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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1976 1
1978 3
1979 1
1980 1
1981 1
1982 1
1983 2
1985 4
1986 3
1987 4
1988 8
1989 5
1990 8
1991 5
1992 8
1993 8
1994 13
1995 12
1996 11
1997 11
1998 20
1999 21
2000 22
2001 22
2002 28
2003 9
2004 10
2005 30
2006 36
2007 21
2008 31
2009 30
2010 15
2011 23
2012 33
2013 35
2014 31
2015 35
2016 30
2017 30
2018 39
2019 38
2020 37
2021 45
2022 15
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721 results
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Melatonin and breast cancer: Evidences from preclinical and human studies.
Kubatka P, Zubor P, Busselberg D, Kwon TK, Adamek M, Petrovic D, Opatrilova R, Gazdikova K, Caprnda M, Rodrigo L, Danko J, Kruzliak P. Kubatka P, et al. Crit Rev Oncol Hematol. 2018 Feb;122:133-143. doi: 10.1016/j.critrevonc.2017.12.018. Epub 2017 Dec 29. Crit Rev Oncol Hematol. 2018. PMID: 29458781 Review.
In breast cancer, melatonin is capable to disrupt estrogen-dependent cell signaling, resulting in a reduction of estrogen-stimulated cells, moreover, it's obvious neuro-immunomodulatory effect in organism was described. Several prospective studies have …
In breast cancer, melatonin is capable to disrupt estrogen-dependent cell signaling, resulting in a reduction of estrog …
Circadian Rhythm and Concentration of Melatonin in Breast Cancer Patients.
Ahabrach H, El Mlili N, Errami M, Cauli O. Ahabrach H, et al. Endocr Metab Immune Disord Drug Targets. 2021;21(10):1869-1881. doi: 10.2174/1871530320666201201110807. Endocr Metab Immune Disord Drug Targets. 2021. PMID: 33261546 Review.
Reduction in melatonin levels and altered circadian rhythms have been associated with a high risk of breast cancer. Melatonin has also been shown to display anti-proliferative effects on breast cancer growth and proliferation. ...
Reduction in melatonin levels and altered circadian rhythms have been associated with a high risk of breast cancer. …
Shift Work and Breast Cancer.
Gehlert S, Clanton M, On Behalf Of The Shift Work And Breast Cancer Strategic Advisory Group. Gehlert S, et al. Int J Environ Res Public Health. 2020 Dec 20;17(24):9544. doi: 10.3390/ijerph17249544. Int J Environ Res Public Health. 2020. PMID: 33419321 Free PMC article. Review.
Women who work lower-wage jobs and part-time workers whose shifts are determined entirely by their supervisors (rotating shifts) may be subject to stress related to efforts to align childcare and other needs with the unpredictable nature of rotating shift work. The causal link be …
Women who work lower-wage jobs and part-time workers whose shifts are determined entirely by their supervisors (rotating shifts) may be subj …
Melatonin for the prevention and treatment of cancer.
Li Y, Li S, Zhou Y, Meng X, Zhang JJ, Xu DP, Li HB. Li Y, et al. Oncotarget. 2017 Jun 13;8(24):39896-39921. doi: 10.18632/oncotarget.16379. Oncotarget. 2017. PMID: 28415828 Free PMC article. Review.
Melatonin could also be utilized as adjuvant of cancer therapies, through reinforcing the therapeutic effects and reducing the side effects of chemotherapies or radiation. Melatonin could be an excellent candidate for the prevention and treatment of several c …
Melatonin could also be utilized as adjuvant of cancer therapies, through reinforcing the therapeutic effects and reducing the …
Melatonin: A Potential Therapeutic Option for Breast Cancer.
Kong X, Gao R, Wang Z, Wang X, Fang Y, Gao J, Reiter RJ, Wang J. Kong X, et al. Trends Endocrinol Metab. 2020 Nov;31(11):859-871. doi: 10.1016/j.tem.2020.08.001. Epub 2020 Sep 3. Trends Endocrinol Metab. 2020. PMID: 32893084 Review.
Melatonin has significant inhibitory effects in numerous cancers, especially breast cancer. In estrogen receptor (ER)-positive human breast cancer, the oncostatic actions of melatonin are mainly achieved by suppressing ER mRNA expression …
Melatonin has significant inhibitory effects in numerous cancers, especially breast cancer. In estrogen receptor (ER)-p …
Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology.
Anderson G. Anderson G. Biochem Pharmacol. 2019 Oct;168:259-268. doi: 10.1016/j.bcp.2019.07.014. Epub 2019 Jul 13. Biochem Pharmacol. 2019. PMID: 31310736 Review.
