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Mepenzolate.
[No authors listed] [No authors listed] 2021 Apr 19. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2021 Apr 19. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000725 Free Books & Documents. Review.
No information is available on the use of mepenzolate during breastfeeding. Because mepenzolate is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant. Long-term use of mepenzolate might reduce milk producti …
No information is available on the use of mepenzolate during breastfeeding. Because mepenzolate is a quaternary ammonium compo …
Mepenzolate.
[No authors listed] [No authors listed] 2017 Jul 7. LiverTox®: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Jul 7. LiverTox®: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643587 Free Books & Documents. Review.
Mepenzolate is an anticholinergic agent used to treat gastrointestinal conditions such as acid peptic disease and irritable bowel syndrome. Mepenzolate has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury....
Mepenzolate is an anticholinergic agent used to treat gastrointestinal conditions such as acid peptic disease and irritable bowel syn …
Mepenzolate bromide promotes diabetic wound healing by modulating inflammation and oxidative stress.
Zheng Y, Wang X, Ji S, Tian S, Wu H, Luo P, Fang H, Wang L, Wu G, Xiao S, Xia Z. Zheng Y, et al. Am J Transl Res. 2016 Jun 15;8(6):2738-47. eCollection 2016. Am J Transl Res. 2016. PMID: 27398156 Free PMC article.
However,the role of mepenzolate bromide in diabetic wound healing is still unclear. In this study, full-thickness excisional skin wounds were created on the backs of db/db mice, and mepenzolate bromide was topically applied to the wound bed. ...These results demonst …
However,the role of mepenzolate bromide in diabetic wound healing is still unclear. In this study, full-thickness excisional skin wou …
Identification of Mepenzolate Derivatives With Long-Acting Bronchodilatory Activity.
Tanaka KI, Yamakawa N, Yamashita Y, Asano T, Kanda Y, Takafuji A, Kawahara M, Takenaga M, Fukunishi Y, Mizushima T. Tanaka KI, et al. Front Pharmacol. 2018 Apr 10;9:344. doi: 10.3389/fphar.2018.00344. eCollection 2018. Front Pharmacol. 2018. PMID: 29692733 Free PMC article.
The standard treatment for chronic obstructive pulmonary disease is a combination of anti-inflammatory drugs and bronchodilators. We recently found that mepenzolate bromide (MP), an antagonist for human muscarinic M3 receptor (hM(3)R), has both anti-inflammatory and short- …
The standard treatment for chronic obstructive pulmonary disease is a combination of anti-inflammatory drugs and bronchodilators. We recentl …
Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.
Tanaka K, Ishihara T, Sugizaki T, Kobayashi D, Yamashita Y, Tahara K, Yamakawa N, Iijima K, Mogushi K, Tanaka H, Sato K, Suzuki H, Mizushima T. Tanaka K, et al. Nat Commun. 2013;4:2686. doi: 10.1038/ncomms3686. Nat Commun. 2013. PMID: 24189798 Free article.
Although mepenzolate bromide shows bronchodilatory activity, most other muscarinic antagonists do not improve elastase-induced pulmonary disorders. ...Based on these results, we propose that mepenzolate bromide may be an effective therapeutic for the treatment of CO …
Although mepenzolate bromide shows bronchodilatory activity, most other muscarinic antagonists do not improve elastase-induced pulmon …
Ameliorative effect of mepenzolate bromide against pulmonary fibrosis.
Kurotsu S, Tanaka K, Niino T, Asano T, Sugizaki T, Azuma A, Suzuki H, Mizushima T. Kurotsu S, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):79-88. doi: 10.1124/jpet.114.213009. Epub 2014 Apr 25. J Pharmacol Exp Ther. 2014. PMID: 24769542
A transforming growth factor (TGF)-beta1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis. We recently found that mepenzolate bromide (mepenzolate), which has been used clinically to treat gastrointestinal disorders, has ROS …
A transforming growth factor (TGF)-beta1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis. We rece …
Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.
Yamashita Y, Tanaka KI, Yamakawa N, Asano T, Kanda Y, Takafuji A, Kawahara M, Takenaga M, Fukunishi Y, Mizushima T. Yamashita Y, et al. Bioorg Med Chem. 2019 Aug 1;27(15):3339-3346. doi: 10.1016/j.bmc.2019.06.016. Epub 2019 Jun 8. Bioorg Med Chem. 2019. PMID: 31204225
The treatment for patients with chronic obstructive pulmonary disease (COPD) usually involves a combination of anti-inflammatory and bronchodilatory drugs. We recently found that mepenzolate bromide (1) and its derivative, 3-(2-hydroxy-2, 2-diphenylacetoxy)-1-(3-phenoxypro …
The treatment for patients with chronic obstructive pulmonary disease (COPD) usually involves a combination of anti-inflammatory and broncho …
Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease.
Tanaka K, Kurotsu S, Asano T, Yamakawa N, Kobayashi D, Yamashita Y, Yamazaki H, Ishihara T, Watanabe H, Maruyama T, Suzuki H, Mizushima T. Tanaka K, et al. Sci Rep. 2014 Mar 28;4:4510. doi: 10.1038/srep04510. Sci Rep. 2014. PMID: 24676126 Free PMC article.
We recently proposed that mepenzolate bromide (mepenzolate) would be therapeutically effective against chronic obstructive pulmonary disease (COPD) due to its both anti-inflammatory and bronchodilatory activities. ...Intravenously or intrarectally administered me …
We recently proposed that mepenzolate bromide (mepenzolate) would be therapeutically effective against chronic obstructive pul …
Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities.
Yamashita Y, Tanaka K, Asano T, Yamakawa N, Kobayashi D, Ishihara T, Hanaya K, Shoji M, Sugai T, Wada M, Mashimo T, Fukunishi Y, Mizushima T. Yamashita Y, et al. Bioorg Med Chem. 2014 Jul 1;22(13):3488-97. doi: 10.1016/j.bmc.2014.04.029. Epub 2014 Apr 30. Bioorg Med Chem. 2014. PMID: 24844758
As predicted by computational simulation, a filter-binding assay in vitro revealed that (R)-mepenzolate showed a higher affinity for the muscarinic M3 receptor than (S)-mepenzolate. In vivo, the bronchodilatory activity of (R)-mepenzolate was superior to that …
As predicted by computational simulation, a filter-binding assay in vitro revealed that (R)-mepenzolate showed a higher affinity for …
45 results