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Is There a Role for Genetics in the Prevention of Sudden Cardiac Death?
Faragli A, Underwood K, Priori SG, Mazzanti A. Faragli A, et al. Among authors: mazzanti a. J Cardiovasc Electrophysiol. 2016 Sep;27(9):1124-32. doi: 10.1111/jce.13028. Epub 2016 Jul 15. J Cardiovasc Electrophysiol. 2016. PMID: 27279603 Review.
The identification of patients at risk for sudden cardiac death (SCD) is fundamental for both acquired cardiovascular diseases (such as coronary artery diseases, CAD) and inherited arrhythmia syndromes (such as the long-QT syndrome, LQTS). Genetics may play a role in both …
The identification of patients at risk for sudden cardiac death (SCD) is fundamental for both acquired cardiovascular diseases (such as coro …
Gene-Specific Therapy With Mexiletine Reduces Arrhythmic Events in Patients With Long QT Syndrome Type 3.
Mazzanti A, Maragna R, Faragli A, Monteforte N, Bloise R, Memmi M, Novelli V, Baiardi P, Bagnardi V, Etheridge SP, Napolitano C, Priori SG. Mazzanti A, et al. J Am Coll Cardiol. 2016 Mar 8;67(9):1053-1058. doi: 10.1016/j.jacc.2015.12.033. J Am Coll Cardiol. 2016. PMID: 26940925 Free PMC article.
BACKGROUND: Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in the SCN5A gene, coding for the alpha-subunit of the sodium channel NaV1.5. Mexiletine is used to block late sodium current and to shorten QT interval in LQT3 patie …
BACKGROUND: Long QT syndrome type 3 (LQT3) is a lethal disease caused by gain-of-function mutations in the SCN5A gene, coding for the …