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11,768 results

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Page 1
Transcription regulation by the Mediator complex.
Soutourina J. Soutourina J. Nat Rev Mol Cell Biol. 2018 Apr;19(4):262-274. doi: 10.1038/nrm.2017.115. Epub 2017 Dec 6. Nat Rev Mol Cell Biol. 2018. PMID: 29209056 Review.
Transcription activation is a key phenomenon in the regulation of gene expression. In all eukaryotes, mediator of RNA polymerase II transcription (Mediator), a large complex with modular organization, is generally required for transcription by RNA polymerase …
Transcription activation is a key phenomenon in the regulation of gene expression. In all eukaryotes, mediator of RNA polymerase II t …
Mediator complex in neurological disease.
Schiano C, Luongo L, Maione S, Napoli C. Schiano C, et al. Life Sci. 2023 Sep 15;329:121986. doi: 10.1016/j.lfs.2023.121986. Epub 2023 Jul 28. Life Sci. 2023. PMID: 37516429 Free article. Review.
Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator complex (MED) is a large, evolut …
Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause …
The Mediator complex as a master regulator of transcription by RNA polymerase II.
Richter WF, Nayak S, Iwasa J, Taatjes DJ. Richter WF, et al. Nat Rev Mol Cell Biol. 2022 Nov;23(11):732-749. doi: 10.1038/s41580-022-00498-3. Epub 2022 Jun 20. Nat Rev Mol Cell Biol. 2022. PMID: 35725906 Free PMC article. Review.
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits, controls many aspects of RNA polymerase II (Pol II) function. ...In this Review, we discuss Mediator structure and function, with emphasis on recent cryogenic electron microsco …
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits, controls many aspects of RNA polymerase II …
Structures of the human Mediator and Mediator-bound preinitiation complex.
Chen X, Yin X, Li J, Wu Z, Qi Y, Wang X, Liu W, Xu Y. Chen X, et al. Science. 2021 Jun 4;372(6546):eabg0635. doi: 10.1126/science.abg0635. Epub 2021 May 6. Science. 2021. PMID: 33958484
We determined the structures of human Mediator in the Tail module-extended (at near-atomic resolution) and Tail-bent conformations and structures of TFIID-based PIC-Mediator (76 polypeptides, ~4.1 megadaltons) in four distinct conformations. ...The TFIID-based PIC a …
We determined the structures of human Mediator in the Tail module-extended (at near-atomic resolution) and Tail-bent conformations an …
Mediator complex: an important regulator of root system architecture.
Agrawal R, Thakur P, Singh A, Panchal P, Thakur JK. Agrawal R, et al. J Exp Bot. 2024 Sep 27;75(18):5521-5530. doi: 10.1093/jxb/erae277. J Exp Bot. 2024. PMID: 38881317 Free article. Review.
Mediator, a multiprotein complex, is an important component of the transcription machinery. ...In this review, we discuss all the known functions of Mediator subunits during root development. We also highlight the role of Mediator as a nodal point for …
Mediator, a multiprotein complex, is an important component of the transcription machinery. ...In this review, we discuss all …
Twenty years of Mediator complex structural studies.
Verger A, Monté D, Villeret V. Verger A, et al. Biochem Soc Trans. 2019 Feb 28;47(1):399-410. doi: 10.1042/BST20180608. Epub 2019 Feb 7. Biochem Soc Trans. 2019. PMID: 30733343 Free PMC article. Review.
Mediator is a large multiprotein complex conserved in all eukaryotes that plays an essential role in transcriptional regulation. ...To celebrate the twentieth anniversary of the first Mediator EM reconstruction, we look back on the structural studies of Me …
Mediator is a large multiprotein complex conserved in all eukaryotes that plays an essential role in transcriptional regulatio …
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases.
Maalouf CA, Alberti A, Soutourina J. Maalouf CA, et al. DNA Repair (Amst). 2024 Sep;141:103714. doi: 10.1016/j.dnarep.2024.103714. Epub 2024 Jun 24. DNA Repair (Amst). 2024. PMID: 38943827 Free article. Review.
The Mediator complex is an essential coregulator of RNA polymerase II transcription. More recent developments suggest Mediator functions as a link between transcription regulation, genome organisation and DNA repair mechanisms including nucleotide excision re …
The Mediator complex is an essential coregulator of RNA polymerase II transcription. More recent developments suggest Media …
The role of mediator complex subunit 19 in human diseases.
Zhang Y, Qin P, Tian L, Yan J, Zhou Y. Zhang Y, et al. Exp Biol Med (Maywood). 2021 Aug;246(15):1681-1687. doi: 10.1177/15353702211011701. Epub 2021 May 26. Exp Biol Med (Maywood). 2021. PMID: 34038190 Free PMC article. Review.
It interacts with RNA polymerase II and participates in the process of gene expression. Mediator complex subunit 19 or regulation by oxygen 3, or lung cancer metastasis-related protein 1 is located at the head of the mediator complex; it is a multi-pro …
It interacts with RNA polymerase II and participates in the process of gene expression. Mediator complex subunit 19 or regulat …
The mediator complex in genomic and non-genomic signaling in cancer.
Weber H, Garabedian MJ. Weber H, et al. Steroids. 2018 May;133:8-14. doi: 10.1016/j.steroids.2017.11.007. Epub 2017 Nov 21. Steroids. 2018. PMID: 29157917 Free PMC article. Review.
Mediator has been shown to affect multiple steps in transcription, including chromatin looping between enhancers and promoters, pre-initiation complex formation, transcriptional elongation, and mRNA splicing. ...Recent structural studies have revealed extensive inte …
Mediator has been shown to affect multiple steps in transcription, including chromatin looping between enhancers and promoters, pre-i …
The plant Mediator complex and its role in jasmonate signaling.
Zhai Q, Li C. Zhai Q, et al. J Exp Bot. 2019 Jul 5;70(13):3415-3424. doi: 10.1093/jxb/erz233. J Exp Bot. 2019. PMID: 31089685 Free PMC article. Review.
The Mediator complex is an essential, multisubunit transcriptional coactivator that is highly conserved in eukaryotes. ...Recent studies of the plant Mediator complex have established that it functions in diverse aspects of plant development and fitnes …
The Mediator complex is an essential, multisubunit transcriptional coactivator that is highly conserved in eukaryotes. ...Rece …
11,768 results
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