Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 1
2000 1
2002 7
2003 4
2004 1
2005 1
2006 5
2007 1
2008 8
2009 8
2010 15
2011 5
2012 10
2013 8
2014 10
2015 18
2016 9
2017 14
2018 8
2019 18
2020 17
2021 21
2022 20
2023 23
2024 21
2025 17
2026 8

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

246 results

Results by year

Filters applied: . Clear all
Page 1
Spatial metabolomics and its application in the liver.
Santos AA, Delgado TC, Marques V, Ramirez-Moncayo C, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP. Santos AA, et al. Hepatology. 2024 May 1;79(5):1158-1179. doi: 10.1097/HEP.0000000000000341. Epub 2023 Feb 23. Hepatology. 2024. PMID: 36811413 Free PMC article. Review.
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism.
Gonzalez-Rellan MJ, Fernández U, Parracho T, Novoa E, Fondevila MF, da Silva Lima N, Ramos L, Rodríguez A, Serrano-Maciá M, Perez-Mejias G, Chantada-Vazquez P, Riobello C, Veyrat-Durebex C, Tovar S, Coppari R, Woodhoo A, Schwaninger M, Prevot V, Delgado TC, Lopez M, Diaz-Quintana A, Dieguez C, Guallar D, Frühbeck G, Diaz-Moreno I, Bravo SB, Martinez-Chantar ML, Nogueiras R. Gonzalez-Rellan MJ, et al. Cell Metab. 2023 Sep 5;35(9):1630-1645.e5. doi: 10.1016/j.cmet.2023.07.003. Epub 2023 Aug 3. Cell Metab. 2023. PMID: 37541251 Free PMC article.
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression.
Juárez-Fernández M, Goikoetxea-Usandizaga N, Porras D, García-Mediavilla MV, Bravo M, Serrano-Maciá M, Simón J, Delgado TC, Lachiondo-Ortega S, Martínez-Flórez S, Lorenzo Ó, Rincón M, Varela-Rey M, Abecia L, Rodríguez H, Anguita J, Nistal E, Martínez-Chantar ML, Sánchez-Campos S. Juárez-Fernández M, et al. Hepatology. 2023 May 1;77(5):1654-1669. doi: 10.1002/hep.32705. Epub 2023 Apr 17. Hepatology. 2023. PMID: 35921199 Free PMC article.
Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway.
Gil-Pitarch C, Serrano-Maciá M, Simon J, Mosca L, Conter C, Rejano-Gordillo CM, Zapata-Pavas LE, Peña-Sanfélix P, Azkargorta M, Rodríguez-Agudo R, Lachiondo-Ortega S, Mercado-Gómez M, Delgado TC, Porcelli M, Aurrekoetxea I, Sutherland JD, Barrio R, Xirodimas D, Aspichueta P, Elortza F, Martínez-Cruz LA, Nogueiras R, Iruzubieta P, Crespo J, Masson S, McCain MV, Reeves HL, Andrade RJ, Lucena MI, Mayor U, Goikoetxea-Usandizaga N, González-Recio I, Martínez-Chantar ML. Gil-Pitarch C, et al. Cell Rep Med. 2024 Jul 16;5(7):101653. doi: 10.1016/j.xcrm.2024.101653. Cell Rep Med. 2024. PMID: 39019009 Free PMC article.
Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting.
Capelo-Diz A, Lachiondo-Ortega S, Fernández-Ramos D, Cañas-Martín J, Goikoetxea-Usandizaga N, Serrano-Maciá M, González-Rellan MJ, Mosca L, Blazquez-Vicens J, Tinahones-Ruano A, Fondevila MF, Buyan M, Delgado TC, Gutierrez de Juan V, Ayuso-García P, Sánchez-Rueda A, Velasco-Avilés S, Fernández-Susavila H, Riobello-Suárez C, Dziechciarz B, Montiel-Duarte C, Lopitz-Otsoa F, Bizkarguenaga M, Bilbao-García J, Bernardo-Seisdedos G, Senra A, Soriano-Navarro M, Millet O, Díaz-Lagares Á, Crujeiras AB, Bao-Caamano A, Cabrera D, van Liempd S, Tamayo-Carro M, Borzacchiello L, Gomez-Santos B, Buqué X, Sáenz de Urturi D, González-Romero F, Simon J, Rodríguez-Agudo R, Ruiz A, Matute C, Beiroa D, Falcon-Perez JM, Aspichueta P, Rodríguez-Cuesta J, Porcelli M, Pajares MA, Ameneiro C, Fidalgo M, Aransay AM, Lama-Díaz T, Blanco MG, López M, Villa-Bellosta R, Müller TD, Nogueiras R, Woodhoo A, Martínez-Chantar ML, Varela-Rey M. Capelo-Diz A, et al. Cell Metab. 2023 Aug 8;35(8):1373-1389.e8. doi: 10.1016/j.cmet.2023.07.002. Epub 2023 Jul 31. Cell Metab. 2023. PMID: 37527658 Free PMC article.
p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway.
Fondevila MF, Novoa E, Gonzalez-Rellan MJ, Fernandez U, Heras V, Porteiro B, Parracho T, Dorta V, Riobello C, da Silva Lima N, Seoane S, Garcia-Vence M, Chantada-Vazquez MP, Bravo SB, Senra A, Leiva M, Marcos M, Sabio G, Perez-Fernandez R, Dieguez C, Prevot V, Schwaninger M, Woodhoo A, Martinez-Chantar ML, Schwabe R, Cubero FJ, Varela-Rey M, Crespo J, Iruzubieta P, Nogueiras R. Fondevila MF, et al. Cell Rep Med. 2024 Feb 20;5(2):101401. doi: 10.1016/j.xcrm.2024.101401. Epub 2024 Feb 9. Cell Rep Med. 2024. PMID: 38340725 Free PMC article.
Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis.
Fondevila MF, Fernandez U, Heras V, Parracho T, Gonzalez-Rellan MJ, Novoa E, Porteiro B, Alonso C, Mayo R, da Silva Lima N, Iglesias C, Filliol AA, Senra A, Delgado TC, Woodhoo A, Herrero L, Serra D, Prevot V, Schwaninger M, López M, Dieguez C, Millet O, Mato JM, Cubero FJ, Varela-Rey M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Schwabe RF, Nogueiras R. Fondevila MF, et al. J Hepatol. 2022 Jul;77(1):15-28. doi: 10.1016/j.jhep.2022.02.003. Epub 2022 Feb 12. J Hepatol. 2022. PMID: 35167910 Free article.
Identification of PRMT5 as a therapeutic target in cholangiocarcinoma.
Elurbide J, Colyn L, Latasa MU, Uriarte I, Mariani S, Lopez-Pascual A, Valbuena E, Castello-Uribe B, Arnes-Benito R, Adan-Villaescusa E, Martinez-Perez LA, Azkargorta M, Elortza F, Wu H, Krawczyk M, Schneider KM, Sangro B, Aldrighetti L, Ratti F, Casadei Gardini A, Marin JJG, Amat I, Urman JM, Arechederra M, Martinez-Chantar ML, Trautwein C, Huch M, Cubero FJ, Berasain C, G Fernandez-Barrena M, Avila MA. Elurbide J, et al. Gut. 2024 Dec 10;74(1):116-127. doi: 10.1136/gutjnl-2024-332998. Gut. 2024. PMID: 39266051 Free PMC article.
NFATc4: New hub in NASH development.
Martinez-Chantar ML, Foti M. Martinez-Chantar ML, et al. J Hepatol. 2020 Dec;73(6):1313-1315. doi: 10.1016/j.jhep.2020.08.034. Epub 2020 Oct 5. J Hepatol. 2020. PMID: 33032848 No abstract available.
SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
Lachiondo-Ortega S, Rejano-Gordillo CM, Simon J, Lopitz-Otsoa F, C Delgado T, Mazan-Mamczarz K, Goikoetxea-Usandizaga N, Zapata-Pavas LE, García-Del Río A, Guerra P, Peña-Sanfélix P, Hermán-Sánchez N, Al-Abdulla R, Fernandez-Rodríguez C, Azkargorta M, Velázquez-Cruz A, Guyon J, Martín C, Zalamea JD, Egia-Mendikute L, Sanz-Parra A, Serrano-Maciá M, González-Recio I, Gonzalez-Lopez M, Martínez-Cruz LA, Pontisso P, Aransay AM, Barrio R, Sutherland JD, Abrescia NGA, Elortza F, Lujambio A, Banales JM, Luque RM, Gahete MD, Palazón A, Avila MA, G Marin JJ, De S, Daubon T, Díaz-Quintana A, Díaz-Moreno I, Gorospe M, Rodríguez MS, Martínez-Chantar ML. Lachiondo-Ortega S, et al. Cell Rep. 2024 Mar 26;43(3):113924. doi: 10.1016/j.celrep.2024.113924. Epub 2024 Mar 18. Cell Rep. 2024. PMID: 38507413 Free PMC article.
Mitochondrial antiviral signaling protein enhances MASLD progression through the ERK/TNFα/NFκβ pathway.
Nóvoa E, da Silva Lima N, Gonzalez-Rellan MJ, Chantada-Vazquez MDP, Verheij J, Rodriguez A, Esquinas-Roman EM, Fondevila MF, Koning M, Fernandez U, Cabaleiro A, Parracho T, Iglesias-Moure J, Seoane S, Porteiro B, Escudero A, Senra A, Perez-Fernandez R, López M, Fidalgo M, Guallar D, Martinez-Chantar ML, Dieguez C, Varela-Rey M, Prevot V, Schwaninger M, Meijnikman A, Bravo SB, Frühbeck G, Nogueiras R. Nóvoa E, et al. Hepatology. 2025 May 1;81(5):1535-1552. doi: 10.1097/HEP.0000000000000930. Epub 2024 May 16. Hepatology. 2025. PMID: 38761407 Free PMC article.
Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals.
Goikoetxea-Usandizaga N, Serrano-Maciá M, Delgado TC, Simón J, Fernández Ramos D, Barriales D, Cornide ME, Jiménez M, Pérez-Redondo M, Lachiondo-Ortega S, Rodríguez-Agudo R, Bizkarguenaga M, Zalamea JD, Pasco ST, Caballero-Díaz D, Alfano B, Bravo M, González-Recio I, Mercado-Gómez M, Gil-Pitarch C, Mabe J, Gracia-Sancho J, Abecia L, Lorenzo Ó, Martín-Sanz P, Abrescia NGA, Sabio G, Rincón M, Anguita J, Miñambres E, Martín C, Berenguer M, Fabregat I, Casado M, Peralta C, Varela-Rey M, Martínez-Chantar ML. Goikoetxea-Usandizaga N, et al. Hepatology. 2022 Mar;75(3):550-566. doi: 10.1002/hep.32149. Epub 2021 Dec 15. Hepatology. 2022. PMID: 34510498 Free PMC article.
Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination.
Ayuso-García P, Sánchez-Rueda A, Velasco-Avilés S, Tamayo-Caro M, Ferrer-Pinós A, Huarte-Sebastian C, Alvarez V, Riobello C, Jiménez-Vega S, Buendia I, Cañas-Martin J, Fernández-Susavila H, Aparicio-Rey A, Esquinas-Román EM, Ponte CR, Guhl R, Laville N, Pérez-Andrés E, Lavín JL, González-Lopez M, Cámara NM, Aransay AM, Lozano JJ, Sutherland JD, Barrio R, Martinez-Chantar ML, Azkargorta M, Elortza F, Soriano-Navarro M, Matute C, Sánchez-Gómez MV, Bayón-Cordero L, Pérez-Samartín A, Bravo SB, Kurz T, Lama-Díaz T, Blanco MG, Haddad S, Record CJ, van Hasselt PM, Reilly MM, Varela-Rey M, Woodhoo A. Ayuso-García P, et al. Sci Adv. 2024 Apr 12;10(15):eadm7600. doi: 10.1126/sciadv.adm7600. Epub 2024 Apr 12. Sci Adv. 2024. PMID: 38608019 Free PMC article.
