Aspartate signalling drives lung metastasis via alternative translation.
Doglioni G, Fernández-García J, Igelmann S, Altea-Manzano P, Blomme A, La Rovere R, Liu XZ, Liu Y, Tricot T, Nobis M, An N, Leclercq M, El Kharraz S, Karras P, Hsieh YH, Solari FA, Martins Nascentes Melo L, Allies G, Scopelliti A, Rossi M, Vermeire I, Broekaert D, Ferreira Campos AM, Neven P, Maetens M, Van Baelen K, Alkan HF, Planque M, Floris G, Sickmann A, Tasdogan A, Marine JC, Scheele CLGJ, Desmedt C, Bultynck G, Close P, Fendt SM.
Doglioni G, et al.
Nature. 2025 Feb;638(8049):244-250. doi: 10.1038/s41586-024-08335-7. Epub 2025 Jan 1.
Nature. 2025.
PMID: 39743589
Free article.
Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative environment that may favour the survival of cancer cells(3). ...In turn, a translational programme with TGFbeta signalling as a central hub promotes …
Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative environment …