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[Vitamin C in the modulation of skin aging: molecular mechanisms and innovative delivery strategies.].
Mikhailova NP, Znatdinov DI, Borzova IV, Selyanin MA. Mikhailova NP, et al. Adv Gerontol. 2025;38(3):427-434. Adv Gerontol. 2025. PMID: 41172317 Review. Russian.
Vitamin C (ascorbic acid) is a key nutrient whose multifunctionality in anti-aging processes remains a subject of intensive research. ...The article comprehensively analyzes the causes of localized vitamin C deficiency in cutaneous tissue …
Vitamin C (ascorbic acid) is a key nutrient whose multifunctionality in anti-aging processes remains a subject o …
Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage.
Chen Y, Huang F, McClements DJ, Xie B, Sun Z, Deng Q. Chen Y, et al. Molecules. 2020 Mar 24;25(6):1458. doi: 10.3390/molecules25061458. Molecules. 2020. PMID: 32213858 Free PMC article.
The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and skin damaging was investigated. Fluorescence spectroscopy showed that, after encapsulation, the LSOPC-nanoliposomes still possessed st …
The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and …
Alpha-hydroxyacids and carboxylic acids.
Yu RJ, Van Scott EJ. Yu RJ, et al. J Cosmet Dermatol. 2004 Apr;3(2):76-87. doi: 10.1111/j.1473-2130.2004.00059.x. J Cosmet Dermatol. 2004. PMID: 17147560
Vitamin C, which is l-ascorbic acid and a lactone form of 3-keto-polyhydroxy acid, is a water-soluble antioxidant. Because of this property vitamin C has been promoted for topical prevention of skin damage caused by …
Vitamin C, which is l-ascorbic acid and a lactone form of 3-keto-polyhydroxy acid, is a water-soluble ant …
FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity.
Moon KM, Lee B, Kim DH, Chung HY. Moon KM, et al. Redox Biol. 2020 Sep;36:101624. doi: 10.1016/j.redox.2020.101624. Epub 2020 Jun 27. Redox Biol. 2020. PMID: 32863230 Free PMC article.
However, the role of FoxO6 in melanogenesis and its related signaling pathways are unclear. We used UV exposed and intrinsically aged mice that exhibited skin aging. Our data showed that FoxO6 activation was markedly decreased in the skin of aging mice …
However, the role of FoxO6 in melanogenesis and its related signaling pathways are unclear. We used UV exposed and intrinsical …
Effect of Ceramides Derivatives from the Peach on Skin Function Improvement in UV-Irradiated Hairless Mice.
Kim J, Lee M, Cho W, Yoo E, Kim J, Gwon Y, Okayasu M, Lee J. Kim J, et al. Foods. 2024 Nov 27;13(23):3824. doi: 10.3390/foods13233824. Foods. 2024. PMID: 39682897 Free PMC article.
This study investigated the protective effects of a ceramides derivates from the peach (PF3) on photoaging by UV-irradiated hairless mice. Mice were randomly divided into seven groups: AIN93G without UVB exposure (normal control, NC), AIN93G with UVB exposure (co …
This study investigated the protective effects of a ceramides derivates from the peach (PF3) on photoaging by UV-irradiated hairless …
Oligomeric proanthocyanidins from grape seeds effectively inhibit ultraviolet-induced melanogenesis of human melanocytes in vitro.
Zi SX, Ma HJ, Li Y, Liu W, Yang QQ, Zhao G, Lian S. Zi SX, et al. Int J Mol Med. 2009 Feb;23(2):197-204. Int J Mol Med. 2009. PMID: 19148543
The oligomeric proanthocyanidins (OPCs) from grape seeds are expected to be novel and potent anti-oxidants that more effectively protect skin cells against oxidative stress. UV-induced oxidative stress is considered to promote melanogenesis and serious ski …
The oligomeric proanthocyanidins (OPCs) from grape seeds are expected to be novel and potent anti-oxidants that more effectively protect …
Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide system.
Panich U, Tangsupa-a-nan V, Onkoksoong T, Kongtaphan K, Kasetsinsombat K, Akarasereenont P, Wongkajornsilp A. Panich U, et al. Arch Pharm Res. 2011 May;34(5):811-20. doi: 10.1007/s12272-011-0515-3. Epub 2011 Jun 9. Arch Pharm Res. 2011. PMID: 21656367
Ascorbic acid (AA) has been well known as a skin whitening agent, although attempts have been made to evaluate its protective role against ultraviolet (UV)-induced skin hyperpigmentation or increased melanin production. While melanogenesis …
Ascorbic acid (AA) has been well known as a skin whitening agent, although attempts have been made to evaluate its prot …
The inhibitory effect of DL-alpha-tocopheryl ferulate in lecithin on melanogenesis.
Ichihashi M, Funasaka Y, Ohashi A, Chacraborty A, Ahmed NU, Ueda M, Osawa T. Ichihashi M, et al. Anticancer Res. 1999 Sep-Oct;19(5A):3769-74. Anticancer Res. 1999. PMID: 10625956
Our aim was to determine whether alpha-TF can be applied to improve and prevent facial hyperpigmentation induced by UV as a whitening agent as well as an antioxidant. In this study, the effects of alpha-TF on melanogenesis were examined using cultured human m …
Our aim was to determine whether alpha-TF can be applied to improve and prevent facial hyperpigmentation induced by UV as a wh …
Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials.
Piffaut V, De Dormael R, Belaidi JP, Bertrand L, Passeron T, Bernerd F, Marionnet C. Piffaut V, et al. Front Pharmacol. 2025 Oct 9;16:1651068. doi: 10.3389/fphar.2025.1651068. eCollection 2025. Front Pharmacol. 2025. PMID: 41142247 Free PMC article.
MATERIAL AND METHODS: Two very potent inhibitors of UV-induced pigmentation, ascorbic acid 7% (powerful antioxidant) and 2-mercaptonicotinoyl glycine (2-MNG, 0.5 or 1%, melanogenesis inhibitor), were assessed in 2 controlled randomized clinical trials …
MATERIAL AND METHODS: Two very potent inhibitors of UV-induced pigmentation, ascorbic acid 7% (powerful antioxidant) an …