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534 results

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Page 1
The role of mechano growth factor in chondrocytes and cartilage defects: a concise review.
Liu Y, Duan M, Zhang D, Xie J. Liu Y, et al. Acta Biochim Biophys Sin (Shanghai). 2023 May 12;55(5):701-712. doi: 10.3724/abbs.2023086. Acta Biochim Biophys Sin (Shanghai). 2023. PMID: 37171185 Free PMC article. Review.
Mechano growth factor (MGF), an isoform of insulin-like growth factor 1 (IGF-1), is recognized as a typical mechanically sensitive growth factor and has been shown to play an indispensable role in the skeletal system. ...
Mechano growth factor (MGF), an isoform of insulin-like growth factor 1 (IGF-1), is recognized as a typic …
Mechano-growth factor E-domain modulates cardiac contractile function through 14-3-3 protein interactomes.
Solís C, Thompson WC, Peña JR, McDermott-Roe C, Langa P, Warren CM, Chrzanowska M, Wolska BM, Solaro RJ, Pieter Detombe, Goldspink PH. Solís C, et al. Front Physiol. 2022 Nov 16;13:1028345. doi: 10.3389/fphys.2022.1028345. eCollection 2022. Front Physiol. 2022. PMID: 36467694 Free PMC article.
In the heart, alternative splicing of the igf-I gene produces two isoforms: IGF-IEa and IGF-IEc, (Mechano-growth factor, MGF). The sequence divergence between their E-domain regions suggests differential isoform function. ...At the lowest (2.25 mg/kg/day) and …
In the heart, alternative splicing of the igf-I gene produces two isoforms: IGF-IEa and IGF-IEc, (Mechano-growth factor …
Mechano growth factor interacts with nucleolin to protect against cisplatin-induced neurotoxicity.
Podratz JL, Tang JJ, Polzin MJ, Schmeichel AM, Nesbitt JJ, Windebank AJ, Madigan NN. Podratz JL, et al. Exp Neurol. 2020 Sep;331:113376. doi: 10.1016/j.expneurol.2020.113376. Epub 2020 Jun 5. Exp Neurol. 2020. PMID: 32511954
Mechano growth factor (MGF) is an alternatively spliced form of insulin-like growth factor-1 (IGF-1) that has shown to be neuroprotective against 6-hydroxydopamine toxicity and ischemic injury in the brain. ...Exogenous MGF and MGF with a cystei …
Mechano growth factor (MGF) is an alternatively spliced form of insulin-like growth factor-1 (IGF-1) that …
Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment.
Tharp KM, Kersten K, Maller O, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward MK, Berestjuk I, Ten Hoeve J, Samad B, Ironside AJ, di Magliano MP, Muir A, Geiger R, Combes AJ, Weaver VM. Tharp KM, et al. Nat Cancer. 2024 Jul;5(7):1045-1062. doi: 10.1038/s43018-024-00775-4. Epub 2024 Jun 3. Nat Cancer. 2024. PMID: 38831058
Here we demonstrate that tumor-associated macrophages (TAMs) respond to the stiffened fibrotic tumor microenvironment (TME) by initiating a collagen biosynthesis program directed by transforming growth factor-beta. A collateral effect of this programming is an unten …
Here we demonstrate that tumor-associated macrophages (TAMs) respond to the stiffened fibrotic tumor microenvironment (TME) by initiating a …
Mechano-growth factor regulates periodontal ligament stem cell proliferation and differentiation through Fyn-RhoA-YAP signaling.
Feng F, Tu T, Wang H, Song R, Li J, Zhu Y, Zhang S, Zhang M, Zhao Y, Liu Y. Feng F, et al. Biochem Biophys Res Commun. 2024 Nov 12;733:150450. doi: 10.1016/j.bbrc.2024.150450. Epub 2024 Jul 25. Biochem Biophys Res Commun. 2024. PMID: 39067248
BACKGROUND: Mechano-growth factor (MGF), which is a growth factor produced specifically in response to mechanical stimuli, with potential of tissue repair and regeneration. ...METHODS: Initially, we investigated how MGF impacts cell growth …
BACKGROUND: Mechano-growth factor (MGF), which is a growth factor produced specifically in response to me …
Mechano-growth Factor Expression in Colorectal Cancer Investigated With Fluorescent Gold Nanoparticles.
