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Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action.
Seckin S, Ramadan H, Mouanness M, Kohansieh M, Merhi Z. Seckin S, et al. J Assist Reprod Genet. 2022 Jan;39(1):37-61. doi: 10.1007/s10815-021-02385-w. Epub 2022 Feb 17. J Assist Reprod Genet. 2022. PMID: 35175511 Free PMC article. Review.
It also presents the most recent data on the use of ovarian PRP in in vitro and animal model studies highlighting the possible mechanisms by which PRP could impact ovarian function. ...Given its low-risk profile, the hypothetical benefit of PRP treatment need …
It also presents the most recent data on the use of ovarian PRP in in vitro and animal model studies highlighting the possible mechan …
Clinical practice perspectives on adipose-derived stem cells and platelet-rich plasma for female infertility treatments.
Merhi Z. Merhi Z. Future Sci OA. 2025 Dec;11(1):2580233. doi: 10.1080/20565623.2025.2580233. Epub 2025 Oct 29. Future Sci OA. 2025. PMID: 41160570 Free PMC article. Review.
The combination of PRP and ADSCs acts better than each one individually and acts synergistically to promote tissue regeneration. ...Collectively, these results underscore the regenerative promise of ADSCs and PRP in overcoming various infertility causes. ADSCs and …
The combination of PRP and ADSCs acts better than each one individually and acts synergistically to promote tissue regeneration. ...C …
Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications for Ovarian Reserve, PCOS, and Endometrial Receptivity.
Merhi Z, Wiltshire McLeod C, Shamim F. Merhi Z, et al. Biomedicines. 2025 Oct 13;13(10):2488. doi: 10.3390/biomedicines13102488. Biomedicines. 2025. PMID: 41153771 Free PMC article. Review.
In reproductive medicine, intraovarian PRP has been evaluated for its potential to restore ovarian function in women with DOR and POI, improve oocyte competence and embryo euploidy, and promote ovulation in PCOS. ...Despite these promising findings, results remain inconsis …
In reproductive medicine, intraovarian PRP has been evaluated for its potential to restore ovarian function in women with DOR and POI …
Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization.
Merhi Z, Seckin S, Mouanness M. Merhi Z, et al. Clin Exp Reprod Med. 2022 Sep;49(3):210-214. doi: 10.5653/cerm.2021.05057. Epub 2022 Aug 31. Clin Exp Reprod Med. 2022. PMID: 36097737 Free PMC article.
Although recent studies have demonstrated that PRP led to improvements in folliculogenesis and biomarkers of ovarian reserve, the effect of intraovarian PRP administration on embryo genetics has not been studied. ...Following cycle 1, autologous intraovarian PRP …
Although recent studies have demonstrated that PRP led to improvements in folliculogenesis and biomarkers of ovarian reserve, the eff …
Intraovarian Platelet-Rich Plasma Therapy for PCOS: Unanswered Questions and Future Research Directions.
Merhi Z. Merhi Z. J Clin Med. 2025 Dec 14;14(24):8845. doi: 10.3390/jcm14248845. J Clin Med. 2025. PMID: 41464746 Free PMC article.
Methods: A literature search for studies pertaining to intraovarian PRP administration and PCOS was performed on PubMed. Results: Preclinical studies in PCOS animal models have demonstrated that intraovarian PRP can improve folliculogenesis, enhance antioxidant defe …
Methods: A literature search for studies pertaining to intraovarian PRP administration and PCOS was performed on PubMed. Results: Pre …
Intraovarian PRP Injection Improved Hot Flashes in a Woman With Very Low Ovarian Reserve.
Merhi Z, Seckin S, Mouanness M. Merhi Z, et al. Reprod Sci. 2022 Feb;29(2):614-619. doi: 10.1007/s43032-021-00655-7. Epub 2021 Jul 6. Reprod Sci. 2022. PMID: 34231167
To date, most prior studies have focused on the effect of PRP on ovarian response pertaining to oocyte production and pregnancy outcome following assisted reproductive technology. This report presents a patient with very low ovarian reserve, with medical problems that prec …
To date, most prior studies have focused on the effect of PRP on ovarian response pertaining to oocyte production and pregnancy outco …
Intraovarian Platelet-rich Plasma Administration Induced Spontaneous Ovulation in an Anovulatory Woman With PCOS.
Merhi Z, Mouanness M, Wang R, Seckin S. Merhi Z, et al. JCEM Case Rep. 2023 Apr 21;1(2):luad038. doi: 10.1210/jcemcr/luad038. eCollection 2023 Mar. JCEM Case Rep. 2023. PMID: 37908477 Free PMC article.
The use of platelet-rich plasma (PRP) has become popular as an adjunct to fertility treatment for women with infertility, particularly those with low ovarian reserve and premature ovarian insufficiency. Recent data in a polycystic ovary syndrome (PCOS) animal model demonst …
The use of platelet-rich plasma (PRP) has become popular as an adjunct to fertility treatment for women with infertility, particularl …
First live births after adipose-derived stem cells and platelet-rich plasma intraovarian administration.
Merhi Z, Garg B, Haroun J. Merhi Z, et al. Am J Stem Cells. 2025 Dec 25;14(5):277-283. doi: 10.62347/KWFR2442. eCollection 2025. Am J Stem Cells. 2025. PMID: 41567622 Free PMC article.
Case 1, a 46-year-old with diminished ovarian reserve and prior miscarriage, underwent adipose-PRP treatment after unsuccessful minimal stimulation IVF. Six months later, she conceived naturally and delivered a healthy infant at age 47. ...This report is, to our knowledge, …
Case 1, a 46-year-old with diminished ovarian reserve and prior miscarriage, underwent adipose-PRP treatment after unsuccessful minim …
Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action.
Mouanness M, Ali-Bynom S, Jackman J, Seckin S, Merhi Z. Mouanness M, et al. Reprod Sci. 2021 Jun;28(6):1659-1670. doi: 10.1007/s43032-021-00579-2. Epub 2021 Apr 22. Reprod Sci. 2021. PMID: 33886116 Review.
Intrauterine autologous platelet-rich plasma (PRP) infusion has been used in infertile women with recurrent implantation failure (RIF) and thin endometrial lining thickness (EMT). ...Case series and cohort studies showed conflicting results pertaining to CPR. Data to date …
Intrauterine autologous platelet-rich plasma (PRP) infusion has been used in infertile women with recurrent implantation failure (RIF …