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[Mechanism of melatonin regulating the expression level of rhythm genes to alleviate interstitial pulmonary fibrosis].
Li B, Zhu L, Wang Y, Bai L. Li B, et al. Beijing Da Xue Xue Bao Yi Xue Ban. 2024 Dec 18;56(6):963-971. doi: 10.19723/j.issn.1671-167X.2024.06.004. Beijing Da Xue Xue Bao Yi Xue Ban. 2024. PMID: 39690756 Free PMC article. Chinese.
OBJECTIVE: To investigate the intervention of melatonin (MT) in the expression of circadian genes in patients with pulmonary fibrosis and to analyze the mechanism by which it alleviates the progression of pulmonary fibrosis. METHODS: By utilizin …
OBJECTIVE: To investigate the intervention of melatonin (MT) in the expression of circadian genes in patients with pulmonary
Analysis of how melatonin-upregulated clock genes PER2 and CRY2 alleviate rheumatoid arthritis-associated interstitial lung disease.
Huo Y, Gao Y, Li B, Zhang P, Liu H, Wang G, Pang C, Wang Y, Bai L. Huo Y, et al. Eur J Pharmacol. 2025 Jan 5;986:177136. doi: 10.1016/j.ejphar.2024.177136. Epub 2024 Nov 15. Eur J Pharmacol. 2025. PMID: 39551335
Melatonin (Mel) serves as the central regulator for maintaining circadian rhythms and plays a crucial role not only in controlling the rhythmic clock, but also in several functional domains such as immunomodulation and anti-inflammation. In this study, we explored the clin
Melatonin (Mel) serves as the central regulator for maintaining circadian rhythms and plays a crucial role not only in controlling th
Melatonin prevents pulmonary fibrosis caused by PM(2.5) exposure by targeting epithelial-mesenchymal transition.
Chen PC, Yen MH, Hsiao SY, Kao WC, Wang MT, Chiou PC, Chao CC. Chen PC, et al. Toxicol Appl Pharmacol. 2024 Jun;487:116949. doi: 10.1016/j.taap.2024.116949. Epub 2024 Apr 28. Toxicol Appl Pharmacol. 2024. PMID: 38688425
In this current study, we found that melatonin effectively prevented pulmonary fibrosis caused by prolonged exposure to PM(2.5) by targeting EMT. ...These findings suggest that melatonin has potential clinical use for the prevention of pulmonary
In this current study, we found that melatonin effectively prevented pulmonary fibrosis caused by prolonged exposure to …
Connexin43, A Promising Target to Reduce Cardiac Arrhythmia Burden in Pulmonary Arterial Hypertension.
Sykora M, Szeiffova Bacova B, Andelova K, Egan Benova T, Martiskova A, Kurahara LH, Hirano K, Tribulova N. Sykora M, et al. Int J Mol Sci. 2024 Mar 14;25(6):3275. doi: 10.3390/ijms25063275. Int J Mol Sci. 2024. PMID: 38542257 Free PMC article. Review.
While essential hypertension (HTN) is very prevalent, pulmonary arterial hypertension (PAH) is very rare in the general population. However, due to progressive heart failure, prognoses and survival rates are much worse in PAH. ...Specifically, the benefits of sodium glucos …
While essential hypertension (HTN) is very prevalent, pulmonary arterial hypertension (PAH) is very rare in the general population. H …
Hypoxia Induces Alterations in the Circadian Rhythm in Patients with Chronic Respiratory Diseases.
Castillejos-López M, Romero Y, Varela-Ordoñez A, Flores-Soto E, Romero-Martinez BS, Velázquez-Cruz R, Vázquez-Pérez JA, Ruiz V, Gomez-Verjan JC, Rivero-Segura NA, Camarena Á, Torres-Soria AK, Gonzalez-Avila G, Sommer B, Solís-Chagoyán H, Jaimez R, Torres-Espíndola LM, Aquino-Gálvez A. Castillejos-López M, et al. Cells. 2023 Nov 29;12(23):2724. doi: 10.3390/cells12232724. Cells. 2023. PMID: 38067152 Free PMC article. Review.
Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulate the circadian cycles, the latter because hypoxia alters the production of melatonin and brain physiology. Additionally, the lack of …
Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulat …
Preventive effects of Ramelteon on bleomycin-induced pulmonary fibrosis in mice.
Zhang L, Cheng T, Chen W, Zhong C, Li M, Xie Y, Deng Q, Wang H, Yang Z, Ju J, Liang H. Zhang L, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun;397(6):4153-4163. doi: 10.1007/s00210-023-02867-x. Epub 2023 Nov 30. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38032492
Pulmonary fibrosis (PF) is a devastating lung disease that leads to impaired lung function and ultimately death. ...Functionally, Ramelteon partially abrogated TGF-beta1-induced pulmonary fibrosis and reduced fibroblast proliferation, extracellular mat
Pulmonary fibrosis (PF) is a devastating lung disease that leads to impaired lung function and ultimately death. ...Functional
SLC6A3-Related Dopamine Transporter Deficiency Syndrome.
