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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
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159 results

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Page 1
Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association.
El Khoudary SR, Aggarwal B, Beckie TM, Hodis HN, Johnson AE, Langer RD, Limacher MC, Manson JE, Stefanick ML, Allison MA; American Heart Association Prevention Science Committee of the Council on Epidemiology and Prevention; and Council on Cardiovascular and Stroke Nursing. El Khoudary SR, et al. Circulation. 2020 Dec 22;142(25):e506-e532. doi: 10.1161/CIR.0000000000000912. Epub 2020 Nov 30. Circulation. 2020. PMID: 33251828 Free article. Review.
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable increase in the risk for this disease after menopause and typically develop coronary heart disease several years later than men. This observation led to the hypothesis that the …
Cardiovascular disease (CVD) is the leading cause of death in women, who have a notable increase in the risk for this disease after menop …
Hormone Therapy in Menopause: Concepts, Controversies, and Approach to Treatment.
Flores VA, Pal L, Manson JE. Flores VA, et al. Endocr Rev. 2021 Nov 16;42(6):720-752. doi: 10.1210/endrev/bnab011. Endocr Rev. 2021. PMID: 33858012 Free article. Review.
Hormone therapy (HT) is an effective treatment for menopausal symptoms, including vasomotor symptoms and genitourinary syndrome of menopause. Randomized trials also demonstrate positive effects on bone health, and age-stratified analyses indicate more favorable effe …
Hormone therapy (HT) is an effective treatment for menopausal symptoms, including vasomotor symptoms and genitourinary syndrome of …
Estrogen and cardiovascular disease.
Gersh F, O'Keefe JH, Elagizi A, Lavie CJ, Laukkanen JA. Gersh F, et al. Prog Cardiovasc Dis. 2024 May-Jun;84:60-67. doi: 10.1016/j.pcad.2024.01.015. Epub 2024 Jan 24. Prog Cardiovasc Dis. 2024. PMID: 38272338 Review.
Hormone replacement therapy (HRT) with E2 and P4 has been shown to cause no harm to younger menopausal women. This robust scientific data supports a reconsideration of the prescriptive use of E2 and P4 as preventative therapeutics for the reduction of CVD, even without add …
Hormone replacement therapy (HRT) with E2 and P4 has been shown to cause no harm to younger menopausal women. This robust scientific …
Oophorectomy, menopause, estrogen, and cognitive aging: the timing hypothesis.
Rocca WA, Grossardt BR, Shuster LT. Rocca WA, et al. Neurodegener Dis. 2010;7(1-3):163-6. doi: 10.1159/000289229. Epub 2010 Mar 3. Neurodegener Dis. 2010. PMID: 20197698 Free PMC article. Review.
BACKGROUND: The concept of neuroprotective effects of estrogen in women remains controversial. OBJECTIVE: To explore the timing hypothesis in relation to cognitive aging and dementia. METHODS: We reviewed existing literature, conducted some reanalyses, and combined …
BACKGROUND: The concept of neuroprotective effects of estrogen in women remains controversial. OBJECTIVE: To explore the timing hy …
Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.
Hodis HN, Mack WJ, Henderson VW, Shoupe D, Budoff MJ, Hwang-Levine J, Li Y, Feng M, Dustin L, Kono N, Stanczyk FZ, Selzer RH, Azen SP; ELITE Research Group. Hodis HN, et al. N Engl J Med. 2016 Mar 31;374(13):1221-31. doi: 10.1056/NEJMoa1505241. N Engl J Med. 2016. PMID: 27028912 Free PMC article. Clinical Trial.
BACKGROUND: Data suggest that estrogen-containing hormone therapy is associated with beneficial effects with regard to cardiovascular disease when the therapy is initiated temporally close to menopause but not when it is initiated later. However, the hypothesis that …
BACKGROUND: Data suggest that estrogen-containing hormone therapy is associated with beneficial effects with regard to cardiovascular diseas …
The timing hypothesis: Do coronary risks of menopausal hormone therapy vary by age or time since menopause onset?
