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Medium-chain triglycerides improved cognition and lipid metabolomics in mild to moderate Alzheimer's disease patients with APOE4(-/-): A double-blind, randomized, placebo-controlled crossover trial.
Xu Q, Zhang Y, Zhang X, Liu L, Zhou B, Mo R, Li Y, Li H, Li F, Tao Y, Liu Y, Xue C. Xu Q, et al. Clin Nutr. 2020 Jul;39(7):2092-2105. doi: 10.1016/j.clnu.2019.10.017. Epub 2019 Oct 22. Clin Nutr. 2020. PMID: 31694759
Participants were randomized between two sequences (placebo followed by MCT or MCT followed by placebo) and took MCT jelly or placebo jelly (canola oil) by mouth three times daily (total daily fat dose: 17.3 g MCT, or 19.7 g canola oil) f …
Participants were randomized between two sequences (placebo followed by MCT or MCT followed by placebo) and took MCT je …
Efficacy of a Therapeutic Diet on Dogs With Signs of Cognitive Dysfunction Syndrome (CDS): A Prospective Double Blinded Placebo Controlled Clinical Study.
Pan Y, Landsberg G, Mougeot I, Kelly S, Xu H, Bhatnagar S, Gardner CL, Milgram NW. Pan Y, et al. Front Nutr. 2018 Dec 12;5:127. doi: 10.3389/fnut.2018.00127. eCollection 2018. Front Nutr. 2018. PMID: 30619873 Free PMC article.
By targeting some of these risk factors, we have developed two nutritional solutions (medium chain triglyceride, MCT and Brain Protection Blend, BPB) to enhance cognitive function and slow aging-induced cognitive decline. ...Eighty-seven dogs were randomly en …
By targeting some of these risk factors, we have developed two nutritional solutions (medium chain triglyceride, MCT and Brain Protec …
Cognition and Synaptic-Plasticity Related Changes in Aged Rats Supplemented with 8- and 10-Carbon Medium Chain Triglycerides.
Wang D, Mitchell ES. Wang D, et al. PLoS One. 2016 Aug 12;11(8):e0160159. doi: 10.1371/journal.pone.0160159. eCollection 2016. PLoS One. 2016. PMID: 27517611 Free PMC article.
Previous studies have shown that cognition is improved by providing AD patients with an alternate energy source: ketones derived from either ketogenic diet or supplementation with medium chain triglycerides (MCT). Recently, data on the neuroprotective capacity of …
Previous studies have shown that cognition is improved by providing AD patients with an alternate energy source: ketones derived from …
Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial.
Rebello CJ, Keller JN, Liu AG, Johnson WD, Greenway FL. Rebello CJ, et al. BBA Clin. 2015 Jan 16;3:123-5. doi: 10.1016/j.bbacli.2015.01.001. eCollection 2015 Jun. BBA Clin. 2015. PMID: 26675661 Free PMC article.
BACKGROUND: Impaired brain glucose metabolism appears to be a potential pathogenic feature of mild cognitive impairment (MCI). ...RESULTS: Intake of MCT oil increased serum ketone bodies and improved memory, while intake of placebo did not show improvement in …
BACKGROUND: Impaired brain glucose metabolism appears to be a potential pathogenic feature of mild cognitive impairment (MCI). ...RES …
Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats.
Kovács Z, D'Agostino DP, Ari C. Kovács Z, et al. Front Behav Neurosci. 2018 Feb 22;12:29. doi: 10.3389/fnbeh.2018.00029. eCollection 2018. Front Behav Neurosci. 2018. PMID: 29520223 Free PMC article.
It has been demonstrated previously that administration of exogenous ketone supplement KSMCT (ketone salt/KS + medium chain triglyceride/MCT oil) by intragastric gavage for 7 days decreased the anxiety level in genetically absence epileptic Wistar Albino Glaxo/Rijsw …
It has been demonstrated previously that administration of exogenous ketone supplement KSMCT (ketone salt/KS + medium chain triglyceride/ …
Short-term effects of parenteral nutrition of cholestatic infants with lipid emulsions based on medium-chain and long-chain triacylglycerols.
Socha P, Koletzko B, Demmelmair H, Jankowska I, Stajniak A, Bednarska-Makaruk M, Socha J. Socha P, et al. Nutrition. 2007 Feb;23(2):121-6. doi: 10.1016/j.nut.2006.10.009. Nutrition. 2007. PMID: 17234505 Clinical Trial.
Because docosahexaenoic acid availability during infancy is important for early visual and cognitive development, the use of soybean oil-based lipid emulsions may be preferable for infants with severe progressive cholestasis. CONCLUSION: The MCT/LCT and LCT e …
Because docosahexaenoic acid availability during infancy is important for early visual and cognitive development, the use of soybean …
Inhibition of adenosine A1 receptors abolished the nutritional ketosis-evoked delay in the onset of isoflurane-induced anesthesia in Wistar Albino Glaxo Rijswijk rats.
Kovács Z, Brunner B, D'Agostino DP, Ari C. Kovács Z, et al. BMC Anesthesiol. 2020 Jan 30;20(1):30. doi: 10.1186/s12871-020-0943-z. BMC Anesthesiol. 2020. PMID: 32000673 Free PMC article.
METHODS: To investigate the effect of exogenous ketone supplements on anesthetic induction we used ketone supplement KE, KS, KEKS (1:1 mix of KE and KS), KSMCT and KEMCT (1:1 mix of KS and KE with medium chain triglyceride/MCT oil, respectively) in WAG/Rij rats. ...
METHODS: To investigate the effect of exogenous ketone supplements on anesthetic induction we used ketone supplement KE, KS, KEKS (1:1 mix o …
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