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.
González-Recio I, Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, Mercado-Gómez M, Rodríguez-Agudo R, Lachiondo-Ortega S, Gil-Pitarch C, Fernández-Rodríguez C, Castellana D, Latasa MU, Abecia L, Anguita J, Delgado TC, Iruzubieta P, Crespo J, Hardy S, Petrov PD, Jover R, Avila MA, Martín C, Schaeper U, Tremblay ML, Dear JW, Masson S, McCain MV, Reeves HL, Andrade RJ, Lucena MI, Buccella D, Martínez-Cruz LA, Martínez-Chantar ML. González-Recio I, et al. Nat Commun. 2022 Nov 25;13(1):6816. doi: 10.1038/s41467-022-34262-0. Nat Commun. 2022. PMID: 36433951 Free PMC article.
Global multi-stakeholder endorsement of the MAFLD definition.
Méndez-Sánchez N, Bugianesi E, Gish RG, Lammert F, Tilg H, Nguyen MH, Sarin SK, Fabrellas N, Zelber-Sagi S, Fan JG, Shiha G, Targher G, Zheng MH, Chan WK, Vinker S, Kawaguchi T, Castera L, Yilmaz Y, Korenjak M, Spearman CW, Ungan M, Palmer M, El-Shabrawi M, Gruss HJ, Dufour JF, Dhawan A, Wedemeyer H, George J, Valenti L, Fouad Y, Romero-Gomez M, Eslam M; Global multi-stakeholder consensus on the redefinition of fatty liver disease. Méndez-Sánchez N, et al. Lancet Gastroenterol Hepatol. 2022 May;7(5):388-390. doi: 10.1016/S2468-1253(22)00062-0. Epub 2022 Mar 3. Lancet Gastroenterol Hepatol. 2022. PMID: 35248211 Free article. No abstract available.
The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent.
Goikoetxea-Usandizaga N, Bravo M, Egia-Mendikute L, Abecia L, Serrano-Maciá M, Urdinguio RG, Clos-García M, Rodríguez-Agudo R, Araujo-Legido R, López-Bermudo L, Delgado TC, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Peña-Cearra A, Simón J, Benedé-Ubieto R, Ariño S, Herranz JM, Azkargorta M, Salazar-Bermeo J, Martí N, Varela-Rey M, Falcón-Pérez JM, Lorenzo Ó, Nogueiras R, Elortza F, Nevzorova YA, Cubero FJ, Saura D, Martínez-Cruz LA, Sabio G, Palazón A, Sancho-Bru P, Elguezabal N, Fraga MF, Ávila MA, Bataller R, Marín JJG, Martín F, Martínez-Chantar ML. Goikoetxea-Usandizaga N, et al. Hepatology. 2023 Sep 1;78(3):878-895. doi: 10.1097/HEP.0000000000000303. Epub 2023 Feb 9. Hepatology. 2023. PMID: 36745935 Free PMC article.
Role of CNNM4 in the progression of cholangiocarcinoma: implications for ferroptosis and therapeutic potential.
Mercado-Gómez M, Goikoetxea-Usandizaga N, Giné AE, Merlos Rodrigo MA, Afonso MB, Azkargorta M, Zapata-Pavas LE, Rejano-Gordillo CM, Romero MR, Mendizabal I, Rodrigues PM, Wu H, Rodríguez-Agudo R, Serrano-Maciá M, Olaizola P, Barrenechea-Barrenechea JA, González Recio I, G Fernandez-Barrena M, Overi D, Gaudio E, Schaeper U, Garcia-Longarte S, Yáñez-Bartolomé M, Peña-SanFelix P, Gil-Pitarch C, Lapitz A, Michalkova H, Heger Z, Conter C, Macias RIR, Carracedo A, Bañales J, Moreno V, Lamarca A, Singh R, Delgado TC, Martínez-Cruz LA, Elortza F, Avila MA, Martín C, Tian TV, Macarulla T, Buccella D, Cubero FJ, Calvisi DF, Carpino G, Marin JJG, Rodrigues CMP, Martinez-Chantar ML. Mercado-Gómez M, et al. Gut. 2026 Jan 8;75(2):341-352. doi: 10.1136/gutjnl-2024-333255. Gut. 2026. PMID: 40764063 Free PMC article.
Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1.
Rodríguez-Agudo R, González-Recio I, Serrano-Maciá M, Bravo M, Petrov P, Blaya D, Herranz JM, Mercado-Gómez M, Rejano-Gordillo CM, Lachiondo-Ortega S, Gil-Pitarch C, Azkargorta M, Van Liempd SM, Martinez-Cruz LA, Simão AL, Elortza F, Martín C, Nevzorova YA, Cubero FJ, Delgado TC, Argemi J, Bataller R, Schoonjans K, Banales JM, Castro RE, Sancho-Bru P, Avila MA, Julve J, Jover R, Mabe J, Simon J, Goikoetxea-Usandizaga N, Martínez-Chantar ML. Rodríguez-Agudo R, et al. JHEP Rep. 2023 Sep 30;6(1):100918. doi: 10.1016/j.jhepr.2023.100918. eCollection 2024 Jan. JHEP Rep. 2023. PMID: 38192540 Free PMC article.
Metabolic dysfunction-associated steatotic liver disease alters brain function and behavior: Insights from liver-targeted siRNA therapy.
Cardoso Delgado T, Martín-Cuevas C, Sánchez Hidalgo AC, Gil Gómez A, Rejano Gordillo CM, Landa J, Gallego Durán R, Goikoetxea-Usandizaga N, González-Recio I, Gil-Pitarch C, Zapata-Pavas LE, Barrenechea-Barrenechea JA, Conter C, Martínez-Cruz LA, Ramos Herrero VD, Nogueiras R, Azkargorta M, Elortza F, Moncho-Amor V, Crespo J, Matheu A, Romero Gómez M, Crespo-Facorro B, Martínez-Chantar ML. Cardoso Delgado T, et al. Sci Adv. 2025 Oct 24;11(43):eady9758. doi: 10.1126/sciadv.ady9758. Epub 2025 Oct 22. Sci Adv. 2025. PMID: 41124271 Free PMC article.
Novel Emerging Mechanisms in Acetaminophen (APAP) Hepatotoxicity.
Hionides-Gutierrez A, Goikoetxea-Usandizaga N, Sanz-García C, Martínez-Chantar ML, Cubero FJ. Hionides-Gutierrez A, et al. Liver Int. 2025 Apr;45(4):e16167. doi: 10.1111/liv.16167. Epub 2024 Nov 15. Liver Int. 2025. PMID: 39548712 Review.
Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function.
Gonzalez-Rellan MJ, Parracho T, Heras V, Rodriguez A, Fondevila MF, Novoa E, Lima N, Varela-Rey M, Senra A, Chantada-Vazquez MDP, Ameneiro C, Bernardo G, Fernandez-Ramos D, Lopitz-Otsoa F, Bilbao J, Guallar D, Fidalgo M, Bravo S, Dieguez C, Martinez-Chantar ML, Millet O, Mato JM, Schwaninger M, Prevot V, Crespo J, Frühbeck G, Iruzubieta P, Nogueiras R. Gonzalez-Rellan MJ, et al. Mol Metab. 2023 Sep;75:101776. doi: 10.1016/j.molmet.2023.101776. Epub 2023 Jul 13. Mol Metab. 2023. PMID: 37453647 Free PMC article.
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. Zabala-Letona A, et al. Nature. 2017 Jul 6;547(7661):109-113. doi: 10.1038/nature22964. Epub 2017 Jun 28. Nature. 2017. PMID: 28658205 Free PMC article.
Identification and experimental validation of druggable epigenetic targets in hepatoblastoma.
Clavería-Cabello A, Herranz JM, Latasa MU, Arechederra M, Uriarte I, Pineda-Lucena A, Prosper F, Berraondo P, Alonso C, Sangro B, García Marin JJ, Martinez-Chantar ML, Ciordia S, Corrales FJ, Francalanci P, Alaggio R, Zucman-Rossi J, Indersie E, Cairo S, Domingo-Sàbat M, Zanatto L, Sancho-Bru P, Armengol C, Berasain C, Fernandez-Barrena MG, Avila MA. Clavería-Cabello A, et al. J Hepatol. 2023 Oct;79(4):989-1005. doi: 10.1016/j.jhep.2023.05.031. Epub 2023 Jun 10. J Hepatol. 2023. PMID: 37302584 Free article.
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.
da Silva Lima N, Fondevila MF, Nóvoa E, Buqué X, Mercado-Gómez M, Gallet S, González-Rellan MJ, Fernandez U, Loyens A, Garcia-Vence M, Chantada-Vazquez MDP, Bravo SB, Marañon P, Senra A, Escudero A, Leiva M, Guallar D, Fidalgo M, Gomes P, Claret M, Sabio G, Varela-Rey M, Delgado TC, Montero-Vallejo R, Ampuero J, López M, Diéguez C, Herrero L, Serra D, Schwaninger M, Prevot V, Gallego-Duran R, Romero-Gomez M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Garcia-Monzon C, Gonzalez-Rodriguez A, Aspichueta P, Nogueiras R. da Silva Lima N, et al. J Hepatol. 2022 Jan;76(1):11-24. doi: 10.1016/j.jhep.2021.09.008. Epub 2021 Sep 21. J Hepatol. 2022. PMID: 34555423 Free article.
E2F1 and E2F2-Mediated Repression of CPT2 Establishes a Lipid-Rich Tumor-Promoting Environment.
González-Romero F, Mestre D, Aurrekoetxea I, O'Rourke CJ, Andersen JB, Woodhoo A, Tamayo-Caro M, Varela-Rey M, Palomo-Irigoyen M, Gómez-Santos B, de Urturi DS, Núñez-García M, García-Rodríguez JL, Fernández-Ares L, Buqué X, Iglesias-Ara A, Bernales I, De Juan VG, Delgado TC, Goikoetxea-Usandizaga N, Lee R, Bhanot S, Delgado I, Perugorria MJ, Errazti G, Mosteiro L, Gaztambide S, Martinez de la Piscina I, Iruzubieta P, Crespo J, Banales JM, Martínez-Chantar ML, Castaño L, Zubiaga AM, Aspichueta P. González-Romero F, et al. Cancer Res. 2021 Jun 1;81(11):2874-2887. doi: 10.1158/0008-5472.CAN-20-2052. Epub 2021 Mar 26. Cancer Res. 2021. PMID: 33771899
Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma.
Espinosa-Sotelo R, Fusté NP, Peñuelas-Haro I, Alay A, Pons G, Almodóvar X, Albaladejo J, Sánchez-Vera I, Bonilla-Amadeo R, Dituri F, Serino G, Ramos E, Serrano T, Calvo M, Martínez-Chantar ML, Giannelli G, Bertran E, Fabregat I. Espinosa-Sotelo R, et al. Redox Biol. 2023 Sep;65:102818. doi: 10.1016/j.redox.2023.102818. Epub 2023 Jul 13. Redox Biol. 2023. PMID: 37463530 Free PMC article.
Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models.
