The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA.
Nucleic Acids Res. 1999.
PMID: 9973615
Free PMC article.
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A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease.
EMBO J. 2011.
PMID: 21811236
Free PMC article.
MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation.
Nucleic Acids Res. 2005.
PMID: 16396833
Free PMC article.
Search results
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The 5.8S pre-rRNA maturation factor, M-phase phosphoprotein 6, is a female fertility factor required for oocyte quality and meiosis.
Cell Prolif. 2020 Mar;53(3):e12769. doi: 10.1111/cpr.12769. Epub 2020 Jan 31.
Cell Prolif. 2020.
PMID: 32003502
Free PMC article.
MPP6 depletion significantly impeded oocyte meiosis. MPP6 depletion increased 5.8S pre-rRNA. The mRNA levels of MPP6 and 5.8S rRNA decreased within ageing oocytes, and MPP6 mRNA injection partially increased 5.8S rRNA mat …
MPP6 depletion significantly impeded oocyte meiosis. MPP6 depletion increased 5.8S pre-rRNA. The mRNA levels of MPP6 and 5 …
The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.
Genes Dev. 1996 Feb 15;10(4):502-13. doi: 10.1101/gad.10.4.502.
Genes Dev. 1996.
PMID: 8600032
Free article.
In yeast strains carrying the temperature-sensitive (ts) rrp4-1 mutation, 5.8S rRNA species were observed with 3' extensions of variable length extending up to the 3' end of the 7S pre-rRNA. These 3'-extended 5.8S rRNA species were observ …
In yeast strains carrying the temperature-sensitive (ts) rrp4-1 mutation, 5.8S rRNA species were observed with 3' exten …
5.8S rRNA forms and ribosome heterogeneity in breast cancer.
Biochimie. 2025 Nov;238(Pt A):57-64. doi: 10.1016/j.biochi.2025.05.010. Epub 2025 May 28.
Biochimie. 2025.
PMID: 40446902
Free article.
Here we investigated the relative abundance of the three 5.8S rRNA isoforms in different contexts. Analyzing total and polysomal RNA from cancer cell lines we detected all the three forms recruited in actively translating ribosomes consistently to the …
Here we investigated the relative abundance of the three 5.8S rRNA isoforms in different contexts. Analyzing total and …
A Novel Model for the RNase MRP-Induced Switch between the Formation of Different Forms of 5.8S rRNA.
Int J Mol Sci. 2021 Jun 22;22(13):6690. doi: 10.3390/ijms22136690.
Int J Mol Sci. 2021.
PMID: 34206573
Free PMC article.
Processing of the RNA polymerase I pre-rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs requires removing the "spacer" sequences. ...The process can generate either a long or a short 5.8S rRNA that differs in the number of …
Processing of the RNA polymerase I pre-rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs requires removin …
Disruption of U8 nucleolar snRNA inhibits 5.8S and 28S rRNA processing in the Xenopus oocyte.
Cell. 1993 Jun 18;73(6):1233-45. doi: 10.1016/0092-8674(93)90651-6.
Cell. 1993.
PMID: 8513505
Antisense deoxyoligonucleotides were microinjected into Xenopus oocytes to deplete the endogenous pool of U8 RNA. Analysis of the mature rRNAs and rRNA intermediates that accumulate in the U8-depleted oocytes indicate that the U8 snRNP is essential for correct ma …
Antisense deoxyoligonucleotides were microinjected into Xenopus oocytes to deplete the endogenous pool of U8 RNA. Analysis of the …
MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation.
Nucleic Acids Res. 2005 Dec 7;33(21):6795-804. doi: 10.1093/nar/gki982. Print 2005.
Nucleic Acids Res. 2005.
PMID: 16396833
Free PMC article.
In agreement with its nucleolar accumulation, siRNA-mediated knock-down experiments revealed that MPP6 is involved in the generation of the 3' end of the 5.8S rRNA. The accumulation of the same processing intermediates after reducing the levels of either MPP6 …
In agreement with its nucleolar accumulation, siRNA-mediated knock-down experiments revealed that MPP6 is involved in the generation of the …
RRP5 is required for formation of both 18S and 5.8S rRNA in yeast.
EMBO J. 1996 Oct 15;15(20):5701-14.
EMBO J. 1996.
PMID: 8896463
Free PMC article.
Three of the four eukaryotic ribosomal RNA molecules (18S, 5.8S and 25-28S) are synthesized as a single precursor which is subsequently processed into the mature rRNAs by a complex series of cleavage and modification reactions. ...Genetic deplet …
Three of the four eukaryotic ribosomal RNA molecules (18S, 5.8S and 25-28S) are synthesized as a single precurso …
A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease.
EMBO J. 2011 Aug 2;30(19):4006-19. doi: 10.1038/emboj.2011.256.
EMBO J. 2011.
PMID: 21811236
Free PMC article.
The major 5.8S 5'-end is generated by Rat1 digestion of the internal transcribed spacer 1 (ITS1) spacer from cleavage site A(3). ...We predict that Nop4 and the A(3) cluster establish long-range interactions between the 5.8S and 25S rRNAs, which …
The major 5.8S 5'-end is generated by Rat1 digestion of the internal transcribed spacer 1 (ITS1) spacer from cleavage s …
The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA.
Nucleic Acids Res. 1999 Mar 1;27(5):1283-8. doi: 10.1093/nar/27.5.1283.
Nucleic Acids Res. 1999.
PMID: 9973615
Free PMC article.
Individual exosome subunits have been implicated in the 3' maturation of the 5.8S rRNA found in 60S ribosomes and the 3' degradation of mRNAs. However, instead of being deficient in 60S ribosomes, Rrp43p-depleted cells were deficient in 40S ribosomes. …
Individual exosome subunits have been implicated in the 3' maturation of the 5.8S rRNA found in 60S ribosomes an …
rRNA maturation in yeast cells depleted of large ribosomal subunit proteins.
PLoS One. 2009 Dec 11;4(12):e8249. doi: 10.1371/journal.pone.0008249.
PLoS One. 2009.
PMID: 20011513
Free PMC article.
The structural constituents of the large eukaryotic ribosomal subunit are 3 ribosomal RNAs, namely the 25S, 5.8S and 5S rRNA and about 46 ribosomal proteins (r-proteins). ...Detailed steady state and metabolic pulse labelling analyses of rRNA pr …
The structural constituents of the large eukaryotic ribosomal subunit are 3 ribosomal RNAs, namely the 25S, 5.8S …
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