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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1984 1
1986 5
1987 16
1988 12
1989 16
1990 18
1991 12
1992 17
1993 11
1994 11
1995 16
1996 15
1997 17
1998 20
1999 20
2000 23
2001 31
2002 37
2003 28
2004 44
2005 41
2006 39
2007 57
2008 61
2009 51
2010 42
2011 59
2012 53
2013 45
2014 44
2015 28
2016 34
2017 30
2018 27
2019 22
2020 25
2021 14
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914 results
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3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial.
Mithoefer MC, Mithoefer AT, Feduccia AA, Jerome L, Wagner M, Wymer J, Holland J, Hamilton S, Yazar-Klosinski B, Emerson A, Doblin R. Mithoefer MC, et al. Lancet Psychiatry. 2018 Jun;5(6):486-497. doi: 10.1016/S2215-0366(18)30135-4. Epub 2018 May 1. Lancet Psychiatry. 2018. PMID: 29728331 Clinical Trial.
BACKGROUND: Post-traumatic stress disorder (PTSD) is prevalent in military personnel and first responders, many of whom do not respond to currently available treatments. This study aimed to assess the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA
BACKGROUND: Post-traumatic stress disorder (PTSD) is prevalent in military personnel and first responders, many of whom do not respond to cu …
The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine.
Steinkellner T, Freissmuth M, Sitte HH, Montgomery T. Steinkellner T, et al. Biol Chem. 2011 Jan;392(1-2):103-15. doi: 10.1515/BC.2011.016. Biol Chem. 2011. PMID: 21194370 Free PMC article. Review.
Amphetamine ('Speed'), methamphetamine ('Ice') and its congener 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') are illicit drugs abused worldwide for their euphoric and stimulant effects. ...In addition, distinct differences in the metabolism and pharmac …
Amphetamine ('Speed'), methamphetamine ('Ice') and its congener 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') are …
The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs.
Kalant H. Kalant H. CMAJ. 2001 Oct 2;165(7):917-28. CMAJ. 2001. PMID: 11599334 Free PMC article. Review.
"Ecstasy" (MDMA) and related drugs are amphetamine derivatives that also have some of the pharmacological properties of mescaline. ...A detailed review of the literature has revealed over 87 "ecstasy"-related fatalities, caused by hyperpyrexia, rhabdomyolysis, intravascula …
"Ecstasy" (MDMA) and related drugs are amphetamine derivatives that also have some of the pharmacological properties of mescaline. .. …
Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects.
Holze F, Vizeli P, Müller F, Ley L, Duerig R, Varghese N, Eckert A, Borgwardt S, Liechti ME. Holze F, et al. Neuropsychopharmacology. 2020 Feb;45(3):462-471. doi: 10.1038/s41386-019-0569-3. Epub 2019 Nov 16. Neuropsychopharmacology. 2020. PMID: 31733631 Free PMC article.
Lysergic acid diethylamide (LSD) is a classic psychedelic, 3,4-methylenedioxymethamphetamine (MDMA) is an empathogen, and D-amphetamine is a classic stimulant. ...These results indicate clearly distinct acute effects of LSD, MDMA, and D-amphetamine and …
Lysergic acid diethylamide (LSD) is a classic psychedelic, 3,4-methylenedioxymethamphetamine (MDMA) is an empathogen, a …
Posttraumatic Growth After MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder.
Gorman I, Belser AB, Jerome L, Hennigan C, Shechet B, Hamilton S, Yazar-Klosinski B, Emerson A, Feduccia AA. Gorman I, et al. J Trauma Stress. 2020 Apr;33(2):161-170. doi: 10.1002/jts.22479. Epub 2020 Feb 19. J Trauma Stress. 2020. PMID: 32073177 Free PMC article. Clinical Trial.
3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder (PTSD) has been shown to significantly reduce clinical symptomatology, but posttraumatic growth (PTG), which consists of positive changes in self-perception, int
3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder (PTSD) has been shown
The emerging role of psilocybin and MDMA in the treatment of mental illness.
