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2018 2
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2020 64
2021 12
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Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons.
Nagy C, Maitra M, Tanti A, Suderman M, Théroux JF, Davoli MA, Perlman K, Yerko V, Wang YC, Tripathy SJ, Pavlidis P, Mechawar N, Ragoussis J, Turecki G. Nagy C, et al. Nat Neurosci. 2020 Jun;23(6):771-781. doi: 10.1038/s41593-020-0621-y. Epub 2020 Apr 27. Nat Neurosci. 2020. PMID: 32341540
Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades. Past molecular studies of MDD employed bulk homogenates of postmortem brain tissue …
Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a lea …
Child and adolescent psychiatry research during the COVID-19 pandemic.
Gnanavel S, Orri M, Mohammed M, Dray J, Baroud E, Kato H, Jui GT, Rajalakshmi AK, Hansen AS, Seker A, Ori D, Munjiza A, Martsenkovskyi D. Gnanavel S, et al. Lancet Psychiatry. 2020 Sep;7(9):735. doi: 10.1016/S2215-0366(20)30314-X. Lancet Psychiatry. 2020. PMID: 32828155 Free PMC article. No abstract available.
Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study.
Correia-Melo FS, Leal GC, Vieira F, Jesus-Nunes AP, Mello RP, Magnavita G, Caliman-Fontes AT, Echegaray MVF, Bandeira ID, Silva SS, Cavalcanti DE, Araújo-de-Freitas L, Sarin LM, Tuena MA, Nakahira C, Sampaio AS, Del-Porto JA, Turecki G, Loo C, Lacerda ALT, Quarantini LC. Correia-Melo FS, et al. J Affect Disord. 2020 Mar 1;264:527-534. doi: 10.1016/j.jad.2019.11.086. Epub 2019 Nov 14. J Affect Disord. 2020. PMID: 31786030 Clinical Trial.
RESULTS: 63 subjects were included and randomly assigned (29 to receive ketamine and 34 to receive esketamine). At 24 h, 24.1% of participants in the ketamine group and 29.4% of participants in the esketamine group showed remission, with a difference of 5.3% (95% CI …
RESULTS: 63 subjects were included and randomly assigned (29 to receive ketamine and 34 to receive esketamine). At 24 h, 24.1% of participan …
Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders.
Zhou Y, Lutz PE, Ibrahim EC, Courtet P, Tzavara E, Turecki G, Belzeaux R. Zhou Y, et al. J Neurosci Res. 2020 Apr;98(4):601-615. doi: 10.1002/jnr.24367. Epub 2018 Dec 18. J Neurosci Res. 2020. PMID: 30561057 Review.
Here, we review how transcriptomic approaches have deepened our understanding of the neurobiological underpinnings of psychiatric disorders and how they have to the identification of biomarkers for these disorders, with a focus on their relevance to suicide and suicide
Here, we review how transcriptomic approaches have deepened our understanding of the neurobiological underpinnings of psychiatric disorders …
Suicide amongst the Inuit of Nunavut: An Exploration of Life Trajectories.
Affleck W, Chachamovich E, Chawky N, Beauchamp G, Turecki G, Séguin M. Affleck W, et al. Int J Environ Res Public Health. 2020 Mar 11;17(6):1812. doi: 10.3390/ijerph17061812. Int J Environ Res Public Health. 2020. PMID: 32168793 Free PMC article.
This article reports results of the life trajectories from 92 Inuit who died by suicide, matched for age and gender with 92 living-controls. A proxy-based procedure and semi-structured interviews with informants were conducted to obtain trajectories of developmental events …
This article reports results of the life trajectories from 92 Inuit who died by suicide, matched for age and gender with 92 living-co …
Mental Health Problems and Risk of Suicidal Ideation and Attempts in Adolescents.
Orri M, Scardera S, Perret LC, Bolanis D, Temcheff C, Séguin JR, Boivin M, Turecki G, Tremblay RE, Côté SM, Geoffroy MC. Orri M, et al. Pediatrics. 2020 Jul;146(1):e20193823. doi: 10.1542/peds.2019-3823. Epub 2020 Jun 8. Pediatrics. 2020. PMID: 32513840
Outcomes were self-reported past-year passive and serious suicidal ideation and suicide attempt. RESULTS: Lifetime prevalence of passive suicidal ideation (13-17 years old), serious suicidal ideation, and suicide attempt (13-20 years old) were 22.2%, 9.8%, and 6.7%, …
Outcomes were self-reported past-year passive and serious suicidal ideation and suicide attempt. RESULTS: Lifetime prevalence of pass …
Perinatal adversity profiles and suicide attempt in adolescence and young adulthood: longitudinal analyses from two 20-year birth cohort studies.
Orri M, Russell AE, Mars B, Turecki G, Gunnell D, Heron J, Tremblay RE, Boivin M, Nuyt AM, Côté SM, Geoffroy MC. Orri M, et al. Psychol Med. 2020 Oct 6:1-13. doi: 10.1017/S0033291720002974. Online ahead of print. Psychol Med. 2020. PMID: 33019954
CONCLUSIONS: Perinatal adversities associated with suicide attempt cluster in distinct profiles. Suicide prevention may begin early in life and requires a multidisciplinary approach targeting a constellation of factors from different domains (psychiatric, obstetric, …
CONCLUSIONS: Perinatal adversities associated with suicide attempt cluster in distinct profiles. Suicide prevention may begin …
Adolescent internalizing symptoms: The importance of multi-informant assessments in childhood.
Navarro MC, Orri M, Nagin D, Tremblay RE, Oncioiu SI, Ahun MN, Melchior M, van der Waerden J, Galéra C, Côté SM. Navarro MC, et al. J Affect Disord. 2020 Apr 1;266:702-709. doi: 10.1016/j.jad.2020.01.106. Epub 2020 Jan 23. J Affect Disord. 2020. PMID: 32056947
Multiple linear regression models were implemented to estimate the association between childhood group membership of internalizing symptoms and self-reported specific internalizing symptoms at 15 years by sex. ...Multiple linear regression models showed that compared to th …
Multiple linear regression models were implemented to estimate the association between childhood group membership of internalizing sy …
Trends and ecological results in suicides among Italian youth aged 10-25 years: A nationwide register study.
Forte A, Vichi M, Ghirini S, Orri M, Pompili M. Forte A, et al. J Affect Disord. 2021 Mar 1;282:165-172. doi: 10.1016/j.jad.2020.12.142. Epub 2020 Dec 29. J Affect Disord. 2021. PMID: 33418363
BACKGROUND: Documenting current trends and sources of variation in youth suicide rates is critical to inform prevention strategies. We aimed to document suicide mortality trends among Italian youth from 1981 to 2016 and to describe age-, gender- and urbanization-spe …
BACKGROUND: Documenting current trends and sources of variation in youth suicide rates is critical to inform prevention strategies. W …
Risky decision-making in suicide attempters, and the choice of a violent suicidal means: an updated meta-analysis.
Perrain R, Dardennes R, Jollant F. Perrain R, et al. J Affect Disord. 2021 Feb 1;280(Pt A):241-249. doi: 10.1016/j.jad.2020.11.052. Epub 2020 Nov 12. J Affect Disord. 2021. PMID: 33220560
BACKGROUND: Studies showed disadvantageous decision-making in suicide attempters. ...Suicide attempters who used a violent means showed poorer IGT performance than those who used a non-violent means (3 studies). ...
BACKGROUND: Studies showed disadvantageous decision-making in suicide attempters. ...Suicide attempters who used a viol …
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