Amended Safety Assessment of Mentha piperita (Peppermint)-Derived Ingredients as Used in Cosmetics

Int J Toxicol. 2023 Dec;42(3_suppl):117S-143S. doi: 10.1177/10915818231205837. Epub 2023 Oct 6.

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of M piperita (peppermint)-derived ingredients. The Panel reviewed data relevant to the safety of these ingredients. Because final product formulations may contain multiple botanicals, each containing the same constituent(s) of concern, formulators are advised to be aware of these constituents and avoid reaching levels that may be hazardous to consumers. Industry should continue to use good manufacturing practices to limit impurities that could be present in botanical ingredients. The Panel concluded that M piperita (Peppermint) Oil, Extract, Leaf, and leaf-derived ingredients are safe in cosmetics in the present practices of use and concentration when formulated to be non-sensitizing, and that the available data are insufficient for determining that M piperita (Peppermint) Flower/Leaf/Stem Extract, M piperita (Peppermint) Flower/Leaf/Stem Water, and M piperita (Peppermint) Meristem Cell Culture are safe under the intended conditions of use in cosmetic formulations.

Keywords: Cosmetics; Mentha Piperita (Peppermint) Extract; Mentha Piperita (Peppermint) Flower/Leaf/Stem Extract; Mentha Piperita (Peppermint) Flower/Leaf/Stem Water; Mentha Piperita (Peppermint) Leaf; Mentha Piperita (Peppermint) Leaf Cell Extract; Mentha Piperita (Peppermint) Leaf Extract; Mentha Piperita (Peppermint) Leaf Juice; Mentha Piperita (Peppermint) Leaf Water; Mentha Piperita (Peppermint) Meristem Cell Culture; Mentha Piperita (Peppermint) Oil; Safety.

MeSH terms

  • Allergens
  • Consumer Product Safety
  • Cosmetics* / toxicity
  • Mentha piperita*
  • Plant Extracts / toxicity

Substances

  • Plant Extracts
  • Allergens
  • Cosmetics