This article proposes that melatonergic pathway regulation within mitochondria provides an integrative framework for the wide array of data driving breast cancer pathophysiology. As melatonin is toxic to breast cancer cells, its production withi …
This article proposes that melatonergic pathway regulation within mitochondria provides an integrative framework for the wide array of data …
Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial.
Palmer ACS, Zortea M, Souza A, Santos V, Biazús JV, Torres ILS, Fregni F, Caumo W. Palmer ACS, et al. PLoS One. 2020 Apr 17;15(4):e0231379. doi: 10.1371/journal.pone.0231379. eCollection 2020. PLoS One. 2020. PMID: 32302347 Free PMC article. Clinical Trial.
This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cycle of adjuvant chemotherapy for breast cancer (ACBC) reduced the side effects associated with cognitive impairment. ...Our re …
This randomized, double-blinded, placebo-controlled trial tested the hypothesis that 20mg of melatonin before and during the first cy …
Melatonin, an inhibitory agent in breast cancer.
Nooshinfar E, Safaroghli-Azar A, Bashash D, Akbari ME. Nooshinfar E, et al. Breast Cancer. 2017 Jan;24(1):42-51. doi: 10.1007/s12282-016-0690-7. Epub 2016 Mar 26. Breast Cancer. 2017. PMID: 27017208 Review.
Due to the stimulatory effect of estrogen in mammary cancer progression, anti-estrogenic agents like melatonin have found their way into breast cancer treatment. Further studies confirmed a reverse correlation between nocturnal melatonin levels …
Due to the stimulatory effect of estrogen in mammary cancer progression, anti-estrogenic agents like melatonin have found thei …
Melatonin is an appropriate candidate for breast cancer treatment: Based on known molecular mechanisms.
Amin N, Shafabakhsh R, Reiter RJ, Asemi Z. Amin N, et al. J Cell Biochem. 2019 Aug;120(8):12208-12215. doi: 10.1002/jcb.28832. Epub 2019 Apr 30. J Cell Biochem. 2019. PMID: 31041825 Review.
It is suggested that melatonin inhibits the development of breast cancer by various mechanisms. This paper summarizes the roles of melatonin in breast cancer treatment from the aspect of its molecular actions....
It is suggested that melatonin inhibits the development of breast cancer by various mechanisms. This paper summarizes t …
[Inhibitory effects of melatonin on breast cancer].
Jiang Z, Ma F. Jiang Z, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Mar 28;42(3):346-351. doi: 10.11817/j.issn.1672-7347.2017.03.018. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017. PMID: 28364111 Free article. Review. Chinese.
Melatonin has a significant inhibitory effect on various cancers, especially on breast cancer. In estrogen receptor (ER)-positive human breast cancer, anti-cancer effects of melatonin on breast cancer cells and transp …
Melatonin has a significant inhibitory effect on various cancers, especially on breast cancer. In estrogen receptor (ER …
The potential therapeutic effects of melatonin on breast cancer: An invasion and metastasis inhibitor.
Maroufi NF, Ashouri N, Mortezania Z, Ashoori Z, Vahedian V, Amirzadeh-Iranaq MT, Fattahi A, Kazemzadeh H, Bizzarri M, Akbarzadeh M, Nejabati HR, Faridvand Y, Rashidi MR, Nouri M. Maroufi NF, et al. Pathol Res Pract. 2020 Oct;216(10):153226. doi: 10.1016/j.prp.2020.153226. Epub 2020 Sep 19. Pathol Res Pract. 2020. PMID: 32987338 Review.
Breast cancer is the most common cancer among women and its metastasis which generally observed at the last stage is the major cause of breast cancer-related death. ...Thus, the aim of this review is to discuss the potential therapeutic effect o …
Breast cancer is the most common cancer among women and its metastasis which generally observed at the last stage is th …
Melatonin: A Molecule for Reducing Breast Cancer Risk.
González-González A, Mediavilla MD, Sánchez-Barceló EJ. González-González A, et al. Molecules. 2018 Feb 6;23(2):336. doi: 10.3390/molecules23020336. Molecules. 2018. PMID: 29415446 Free PMC article. Review.
The objective of this article is to review the basis supporting the usefulness of melatonin as an adjuvant therapy for breast cancer (BC) prevention in several groups of individuals at high risk for this disease. ...Despite compelling experimental evidence of …
The objective of this article is to review the basis supporting the usefulness of melatonin as an adjuvant therapy for breast …
Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin.
Tascioglu Aliyev A, Panieri E, Stepanić V, Gurer-Orhan H, Saso L. Tascioglu Aliyev A, et al. Molecules. 2021 Mar 25;26(7):1853. doi: 10.3390/molecules26071853. Molecules. 2021. PMID: 33805996 Free PMC article. Review.
