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1942 1
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1946 2
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1949 1
1953 4
1954 3
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1957 7
1958 2
1959 3
1960 6
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1962 6
1963 8
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1965 6
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1967 22
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1974 65
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1976 500
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1980 591
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1986 1170
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1988 1170
1989 1317
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2002 2009
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2014 3030
2015 3071
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93,863 results

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Page 1
Why maximum tolerated dose?
Stampfer HG, Gabb GM, Dimmitt SB. Stampfer HG, et al. Br J Clin Pharmacol. 2019 Oct;85(10):2213-2217. doi: 10.1111/bcp.14032. Epub 2019 Jul 22. Br J Clin Pharmacol. 2019. PMID: 31219196 Free PMC article. Review.
However, clinicians often prescribe up to maximum tolerated dose (MTD), especially when treating acute and more severe disease, without evidence to show that MTD is more likely to improve outcomes. ...This review explores the origins and potential problems of prescr …
However, clinicians often prescribe up to maximum tolerated dose (MTD), especially when treating acute and more severe disease …
Maximum Dose Rate of Intrapartum Oxytocin Infusion and Associated Obstetric and Perinatal Outcomes.
Son M, Roy A, Grobman WA, Miller ES, Dude A, Peaceman AM, Stetson B. Son M, et al. Obstet Gynecol. 2023 Feb 1;141(2):379-386. doi: 10.1097/AOG.0000000000005058. Epub 2023 Jan 4. Obstet Gynecol. 2023. PMID: 36649339 Clinical Trial.
In addition, the cumulative proportions of labor and birth outcomes were calculated for each maximum dose rate of oxytocin reached among this study cohort. RESULTS: Of the 1,003 participants in the parent trial, 955 (95.2%) received oxytocin, as planned, and were in …
In addition, the cumulative proportions of labor and birth outcomes were calculated for each maximum dose rate of oxytocin rea …
Dose translation between laboratory animals and human in preclinical and clinical phases of drug development.
Nair A, Morsy MA, Jacob S. Nair A, et al. Drug Dev Res. 2018 Dec;79(8):373-382. doi: 10.1002/ddr.21461. Epub 2018 Oct 21. Drug Dev Res. 2018. PMID: 30343496
Allometric scaling is the most frequently used approach for dose extrapolation based on normalization of dose-to-body surface area. Misinterpretation of allometric dose conversion and safety factor application can lead to major problems in calculating maxi …
Allometric scaling is the most frequently used approach for dose extrapolation based on normalization of dose-to-body surface …
Maximum Oxytocin Dose and Uterine Rupture During Trial of Labor After Cesarean.
Bruno AM, Allshouse AA, Metz TD. Bruno AM, et al. Obstet Gynecol. 2025 Dec 1;146(6):843-850. doi: 10.1097/AOG.0000000000006106. Epub 2025 Oct 30. Obstet Gynecol. 2025. PMID: 41325062 Free PMC article.
Maximum oxytocin dose was not associated with blood transfusion or ICU admission. Longer duration of any intrapartum oxytocin and longer duration at maximum oxytocin dose also were associated with higher odds of uterine rupture. ...Thus, an upper safet …
Maximum oxytocin dose was not associated with blood transfusion or ICU admission. Longer duration of any intrapartum oxytocin …
A proposal for reducing maximum target doses of drugs for psychosis: Reviewing dose-response literature.
O'Neill JR, Jameson A, McLean SL, Dixon M, Cardno AG, Lawrence C. O'Neill JR, et al. J Psychopharmacol. 2024 Apr;38(4):344-352. doi: 10.1177/02698811241239543. Epub 2024 Mar 17. J Psychopharmacol. 2024. PMID: 38494791 Free article. Review.
RESULTS: We found that the likely threshold dose for achieving remission of psychotic symptoms was often significantly below the currently licensed dose for these drugs. ...CONCLUSIONS: In summary, we propose a new set of maximum target doses for psychosis dr …
RESULTS: We found that the likely threshold dose for achieving remission of psychotic symptoms was often significantly below the curr …
Adaptive design for identifying maximum tolerated dose early to accelerate dose-finding trial.
Kojima M. Kojima M. BMC Med Res Methodol. 2022 Apr 6;22(1):97. doi: 10.1186/s12874-022-01584-y. BMC Med Res Methodol. 2022. PMID: 35382745 Free PMC article.
PURPOSE: The early identification of maximum tolerated dose (MTD) in phase I trial leads to faster progression to a phase II trial or an expansion cohort to confirm efficacy. METHODS: We propose a novel adaptive design for identifying MTD early to accelerate dose …
PURPOSE: The early identification of maximum tolerated dose (MTD) in phase I trial leads to faster progression to a phase II t …
Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents.
Manavi MA, Fathian Nasab MH, Mohammad Jafari R, Dehpour AR. Manavi MA, et al. J Chemother. 2024 Dec;36(8):623-653. doi: 10.1080/1120009X.2023.2300217. Epub 2024 Jan 5. J Chemother. 2024. PMID: 38179685 Review.
Dose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated dose of a cancer drug. ...The dose-limiting toxicity of most anticancer drugs occurs via the activation of inflammatory/apoptosis/ROS pathways.Regarding the …
Dose-limiting toxicities (DLTs) are severe adverse effects that define the maximum tolerated dose of a cancer drug. ... …
Maximum insulin dose in patients admitted to the intensive care units with severe COVID-19 in the "Cross ICU Searchable Information System" study: A multicenter retrospective cohort study.
Ushigome E, Imai D, Hamaguchi M, Hashimoto S, Fukui M. Ushigome E, et al. J Diabetes Investig. 2025 Mar;16(3):555-560. doi: 10.1111/jdi.14380. Epub 2024 Dec 10. J Diabetes Investig. 2025. PMID: 39658883 Free PMC article.
Their mean age, glycated hemoglobin level, maximum daily insulin dose, and time from admission to the maximum daily insulin dose were 65.2 13.0 years, 7.0 1.5% (53.0 7.1 mmol/mol), 46.0 43.6 U/day, and 7.3 7.0 days, respectively. ...Glycated …
Their mean age, glycated hemoglobin level, maximum daily insulin dose, and time from admission to the maximum daily ins …
Determining the maximum tolerated dose of paclitaxel combined with fixed dose of cisplatin for hyperthermic intraperitoneal chemotherapy in ovarian cancer: A multicenter phase I trial.
Wu MF, Cheng XY, Wang DY, Lai YT, Li H, Ye YF, Peng YP, Chen Q, Zhang BZ, Lin ZQ, Li J. Wu MF, et al. Gynecol Oncol. 2024 Feb;181:125-132. doi: 10.1016/j.ygyno.2023.12.019. Epub 2023 Dec 30. Gynecol Oncol. 2024. PMID: 38159362 Free article. Clinical Trial.
OBJECTIVE: To determine the maximum tolerated dose (MTD) of paclitaxel combined with a fixed dose of cisplatin (75 mg/m(2)) delivered via hyperthermic intraperitoneal chemotherapy (HIPEC) to patients with ovarian cancer. ...The MTD was determined to have a ta …
OBJECTIVE: To determine the maximum tolerated dose (MTD) of paclitaxel combined with a fixed dose of cisplatin (75 mg/m …
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