Bassuk SS, Manson JE. Bassuk SS, et al. Metabolism. 2016 May;65(5):794-803. doi: 10.1016/j.metabol.2016.01.004. Epub 2016 Jan 12. Metabolism. 2016. PMID: 27085786 Free PMC article. Review.
Estrogen may have a beneficial effect on the heart if started in early menopause, when a woman's arteries are likely to be relatively healthy, but a harmful effect if started in late menopause, when those arteries are more likely to show signs of atherosclerotic dis …
Estrogen may have a beneficial effect on the heart if started in early menopause, when a woman's arteries are likely to be relatively …
The Kronos Early Estrogen Prevention Study (KEEPS): what have we learned?
Miller VM, Naftolin F, Asthana S, Black DM, Brinton EA, Budoff MJ, Cedars MI, Dowling NM, Gleason CE, Hodis HN, Jayachandran M, Kantarci K, Lobo RA, Manson JE, Pal L, Santoro NF, Taylor HS, Harman SM. Miller VM, et al. Menopause. 2019 Sep;26(9):1071-1084. doi: 10.1097/GME.0000000000001326. Menopause. 2019. PMID: 31453973 Free PMC article. Review.
OBJECTIVE: The Kronos Early Estrogen Prevention Study (KEEPS) was designed to address gaps in understanding the effects of timely menopausal hormone treatments (HT) on cardiovascular health and other effects of menopause after the premature termination of the …
OBJECTIVE: The Kronos Early Estrogen Prevention Study (KEEPS) was designed to address gaps in understanding the effects of timely …
The Timing Hypothesis: Hormone Therapy for Treating Symptomatic Women During Menopause and Its Relationship to Cardiovascular Disease.
Mehta JM, Chester RC, Kling JM. Mehta JM, et al. J Womens Health (Larchmt). 2019 May;28(5):705-711. doi: 10.1089/jwh.2018.7201. Epub 2018 Nov 28. J Womens Health (Larchmt). 2019. PMID: 30484736
The timing hypothesis, which posits that the cardiovascular effects of HT depend on the timing of initiation of HT in relation to menopause, has helped shape our understanding of the cardiovascular outcomes related to HT. Based on results from female m …
The timing hypothesis, which posits that the cardiovascular effects of HT depend on the timing of initiation of HT in r …
Back to the future: Hormone replacement therapy as part of a prevention strategy for women at the onset of menopause.
Lobo RA, Pickar JH, Stevenson JC, Mack WJ, Hodis HN. Lobo RA, et al. Atherosclerosis. 2016 Nov;254:282-290. doi: 10.1016/j.atherosclerosis.2016.10.005. Epub 2016 Oct 6. Atherosclerosis. 2016. PMID: 27745704 Free article. Review.
It has also been reported that many women who abruptly stopped HRT had more risks, including more osteoporotic fractures. The current data confirm a "timing" hypothesis for benefits and risks of HRT, showing that younger have many benefits and few risks, particularl …
It has also been reported that many women who abruptly stopped HRT had more risks, including more osteoporotic fractures. The current data c …
Perimenopause and cognition.
Greendale GA, Derby CA, Maki PM. Greendale GA, et al. Obstet Gynecol Clin North Am. 2011 Sep;38(3):519-35. doi: 10.1016/j.ogc.2011.05.007. Obstet Gynecol Clin North Am. 2011. PMID: 21961718 Free PMC article. Review.
Estradiol has been found to protect against changes resulting from serotonin withdrawal and defend against changes from cholinergic depletion. There is support for the critical timing hypothesis--that estrogen benefits cognitive function when instituted early, but n …
Estradiol has been found to protect against changes resulting from serotonin withdrawal and defend against changes from cholinergic depletio …
159 results