Olaizola P, Lee-Law PY, Fernandez-Barrena MG, Alvarez L, Cadamuro M, Azkargorta M, O'Rourke CJ, Caballero-Camino FJ, Olaizola I, Macias RIR, Marin JJG, Serrano-Maciá M, Martinez-Chantar ML, Avila MA, Aspichueta P, Calvisi DF, Evert M, Fabris L, Castro RE, Elortza F, Andersen JB, Bujanda L, Rodrigues PM, Perugorria MJ, Banales JM. Olaizola P, et al. J Hepatol. 2022 Jul;77(1):177-190. doi: 10.1016/j.jhep.2022.02.007. Epub 2022 Feb 23. J Hepatol. 2022. PMID: 35217064 Free article.
NEDDylation Regulates CD8+ T-cell Metabolism and Antitumor Immunity.
Jiménez-Lasheras B, Velasco-Beltrán P, Egia-Mendikute L, Pérez-Gutiérrez L, Lee SY, de Blas A, García-Del Río A, Zanetti SR, Antoñana-Vildosola A, Barreira-Manrique A, Bosch A, Etxaniz-Díaz de Durana J, Prieto-Fernández E, Serrano-Maciá M, Goikoetxea-Usandizaga N, Azkargorta M, Elortza F, Gruber T, Peer S, Baier G, Woodhoo A, Martínez-Chantar ML, Palazon A. Jiménez-Lasheras B, et al. Cancer Immunol Res. 2025 Jul 2;13(7):1004-1021. doi: 10.1158/2326-6066.CIR-24-0127. Cancer Immunol Res. 2025. PMID: 40261130 Free PMC article.
Magnesium and Liver Metabolism Through the Lifespan.
Bravo M, Simón J, González-Recio I, Martinez-Cruz LA, Goikoetxea-Usandizaga N, Martínez-Chantar ML. Bravo M, et al. Adv Nutr. 2023 Jul;14(4):739-751. doi: 10.1016/j.advnut.2023.05.009. Epub 2023 May 18. Adv Nutr. 2023. PMID: 37207838 Free PMC article. Review.
Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis.
Martínez García de la Torre RA, Vallverdú J, Xu Z, Ariño S, Ferrer-Lorente R, Zanatto L, Mercado-Gómez M, Aguilar-Bravo B, Ruiz-Blázquez P, Fernandez-Fernandez M, Navarro-Gascon A, Blasco-Roset A, Sànchez-Fernàndez-de-Landa P, Pera J, Romero-Moya D, Ayuso Garcia P, Martínez Sánchez C, Sererols Viñas L, Cantallops Vilà P, Cárcamo Giráldez CI, McQuillin A, Morgan MY, Moya-Rull D, Montserrat N, Eberlé D, Staels B, Antoine B, Azkargorta M, Lozano JJ, Martínez-Chantar ML, Giorgetti A, Elortza F, Planavila A, Varela-Rey M, Woodhoo A, Zorzano A, Graupera I, Moles A, Coll M, Affo S, Sancho-Bru P. Martínez García de la Torre RA, et al. Nat Commun. 2025 Feb 10;16(1):1489. doi: 10.1038/s41467-025-56024-4. Nat Commun. 2025. PMID: 39929812 Free PMC article.
Targeting protein hyper-SUMOylation halts cholangiocarcinoma progression by impairing cancer cell viability and tumor-stroma cross talk.
Olaizola P, Olaizola I, Fernandez de Ara M, Lapitz A, Val B, Izquierdo-Sanchez L, Fernandez-Barrena MG, Alvarez L, O'Rourke CJ, Lee-Law PY, Davies K, Gradinaru A, Jimenez-Agüero R, La Casta A, Riaño I, Macias RIR, Marin JJG, Martinez-Chantar ML, Avila MA, Aspichueta P, Andersen JB, Boulter L, Bujanda L, Rodrigues PM, Perugorria MJ, Banales JM. Olaizola P, et al. Hepatology. 2025 Dec 1;82(6):1461-1479. doi: 10.1097/HEP.0000000000001259. Epub 2025 Feb 11. Hepatology. 2025. PMID: 39932259 Free PMC article.
Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis.
Lamas-Paz A, Hionides-Gutiérrez A, Guo F, Jorquera G, Morán-Blanco L, Benedé-Ubieto R, Mesquita M, Estévez-Vázquez O, Zheng K, Mazariegos M, Vázquez-Ogando E, Blázquez-López E, Asensio I, Mutlu B, Gomez-Santos B, Peligros MI, Vaquero J, Bañares R, Delgado TC, Martínez-Chantar ML, Martínez-Naves E, Sanz-García C, Mohamed MR, Tesolato S, Iniesta P, Gallego-Durán R, Maya-Miles D, Ampuero J, Romero-Gómez M, Martínez-Alcocer A, Sanfeliu-Redondo D, Fernández-Iglesias A, Gracia-Sancho J, Coll M, Graupera I, Ginès P, Ciudin A, Rivera-Esteban J, Pericàs JM, Ávila MA, Frutos MD, Martínez-Cáceres CM, Ramos-Molina B, Aspichueta P, Puigserver P, Nevzorova YA, Cubero FJ. Lamas-Paz A, et al. JHEP Rep. 2024 Oct 5;7(1):101230. doi: 10.1016/j.jhepr.2024.101230. eCollection 2025 Jan. JHEP Rep. 2024. PMID: 39659733 Free PMC article.
Methionine metabolism and liver disease.
Mato JM, Martínez-Chantar ML, Lu SC. Mato JM, et al. Annu Rev Nutr. 2008;28:273-93. doi: 10.1146/annurev.nutr.28.061807.155438. Annu Rev Nutr. 2008. PMID: 18331185 Review.
Research Priorities for Precision Medicine in NAFLD.
Iruzubieta P, Bataller R, Arias-Loste MT, Arrese M, Calleja JL, Castro-Narro G, Cusi K, Dillon JF, Martínez-Chantar ML, Mateo M, Pérez A, Rinella ME, Romero-Gómez M, Schattenberg JM, Zelber-Sagi S, Crespo J, Lazarus JV. Iruzubieta P, et al. Clin Liver Dis. 2023 May;27(2):535-551. doi: 10.1016/j.cld.2023.01.016. Epub 2023 Feb 26. Clin Liver Dis. 2023. PMID: 37024222 Review.
Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death.
Sauve F, Nampoothiri S, Clarke SA, Fernandois D, Ferreira Coêlho CF, Dewisme J, Mills EG, Ternier G, Cotellessa L, Iglesias-Garcia C, Mueller-Fielitz H, Lebouvier T, Perbet R, Florent V, Baroncini M, Sharif A, Ereño-Orbea J, Mercado-Gómez M, Palazon A, Mattot V, Pasquier F, Catteau-Jonard S, Martinez-Chantar M, Hrabovszky E, Jourdain M, Deplanque D, Morelli A, Guarnieri G, Storme L, Robil C, Trottein F, Nogueiras R, Schwaninger M, Pigny P, Poissy J, Chachlaki K, Maurage CA, Giacobini P, Dhillo W, Rasika S, Prevot V. Sauve F, et al. EBioMedicine. 2023 Oct;96:104784. doi: 10.1016/j.ebiom.2023.104784. Epub 2023 Sep 13. EBioMedicine. 2023. PMID: 37713808 Free PMC article.
Modulatory effects of CNNM4 on protein- l -isoaspartyl- O -methyltransferase repair function during alcohol-induced hepatic damage.
González-Recio I, Goikoetxea-Usandizaga N, Rejano-Gordillo CM, Conter C, Rodríguez Agudo R, Serrano-Maciá M, Zapata-Pavas LE, Peña-Sanfélix P, Azkargorta M, Elortza F, Herranz JM, Guillamon Thiery Á, Guerra-Ruiz AR, Jover R, Galicia-Garcia U, Martín C, Schaeper U, Delgado TC, Díaz-Moreno I, Díaz Quintana A, Buccella D, Nogueiras R, Argemi J, Ávila MA, Gratacós-Ginès J, Iruzubieta P, Pose E, Bataller R, Crespo J, Martínez-Cruz LA, Martínez-Chantar ML. González-Recio I, et al. Hepatology. 2025 Aug 1;82(2):388-404. doi: 10.1097/HEP.0000000000001156. Epub 2024 Nov 19. Hepatology. 2025. PMID: 39641635 Free PMC article.
Glutamine, fatty liver disease and aging.
Simón J, Martínez-Chantar ML, Delgado TC. Simón J, et al. Aging (Albany NY). 2021 Feb 11;13(3):3165-3166. doi: 10.18632/aging.202666. Epub 2021 Feb 11. Aging (Albany NY). 2021. PMID: 33589573 Free PMC article. No abstract available.
NEDD8-specific protease 1 deficiency as a novel driver of hepatoblastoma development through dysregulation of the CAND1-NEDD8 pathway.
Zapata-Pavas LE, Serrano-Macia M, Merlos Rodrigo MÁ, Barrenechea-Barrenechea JA, Peña-SanFelix P, Del Río-Álvarez Á, Gil-Pitarch C, Rejano-Gordillo CM, Goikoetxea-Usandizaga N, González-Recio I, Michalkova H, Mercado-Gómez M, Lachiondo-Ortega S, Castañeda A, Asensio M, Murti A, Lelou E, Nogueiras R, Mayor U, Heger Z, Sancho-Bru P, Delgado TC, Calvisi DF, Xirodimas DP, Wang B, Marin JJG, Fernandez-Barrena MG, Armengol C, Ávila M, Martínez-Chantar ML. Zapata-Pavas LE, et al. Hepatology. 2025 Nov 14. doi: 10.1097/HEP.0000000000001614. Online ahead of print. Hepatology. 2025. PMID: 41236496
Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis.
Novoa E, Parracho T, Inderhees J, Rodriguez A, Riobello C, Iglesias-Moure J, Fernández-Iglesias A, Martinez-Martinez S, Senra A, Seoane S, Fondevila M, Iglesias C, Cabaleiro A, da Silva Lima N, Dorta V, López-Picallo B, Ramos-Lage L, Woodhoo A, Fidalgo M, Martínez-Chantar ML, Cubero FJ, López M, Dieguez C, Guallar D, Prevot V, Schwabe RF, Frühbeck G, Crespo J, Varela-Rey M, Gonzalez-Rellan MJ, Gracia-Sancho J, Iruzubieta P, Schwaninger M, Nogueiras R. Novoa E, et al. Cell Metab. 2026 Apr 7;38(4):729-745.e9. doi: 10.1016/j.cmet.2026.01.016. Epub 2026 Feb 23. Cell Metab. 2026. PMID: 41734768
Deregulated neddylation in liver fibrosis.
Zubiete-Franco I, Fernández-Tussy P, Barbier-Torres L, Simon J, Fernández-Ramos D, Lopitz-Otsoa F, Gutiérrez-de Juan V, de Davalillo SL, Duce AM, Iruzubieta P, Taibo D, Crespo J, Caballeria J, Villa E, Aurrekoetxea I, Aspichueta P, Varela-Rey M, Lu SC, Mato JM, Beraza N, Delgado TC, Martínez-Chantar ML. Zubiete-Franco I, et al. Hepatology. 2017 Feb;65(2):694-709. doi: 10.1002/hep.28933. Epub 2016 Dec 30. Hepatology. 2017. PMID: 28035772 Free PMC article.
Alcohol, DNA methylation, and cancer.
Varela-Rey M, Woodhoo A, Martinez-Chantar ML, Mato JM, Lu SC. Varela-Rey M, et al. Alcohol Res. 2013;35(1):25-35. doi: 10.35946/arcr.v35.1.04. Alcohol Res. 2013. PMID: 24313162 Free PMC article. Review.
Neddylation, a novel paradigm in liver cancer.
