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2018 2
2019 7
2020 64
2021 18
2022 2
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64 results
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Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons.
Nagy C, Maitra M, Tanti A, Suderman M, Théroux JF, Davoli MA, Perlman K, Yerko V, Wang YC, Tripathy SJ, Pavlidis P, Mechawar N, Ragoussis J, Turecki G. Nagy C, et al. Nat Neurosci. 2020 Jun;23(6):771-781. doi: 10.1038/s41593-020-0621-y. Epub 2020 Apr 27. Nat Neurosci. 2020. PMID: 32341540
Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades. Past molecular studies of MDD employed bulk homogenates of postmortem brain tissue …
Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a lea …
Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: A randomized, double-blind, non-inferiority study.
Correia-Melo FS, Leal GC, Vieira F, Jesus-Nunes AP, Mello RP, Magnavita G, Caliman-Fontes AT, Echegaray MVF, Bandeira ID, Silva SS, Cavalcanti DE, Araújo-de-Freitas L, Sarin LM, Tuena MA, Nakahira C, Sampaio AS, Del-Porto JA, Turecki G, Loo C, Lacerda ALT, Quarantini LC. Correia-Melo FS, et al. J Affect Disord. 2020 Mar 1;264:527-534. doi: 10.1016/j.jad.2019.11.086. Epub 2019 Nov 14. J Affect Disord. 2020. PMID: 31786030 Clinical Trial.
RESULTS: 63 subjects were included and randomly assigned (29 to receive ketamine and 34 to receive esketamine). At 24 h, 24.1% of participants in the ketamine group and 29.4% of participants in the esketamine group showed remission, with a difference of 5.3% (95% CI …
RESULTS: 63 subjects were included and randomly assigned (29 to receive ketamine and 34 to receive esketamine). At 24 h, 24.1% of participan …
Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders.
Zhou Y, Lutz PE, Ibrahim EC, Courtet P, Tzavara E, Turecki G, Belzeaux R. Zhou Y, et al. J Neurosci Res. 2020 Apr;98(4):601-615. doi: 10.1002/jnr.24367. Epub 2018 Dec 18. J Neurosci Res. 2020. PMID: 30561057 Review.
Here, we review how transcriptomic approaches have deepened our understanding of the neurobiological underpinnings of psychiatric disorders and how they have to the identification of biomarkers for these disorders, with a focus on their relevance to suicide and suicide
Here, we review how transcriptomic approaches have deepened our understanding of the neurobiological underpinnings of psychiatric disorders …
Suicide amongst the Inuit of Nunavut: An Exploration of Life Trajectories.
Affleck W, Chachamovich E, Chawky N, Beauchamp G, Turecki G, Séguin M. Affleck W, et al. Int J Environ Res Public Health. 2020 Mar 11;17(6):1812. doi: 10.3390/ijerph17061812. Int J Environ Res Public Health. 2020. PMID: 32168793 Free PMC article.
This article reports results of the life trajectories from 92 Inuit who died by suicide, matched for age and gender with 92 living-controls. A proxy-based procedure and semi-structured interviews with informants were conducted to obtain trajectories of developmental events …
This article reports results of the life trajectories from 92 Inuit who died by suicide, matched for age and gender with 92 living-co …
Regulation of impulsive and aggressive behaviours by a novel lncRNA.
Labonté B, Abdallah K, Maussion G, Yerko V, Yang J, Bittar T, Quessy F, Golden SA, Navarro L, Checknita D, Gigek C, Lopez JP, Neve RL, Russo SJ, Tremblay RE, Côté G, Meaney MJ, Mechawar N, Nestler EJ, Turecki G. Labonté B, et al. Mol Psychiatry. 2021 Aug;26(8):3751-3764. doi: 10.1038/s41380-019-0637-4. Epub 2020 Jan 6. Mol Psychiatry. 2021. PMID: 31907380 Free PMC article.
Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expression of impulsive and aggressive traits remain poorly understood. Here, we identified and characterized a novel long noncoding RNA (lncRNA) …
Despite their importance in predicting behavioural negative outcomes including suicide, the molecular mechanisms underlying the expre …
Mental Health Problems and Risk of Suicidal Ideation and Attempts in Adolescents.