However, its overactivation may lead to a negative clinical impact on breast cancer therapy by causing chemoresistance. Some known "oxidative stress modulators", such as melatonin and polyphenols, are suggested to play an important role in the prevention and …
However, its overactivation may lead to a negative clinical impact on breast cancer therapy by causing chemoresistance. Some k …
Melatonin as an Oncostatic Molecule Based on Its Anti-Aromatase Role in Breast Cancer.
Jin Y, Choi YJ, Heo K, Park SJ. Jin Y, et al. Int J Mol Sci. 2021 Jan 4;22(1):438. doi: 10.3390/ijms22010438. Int J Mol Sci. 2021. PMID: 33406787 Free PMC article. Review.
Breast cancer is the most common type of cancer. In the developmental stages of breast cancer, estrogens are strongly involved. ...In this manner, this review summarizes the inhibitory role of melatonin in aromatase action, suggesting its …
Breast cancer is the most common type of cancer. In the developmental stages of breast cancer, estrogens …
Night Shift Work and Risk of Breast Cancer.
Hansen J. Hansen J. Curr Environ Health Rep. 2017 Sep;4(3):325-339. doi: 10.1007/s40572-017-0155-y. Curr Environ Health Rep. 2017. PMID: 28770538 Review.
The large differences in definitions of both exposure and outcome may contribute to the observed heterogeneity of results from studies of night work and breast cancer, which overall points in the direction of an increased breast cancer risk, in particu …
The large differences in definitions of both exposure and outcome may contribute to the observed heterogeneity of results from studies of ni …
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.
Reiter RJ, Rosales-Corral SA, Tan DX, Acuna-Castroviejo D, Qin L, Yang SF, Xu K. Reiter RJ, et al. Int J Mol Sci. 2017 Apr 17;18(4):843. doi: 10.3390/ijms18040843. Int J Mol Sci. 2017. PMID: 28420185 Free PMC article. Review.
There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. ...While the emphasis of melatonin/cancer research has been on the role of the indoleamine in restraining breast cancer …
There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. ...Whi …
Therapeutic potential of melatonin for breast cancer radiation therapy patients.
Griffin F, Marignol L. Griffin F, et al. Int J Radiat Biol. 2018 May;94(5):472-477. doi: 10.1080/09553002.2018.1446227. Epub 2018 Mar 14. Int J Radiat Biol. 2018. PMID: 29521142 Review.
But pre-clinical studies are reporting both its radioprotective and radiosensitizing properties, possibly mediated through an interaction between melatonin and the regulation of estrogens. Melatonin pre-treatment prior to ionizing radiation was associated with a dec …
But pre-clinical studies are reporting both its radioprotective and radiosensitizing properties, possibly mediated through an interaction be …
Melatonin: an inhibitor of breast cancer.
Hill SM, Belancio VP, Dauchy RT, Xiang S, Brimer S, Mao L, Hauch A, Lundberg PW, Summers W, Yuan L, Frasch T, Blask DE. Hill SM, et al. Endocr Relat Cancer. 2015 Jun;22(3):R183-204. doi: 10.1530/ERC-15-0030. Epub 2015 Apr 15. Endocr Relat Cancer. 2015. PMID: 25876649 Free PMC article. Review.
The anti-cancer actions of the circadian melatonin signal in human breast cancer cell lines and xenografts heavily involve MT1 receptor-mediated mechanisms. ...Melatonin demonstrates both cytostatic and cytotoxic activity in breast can …
The anti-cancer actions of the circadian melatonin signal in human breast cancer cell lines and xenografts heavi …
Melatonin inhibits breast cancer cell invasion through modulating DJ-1/KLF17/ID-1 signaling pathway.
El-Sokkary GH, Ismail IA, Saber SH. El-Sokkary GH, et al. J Cell Biochem. 2019 Mar;120(3):3945-3957. doi: 10.1002/jcb.27678. Epub 2018 Sep 27. J Cell Biochem. 2019. PMID: 30260001
The main goal of this study was to explore the effect of melatonin against breast cancer metastasis and compared this with the actions of taxol (a well-known chemotherapeutic drug), and the impact of their combination against breast cancer metas …
The main goal of this study was to explore the effect of melatonin against breast cancer metastasis and compared this w …
[Restful sleep, melatonin and breast cancer].
Santisteban M. Santisteban M. An Sist Sanit Navar. 2019 Aug 23;42(2):245-248. doi: 10.23938/ASSN.0714. An Sist Sanit Navar. 2019. PMID: 31327869 Free article. Spanish. No abstract available.
721 results