Delgado TC, Barbier-Torres L, Zubiete-Franco I, Lopitz-Otsoa F, Varela-Rey M, Fernández-Ramos D, Martínez-Chantar ML. Delgado TC, et al. Transl Gastroenterol Hepatol. 2018 Jun 30;3:37. doi: 10.21037/tgh.2018.06.05. eCollection 2018. Transl Gastroenterol Hepatol. 2018. PMID: 30050997 Free PMC article. Review.
Nutraceutical Properties of Polyphenols against Liver Diseases.
Simón J, Casado-Andrés M, Goikoetxea-Usandizaga N, Serrano-Maciá M, Martínez-Chantar ML. Simón J, et al. Nutrients. 2020 Nov 15;12(11):3517. doi: 10.3390/nu12113517. Nutrients. 2020. PMID: 33203174 Free PMC article. Review.
Systems biology for hepatologists.
Mato JM, Martínez-Chantar ML, Lu SC. Mato JM, et al. Hepatology. 2014 Aug;60(2):736-43. doi: 10.1002/hep.27023. Epub 2014 Jun 18. Hepatology. 2014. PMID: 24449428 Free PMC article. Review.
Relevance of transportome among the mechanisms of chemoresistance in hepatoblastoma.
Cives-Losada C, Asensio M, Briz O, Chinchilla-Tábora LM, Barranco MM, Río-Álvarez ÁD, Martinez-Chantar ML, Avila MA, Cairo S, Armengol C, Marin JJG, Macias RIR. Cives-Losada C, et al. Biochem Pharmacol. 2025 Jul;237:116914. doi: 10.1016/j.bcp.2025.116914. Epub 2025 Apr 2. Biochem Pharmacol. 2025. PMID: 40185314 Free article.
The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis.
Mercado-Gómez M, Goikoetxea-Usandizaga N, Kerbert AJC, Gracianteparaluceta LU, Serrano-Maciá M, Lachiondo-Ortega S, Rodriguez-Agudo R, Gil-Pitarch C, Simón J, González-Recio I, Fondevila MF, Santamarina-Ojeda P, Fraga MF, Nogueiras R, Heras JL, Jalan R, Martínez-Chantar ML, Delgado TC. Mercado-Gómez M, et al. Metabolism. 2024 Sep;158:155952. doi: 10.1016/j.metabol.2024.155952. Epub 2024 Jun 19. Metabolism. 2024. PMID: 38906371 Free article.
Hepatic HuR modulates glucose metabolism through the C/EBPβ/PCK1 pathway.
Lachiondo-Ortega S, González-Recio I, Bravo M, Gonzalez-Rellan MJ, Sanz-Parra A, Porteiro B, Goikoetxea-Usandizaga N, Rejano-Gordillo CM, Zapata-Pavas LE, Peña-Sanfélix P, Conter C, Barrenechea-Barrenechea JA, Mercado-Gómez M, Abruzzese GA, Ortega FJ, Aransay AM, Delgado TC, Frühbeck G, Gorospe M, Nogueiras R, Martínez-Chantar ML. Lachiondo-Ortega S, et al. Mol Metab. 2026 Mar 14;107:102354. doi: 10.1016/j.molmet.2026.102354. Online ahead of print. Mol Metab. 2026. PMID: 41839332 Free PMC article.
The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes.
Mercado-Gómez M, Prieto-Fernández E, Goikoetxea-Usandizaga N, Vila-Vecilla L, Azkargorta M, Bravo M, Serrano-Maciá M, Egia-Mendikute L, Rodríguez-Agudo R, Lachiondo-Ortega S, Lee SY, Eguileor Giné A, Gil-Pitarch C, González-Recio I, Simón J, Petrov P, Jover R, Martínez-Cruz LA, Ereño-Orbea J, Delgado TC, Elortza F, Jiménez-Barbero J, Nogueiras R, Prevot V, Palazon A, Martínez-Chantar ML. Mercado-Gómez M, et al. Commun Biol. 2022 Aug 17;5(1):827. doi: 10.1038/s42003-022-03789-9. Commun Biol. 2022. PMID: 35978143 Free PMC article.
A novel noninvasive test based on near-infrared fluorescent cholephilic probes for hepatobiliary secretory function assessment.
Sanchez de Blas B, Temprano AG, Cives-Losada C, Briz O, Lozano E, Martinez-Chantar ML, Avila MA, Mori M, Ghallab A, Hengstler JG, Perez-Melero C, Bermejo-Gonzalez FA, Monte MJ, Romero MR, Marin JJG. Sanchez de Blas B, et al. Biomed Pharmacother. 2025 Jun;187:118074. doi: 10.1016/j.biopha.2025.118074. Epub 2025 Apr 28. Biomed Pharmacother. 2025. PMID: 40300393 Free article.
Non-alcoholic fatty liver disease proteomics.
Rodríguez-Suárez E, Duce AM, Caballería J, Martínez Arrieta F, Fernández E, Gómara C, Alkorta N, Ariz U, Martínez-Chantar ML, Lu SC, Elortza F, Mato JM. Rodríguez-Suárez E, et al. Proteomics Clin Appl. 2010 Apr;4(4):362-71. doi: 10.1002/prca.200900119. Epub 2010 Feb 3. Proteomics Clin Appl. 2010. PMID: 21137056 Free PMC article.
Regulation of mammalian liver methionine adenosyltransferase.
Corrales FJ, Pérez-Mato I, Sánchez Del Pino MM, Ruiz F, Castro C, García-Trevijano ER, Latasa U, Martínez-Chantar ML, Martínez-Cruz A, Avila MA, Mato JM. Corrales FJ, et al. J Nutr. 2002 Aug;132(8 Suppl):2377S-2381S. doi: 10.1093/jn/132.8.2377S. J Nutr. 2002. PMID: 12163696 Free article.
Feasibility, safety, and outcome of second-line nivolumab/bevacizumab in liver transplant patients with recurrent hepatocellular carcinoma.
Di Marco L, Pivetti A, Foschi FG, D'Amico R, Schepis F, Caporali C, Casari F, Lasagni S, Critelli RM, Milosa F, Romanzi A, Marcelli G, De Maria N, Romagnoli D, Catellani B, Scianò F, Magistri P, Colecchia A, Sighinolfi P, Di Benedetto F, Martinez-Chantar ML, Villa E. Di Marco L, et al. Liver Transpl. 2023 May 1;29(5):559-563. doi: 10.1097/LVT.0000000000000087. Epub 2023 Feb 8. Liver Transpl. 2023. PMID: 36747351 Free PMC article. No abstract available.
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression.
Peñuelas-Haro I, Espinosa-Sotelo R, Crosas-Molist E, Herranz-Itúrbide M, Caballero-Díaz D, Alay A, Solé X, Ramos E, Serrano T, Martínez-Chantar ML, Knaus UG, Cuezva JM, Zorzano A, Bertran E, Fabregat I. Peñuelas-Haro I, et al. Hepatology. 2023 Aug 1;78(2):416-433. doi: 10.1002/hep.32702. Epub 2022 Sep 17. Hepatology. 2023. PMID: 35920301 Free PMC article.
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.
Feitelson MA, Arzumanyan A, Kulathinal RJ, Blain SW, Holcombe RF, Mahajna J, Marino M, Martinez-Chantar ML, Nawroth R, Sanchez-Garcia I, Sharma D, Saxena NK, Singh N, Vlachostergios PJ, Guo S, Honoki K, Fujii H, Georgakilas AG, Bilsland A, Amedei A, Niccolai E, Amin A, Ashraf SS, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Azmi AS, Bhakta D, Halicka D, Keith WN, Nowsheen S. Feitelson MA, et al. Semin Cancer Biol. 2015 Dec;35 Suppl(Suppl):S25-S54. doi: 10.1016/j.semcancer.2015.02.006. Epub 2015 Apr 17. Semin Cancer Biol. 2015. PMID: 25892662 Free PMC article. Review.
Hepatic p63 regulates steatosis via IKKβ/ER stress.
Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R. Porteiro B, et al. Nat Commun. 2017 May 8;8:15111. doi: 10.1038/ncomms15111. Nat Commun. 2017. PMID: 28480888 Free PMC article.
Designing a broad-spectrum integrative approach for cancer prevention and treatment.
Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Moha… See abstract for full author list ➔ Block KI, et al. Semin Cancer Biol. 2015 Dec;35 Suppl(Suppl):S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Semin Cancer Biol. 2015. PMID: 26590477 Free PMC article. Review.
Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis.
Peña-Cearra A, Castelo J, Lavín JL, Gonzalez-Lopez M, Pascual-Itoiz MA, Fuertes M, Gutiérrez de Juan V, Bárcena L, Martín-Ruiz I, Pellón A, Seoane I, Barriales D, Palacios A, Fullaondo A, Rodríguez-Lago I, Martinez-Chantar ML, Aransay AM, Rodriguez H, Anguita J, Abecia L. Peña-Cearra A, et al. Gut Microbes. 2023 Dec;15(2):2266626. doi: 10.1080/19490976.2023.2266626. Epub 2023 Oct 16. Gut Microbes. 2023. PMID: 37842919 Free PMC article.
Neddylation tunes peripheral blood mononuclear cells immune response in COVID-19 patients.
Serrano-Maciá M, Lachiondo-Ortega S, Iruzubieta P, Goikoetxea-Usandizaga N, Bosch A, Egia-Mendikute L, Jiménez-Lasheras B, Azkargorta M, Elortza F, Martinez-Redondo D, Castro B, Lozano JJ, Nogueiras R, Irure-Ventura J, Crespo J, Palazón A, Fariñas MC, Delgado TC, López-Hoyos M, Martínez-Chantar ML. Serrano-Maciá M, et al. Cell Death Discov. 2022 Jul 12;8(1):316. doi: 10.1038/s41420-022-01115-0. Cell Death Discov. 2022. PMID: 35831294 Free PMC article.
The disease-linked R336C mutation in cystathionine β-synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity.
Conter C, Núñez-Franco R, Al-Sadeq DW, Fernández-Rodríguez C, Goikoetxea-Usandizaga N, Nasrallah GK, Nomikos M, Martinez-Chantar ML, Astegno A, Jiménez-Osés G, Martínez-Cruz LA. Conter C, et al. FEBS J. 2025 Sep;292(18):4933-4954. doi: 10.1111/febs.70116. Epub 2025 May 6. FEBS J. 2025. PMID: 40327797
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.
Simon J, Nuñez-García M, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gómez-Santos B, Buqué X, Lopitz-Otsoa F, Goikoetxea-Usandizaga N, Serrano-Macia M, Rodriguez-Agudo R, Bizkarguenaga M, Zubiete-Franco I, Gutiérrez-de Juan V, Cabrera D, Alonso C, Iruzubieta P, Romero-Gomez M, van Liempd S, Castro A, Nogueiras R, Varela-Rey M, Falcón-Pérez JM, Villa E, Crespo J, Lu SC, Mato JM, Aspichueta P, Delgado TC, Martínez-Chantar ML. Simon J, et al. Cell Metab. 2020 Mar 3;31(3):605-622.e10. doi: 10.1016/j.cmet.2020.01.013. Epub 2020 Feb 21. Cell Metab. 2020. PMID: 32084378 Free PMC article.
Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH.
Simón J, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Ramos D, Sáenz de Urturi D, Gruskos JJ, Fernández-Tussy P, Lachiondo-Ortega S, González-Recio I, Rodríguez-Agudo R, Gutiérrez-de-Juan V, Rodríguez-Iruretagoyena B, Varela-Rey M, Gimenez-Mascarell P, Mercado-Gomez M, Gómez-Santos B, Fernandez-Rodriguez C, Lopitz-Otsoa F, Bizkarguenaga M, Dames S, Schaeper U, Martin F, Sabio G, Iruzubieta P, Crespo J, Aspichueta P, Chu KH, Buccella D, Martín C, Delgado TC, Martínez-Cruz LA, Martínez-Chantar ML. Simón J, et al. J Hepatol. 2021 Jul;75(1):34-45. doi: 10.1016/j.jhep.2021.01.043. Epub 2021 Feb 9. J Hepatol. 2021. PMID: 33571553 Free PMC article.
