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Year Number of Results
1991 1
1993 1
1994 3
1995 8
1996 12
1997 8
1998 7
1999 12
2000 16
2001 12
2002 9
2003 16
2004 16
2005 15
2006 13
2007 19
2008 18
2009 18
2010 38
2011 28
2012 20
2013 45
2014 90
2015 120
2016 138
2017 146
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2024 138
2025 1

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509 results

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Page 1
Update 2020: Management of Non-Small Cell Lung Cancer.
Alexander M, Kim SY, Cheng H. Alexander M, et al. Lung. 2020 Dec;198(6):897-907. doi: 10.1007/s00408-020-00407-5. Epub 2020 Nov 11. Lung. 2020. PMID: 33175991 Free PMC article. Review.
The past decade has seen a revolution of new advances in the management of non-small cell lung cancer (NSCLC) with remarkable progresses in screening, diagnosis, and treatment. The advances in systemic treatment have been driven primarily by the development of molecularly …
The past decade has seen a revolution of new advances in the management of non-small cell lung cancer (NSCLC) with remarkable progres …
DNA methylation-based classification of central nervous system tumours.
Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss DE, Kratz A, Wefers AK, Huang K, Pajtler KW, Schweizer L, Stichel D, Olar A, Engel NW, Lindenberg K, Harter PN, Braczynski AK, Plate KH, Dohmen H, Garvalov BK, Coras R, Hölsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez FJ, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Brück W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hänggi D, Hans V, Rozsnoki S, Hansford JR, Kohlhof P, Kristensen BW, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, Mühleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo NG, Driever PH, Kramm CM, Müller HL, Rutkowski S, von Hoff K, Frühwald MC, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu CM, Perry A, Jones C, Jacques TS, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberg… See abstract for full author list ➔ Capper D, et al. Nature. 2018 Mar 22;555(7697):469-474. doi: 10.1038/nature26000. Epub 2018 Mar 14. Nature. 2018. PMID: 29539639 Free PMC article.
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial i …
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour typ …
Sphingolipid metabolism in cancer signalling and therapy.
Ogretmen B. Ogretmen B. Nat Rev Cancer. 2018 Jan;18(1):33-50. doi: 10.1038/nrc.2017.96. Epub 2017 Nov 17. Nat Rev Cancer. 2018. PMID: 29147025 Free PMC article. Review.
This Review summarizes how ceramide-induced cellular stress mediates cancer cell death through various mechanisms involving the induction of apoptosis, necroptosis and/or mitophagy. ...Finally, studies targeting enzymes involved in sphingolipid metabolism and/or signalling …
This Review summarizes how ceramide-induced cellular stress mediates cancer cell death through various mechanisms involving the induc …
Cyclin D-CDK4/6 functions in cancer.
Gao X, Leone GW, Wang H. Gao X, et al. Adv Cancer Res. 2020;148:147-169. doi: 10.1016/bs.acr.2020.02.002. Epub 2020 Apr 2. Adv Cancer Res. 2020. PMID: 32723562 Review.
A body of evidence shows that the cyclin Ds-CDKs axis plays a critical role in cancer through various aspects, such as control of proliferation, senescence, migration, apoptosis, and angiogenesis. ...Of note, as the associated partner of D-type cyclins, CDK6 shows multiple …
A body of evidence shows that the cyclin Ds-CDKs axis plays a critical role in cancer through various aspects, such as control of pro …
Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML.
Perl AE, Martinelli G, Cortes JE, Neubauer A, Berman E, Paolini S, Montesinos P, Baer MR, Larson RA, Ustun C, Fabbiano F, Erba HP, Di Stasi A, Stuart R, Olin R, Kasner M, Ciceri F, Chou WC, Podoltsev N, Recher C, Yokoyama H, Hosono N, Yoon SS, Lee JH, Pardee T, Fathi AT, Liu C, Hasabou N, Liu X, Bahceci E, Levis MJ. Perl AE, et al. N Engl J Med. 2019 Oct 31;381(18):1728-1740. doi: 10.1056/NEJMoa1902688. N Engl J Med. 2019. PMID: 31665578 Clinical Trial.
Modeling Human Cancer-induced Cachexia.
Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC. Talbert EE, et al. Cell Rep. 2019 Aug 6;28(6):1612-1622.e4. doi: 10.1016/j.celrep.2019.07.016. Cell Rep. 2019. PMID: 31390573 Free PMC article.
Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In cancer, cachexia is associated with increased morbidity and mortality and decreased treatment tolerance. ...We envision that the KPP model will be a useful resource for advancing our mechan …
Cachexia is a wasting syndrome characterized by pronounced skeletal muscle loss. In cancer, cachexia is associated with increased mor …
CPX-351 versus 7+3 cytarabine and daunorubicin chemotherapy in older adults with newly diagnosed high-risk or secondary acute myeloid leukaemia: 5-year results of a randomised, open-label, multicentre, phase 3 trial.
Lancet JE, Uy GL, Newell LF, Lin TL, Ritchie EK, Stuart RK, Strickland SA, Hogge D, Solomon SR, Bixby DL, Kolitz JE, Schiller GJ, Wieduwilt MJ, Ryan DH, Faderl S, Cortes JE. Lancet JE, et al. Lancet Haematol. 2021 Jul;8(7):e481-e491. doi: 10.1016/S2352-3026(21)00134-4. Lancet Haematol. 2021. PMID: 34171279 Clinical Trial.
METHODS: This randomised, open-label, multicentre, phase 3 trial was done across 39 academic and regional cancer centres in the USA and Canada. Eligible patients were aged 60-75 years and had a pathological diagnosis of acute myeloid leukaemia according to WHO 2008 …
METHODS: This randomised, open-label, multicentre, phase 3 trial was done across 39 academic and regional cancer centres in th …
The broken cycle: E2F dysfunction in cancer.
Kent LN, Leone G. Kent LN, et al. Nat Rev Cancer. 2019 Jun;19(6):326-338. doi: 10.1038/s41568-019-0143-7. Nat Rev Cancer. 2019. PMID: 31053804 Review.
Alterations in one or more key components of this axis (CDKs, cyclins, CDK inhibitors and the RB family of proteins) occur in virtually all cancers and result in heightened oncogenic E2F activity, leading to uncontrolled proliferation. In this Review, we discuss the activi …
Alterations in one or more key components of this axis (CDKs, cyclins, CDK inhibitors and the RB family of proteins) occur in virtually all …
Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML.
DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM. DiNardo CD, et al. N Engl J Med. 2018 Jun 21;378(25):2386-2398. doi: 10.1056/NEJMoa1716984. Epub 2018 Jun 2. N Engl J Med. 2018. PMID: 29860938 Free article. Clinical Trial.
Hepatitis B Virus Reactivation: Risk Factors and Current Management Strategies.
Smalls DJ, Kiger RE, Norris LB, Bennett CL, Love BL. Smalls DJ, et al. Pharmacotherapy. 2019 Dec;39(12):1190-1203. doi: 10.1002/phar.2340. Epub 2019 Nov 3. Pharmacotherapy. 2019. PMID: 31596963 Free PMC article. Review.
Hepatitis B virus reactivation is an underappreciated but important complication of common medical therapies that can delay treatment or result in clinical episodes of hepatitis, hepatic failure, or death. In this review, factors associated with HBVr, particularly medic
Hepatitis B virus reactivation is an underappreciated but important complication of common medical therapies that can delay treatment …
509 results