Gill H, Gill B, Chen-Li D, El-Halabi S, Rodrigues NB, Cha DS, Lipsitz O, Lee Y, Rosenblat JD, Majeed A, Mansur RB, Nasri F, Ho R, McIntyre RS. Gill H, et al. Expert Rev Neurother. 2020 Dec;20(12):1263-1273. doi: 10.1080/14737175.2020.1826931. Epub 2020 Sep 30. Expert Rev Neurother. 2020. PMID: 32954860 Review.
Herein, the authors will evaluate the therapeutic potential of traditional psychedelics, psilocybin, and MDMA, in the treatment of mental illness with a narrative review of available literature. EXPERT OPINION: Psychedelics, such as psilocybin and MDMA, offer an alt …
Herein, the authors will evaluate the therapeutic potential of traditional psychedelics, psilocybin, and MDMA, in the treatment of me …
A randomized, controlled pilot study of MDMA ( 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD).
Oehen P, Traber R, Widmer V, Schnyder U. Oehen P, et al. J Psychopharmacol. 2013 Jan;27(1):40-52. doi: 10.1177/0269881112464827. Epub 2012 Oct 31. J Psychopharmacol. 2013. PMID: 23118021 Free article. Clinical Trial.
Designed to test the safety and efficacy of MDMA-assisted psychotherapy in patients with treatment-resistant PTSD; our randomized, double-blind, active-placebo controlled trial enrolled 12 patients for treatment with either low-dose (25 mg, plus 12.5 mg supplemental …
Designed to test the safety and efficacy of MDMA-assisted psychotherapy in patients with treatment-resistant PTSD; our randomized, do …
Cognitive Effects of MDMA in Laboratory Animals: A Systematic Review Focusing on Dose.
Pantoni MM, Anagnostaras SG. Pantoni MM, et al. Pharmacol Rev. 2019 Jul;71(3):413-449. doi: 10.1124/pr.118.017087. Pharmacol Rev. 2019. PMID: 31249067 Free PMC article.
3,4-Methylenedioxymethamphetamine (MDMA) is a synthetic, psychoactive drug that is primarily used recreationally but also may have some therapeutic value. ...Here, we systematically review 25 years of research on the cognitive effects of MDMA in animal
3,4-Methylenedioxymethamphetamine (MDMA) is a synthetic, psychoactive drug that is primarily used recreationally but al
Oxytocin-dependent reopening of a social reward learning critical period with MDMA.
Nardou R, Lewis EM, Rothhaas R, Xu R, Yang A, Boyden E, Dölen G. Nardou R, et al. Nature. 2019 May;569(7754):116-120. doi: 10.1038/s41586-019-1075-9. Epub 2019 Apr 3. Nature. 2019. PMID: 30944474
Here we provide evidence that developmental regulation of oxytocin-mediated synaptic plasticity (long-term depression) in the nucleus accumbens establishes a critical period for social reward learning. Furthermore, we show that a single dose of (+/-)-3,4-meth …
Here we provide evidence that developmental regulation of oxytocin-mediated synaptic plasticity (long-term depression) in the nucleus accumb …
Dose concentration and spatial memory and brain mitochondrial function association after 3,4-methylenedioxymethamphetamine (MDMA) administration in rats.
Taghizadeh G, Mehdizadeh H, Lavasani H, Hosseinzadeh Ardakani Y, Foroumadi A, Halvaei Khankahdani Z, Moshtagh A, Pourahmad J, Sharifzadeh M, Rouini MR. Taghizadeh G, et al. Arch Toxicol. 2020 Mar;94(3):911-925. doi: 10.1007/s00204-020-02673-x. Epub 2020 Feb 18. Arch Toxicol. 2020. PMID: 32067070
Therefore, the aim of this study was to investigate the dose concentration and spatial memory as well as brain mitochondrial function association after MDMA administration in rats. ...Concentrations of MDMA and its metabolite, MDA, were determined in plasma, …
Therefore, the aim of this study was to investigate the dose concentration and spatial memory as well as brain mitochondrial function …
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