A morphological method for ammonia detection in liver.
Gutiérrez-de-Juan V, López de Davalillo S, Fernández-Ramos D, Barbier-Torres L, Zubiete-Franco I, Fernández-Tussy P, Simon J, Lopitz-Otsoa F, de Las Heras J, Iruzubieta P, Arias-Loste MT, Villa E, Crespo J, Andrade R, Lucena MI, Varela-Rey M, Lu SC, Mato JM, Delgado TC, Martínez-Chantar ML. Gutiérrez-de-Juan V, et al. PLoS One. 2017 Mar 20;12(3):e0173914. doi: 10.1371/journal.pone.0173914. eCollection 2017. PLoS One. 2017. PMID: 28319158 Free PMC article.
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen.
Rodríguez-Agudo R, Goikoetxea-Usandizaga N, Serrano-Maciá M, Fernández-Tussy P, Fernández-Ramos D, Lachiondo-Ortega S, González-Recio I, Gil-Pitarch C, Mercado-Gómez M, Morán L, Bizkarguenaga M, Lopitz-Otsoa F, Petrov P, Bravo M, Van Liempd SM, Falcon-Perez JM, Zabala-Letona A, Carracedo A, Castell JV, Jover R, Martínez-Cruz LA, Delgado TC, Cubero FJ, Lucena MI, Andrade RJ, Mabe J, Simón J, Martínez-Chantar ML. Rodríguez-Agudo R, et al. Antioxidants (Basel). 2022 Apr 30;11(5):897. doi: 10.3390/antiox11050897. Antioxidants (Basel). 2022. PMID: 35624761 Free PMC article.
Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity.
Fernández-Tussy P, Rodríguez-Agudo R, Fernández-Ramos D, Barbier-Torres L, Zubiete-Franco I, Davalillo SL, Herraez E, Goikoetxea-Usandizaga N, Lachiondo-Ortega S, Simón J, Lopitz-Otsoa F, Juan VG, McCain MV, Perugorria MJ, Mabe J, Navasa N, Rodrigues CMP, Fabregat I, Boix L, Sapena V, Anguita J, Lu SC, Mato JM, Banales JM, Villa E, Reeves HL, Bruix J, Reig M, Marin JJG, Delgado TC, Martínez-Chantar ML. Fernández-Tussy P, et al. Cell Death Dis. 2021 May 28;12(6):555. doi: 10.1038/s41419-021-03827-0. Cell Death Dis. 2021. PMID: 34050139 Free PMC article.
An update on the use of benzoate, phenylacetate and phenylbutyrate ammonia scavengers for interrogating and modifying liver nitrogen metabolism and its implications in urea cycle disorders and liver disease.
De Las Heras J, Aldámiz-Echevarría L, Martínez-Chantar ML, Delgado TC. De Las Heras J, et al. Expert Opin Drug Metab Toxicol. 2017 Apr;13(4):439-448. doi: 10.1080/17425255.2017.1262843. Epub 2016 Nov 28. Expert Opin Drug Metab Toxicol. 2017. PMID: 27860485 Free PMC article. Review.
Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.
Alonso C, Fernández-Ramos D, Varela-Rey M, Martínez-Arranz I, Navasa N, Van Liempd SM, Lavín Trueba JL, Mayo R, Ilisso CP, de Juan VG, Iruarrizaga-Lejarreta M, delaCruz-Villar L, Mincholé I, Robinson A, Crespo J, Martín-Duce A, Romero-Gómez M, Sann H, Platon J, Van Eyk J, Aspichueta P, Noureddin M, Falcón-Pérez JM, Anguita J, Aransay AM, Martínez-Chantar ML, Lu SC, Mato JM. Alonso C, et al. Gastroenterology. 2017 May;152(6):1449-1461.e7. doi: 10.1053/j.gastro.2017.01.015. Epub 2017 Jan 26. Gastroenterology. 2017. PMID: 28132890 Free PMC article.
Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis.
Shahrouzi P, Astobiza I, Cortazar AR, Torrano V, Macchia A, Flores JM, Niespolo C, Mendizabal I, Caloto R, Ercilla A, Camacho L, Arreal L, Bizkarguenaga M, Martinez-Chantar ML, Bustelo XR, Berra E, Kiss-Toth E, Velasco G, Zabala-Letona A, Carracedo A. Shahrouzi P, et al. Cancers (Basel). 2020 Sep 11;12(9):2593. doi: 10.3390/cancers12092593. Cancers (Basel). 2020. PMID: 32932846 Free PMC article.
Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
Serrano-Maciá M, Simón J, González-Rellan MJ, Azkargorta M, Goikoetxea-Usandizaga N, Lopitz-Otsoa F, De Urturi DS, Rodríguez-Agudo R, Lachiondo-Ortega S, Mercado-Gomez M, Gutiérrez de Juan V, Bizkarguenaga M, Fernández-Ramos D, Buque X, Baselli GA, Valenti LVC, Iruzubieta P, Crespo J, Villa E, Banales JM, Avila MA, Marin JJG, Aspichueta P, Sutherland J, Barrio R, Mayor U, Elortza F, Xirodimas DP, Nogueiras R, Delgado TC, Martínez-Chantar ML. Serrano-Maciá M, et al. Mol Metab. 2021 Nov;53:101275. doi: 10.1016/j.molmet.2021.101275. Epub 2021 Jun 18. Mol Metab. 2021. PMID: 34153521 Free PMC article.
PI3K-regulated Glycine N-methyltransferase is required for the development of prostate cancer.
Zabala-Letona A, Arruabarrena-Aristorena A, Fernandez-Ruiz S, Viera C, Carlevaris O, Ercilla A, Mendizabal I, Martin T, Macchia A, Camacho L, Pujana-Vaquerizo M, Sanchez-Mosquera P, Torrano V, Martin-Martin N, Zuniga-Garcia P, Castillo-Martin M, Ugalde-Olano A, Loizaga-Iriarte A, Unda M, Mato JM, Berra E, Martinez-Chantar ML, Carracedo A. Zabala-Letona A, et al. Oncogenesis. 2022 Feb 23;11(1):10. doi: 10.1038/s41389-022-00382-x. Oncogenesis. 2022. PMID: 35197445 Free PMC article.
Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress.
Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R. Porteiro B, et al. Nat Commun. 2017 Jun 16;8:16059. doi: 10.1038/ncomms16059. Nat Commun. 2017. PMID: 28621331 Free PMC article.
Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points.
Fondevila MF, Mercado-Gómez M, Rodríguez A, Gonzalez-Rellan MJ, Iruzubieta P, Valentí V, Escalada J, Schwaninger M, Prevot V, Dieguez C, Crespo J, Frühbeck G, Martinez-Chantar ML, Nogueiras R. Fondevila MF, et al. J Hepatol. 2021 Feb;74(2):469-471. doi: 10.1016/j.jhep.2020.09.027. Epub 2020 Oct 20. J Hepatol. 2021. PMID: 33096086 Free PMC article. No abstract available.
S-adenosylmethionine and proliferation: new pathways, new targets.
Martínez-López N, Varela-Rey M, Ariz U, Embade N, Vazquez-Chantada M, Fernandez-Ramos D, Gomez-Santos L, Lu SC, Mato JM, Martinez-Chantar ML. Martínez-López N, et al. Biochem Soc Trans. 2008 Oct;36(Pt 5):848-52. doi: 10.1042/BST0360848. Biochem Soc Trans. 2008. PMID: 18793149
The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis.
Carracedo A, Rousseau D, Douris N, Fernández-Ruiz S, Martín-Martín N, Weiss D, Webster K, Adams AC, Vazquez-Chantada M, Martinez-Chantar ML, Anty R, Tran A, Maratos-Flier E, Gual P, Pandolfi PP. Carracedo A, et al. Int J Biol Sci. 2015 Apr 11;11(6):629-32. doi: 10.7150/ijbs.11615. eCollection 2015. Int J Biol Sci. 2015. PMID: 25999785 Free PMC article. No abstract available.
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, Guitiérrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fernández-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hernández-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rincón M, Martínez-Chantar ML. Barbier-Torres L, et al. Nat Commun. 2017 Dec 12;8(1):2068. doi: 10.1038/s41467-017-01970-x. Nat Commun. 2017. PMID: 29233977 Free PMC article.
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.
Gonzalez-Rellan MJ, Fondevila MF, Fernandez U, Rodríguez A, Varela-Rey M, Veyrat-Durebex C, Seoane S, Bernardo G, Lopitz-Otsoa F, Fernández-Ramos D, Bilbao J, Iglesias C, Novoa E, Ameneiro C, Senra A, Beiroa D, Cuñarro J, Dp Chantada-Vazquez M, Garcia-Vence M, Bravo SB, Da Silva Lima N, Porteiro B, Carneiro C, Vidal A, Tovar S, Müller TD, Ferno J, Guallar D, Fidalgo M, Sabio G, Herzig S, Yang WH, Cho JW, Martinez-Chantar ML, Perez-Fernandez R, López M, Dieguez C, Mato JM, Millet O, Coppari R, Woodhoo A, Fruhbeck G, Nogueiras R. Gonzalez-Rellan MJ, et al. Nat Commun. 2021 Aug 20;12(1):5068. doi: 10.1038/s41467-021-25390-0. Nat Commun. 2021. PMID: 34417460 Free PMC article.
Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.
Ye H, Chen C, Wu H, Zheng K, Martín-Adrados B, Caparros E, Francés R, Nelson LJ, Gómez Del Moral M, Asensio I, Vaquero J, Bañares R, Ávila MA, Andrade RJ, Isabel Lucena M, Martínez-Chantar ML, Reeves HL, Masson S, Blumberg RS, Gracia-Sancho J, Nevzorova YA, Martínez-Naves E, Cubero FJ. Ye H, et al. Cell Death Dis. 2022 Feb 10;13(2):143. doi: 10.1038/s41419-022-04580-8. Cell Death Dis. 2022. PMID: 35145060 Free PMC article.
S-adenosylmethionine levels regulate the schwann cell DNA methylome.
Varela-Rey M, Iruarrizaga-Lejarreta M, Lozano JJ, Aransay AM, Fernandez AF, Lavin JL, Mósen-Ansorena D, Berdasco M, Turmaine M, Luka Z, Wagner C, Lu SC, Esteller M, Mirsky R, Jessen KR, Fraga MF, Martínez-Chantar ML, Mato JM, Woodhoo A. Varela-Rey M, et al. Neuron. 2014 Mar 5;81(5):1024-1039. doi: 10.1016/j.neuron.2014.01.037. Neuron. 2014. PMID: 24607226 Free PMC article.
MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis.
Fernández-Ramos D, Fernández-Tussy P, Lopitz-Otsoa F, Gutiérrez-de-Juan V, Navasa N, Barbier-Torres L, Zubiete-Franco I, Simón J, Fernández AF, Arbelaiz A, Aransay AM, Lavín JL, Beraza N, Perugorria MJ, Banales JM, Villa E, Fraga MF, Anguita J, Avila MA, Berasain C, Iruzibieta P, Crespo J, Lu SC, Varela-Rey M, Mato JM, Delgado TC, Martínez-Chantar ML. Fernández-Ramos D, et al. Cell Death Dis. 2018 Sep 20;9(10):958. doi: 10.1038/s41419-018-1014-y. Cell Death Dis. 2018. PMID: 30237481 Free PMC article.