Spaull RVV, Kurian MA. Spaull RVV, et al. 2017 Jul 27 [updated 2023 Sep 28]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2017 Jul 27 [updated 2023 Sep 28]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 28749637 Free Books & Documents. Review.
Supportive management and developmental support includes: nutrition management and feeding support for oral feeding issues; alternative and augmentative communication devices when needed; medical management of tone issues and regular physical therapy to reduce the risk of contrac …
Supportive management and developmental support includes: nutrition management and feeding support for oral feeding issues; alternative and …
The melatonin agonist ramelteon attenuates bleomycin-induced lung fibrosis by suppressing the NLRP3/TGF-beta1/HMGB1 signaling pathway.
Aydin P, Aksakalli-Magden ZB, Civelek MS, Karabulut-Uzuncakmak S, Mokhtare B, Ozkaraca M, Alper F, Halici Z. Aydin P, et al. Adv Med Sci. 2023 Sep;68(2):322-331. doi: 10.1016/j.advms.2023.09.004. Epub 2023 Sep 14. Adv Med Sci. 2023. PMID: 37716182
MATERIALS AND METHODS: Bleomycin (0.1 mL of 5 mg/kg) was administered by intratracheal instillation to induce pulmonary fibrosis (PF). Starting 24 h after bleomycin administration, a single dose of ramelteon was administered by oral gavage to the healthy groups, i.e …
MATERIALS AND METHODS: Bleomycin (0.1 mL of 5 mg/kg) was administered by intratracheal instillation to induce pulmonary fibrosis
PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis.
Li N, Xiong R, Li G, Wang B, Geng Q. Li N, et al. Free Radic Biol Med. 2023 Aug 20;205:291-304. doi: 10.1016/j.freeradbiomed.2023.06.017. Epub 2023 Jun 20. Free Radic Biol Med. 2023. PMID: 37348684
Previous studies have reported that particulate matter 2.5 (PM2.5) could trigger pulmonary inflammation and fibrosis by inducing pulmonary epithelial senescence and ferroptosis. ...Finally, we found that SIRT3 agonist, melatonin treatment could allevia …
Previous studies have reported that particulate matter 2.5 (PM2.5) could trigger pulmonary inflammation and fibrosis by induci …
Ramelteon and mechanism of its restorative effect in an experimental lung disease model.
Armağan İ, Aşcı H, Erzurumlu Y, Özkula S, Hasseyid N, Kumbul Doğuç D, Okuyucu G, Varel A. Armağan İ, et al. Toxicol Mech Methods. 2023 Mar;33(3):239-247. doi: 10.1080/15376516.2022.2156006. Epub 2022 Dec 13. Toxicol Mech Methods. 2023. PMID: 36482745
In addition, diffuse alveolar damage, interstitial pneumonia, fibrosis, and pleural reactions may be encountered in MTX-induced pulmonary toxicity. Ramelteon (RML), a melatonin receptor agonist, has antioxidant, anti-inflammatory, and protective effects are s …
In addition, diffuse alveolar damage, interstitial pneumonia, fibrosis, and pleural reactions may be encountered in MTX-induced pu
Melatonin ameliorates bleomycin-induced pulmonary fibrosis via activating NRF2 and inhibiting galectin-3 expression.
Lan YJ, Cheng MH, Ji HM, Bi YQ, Han YY, Yang CY, Gu X, Gao J, Dong HL. Lan YJ, et al. Acta Pharmacol Sin. 2023 May;44(5):1029-1037. doi: 10.1038/s41401-022-01018-x. Epub 2022 Nov 4. Acta Pharmacol Sin. 2023. PMID: 36333557 Free PMC article.
Pulmonary fibrosis (PF) is a chronic interstitial lung disease with no effective therapies. ...Fibroblast-myofibroblast differentiation (FMD) is an important source of fibrotic cells in PF. Previous studies showed that melatonin (MT) exerted anti-fibrotic eff
Pulmonary fibrosis (PF) is a chronic interstitial lung disease with no effective therapies. ...Fibroblast-myofibroblast differ
Melatonin activates the Mst1-Nrf2 signaling to alleviate cardiac hypertrophy in pulmonary arterial hypertension.
Chen S, Sun P, Li Y, Shen W, Wang C, Zhao P, Cui H, Xue JY, Du GQ. Chen S, et al. Eur J Pharmacol. 2022 Oct 15;933:175262. doi: 10.1016/j.ejphar.2022.175262. Epub 2022 Sep 10. Eur J Pharmacol. 2022. PMID: 36100129
Among pulmonary arterial hypertension (PAH) patients, right ventricular (RV) functioning has been considered a major determining factor for cardiac capacity and survival. ...This study aims to suggest one such possible treatment, through investigating the cardio-protective …
Among pulmonary arterial hypertension (PAH) patients, right ventricular (RV) functioning has been considered a major determining fact …
Role of melatonin in respiratory diseases (Review).