Orri M, Scardera S, Perret LC, Bolanis D, Temcheff C, Séguin JR, Boivin M, Turecki G, Tremblay RE, Côté SM, Geoffroy MC. Orri M, et al. Pediatrics. 2020 Jul;146(1):e20193823. doi: 10.1542/peds.2019-3823. Epub 2020 Jun 8. Pediatrics. 2020. PMID: 32513840
Outcomes were self-reported past-year passive and serious suicidal ideation and suicide attempt. RESULTS: Lifetime prevalence of passive suicidal ideation (13-17 years old), serious suicidal ideation, and suicide attempt (13-20 years old) were 22.2%, 9.8%, and 6.7%, …
Outcomes were self-reported past-year passive and serious suicidal ideation and suicide attempt. RESULTS: Lifetime prevalence of pass …
Trends and ecological results in suicides among Italian youth aged 10-25 years: A nationwide register study.
Forte A, Vichi M, Ghirini S, Orri M, Pompili M. Forte A, et al. J Affect Disord. 2021 Mar 1;282:165-172. doi: 10.1016/j.jad.2020.12.142. Epub 2020 Dec 29. J Affect Disord. 2021. PMID: 33418363
BACKGROUND: Documenting current trends and sources of variation in youth suicide rates is critical to inform prevention strategies. We aimed to document suicide mortality trends among Italian youth from 1981 to 2016 and to describe age-, gender- and urbanization-spe …
BACKGROUND: Documenting current trends and sources of variation in youth suicide rates is critical to inform prevention strategies. W …
Cohort Profile: Quebec Longitudinal Study of Child Development (QLSCD).
Orri M, Boivin M, Chen C, Ahun MN, Geoffroy MC, Ouellet-Morin I, Tremblay RE, Côté SM. Orri M, et al. Soc Psychiatry Psychiatr Epidemiol. 2021 May;56(5):883-894. doi: 10.1007/s00127-020-01972-z. Epub 2020 Nov 13. Soc Psychiatry Psychiatr Epidemiol. 2021. PMID: 33185737
QLSCD articles have advanced scientific knowledge on the influence of early childhood factors on childhood, adolescent, and young adult mental health, including the effect of participation in early childcare on cognitive and behavioural development, the developmental origins of a …
QLSCD articles have advanced scientific knowledge on the influence of early childhood factors on childhood, adolescent, and young adult ment …
Risky decision-making in suicide attempters, and the choice of a violent suicidal means: an updated meta-analysis.
Perrain R, Dardennes R, Jollant F. Perrain R, et al. J Affect Disord. 2021 Feb 1;280(Pt A):241-249. doi: 10.1016/j.jad.2020.11.052. Epub 2020 Nov 12. J Affect Disord. 2021. PMID: 33220560
BACKGROUND: Studies showed disadvantageous decision-making in suicide attempters. ...Suicide attempters who used a violent means showed poorer IGT performance than those who used a non-violent means (3 studies). ...
BACKGROUND: Studies showed disadvantageous decision-making in suicide attempters. ...Suicide attempters who used a viol …
Decision-making and cognitive control in adolescent suicidal behaviors: a qualitative systematic review of the literature.
Gifuni AJ, Perret LC, Lacourse E, Geoffroy MC, Mbekou V, Jollant F, Renaud J. Gifuni AJ, et al. Eur Child Adolesc Psychiatry. 2021 Dec;30(12):1839-1855. doi: 10.1007/s00787-020-01550-3. Epub 2020 May 9. Eur Child Adolesc Psychiatry. 2021. PMID: 32388626 Review.
Suicide and suicidal behaviors represent a leading cause of morbidity and mortality during adolescence. ...Several studies have reported that adolescents with a history of suicidal behaviors present neuropsychological differences in the cognitive control (using Go/N
Suicide and suicidal behaviors represent a leading cause of morbidity and mortality during adolescence. ...Several studies hav
64 results