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.
Martínez-Chantar ML, Vázquez-Chantada M, Garnacho M, Latasa MU, Varela-Rey M, Dotor J, Santamaria M, Martínez-Cruz LA, Parada LA, Lu SC, Mato JM. Martínez-Chantar ML, et al. Gastroenterology. 2006 Jul;131(1):223-32. doi: 10.1053/j.gastro.2006.04.019. Gastroenterology. 2006. PMID: 16831604
Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis.
Sáenz de Urturi D, Buqué X, Porteiro B, Folgueira C, Mora A, Delgado TC, Prieto-Fernández E, Olaizola P, Gómez-Santos B, Apodaka-Biguri M, González-Romero F, Nieva-Zuluaga A, Ruiz de Gauna M, Goikoetxea-Usandizaga N, García-Rodríguez JL, Gutierrez de Juan V, Aurrekoetxea I, Montalvo-Romeral V, Novoa EM, Martín-Guerrero I, Varela-Rey M, Bhanot S, Lee R, Banales JM, Syn WK, Sabio G, Martínez-Chantar ML, Nogueiras R, Aspichueta P. Sáenz de Urturi D, et al. Nat Commun. 2022 Mar 1;13(1):1096. doi: 10.1038/s41467-022-28749-z. Nat Commun. 2022. PMID: 35232994 Free PMC article.
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.
Barbier-Torres L, Delgado TC, García-Rodríguez JL, Zubiete-Franco I, Fernández-Ramos D, Buqué X, Cano A, Gutiérrez-de Juan V, Fernández-Domínguez I, Lopitz-Otsoa F, Fernández-Tussy P, Boix L, Bruix J, Villa E, Castro A, Lu SC, Aspichueta P, Xirodimas D, Varela-Rey M, Mato JM, Beraza N, Martínez-Chantar ML. Barbier-Torres L, et al. Oncotarget. 2015 Feb 10;6(4):2509-23. doi: 10.18632/oncotarget.3191. Oncotarget. 2015. PMID: 25650664 Free PMC article.
Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1.
Barbier-Torres L, Beraza N, Fernández-Tussy P, Lopitz-Otsoa F, Fernández-Ramos D, Zubiete-Franco I, Varela-Rey M, Delgado TC, Gutiérrez V, Anguita J, Pares A, Banales JM, Villa E, Caballería J, Alvarez L, Lu SC, Mato JM, Martínez-Chantar ML. Barbier-Torres L, et al. Hepatology. 2015 Oct;62(4):1237-48. doi: 10.1002/hep.27959. Epub 2015 Jul 31. Hepatology. 2015. PMID: 26109312 Free PMC article.
miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.
Fernández-Tussy P, Fernández-Ramos D, Lopitz-Otsoa F, Simón J, Barbier-Torres L, Gomez-Santos B, Nuñez-Garcia M, Azkargorta M, Gutiérrez-de Juan V, Serrano-Macia M, Rodríguez-Agudo R, Iruzubieta P, Anguita J, Castro RE, Champagne D, Rincón M, Elortza F, Arslanow A, Krawczyk M, Lammert F, Kirchmeyer M, Behrmann I, Crespo J, Lu SC, Mato JM, Varela-Rey M, Aspichueta P, Delgado TC, Martínez-Chantar ML. Fernández-Tussy P, et al. Mol Metab. 2019 Nov;29:40-54. doi: 10.1016/j.molmet.2019.08.008. Epub 2019 Aug 16. Mol Metab. 2019. PMID: 31668391 Free PMC article.
HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.
Palomo-Irigoyen M, Pérez-Andrés E, Iruarrizaga-Lejarreta M, Barreira-Manrique A, Tamayo-Caro M, Vila-Vecilla L, Moreno-Cugnon L, Beitia N, Medrano D, Fernández-Ramos D, Lozano JJ, Okawa S, Lavín JL, Martín-Martín N, Sutherland JD, de Juan VG, Gonzalez-Lopez M, Macías-Cámara N, Mosén-Ansorena D, Laraba L, Hanemann CO, Ercolano E, Parkinson DB, Schultz CW, Araúzo-Bravo MJ, Ascensión AM, Gerovska D, Iribar H, Izeta A, Pytel P, Krastel P, Provenzani A, Seneci P, Carrasco RD, Del Sol A, Martinez-Chantar ML, Barrio R, Serra E, Lazaro C, Flanagan AM, Gorospe M, Ratner N, Aransay AM, Carracedo A, Varela-Rey M, Woodhoo A. Palomo-Irigoyen M, et al. J Clin Invest. 2020 Jul 1;130(7):3848-3864. doi: 10.1172/JCI130379. J Clin Invest. 2020. PMID: 32315290 Free PMC article.
A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants.
Egia-Mendikute L, Bosch A, Prieto-Fernández E, Vila-Vecilla L, Zanetti SR, Lee SY, Jiménez-Lasheras B, García Del Río A, Antoñana-Vildosola A, de Blas A, Velasco-Beltrán P, Serrano-Maciá M, Iruzubieta P, Mehrpouyan M, Goldberg EM, Bornheimer SJ, Embade N, Martínez-Chantar ML, López-Hoyos M, Mato JM, Millet Ó, Palazón A. Egia-Mendikute L, et al. Front Immunol. 2022 Nov 24;13:1014309. doi: 10.3389/fimmu.2022.1014309. eCollection 2022. Front Immunol. 2022. PMID: 36505411 Free PMC article.
Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves.
Gomez-Sanchez JA, Carty L, Iruarrizaga-Lejarreta M, Palomo-Irigoyen M, Varela-Rey M, Griffith M, Hantke J, Macias-Camara N, Azkargorta M, Aurrekoetxea I, De Juan VG, Jefferies HB, Aspichueta P, Elortza F, Aransay AM, Martínez-Chantar ML, Baas F, Mato JM, Mirsky R, Woodhoo A, Jessen KR. Gomez-Sanchez JA, et al. J Cell Biol. 2015 Jul 6;210(1):153-68. doi: 10.1083/jcb.201503019. J Cell Biol. 2015. PMID: 26150392 Free PMC article.
Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals.
Egia-Mendikute L, Bosch A, Prieto-Fernández E, Lee SY, Jiménez-Lasheras B, García Del Río A, Antoñana-Vildosola A, Bruzzone C, Bizkarguenaga M, Embade N, Gil-Redondo R, Martínez-Chantar ML, López-Hoyos M, Abrescia NGA, Mato JM, Millet Ó, Palazón A. Egia-Mendikute L, et al. Commun Biol. 2021 Apr 20;4(1):486. doi: 10.1038/s42003-021-02011-6. Commun Biol. 2021. PMID: 33879833 Free PMC article.
Exogenous aralar/slc25a12 can replace citrin/slc25a13 as malate aspartate shuttle component in liver.
González-Moreno L, Santamaría-Cano A, Paradela A, Martínez-Chantar ML, Martín MÁ, Pérez-Carreras M, García-Picazo A, Vázquez J, Calvo E, González-Aseguinolaza G, Saheki T, Del Arco A, Satrústegui J, Contreras L. González-Moreno L, et al. Mol Genet Metab Rep. 2023 Mar 16;35:100967. doi: 10.1016/j.ymgmr.2023.100967. eCollection 2023 Jun. Mol Genet Metab Rep. 2023. PMID: 36967723 Free PMC article.
Corrigendum: mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. Zabala-Letona A, et al. Nature. 2018 Feb 22;554(7693):554. doi: 10.1038/nature25470. Epub 2018 Jan 17. Nature. 2018. PMID: 29342137
Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury.
Iruzubieta P, Goikoetxea-Usandizaga N, Barbier-Torres L, Serrano-Maciá M, Fernández-Ramos D, Fernández-Tussy P, Gutiérrez-de-Juan V, Lachiondo-Ortega S, Simon J, Bravo M, Lopitz-Otsoa F, Robles M, Ferre-Aracil C, Varela-Rey M, Elguezabal N, Calleja JL, Lu SC, Milkiewicz M, Milkiewicz P, Anguita J, Monte MJ, Marin JJG, López-Hoyos M, Delgado TC, Rincón M, Crespo J, Martínez-Chantar ML. Iruzubieta P, et al. JHEP Rep. 2021 Mar 18;3(3):100276. doi: 10.1016/j.jhepr.2021.100276. eCollection 2021 Jun. JHEP Rep. 2021. PMID: 33997750 Free PMC article.
Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart.
Barriales D, Martín-Ruiz I, Carreras-González A, Montesinos-Robledo M, Azkargorta M, Iloro I, Escobés I, Martín-Mateos T, Atondo E, Palacios A, Gonzalez-Lopez M, Bárcena L, Cortázar AR, Cabrera D, Peña-Cearra A, van Liempd SM, Falcón-Pérez JM, Pascual-Itoiz MA, Flores JM, Abecia L, Pellon A, Martínez-Chantar ML, Aransay AM, Pascual A, Elortza F, Berra E, Lavín JL, Rodríguez H, Anguita J. Barriales D, et al. PLoS Biol. 2021 Jan 4;19(1):e3001062. doi: 10.1371/journal.pbio.3001062. eCollection 2021 Jan. PLoS Biol. 2021. PMID: 33395408 Free PMC article.
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation.
Barbier-Torres L, Fortner KA, Iruzubieta P, Delgado TC, Giddings E, Chen Y, Champagne D, Fernández-Ramos D, Mestre D, Gomez-Santos B, Varela-Rey M, de Juan VG, Fernández-Tussy P, Zubiete-Franco I, García-Monzón C, González-Rodríguez Á, Oza D, Valença-Pereira F, Fang Q, Crespo J, Aspichueta P, Tremblay F, Christensen BC, Anguita J, Martínez-Chantar ML, Rincón M. Barbier-Torres L, et al. Nat Commun. 2020 Jul 3;11(1):3360. doi: 10.1038/s41467-020-16991-2. Nat Commun. 2020. PMID: 32620763 Free PMC article.
Sensitizing cholangiocarcinoma to chemotherapy by inhibition of the drug-export pump MRP3.
Asensio M, Briz O, Herraez E, Perez-Silva L, Espinosa-Escudero R, Bueno-Sacristan D, Peleteiro-Vigil A, Hammer H, Pötz O, Kadioglu O, Banales JM, Martinez-Chantar ML, Avila MA, Macias RIR, Efferth T, Marin JJG, Lozano E. Asensio M, et al. Biomed Pharmacother. 2024 Nov;180:117533. doi: 10.1016/j.biopha.2024.117533. Epub 2024 Oct 13. Biomed Pharmacother. 2024. PMID: 39405909 Free article.
Role of Aramchol in steatohepatitis and fibrosis in mice.
Iruarrizaga-Lejarreta M, Varela-Rey M, Fernández-Ramos D, Martínez-Arranz I, Delgado TC, Simon J, Juan VG, delaCruz-Villar L, Azkargorta M, Lavin JL, Mayo R, Van Liempd SM, Aurrekoetxea I, Buqué X, Cave DD, Peña A, Rodríguez-Cuesta J, Aransay AM, Elortza F, Falcón-Pérez JM, Aspichueta P, Hayardeny L, Noureddin M, Sanyal AJ, Alonso C, Anguita J, Martínez-Chantar ML, Lu SC, Mato JM. Iruarrizaga-Lejarreta M, et al. Hepatol Commun. 2017 Nov;1(9):911-927. doi: 10.1002/hep4.1107. Epub 2017 Oct 4. Hepatol Commun. 2017. PMID: 29159325 Free PMC article.
Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma.