Li L, Gang X, Wang J, Gong X. Li L, et al. Exp Ther Med. 2022 Apr;23(4):271. doi: 10.3892/etm.2022.11197. Epub 2022 Feb 9. Exp Ther Med. 2022. PMID: 35251337 Free PMC article. Review.
Melatonin has been reported to have great potential to treat patients with pulmonary disorders. The present review discusses the relationship between melatonin and pulmonary disorders, including coronavirus disease-2019, chronic obstructive pulmonar
Melatonin has been reported to have great potential to treat patients with pulmonary disorders. The present review discusses t
Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/beta-catenin signaling pathway in mice.
Li X, Zhang T, Lv W, Wang H, Chen H, Xu Q, Cai H, Dai J. Li X, et al. Ecotoxicol Environ Saf. 2022 Mar 1;232:113238. doi: 10.1016/j.ecoenv.2022.113238. Epub 2022 Feb 1. Ecotoxicol Environ Saf. 2022. PMID: 35121255 Free article.

Our analyzes demonstrated that inhalation of the PS-MPs induces pulmonary fibrosis in a dose-dependent manner in mice. In high dose group (6.25 mg/kg), the PS-MPs significantly increased the expression of alpha-SMA, Vimentin and Col1a (p < 0.05). ...In addition,

Our analyzes demonstrated that inhalation of the PS-MPs induces pulmonary fibrosis in a dose-dependent manner in mice. In high …
The role of melatonin on radiation-induced pneumonitis and lung fibrosis: A systematic review.
Sheikholeslami S, Aryafar T, Abedi-Firouzjah R, Banaei A, Dorri-Giv M, Zamani H, Ataei G, Majdaeen M, Farhood B. Sheikholeslami S, et al. Life Sci. 2021 Sep 15;281:119721. doi: 10.1016/j.lfs.2021.119721. Epub 2021 Jun 16. Life Sci. 2021. PMID: 34146555
This study aimed to review the potential protective role of melatonin in the treatment of radiation-induced Pneumonitis and lung fibrosis. METHODS: The current systematic study was conducted based on PRISMA guidelines to identify relevant literature on " the effect …
This study aimed to review the potential protective role of melatonin in the treatment of radiation-induced Pneumonitis and lung f
Effects of Exogenous Melatonin on MAM Induced Lung Injury and Lung Development in Mice Offspring.
Azizi M, Pasbakhsh P, Sadr M, Mokhtari T, Pourabdollah M, Nadji SA, Ragerdi Kashani I. Azizi M, et al. Tanaffos. 2020 Jan;19(1):66-73. Tanaffos. 2020. PMID: 33101434 Free PMC article.
RESULTS: In histological examination, hemorrhage, neutrophils infiltration and fibrosis were seen in the MAM and Luz groups; however, these injuries were attenuated in the MAM plus melatonin group. ...CONCLUSION: Administration of exogenous melatonin in pregn …
RESULTS: In histological examination, hemorrhage, neutrophils infiltration and fibrosis were seen in the MAM and Luz groups; however, …
Melatonin prevents LPS-induced epithelial-mesenchymal transition in human alveolar epithelial cells via the GSK-3beta/Nrf2 pathway.
Ding Z, Wu X, Wang Y, Ji S, Zhang W, Kang J, Li J, Fei G. Ding Z, et al. Biomed Pharmacother. 2020 Dec;132:110827. doi: 10.1016/j.biopha.2020.110827. Epub 2020 Oct 13. Biomed Pharmacother. 2020. PMID: 33065391 Free article.
BACKGROUND: Oxidative stress plays a critical role in pulmonary fibrosis after acute lung injury (ALI), and epithelial-mesenchymal transition (EMT) events are involved in this process. ...Further studies are warranted to investigate the role of melatonin for …
BACKGROUND: Oxidative stress plays a critical role in pulmonary fibrosis after acute lung injury (ALI), and epithelial-mesench …
Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1alpha/Nrf2 pathway.
Han B, Li S, Lv Y, Yang D, Li J, Yang Q, Wu P, Lv Z, Zhang Z. Han B, et al. Food Funct. 2019 Sep 1;10(9):5555-5565. doi: 10.1039/c9fo01152h. Epub 2019 Aug 20. Food Funct. 2019. PMID: 31429458
Exposure to chromium (Cr) causes a number of respiratory diseases, including lung cancer and pulmonary fibrosis. However, there is currently no safe treatment for Cr-induced lung damage. Here, we used in vivo and in vitro approaches to examine the protective effects …
Exposure to chromium (Cr) causes a number of respiratory diseases, including lung cancer and pulmonary fibrosis. However, ther …
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Zhang L, Li F, Su X, Li Y, Wang Y, Fang R, Guo Y, Jin T, Shan H, Zhao X, Yang R, Shan H, Liang H. Zhang L, et al. Exp Mol Med. 2019 Jul 4;51(7):1-12. doi: 10.1038/s12276-019-0273-8. Exp Mol Med. 2019. PMID: 31273199 Free PMC article.
Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring. ...However, the function of melatonin in the development of bleomycin-ind
Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extra
46 results