Alagaratnam S, Yang SY, Loizidou M, Fuller B, Ramesh B. Alagaratnam S, et al. Anticancer Res. 2019 Apr;39(4):1705-1710. doi: 10.21873/anticanres.13276. Anticancer Res. 2019. PMID: 30952709
BACKGROUND/AIM: Fluorescent gold nanoparticles demonstrate strong photoluminescence, photostability, and low cellular toxicity, making them attractive agents for biomedical applications. Mechano-growth factor (MGF) is an isoform of IGF1 and its expression has …
BACKGROUND/AIM: Fluorescent gold nanoparticles demonstrate strong photoluminescence, photostability, and low cellular toxicity, making them …
Mechano Growth Factor Accelerates ACL Repair and Improves Cell Mobility of Mechanically Injured Human ACL Fibroblasts by Targeting Rac1-PAK1/2 and RhoA-ROCK1 Pathways.
Sha Y, Zhang B, Chen L, Hong H, Chi Q. Sha Y, et al. Int J Mol Sci. 2022 Apr 14;23(8):4331. doi: 10.3390/ijms23084331. Int J Mol Sci. 2022. PMID: 35457148 Free PMC article.
Exceeded mechanical stress leads to a sublethal injury to anterior cruciate ligament (ACL) fibroblasts, and it will hinder cell mobility and ACL regeneration, and even induce osteoarthritis. The mechano growth factor (MGF) could be responsible for mechanical …
Exceeded mechanical stress leads to a sublethal injury to anterior cruciate ligament (ACL) fibroblasts, and it will hinder cell mobility and …
Mechano-growth factor enhances differentiation of bone marrow-derived mesenchymal stem cells.
Li H, Lei M, Luo Z, Wu S, Zhong L, Xu Z, Lv Y, Yang L. Li H, et al. Biotechnol Lett. 2015 Nov;37(11):2341-8. doi: 10.1007/s10529-015-1915-0. Epub 2015 Sep 2. Biotechnol Lett. 2015. PMID: 26330369
OBJECTIVES: To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro. ...
OBJECTIVES: To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derive …
Mechano growth factor attenuates mechanical overload-induced nucleus pulposus cell apoptosis through inhibiting the p38 MAPK pathway.
Xu Q, Fang H, Zhao L, Zhang C, Zhang L, Tian B. Xu Q, et al. Biosci Rep. 2019 Mar 28;39(3):BSR20182462. doi: 10.1042/BSR20182462. Print 2019 Mar 29. Biosci Rep. 2019. Retraction in: Biosci Rep. 2024 Aug 28;44(8):BSR-2018-2462_RET. doi: 10.1042/BSR-2018-2462_RET PMID: 30858307 Free PMC article. Retracted.
Mechanical overload is a risk factor of disc degeneration. It can induce disc degeneration through mediating cell apoptosis. Mechano growth factor (MGF) has been reported to inhibit mechanical overload-induced apoptosis of chondrocytes. ...
Mechanical overload is a risk factor of disc degeneration. It can induce disc degeneration through mediating cell apoptosis. Mecha …
Mechano growth factor pretreatment yield mechanical stimuli induced cell stress responses in ligament fibroblasts of osteoarthritis via activating ATF-2.
Ma Y, Song Y, Li L, Dong L, Wang C, Wang P, Yang L. Ma Y, et al. Biotechnol Lett. 2020 Aug;42(8):1337-1349. doi: 10.1007/s10529-020-02866-5. Epub 2020 Mar 28. Biotechnol Lett. 2020. PMID: 32222864
OBJECTIVE: The purpose of this study is to investigate whether mechanical growth factor (MGF) promotes mechanical response to ligament fibroblasts in osteoarthritis knee cavity via activating transcription factor 2 (ATF-2). ...
OBJECTIVE: The purpose of this study is to investigate whether mechanical growth factor (MGF) promotes mechanical response to …
534 results