Colyn L, Bárcena-Varela M, Álvarez-Sola G, Latasa MU, Uriarte I, Santamaría E, Herranz JM, Santos-Laso A, Arechederra M, Ruiz de Gauna M, Aspichueta P, Canale M, Casadei-Gardini A, Francesconi M, Carotti S, Morini S, Nelson LJ, Iraburu MJ, Chen C, Sangro B, Marin JJG, Martinez-Chantar ML, Banales JM, Arnes-Benito R, Huch M, Patino JM, Dar AA, Nosrati M, Oyarzábal J, Prósper F, Urman J, Cubero FJ, Trautwein C, Berasain C, Fernandez-Barrena MG, Avila MA. Colyn L, et al. Hepatology. 2021 Jun;73(6):2380-2396. doi: 10.1002/hep.31642. Hepatology. 2021. PMID: 33222246
Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models.
Lee-Law PY, Olaizola P, Caballero-Camino FJ, Izquierdo-Sanchez L, Rodrigues PM, Santos-Laso A, Azkargorta M, Elortza F, Martinez-Chantar ML, Perugorria MJ, Aspichueta P, Marzioni M, LaRusso NF, Bujanda L, Drenth JPH, Banales JM. Lee-Law PY, et al. J Hepatol. 2021 Feb;74(2):394-406. doi: 10.1016/j.jhep.2020.09.010. Epub 2020 Sep 17. J Hepatol. 2021. PMID: 32950589 Free PMC article.
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.
Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballería J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martínez-Chantar ML. Vázquez-Chantada M, et al. Gastroenterology. 2010 May;138(5):1943-53. doi: 10.1053/j.gastro.2010.01.032. Epub 2010 Jan 25. Gastroenterology. 2010. PMID: 20102719 Free PMC article.
Impact of lifestyle interventions targeting physical exercise and caloric intake on cirrhosis regression in rats.
Lafoz E, Campreciós G, García-Calderó H, Anton A, Vilaseca M, Ruart M, Guasch E, Garrabou G, Delgado TC, Martínez-Chantar ML, García-Martínez R, Gracia-Sancho J, Hernández-Gea V, García-Pagán JC. Lafoz E, et al. Am J Physiol Gastrointest Liver Physiol. 2021 Dec 1;321(6):G603-G616. doi: 10.1152/ajpgi.00191.2021. Epub 2021 Sep 29. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 34585619 Free article.
Structural insight into the unique conformation of cystathionine β-synthase from Toxoplasma gondii.
Fernández-Rodríguez C, Oyenarte I, Conter C, González-Recio I, Núñez-Franco R, Gil-Pitarch C, Quintana I, Jiménez-Osés G, Dominici P, Martinez-Chantar ML, Astegno A, Martínez-Cruz LA. Fernández-Rodríguez C, et al. Comput Struct Biotechnol J. 2021 Jun 6;19:3542-3555. doi: 10.1016/j.csbj.2021.05.052. eCollection 2021. Comput Struct Biotechnol J. 2021. PMID: 34194677 Free PMC article.
Metallothionein-3 is a multifunctional driver that modulates the development of sorafenib-resistant phenotype in hepatocellular carcinoma cells.
Rodrigo MAM, Michalkova H, Jimenez AMJ, Petrlak F, Do T, Sivak L, Haddad Y, Kubickova P, de Los Rios V, Casal JI, Serrano-Macia M, Delgado TC, Boix L, Bruix J, Martinez Chantar ML, Adam V, Heger Z. Rodrigo MAM, et al. Biomark Res. 2024 Apr 9;12(1):38. doi: 10.1186/s40364-024-00584-y. Biomark Res. 2024. PMID: 38594765 Free PMC article.
Microenvironment inflammatory infiltrate drives growth speed and outcome of hepatocellular carcinoma: a prospective clinical study.
Critelli R, Milosa F, Faillaci F, Condello R, Turola E, Marzi L, Lei B, Dituri F, Andreani S, Sighinolfi P, Manni P, Maiorana A, Caporali C, di Benedetto F, Del Buono M, De Maria N, Schepis F, Martinez-Chantar ML, Giannelli G, Villa E. Critelli R, et al. Cell Death Dis. 2017 Aug 24;8(8):e3017. doi: 10.1038/cddis.2017.395. Cell Death Dis. 2017. PMID: 28837142 Free PMC article.
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.
Embade N, Fernández-Ramos D, Varela-Rey M, Beraza N, Sini M, Gutiérrez de Juan V, Woodhoo A, Martínez-López N, Rodríguez-Iruretagoyena B, Bustamante FJ, de la Hoz AB, Carracedo A, Xirodimas DP, Rodríguez MS, Lu SC, Mato JM, Martínez-Chantar ML. Embade N, et al. Hepatology. 2012 Apr;55(4):1237-48. doi: 10.1002/hep.24795. Epub 2012 Mar 1. Hepatology. 2012. PMID: 22095636 Free PMC article.
Stratification and therapeutic potential of PML in metastatic breast cancer.
Martín-Martín N, Piva M, Urosevic J, Aldaz P, Sutherland JD, Fernández-Ruiz S, Arreal L, Torrano V, Cortazar AR, Planet E, Guiu M, Radosevic-Robin N, Garcia S, Macías I, Salvador F, Domenici G, Rueda OM, Zabala-Letona A, Arruabarrena-Aristorena A, Zúñiga-García P, Caro-Maldonado A, Valcárcel-Jiménez L, Sánchez-Mosquera P, Varela-Rey M, Martínez-Chantar ML, Anguita J, Ibrahim YH, Scaltriti M, Lawrie CH, Aransay AM, Iovanna JL, Baselga J, Caldas C, Barrio R, Serra V, Vivanco Md, Matheu A, Gomis RR, Carracedo A. Martín-Martín N, et al. Nat Commun. 2016 Aug 24;7:12595. doi: 10.1038/ncomms12595. Nat Commun. 2016. PMID: 27553708 Free PMC article.
The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis.
Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R. Fondevila MF, et al. Hepatology. 2021 Feb;73(2):606-624. doi: 10.1002/hep.31290. Epub 2020 Nov 13. Hepatology. 2021. PMID: 32329085 Free PMC article.
Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease.
Gómez-Santos B, Saenz de Urturi D, Nuñez-García M, Gonzalez-Romero F, Buque X, Aurrekoetxea I, Gutiérrez de Juan V, Gonzalez-Rellan MJ, García-Monzón C, González-Rodríguez Á, Mosteiro L, Errazti G, Mifsut P, Gaztambide S, Castaño L, Martin C, Nogueiras R, Martinez-Chantar ML, Syn WK, Aspichueta P. Gómez-Santos B, et al. Aging Cell. 2020 Aug;19(8):e13183. doi: 10.1111/acel.13183. Epub 2020 Jul 7. Aging Cell. 2020. PMID: 32638492 Free PMC article.
Upregulation of the oestrogen target gene SIX1 is associated with higher growth speed and decreased survival in HCV-positive women with hepatocellular carcinoma.
Critelli RM, Milosa F, Romanzi A, Lasagni S, Marcelli G, Di Marco L, Pivetti A, Schepis F, Romagnoli D, Mancarella S, Dituri F, Martinez-Chantar ML, Giannelli G, Villa E. Critelli RM, et al. Oncol Lett. 2022 Sep 21;24(5):395. doi: 10.3892/ol.2022.13515. eCollection 2022 Nov. Oncol Lett. 2022. PMID: 36276500 Free PMC article.
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.
García-Rodríguez JL, Barbier-Torres L, Fernández-Álvarez S, Gutiérrez-de Juan V, Monte MJ, Halilbasic E, Herranz D, Álvarez L, Aspichueta P, Marín JJ, Trauner M, Mato JM, Serrano M, Beraza N, Martínez-Chantar ML. García-Rodríguez JL, et al. Hepatology. 2014 May;59(5):1972-83. doi: 10.1002/hep.26971. Epub 2014 Mar 31. Hepatology. 2014. PMID: 24338587 Free PMC article.
Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis.
Zubiete-Franco I, García-Rodríguez JL, Martínez-Uña M, Martínez-Lopez N, Woodhoo A, Juan VG, Beraza N, Lage-Medina S, Andrade F, Fernandez ML, Aldámiz-Echevarría L, Fernández-Ramos D, Falcon-Perez JM, Lopitz-Otsoa F, Fernandez-Tussy P, Barbier-Torres L, Luka Z, Wagner C, García-Monzón C, Lu SC, Aspichueta P, Mato JM, Martínez-Chantar ML, Varela-Rey M. Zubiete-Franco I, et al. J Hepatol. 2016 Feb;64(2):409-418. doi: 10.1016/j.jhep.2015.08.037. Epub 2015 Sep 21. J Hepatol. 2016. PMID: 26394163 Free PMC article.
Causes of hOCT1-Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor-Selective Gene Therapy.
Lozano E, Macias RIR, Monte MJ, Asensio M, Del Carmen S, Sanchez-Vicente L, Alonso-Peña M, Al-Abdulla R, Munoz-Garrido P, Satriano L, O'Rourke CJ, Banales JM, Avila MA, Martinez-Chantar ML, Andersen JB, Briz O, Marin JJG. Lozano E, et al. Hepatology. 2019 Oct;70(4):1246-1261. doi: 10.1002/hep.30656. Epub 2019 May 20. Hepatology. 2019. PMID: 30972782
Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis.
Banales JM, Iñarrairaegui M, Arbelaiz A, Milkiewicz P, Muntané J, Muñoz-Bellvis L, La Casta A, Gonzalez LM, Arretxe E, Alonso C, Martínez-Arranz I, Lapitz A, Santos-Laso A, Avila MA, Martínez-Chantar ML, Bujanda L, Marin JJG, Sangro B, Macias RIR. Banales JM, et al. Hepatology. 2019 Aug;70(2):547-562. doi: 10.1002/hep.30319. Epub 2019 Feb 14. Hepatology. 2019. PMID: 30325540 Free PMC article.
Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis.
Espinosa-Diez C, Fierro-Fernández M, Sánchez-Gómez F, Rodríguez-Pascual F, Alique M, Ruiz-Ortega M, Beraza N, Martínez-Chantar ML, Fernández-Hernando C, Lamas S. Espinosa-Diez C, et al. Antioxid Redox Signal. 2015 Nov 10;23(14):1092-105. doi: 10.1089/ars.2014.6025. Epub 2015 Jan 9. Antioxid Redox Signal. 2015. PMID: 25353619 Free PMC article.
Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease.
Blokker BA, Maijo M, Echeandia M, Galduroz M, Patterson AM, Ten A, Philo M, Schungel R, Gutierrez-de Juan V, Halilbasic E, Fuchs C, Le Gall G, Milkiewicz M, Milkiewicz P, Banales JM, Rushbrook SM, Mato JM, Trauner M, Müller M, Martínez-Chantar ML, Varela-Rey M, Beraza N. Blokker BA, et al. Hepatology. 2019 Feb;69(2):699-716. doi: 10.1002/hep.30275. Hepatology. 2019. PMID: 30229970 Free PMC article.
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer.
Zubiete-Franco I, García-Rodríguez JL, Lopitz-Otsoa F, Serrano-Macia M, Simon J, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gutiérrez-de-Juan V, López de Davalillo S, Carlevaris O, Beguiristain Gómez A, Villa E, Calvisi D, Martín C, Berra E, Aspichueta P, Beraza N, Varela-Rey M, Ávila M, Rodríguez MS, Mato JM, Díaz-Moreno I, Díaz-Quintana A, Delgado TC, Martínez-Chantar ML. Zubiete-Franco I, et al. EBioMedicine. 2019 Feb;40:406-421. doi: 10.1016/j.ebiom.2018.12.031. Epub 2018 Dec 26. EBioMedicine. 2019. PMID: 30594553 Free PMC article.
