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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1959 1
1960 5
1961 5
1962 1
1963 7
1964 19
1965 25
1966 23
1967 32
1968 52
1969 46
1970 52
1971 71
1972 59
1973 59
1974 71
1975 87
1976 102
1977 90
1978 116
1979 153
1980 131
1981 138
1982 174
1983 162
1984 186
1985 247
1986 261
1987 249
1988 314
1989 324
1990 344
1991 369
1992 384
1993 402
1994 413
1995 466
1996 529
1997 614
1998 653
1999 725
2000 653
2001 723
2002 724
2003 752
2004 654
2005 799
2006 865
2007 812
2008 837
2009 869
2010 933
2011 965
2012 1036
2013 1074
2014 1215
2015 1199
2016 1208
2017 1316
2018 1410
2019 1561
2020 1838
2021 1948
2022 2072
2023 1940
2024 1975
2025 2187
2026 1524
2027 1

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37,618 results

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Page 1
Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements.
Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J. Minich DM, et al. Nutrients. 2022 Sep 22;14(19):3934. doi: 10.3390/nu14193934. Nutrients. 2022. PMID: 36235587 Free PMC article. Review.
Melatonin has become a popular dietary supplement, most known as a chronobiotic, and for establishing healthy sleep. ...This review aims to evaluate the recent data on melatonin's mechanisms, its clinical uses beyond sleep, safety concerns, and a thorough sum …
Melatonin has become a popular dietary supplement, most known as a chronobiotic, and for establishing healthy sleep. ...This review a …
Melatonin: the placental antioxidant and anti-inflammatory.
Joseph TT, Schuch V, Hossack DJ, Chakraborty R, Johnson EL. Joseph TT, et al. Front Immunol. 2024 Feb 1;15:1339304. doi: 10.3389/fimmu.2024.1339304. eCollection 2024. Front Immunol. 2024. PMID: 38361952 Free PMC article. Review.
Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many physiological and biological roles. ...This literature review aims to identify and summarize melatonin's role as a powerful antioxidant and anti-inflammatory that reduces oxidative st …
Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many physiological and biological roles. ...This literature re …
Melatonin: exceeding expectations.
Reiter RJ, Tan DX, Galano A. Reiter RJ, et al. Physiology (Bethesda). 2014 Sep;29(5):325-33. doi: 10.1152/physiol.00011.2014. Physiology (Bethesda). 2014. PMID: 25180262 Free article. Review.
The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart a …
The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby pro …
Melatonin as an antioxidant: under promises but over delivers.
Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L. Reiter RJ, et al. J Pineal Res. 2016 Oct;61(3):253-78. doi: 10.1111/jpi.12360. Epub 2016 Sep 1. J Pineal Res. 2016. PMID: 27500468 Review.
Melatonin's ubiquitous but unequal intracellular distribution, including its high concentrations in mitochondria, likely aid in its capacity to resist oxidative stress and cellular apoptosis. There is credible evidence to suggest that melatonin should be clas …
Melatonin's ubiquitous but unequal intracellular distribution, including its high concentrations in mitochondria, likely aid i …
Melatonin's paradox: From therapeutic benefits to toxicity warnings.
Amrollahi-Sharifabadi M, Oladejo TO, Ibrahim AS, Shakoor B, Mehrpour O, Sadeghi-Hashjin G, Gonçalves S. Amrollahi-Sharifabadi M, et al. Chem Biol Interact. 2025 Aug 25;417:111556. doi: 10.1016/j.cbi.2025.111556. Epub 2025 May 16. Chem Biol Interact. 2025. PMID: 40383469 Review.
However, emerging studies highlight potential toxicological concerns associated with exogenous melatonin use, especially in specific populations. This review provided a comprehensive exploration of melatonin's dual role as a therapeutic and potentially toxic …
However, emerging studies highlight potential toxicological concerns associated with exogenous melatonin use, especially in specific …
Melatonin: A Neurotrophic Factor?
Miranda-Riestra A, Estrada-Reyes R, Torres-Sanchez ED, Carreño-García S, Ortiz GG, Benítez-King G. Miranda-Riestra A, et al. Molecules. 2022 Nov 10;27(22):7742. doi: 10.3390/molecules27227742. Molecules. 2022. PMID: 36431847 Free PMC article. Review.
Melatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal environment with the photoperiod. ...This review presents evidence suggesting melatonin's role as a neurotrophic factor, describes the signaling pathways involved in these pr …
Melatonin, N-acetyl-5-hydroxytryptamine, is a hormone that synchronizes the internal environment with the photoperiod. ...This review …
Melatonin's Antineoplastic Potential Against Glioblastoma.
Moretti E, Favero G, Rodella LF, Rezzani R. Moretti E, et al. Cells. 2020 Mar 3;9(3):599. doi: 10.3390/cells9030599. Cells. 2020. PMID: 32138190 Free PMC article. Review.
To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties. Due to evidence demonstrating melatonin's activity against several cancer hallm …
To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indolea …
Melatonin and ferroptosis: Mechanisms and therapeutic implications.
Zhang D, Jia X, Lin D, Ma J. Zhang D, et al. Biochem Pharmacol. 2023 Dec;218:115909. doi: 10.1016/j.bcp.2023.115909. Epub 2023 Nov 4. Biochem Pharmacol. 2023. PMID: 37931663 Review.
This review outlines the molecular mechanisms of ferroptosis, investigates melatonin's potential effects on ferroptosis, and discusses melatonin's therapeutic potential as a promising intervention against diseases associated with ferroptosis. Through t …
This review outlines the molecular mechanisms of ferroptosis, investigates melatonin's potential effects on ferroptosis, and d …
Melatonin and the Programming of Stem Cells.
Hardeland R. Hardeland R. Int J Mol Sci. 2022 Feb 10;23(4):1971. doi: 10.3390/ijms23041971. Int J Mol Sci. 2022. PMID: 35216086 Free PMC article. Review.
These various properties are frequently intertwined but may not be always jointly present. Melatonin typically stimulates proliferation and transition to the mature cell type. For all sufficiently studied stem or progenitor cells, melatonin's signaling pathwa …
These various properties are frequently intertwined but may not be always jointly present. Melatonin typically stimulates proliferati …
The Vital Role of Melatonin and Its Metabolites in the Neuroprotection and Retardation of Brain Aging.
Bocheva G, Bakalov D, Iliev P, Tafradjiiska-Hadjiolova R. Bocheva G, et al. Int J Mol Sci. 2024 May 8;25(10):5122. doi: 10.3390/ijms25105122. Int J Mol Sci. 2024. PMID: 38791160 Free PMC article. Review.
While primarily produced in the pineal gland, melatonin's influence goes beyond its well-known role in regulating sleep, nighttime metabolism, and circadian rhythms, in the field of chronobiology. ...Melatonin and its metabolites exert multiple beneficial eff …
While primarily produced in the pineal gland, melatonin's influence goes beyond its well-known role in regulating sleep, night …
37,618 results
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