collagen, and can cause a variety of …