Identification of a gene-pathway associated with non-alcoholic steatohepatitis.
Rubio A, Guruceaga E, Vázquez-Chantada M, Sandoval J, Martínez-Cruz LA, Segura V, Sevilla JL, Podhorski A, Corrales FJ, Torres L, Rodríguez M, Aillet F, Ariz U, Arrieta FM, Caballería J, Martín-Duce A, Lu SC, Martínez-Chantar ML, Mato JM. Rubio A, et al. J Hepatol. 2007 Apr;46(4):708-18. doi: 10.1016/j.jhep.2006.10.021. Epub 2006 Nov 30. J Hepatol. 2007. PMID: 17275126 Free article.
Sirtuin 1 regulation of developmental genes during differentiation of stem cells.
Calvanese V, Lara E, Suárez-Alvarez B, Abu Dawud R, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, Andrews PW, López-Larrea C, Esteller M, Fraga MF. Calvanese V, et al. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13736-41. doi: 10.1073/pnas.1001399107. Epub 2010 Jul 14. Proc Natl Acad Sci U S A. 2010. PMID: 20631301 Free PMC article.
Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH).
Alvarado-Tapias E, Maya-Miles D, Albillos A, Aller R, Ampuero J, Andrade RJ, Arechederra M, Aspichueta P, Banales JM, Blas-García A, Caparros E, Cardoso Delgado T, Carrillo-Vico A, Claria J, Cubero FJ, Díaz-Ruiz A, Fernández-Barrena MG, Fernández-Iglesias A, Fernández-Veledo S, Francés R, Gallego-Durán R, Gracia-Sancho J, Irimia M, Lens S, Martínez-Chantar ML, Mínguez B, Muñoz-Hernández R, Nogueiras R, Ramos-Molina B, Riveiro-Barciela M, Rodríguez-Perálvarez ML, Romero-Gómez M, Sabio G, Sancho-Bru P, Ventura-Cots M, Vidal S, Gahete MD. Alvarado-Tapias E, et al. Gastroenterol Hepatol. 2024 Dec;47(10):502207. doi: 10.1016/j.gastrohep.2024.502207. Epub 2024 May 8. Gastroenterol Hepatol. 2024. PMID: 38723772 Free article. English, Spanish.
Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis.
Martínez-López N, Varela-Rey M, Fernández-Ramos D, Woodhoo A, Vázquez-Chantada M, Embade N, Espinosa-Hevia L, Bustamante FJ, Parada LA, Rodriguez MS, Lu SC, Mato JM, Martínez-Chantar ML. Martínez-López N, et al. Hepatology. 2010 Nov;52(5):1621-31. doi: 10.1002/hep.23860. Hepatology. 2010. PMID: 20815019 Free PMC article.
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease.
Lee-Law PY, Olaizola P, Caballero-Camino FJ, Izquierdo-Sanchez L, Rodrigues PM, Perugorria MJ, Azkargorta M, Elortza F, Martinez-Chantar ML, Aspichueta P, Marzioni M, Bujanda L, Drenth JPH, Banales JM. Lee-Law PY, et al. United European Gastroenterol J. 2021 Sep;9(7):848-859. doi: 10.1002/ueg2.12126. Epub 2021 Jul 26. United European Gastroenterol J. 2021. PMID: 34310849 Free PMC article.
Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes.
Cano A, Vazquez-Chantada M, Conde-Vancells J, Gonzalez-Lahera A, Mosen-Ansorena D, Blanco FJ, Clément K, Aron-Wisnewsky J, Tran A, Gual P, García-Monzón C, Caballería J, Castro A, Martínez-Chantar ML, Mato JM, Zhu H, Finnell RH, Aransay AM. Cano A, et al. Biomedicines. 2023 Jan 31;11(2):337. doi: 10.3390/biomedicines11020337. Biomedicines. 2023. PMID: 36830876 Free PMC article.
Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis.
Martínez-Uña M, Varela-Rey M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martínez-Arranz I, García-Rodríguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martínez-Chantar ML, Aspichueta P, Mato JM. Martínez-Uña M, et al. Hepatology. 2013 Oct;58(4):1296-305. doi: 10.1002/hep.26399. Epub 2013 Aug 14. Hepatology. 2013. PMID: 23505042 Free PMC article.
Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
Giménez-Mascarell P, Oyenarte I, Hardy S, Breiderhoff T, Stuiver M, Kostantin E, Diercks T, Pey AL, Ereño-Orbea J, Martínez-Chantar ML, Khalaf-Nazzal R, Claverie-Martin F, Müller D, Tremblay ML, Martínez-Cruz LA. Giménez-Mascarell P, et al. J Biol Chem. 2017 Jan 20;292(3):786-801. doi: 10.1074/jbc.M116.759944. Epub 2016 Nov 29. J Biol Chem. 2017. PMID: 27899452 Free PMC article.
The Neoangiogenic Transcriptomic Signature Impacts Hepatocellular Carcinoma Prognosis and Can Be Triggered by Transarterial Chemoembolization Treatment.
Critelli RM, Casari F, Borghi A, Serino G, Caporali C, Magistri P, Pecchi A, Shahini E, Milosa F, Di Marco L, Pivetti A, Lasagni S, Schepis F, De Maria N, Dituri F, Martínez-Chantar ML, Di Benedetto F, Giannelli G, Villa E. Critelli RM, et al. Cancers (Basel). 2024 Oct 21;16(20):3549. doi: 10.3390/cancers16203549. Cancers (Basel). 2024. PMID: 39456643 Free PMC article.
Obesity-dependent metabolic signatures associated with nonalcoholic fatty liver disease progression.
Barr J, Caballería J, Martínez-Arranz I, Domínguez-Díez A, Alonso C, Muntané J, Pérez-Cormenzana M, García-Monzón C, Mayo R, Martín-Duce A, Romero-Gómez M, Lo Iacono O, Tordjman J, Andrade RJ, Pérez-Carreras M, Le Marchand-Brustel Y, Tran A, Fernández-Escalante C, Arévalo E, García-Unzueta M, Clement K, Crespo J, Gual P, Gómez-Fleitas M, Martínez-Chantar ML, Castro A, Lu SC, Vázquez-Chantada M, Mato JM. Barr J, et al. J Proteome Res. 2012 Apr 6;11(4):2521-32. doi: 10.1021/pr201223p. Epub 2012 Mar 15. J Proteome Res. 2012. PMID: 22364559 Free PMC article.
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF. Lara E, et al. Oncogene. 2009 Feb 12;28(6):781-91. doi: 10.1038/onc.2008.436. Epub 2008 Dec 8. Oncogene. 2009. PMID: 19060927
S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease.
Martínez-Uña M, Varela-Rey M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, Gutiérrez-de Juan V, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, García-Monzón C, Finnell RH, Aurrekoetxea I, Buqué X, Martínez-Chantar ML, Mato JM, Aspichueta P. Martínez-Uña M, et al. J Hepatol. 2015 Mar;62(3):673-81. doi: 10.1016/j.jhep.2014.10.019. Epub 2014 Oct 18. J Hepatol. 2015. PMID: 25457203 Free PMC article.
S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.
Lozano-Sepulveda SA, Bautista-Osorio E, Merino-Mascorro JA, Varela-Rey M, Muñoz-Espinosa LE, Cordero-Perez P, Martinez-Chantar ML, Rivas-Estilla AM. Lozano-Sepulveda SA, et al. World J Gastroenterol. 2016 Apr 14;22(14):3746-57. doi: 10.3748/wjg.v22.i14.3746. World J Gastroenterol. 2016. PMID: 27076759 Free PMC article.
Human antigen R contributes to hepatic stellate cell activation and liver fibrosis.
Woodhoo A, Iruarrizaga-Lejarreta M, Beraza N, García-Rodríguez JL, Embade N, Fernández-Ramos D, Martínez-López N, Gutiérrez-De Juan V, Arteta B, Caballeria J, Lu SC, Mato JM, Varela-Rey M, Martínez-Chantar ML. Woodhoo A, et al. Hepatology. 2012 Nov;56(5):1870-82. doi: 10.1002/hep.25828. Epub 2012 Oct 9. Hepatology. 2012. PMID: 22576182 Free PMC article.
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis.
Mercado-Gómez M, Lopitz-Otsoa F, Azkargorta M, Serrano-Maciá M, Lachiondo-Ortega S, Goikoetxea-Usandizaga N, Rodríguez-Agudo R, Fernández-Ramos D, Bizkarguenaga M, Juan VG, Lectez B, Aloria K, Arizmendi JM, Simon J, Alonso C, Lozano JJ, Avila MA, Banales JM, Marin JJG, Beraza N, Mato JM, Elortza F, Barrio R, Sutherland JD, Mayor U, Martínez-Chantar ML, Delgado TC. Mercado-Gómez M, et al. Int J Mol Sci. 2020 Nov 27;21(23):9043. doi: 10.3390/ijms21239043. Int J Mol Sci. 2020. PMID: 33261190 Free PMC article.
Purification, crystallization and preliminary X-ray diffraction analysis of the CBS-domain pair from the Methanococcus jannaschii protein MJ0100.
Lucas M, Kortazar D, Astigarraga E, Fernández JA, Mato JM, Martínez-Chantar ML, Martínez-Cruz LA. Lucas M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Oct 1;64(Pt 10):936-41. doi: 10.1107/S1744309108027930. Epub 2008 Sep 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008. PMID: 18931440 Free PMC article.
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma.
Huidobro C, Toraño EG, Fernández AF, Urdinguio RG, Rodríguez RM, Ferrero C, Martínez-Camblor P, Boix L, Bruix J, García-Rodríguez JL, Varela-Rey M, Mato JM, Martínez-Chantar ML, Fraga MF. Huidobro C, et al. J Mol Med (Berl). 2013 Aug;91(8):939-50. doi: 10.1007/s00109-013-1010-8. Epub 2013 Mar 12. J Mol Med (Berl). 2013. PMID: 23475283
Endothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after liver transplantation.
Lasagni S, Leonardi F, Pivetti A, Di Marco L, Ravaioli F, Serenari M, Gitto S, Critelli RM, Milosa F, Romanzi A, Mancarella S, Dituri F, Riefolo M, Catellani B, Magistri P, Romagnoli D, Celsa C, Enea M, de Maria N, Schepis F, Colecchia A, Cammà C, Cescon M, d'Errico A, di Benedetto F, Giannelli G, Martinez-Chantar ML, Villa E. Lasagni S, et al. Front Oncol. 2022 Sep 8;12:960808. doi: 10.3389/fonc.2022.960808. eCollection 2022. Front Oncol. 2022. PMID: 36158651 Free PMC article.
New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming.
Colyn L, Alvarez-Sola G, Latasa MU, Uriarte I, Herranz JM, Arechederra M, Vlachogiannis G, Rae C, Pineda-Lucena A, Casadei-Gardini A, Pedica F, Aldrighetti L, López-López A, López-Gonzálvez A, Barbas C, Ciordia S, Van Liempd SM, Falcón-Pérez JM, Urman J, Sangro B, Vicent S, Iraburu MJ, Prosper F, Nelson LJ, Banales JM, Martinez-Chantar ML, Marin JJG, Braconi C, Trautwein C, Corrales FJ, Cubero FJ, Berasain C, Fernandez-Barrena MG, Avila MA. Colyn L, et al. J Exp Clin Cancer Res. 2022 May 26;41(1):183. doi: 10.1186/s13046-022-02386-2. J Exp Clin Cancer Res. 2022. PMID: 35619118 Free PMC article.
246 results