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Page 1
Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult.
Li J, Sun Z, Luo G, Wang S, Cui H, Yao Z, Xiong H, He Y, Qian Y, Fan C. Li J, et al. Front Immunol. 2021 May 20;12:649285. doi: 10.3389/fimmu.2021.649285. eCollection 2021. Front Immunol. 2021. PMID: 34093537 Free PMC article.
Macrophage depletion by clodronate liposomes and mast cell stabilization by cromolyn sodium significantly impeded HO formation. Therefore, we proposed that the dietary phytochemical quercetin could also suppress immune cell recruitment and relat …
Macrophage depletion by clodronate liposomes and mast cell stabilization by cromolyn sodium significantly impeded HO fo …
Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans.
Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. Weng Z, et al. PLoS One. 2012;7(3):e33805. doi: 10.1371/journal.pone.0033805. Epub 2012 Mar 28. PLoS One. 2012. PMID: 22470478 Free PMC article.
Contact dermatitis and photosensitivity are skin conditions that involve non-immune triggers such as substance P (SP), and do not respond to conventional treatment. Inhibition of mast cell cytokine release could be effective therapy for such diseases. Unfortunately, …
Contact dermatitis and photosensitivity are skin conditions that involve non-immune triggers such as substance P (SP), and do not respond to …
Mast cells promote viral entry of SARS-CoV-2 via formation of chymase/spike protein complex.
Liu S, Suzuki Y, Takemasa E, Watanabe R, Mogi M. Liu S, et al. Eur J Pharmacol. 2022 Sep 5;930:175169. doi: 10.1016/j.ejphar.2022.175169. Epub 2022 Jul 31. Eur J Pharmacol. 2022. PMID: 35921955 Free PMC article.
Pseudovirions, in which the spike glycoprotein of SARS-CoV-2 was incorporated, triggered activation of mast cells, and a mast cell-derived chymase, MCP2, formed a complex with spike protein, which promoted protease-dependent viral entry. According to t …
Pseudovirions, in which the spike glycoprotein of SARS-CoV-2 was incorporated, triggered activation of mast cells, and a ma …
Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCepsilon-dependent activation of TRPV1.
Gao W, Zan Y, Wang ZJ, Hu XY, Huang F. Gao W, et al. Acta Pharmacol Sin. 2016 Sep;37(9):1166-77. doi: 10.1038/aps.2016.58. Epub 2016 Aug 8. Acta Pharmacol Sin. 2016. PMID: 27498772 Free PMC article.
AIM: Severe painful sensory neuropathy often occurs during paclitaxel chemotherapy. Since paclitaxel can activate mast cell and basophils, whereas quercetin, a polyphenolic flavonoid contained in various plants, which can specifically inhibit histamine releas …
AIM: Severe painful sensory neuropathy often occurs during paclitaxel chemotherapy. Since paclitaxel can activate mast cell an …
Effect of quercetin and Albizzia saponins on rat mast cell.
Johri RK, Zutshi U, Kameshwaran L, Atal CK. Johri RK, et al. Indian J Physiol Pharmacol. 1985 Jan-Mar;29(1):43-6. Indian J Physiol Pharmacol. 1985. PMID: 3932203
In the present work the effect of quercetin obtained from (Allium cepa). Albizzia lebbek (crude extract of seeds) and a pure saponin fraction of Albizzia has been studied on the mast cells in the mesentery and peritoneal fluid of rats subjected to anaphylaxis …
In the present work the effect of quercetin obtained from (Allium cepa). Albizzia lebbek (crude extract of seeds) and a pure saponin …
Quercetin inhibits Mrgprx2-induced pseudo-allergic reaction via PLCgamma-IP3R related Ca(2+) fluctuations.
Ding Y, Che D, Li C, Cao J, Wang J, Ma P, Zhao T, An H, Zhang T. Ding Y, et al. Int Immunopharmacol. 2019 Jan;66:185-197. doi: 10.1016/j.intimp.2018.11.025. Epub 2018 Nov 21. Int Immunopharmacol. 2019. PMID: 30471617
Therefore, the purpose of this study was to evaluate the anti-pseudo-allergic effect of Quercetin in vivo and to explore the mechanism in vitro. The anti-pseudo-allergic activity of Quercetin was evaluated in vivo using a mouse model, while Quercetin mechanis …
Therefore, the purpose of this study was to evaluate the anti-pseudo-allergic effect of Quercetin in vivo and to explore the mechanis …
Double Emulsion-Mediated Delivery of Polyphenol Mixture Alleviates Atopic Dermatitis.
Choi S, Ko J, Park SB, Kim JY, Ha JH, Roh S, An YH, Hwang NS. Choi S, et al. Adv Healthc Mater. 2023 Dec;12(30):e2300998. doi: 10.1002/adhm.202300998. Epub 2023 Sep 17. Adv Healthc Mater. 2023. PMID: 37677107
Through the in vitro anti-degranulation assay, the optimal molar ratio of each polyphenol (Q:P:E = 5:1:1) is obtained, and the PM shows at most a 43.6% reduction of degranulation of immune cells, which is the primary factor of AD. Moreover, the water-in-oil-in-water double …
Through the in vitro anti-degranulation assay, the optimal molar ratio of each polyphenol (Q:P:E = 5:1:1) is obtained, and the PM shows at m …
Role of mast cells in gastrointestinal mucosal defense.
Penissi AB, Rudolph MI, Piezzi RS. Penissi AB, et al. Biocell. 2003 Aug;27(2):163-72. Biocell. 2003. PMID: 14510234 Review.
Few molecules are known to possess both mast cell stabilizing and gastrointestinal cytoprotective activity. These include zinc compounds, sodium cromoglycate, FPL 52694, ketotifen, aloe vera, certain flavonoids such as quercetin, some sulfated proteogl …
Few molecules are known to possess both mast cell stabilizing and gastrointestinal cytoprotective activity. These inclu …
The role of mast cells in mucosal permeability changes during ischemia-reperfusion injury of the small intestine.
Szabó A, Boros M, Kaszaki J, Nagy S. Szabó A, et al. Shock. 1997 Oct;8(4):284-91. doi: 10.1097/00024382-199710000-00008. Shock. 1997. PMID: 9329130
The rates of changes in permeability of the mucosa to sodium fluorescein (NaFL) in the plasma-to-lumen and lumen-to-plasma directions were studied, the local hemodynamics, intramucosal pH (pHi) alterations, mast cell number and degranulation, and degree of tissue in …
The rates of changes in permeability of the mucosa to sodium fluorescein (NaFL) in the plasma-to-lumen and lumen-to-plasma directions were s …
A topical formulation containing quercetin-loaded microcapsules protects against oxidative and inflammatory skin alterations triggered by UVB irradiation: enhancement of activity by microencapsulation.
Vale DL, Martinez RM, Medeiros DC, da Rocha C, Sfeir N, Lopez RFV, Vicentini FTMC, Verri WA Jr, Georgetti SR, Baracat MM, Casagrande R. Vale DL, et al. J Drug Target. 2021 Nov;29(9):983-997. doi: 10.1080/1061186X.2021.1898621. Epub 2021 Mar 15. J Drug Target. 2021. PMID: 33685319
Thus, this study evaluated whether microencapsulation of QC would enhance its activity in comparison with the same dose of free QC (non-active dose) and unloaded-microcapsules added in formulation for topical administration in a mouse model of UVB irradiation targeting the skin. …
Thus, this study evaluated whether microencapsulation of QC would enhance its activity in comparison with the same dose of free QC (non-acti …
17 results