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Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.
Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE. Murphy MB, et al. Among authors: medvedev ae. J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26. J Leukoc Biol. 2015. PMID: 26310831 Free PMC article.
However, endotoxin tolerance renders septic patients immunocompromised and unable to control secondary infections. Although previous studies have revealed the importance of several negative regulators of Toll-like receptor signaling in endotoxin tolerance, the role …
However, endotoxin tolerance renders septic patients immunocompromised and unable to control secondary infections. Although previous …
Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases.
Xiong Y, Murphy M, Manavalan TT, Pattabiraman G, Qiu F, Chang HH, Ho IC, Medvedev AE. Xiong Y, et al. Among authors: medvedev ae. J Innate Immun. 2016;8(2):171-84. doi: 10.1159/000440838. Epub 2015 Oct 13. J Innate Immun. 2016. PMID: 26457672 Free PMC article.
Endotoxin tolerance protects the host by limiting excessive 'cytokine storm' during sepsis, but compromises the ability to counteract infections in septic shock survivors. ...Chemical PP inhibitors, okadaic acid, dephostatin and cantharidic acid markedly decreased or compl …
Endotoxin tolerance protects the host by limiting excessive 'cytokine storm' during sepsis, but compromises the ability to counteract …
Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease.
Medvedev AE, Sabroe I, Hasday JD, Vogel SN. Medvedev AE, et al. J Endotoxin Res. 2006;12(3):133-50. doi: 10.1179/096805106X102255. J Endotoxin Res. 2006. PMID: 16719986 Review.
However, tolerance may compromise the host's ability to counteract subsequent bacterial challenge since many septic patients exhibit an increased incidence of recurrent bacterial infection and suppressed monocyte responsiveness to LPS, closely resembling the tolerant
However, tolerance may compromise the host's ability to counteract subsequent bacterial challenge since many septic patients exhibit …
Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.
Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. Murphy M, et al. Among authors: medvedev ae. J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16. J Biol Chem. 2015. PMID: 26082489 Free PMC article.
Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory cytokines while retaining expression of anti-inflammatory and antimicrobial mediators. We previously demonstrated deficient TLR4-induced acti …
Endotoxin tolerance reprograms Toll-like receptor (TLR) 4-mediated macrophage responses by attenuating induction of proinflammatory c …
Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression.
Xiong Y, Qiu F, Piao W, Song C, Wahl LM, Medvedev AE. Xiong Y, et al. Among authors: medvedev ae. J Biol Chem. 2011 Mar 11;286(10):7905-16. doi: 10.1074/jbc.M110.182873. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220427 Free PMC article.
In septic patients, Toll-like receptor tolerance is thought to underlie decreased pro-inflammatory cytokine expression in response to LPS and increased incidence of microbial infections. ...A20 shRNA knockdown abolished LPS tolerization of THP1 cells, mechanistically linki …
In septic patients, Toll-like receptor tolerance is thought to underlie decreased pro-inflammatory cytokine expression in response to …
Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20.
Xiong Y, Medvedev AE. Xiong Y, et al. Among authors: medvedev ae. J Leukoc Biol. 2011 Dec;90(6):1141-8. doi: 10.1189/jlb.0611273. Epub 2011 Sep 20. J Leukoc Biol. 2011. PMID: 21934070 Free PMC article.
Molecular mechanisms of reprogramming of TLR4 signaling upon in vivo induction of endotoxin tolerance are incompletely understood. We used an in vivo model of endotoxin tolerance, whereby C57BL/6 mice were i.p....Macrophages from control and endotoxin-tolerant
Molecular mechanisms of reprogramming of TLR4 signaling upon in vivo induction of endotoxin tolerance are incompletely understood. We …
Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.
Piao W, Song C, Chen H, Diaz MA, Wahl LM, Fitzgerald KA, Li L, Medvedev AE. Piao W, et al. Among authors: medvedev ae. J Leukoc Biol. 2009 Oct;86(4):863-75. doi: 10.1189/jlb.0309189. Epub 2009 Aug 5. J Leukoc Biol. 2009. PMID: 19656901 Free PMC article.
Endotoxin tolerance reprograms cell responses to LPS by repressing expression of proinflammatory cytokines, while not inhibiting production of anti-inflammatory cytokines and antimicrobial effectors. ...These data demonstrate dysregulation of TLR4-triggered MyD88- and TRIF …
Endotoxin tolerance reprograms cell responses to LPS by repressing expression of proinflammatory cytokines, while not inhibiting prod …
Long noncoding RNAs as regulators of Toll-like receptor signaling and innate immunity.
Murphy MB, Medvedev AE. Murphy MB, et al. Among authors: medvedev ae. J Leukoc Biol. 2016 Jun;99(6):839-50. doi: 10.1189/jlb.2RU1215-575R. Epub 2016 Mar 10. J Leukoc Biol. 2016. PMID: 26965636 Free PMC article. Review.
Long noncoding RNAs have emerged as new regulators of inflammatory mediators in the immune system. They are expressed in macrophages, dendritic cells, neutrophils, NK cells, and T- and B-lymphocytes and are involved in immune cell differentiation and activation. ... …
Long noncoding RNAs have emerged as new regulators of inflammatory mediators in the immune system. They are expressed in macrophages, …
Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.
Medvedev AE, Piao W, Shoenfelt J, Rhee SH, Chen H, Basu S, Wahl LM, Fenton MJ, Vogel SN. Medvedev AE, et al. J Biol Chem. 2007 Jun 1;282(22):16042-53. doi: 10.1074/jbc.M606781200. Epub 2007 Mar 28. J Biol Chem. 2007. PMID: 17392283 Free PMC article.
TLR2 and TLR4 agonists induced TLR tyrosine phosphorylation in HEK293 cells overexpressing CD14, MD-2, and TLR4 or TLR2. Induction of endotoxin tolerance in HEK293/TLR4/MD-2 transfectants and in human monocytes markedly suppressed LPS-mediated TLR4 tyrosine phosphorylation …
TLR2 and TLR4 agonists induced TLR tyrosine phosphorylation in HEK293 cells overexpressing CD14, MD-2, and TLR4 or TLR2. Induction of endoto …
Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
Medvedev AE, Henneke P, Schromm A, Lien E, Ingalls R, Fenton MJ, Golenbock DT, Vogel SN. Medvedev AE, et al. J Immunol. 2001 Aug 15;167(4):2257-67. doi: 10.4049/jimmunol.167.4.2257. J Immunol. 2001. PMID: 11490013 Free article.
Down-regulation of cell surface expression of Toll-like receptor (TLR) 4 following LPS stimulation has been suggested to underlie endotoxin tolerance. In this study, we examined whether overexpression of TLR2 or TLR4 would affect the ability of cells to become tolerant
Down-regulation of cell surface expression of Toll-like receptor (TLR) 4 following LPS stimulation has been suggested to underlie endotoxin …
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