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256 results

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Page 1
Human umbilical cord-derived mesenchymal stem cells not only ameliorate blood glucose but also protect vascular endothelium from diabetic damage through a paracrine mechanism mediated by MAPK/ERK signaling.
Liu Y, Chen J, Liang H, Cai Y, Li X, Yan L, Zhou L, Shan L, Wang H. Liu Y, et al. Stem Cell Res Ther. 2022 Jun 17;13(1):258. doi: 10.1186/s13287-022-02927-8. Stem Cell Res Ther. 2022. PMID: 35715841 Free PMC article.
BACKGROUND: Endothelial damage is an initial step of macro- and micro-vasculature dysfunctions in diabetic patients, accounting for a high incidence of diabetic vascular complications, such as atherosclerosis, nephropathy, retinopathy, and neuropathy. However, clinic lacks …
BACKGROUND: Endothelial damage is an initial step of macro- and micro-vasculature dysfunctions in diabetic patients, accounting for a high i …
Evaluating the efficacy of mesenchymal stem cells for diabetic neuropathy: A systematic review and meta-analysis of preclinical studies.
Li Y, Yue G, Yu S, Cheng X, Cao Y, Wang X. Li Y, et al. Front Bioeng Biotechnol. 2024 May 6;12:1349050. doi: 10.3389/fbioe.2024.1349050. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 38770273 Free PMC article.
Diabetic neuropathy affects nearly half of all diabetics and poses a significant threat to public health. Recent preclinical studies suggest that mesenchymal stem cells (MSCs) may represent a promising solution for the treatment of diabetic neuropat …
Diabetic neuropathy affects nearly half of all diabetics and poses a significant threat to public health. Recent preclinical studies …
Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic.
Zhou JY, Zhang Z, Qian GS. Zhou JY, et al. Cell Death Discov. 2016 Jul 11;2:16055. doi: 10.1038/cddiscovery.2016.55. eCollection 2016. Cell Death Discov. 2016. PMID: 27551543 Free PMC article. Review.
Mesenchymal stem cells (MSCs) have been indicated as a novel emerging regenerative therapy for diabetic neuropathy because of their multipotency. We will briefly review the pathogenesis of diabetic neuropathy, characteristic of MSCs, effects of …
Mesenchymal stem cells (MSCs) have been indicated as a novel emerging regenerative therapy for diabetic neuropathy …
HLA-Homozygous iPSC-Derived Mesenchymal Stem Cells Rescue Rotenone-Induced Experimental Leber's Hereditary Optic Neuropathy-like Models In Vitro and In Vivo.
Tsai ET, Peng SY, Wu YR, Lin TC, Chen CY, Liu YH, Tseng YH, Hsiao YJ, Tseng HC, Lai WY, Lin YY, Yang YP, Chiou SH, Chen SP, Chien Y. Tsai ET, et al. Cells. 2023 Nov 13;12(22):2617. doi: 10.3390/cells12222617. Cells. 2023. PMID: 37998352 Free PMC article.
BACKGROUND: Mesenchymal stem cells (MSCs) hold promise for cell-based therapy, yet the sourcing, quality, and invasive methods of MSCs impede their mass production and quality control. ...METHODS: The potential of MSC therapy for Leber's hereditary optic n …
BACKGROUND: Mesenchymal stem cells (MSCs) hold promise for cell-based therapy, yet the sourcing, quality, and invasive …
Bone marrow-derived mesenchymal stem cells mitigate chronic colitis and enteric neuropathy via anti-inflammatory and anti-oxidative mechanisms.
Stavely R, Robinson AM, Fraser S, Filippone RT, Stojanovska V, Eri R, Apostolopoulos V, Sakkal S, Nurgali K. Stavely R, et al. Sci Rep. 2024 Mar 20;14(1):6649. doi: 10.1038/s41598-024-57070-6. Sci Rep. 2024. PMID: 38503815 Free PMC article.
In this study, we investigated the therapeutic potential of bone marrow-derived mesenchymal stem cell (BM-MSC) treatments in spontaneous chronic colitis using the Winnie mouse model which closely replicates the presentation and inflammatory profile of ulcerative col …
In this study, we investigated the therapeutic potential of bone marrow-derived mesenchymal stem cell (BM-MSC) treatments in s …
Mesenchymal stem cells (MSCs) in Leber's hereditary optic neuropathy (LHON): a potential therapeutic approach for future.
Subramaniam MD, Chirayath RB, Iyer M, Nair AP, Vellingiri B. Subramaniam MD, et al. Int Ophthalmol. 2022 Sep;42(9):2949-2964. doi: 10.1007/s10792-022-02267-9. Epub 2022 Mar 31. Int Ophthalmol. 2022. PMID: 35357640 Review.
BACKGROUND: Optic neuropathy has become a new typical syndromic multi-system disease that leads to optic atrophy. ...Here, we focus more on treatment based on mesenchymal stem cells-mediated mitochondrial transfer via various techniques. We discuss dif …
BACKGROUND: Optic neuropathy has become a new typical syndromic multi-system disease that leads to optic atrophy. ...Here, we focus m …
Therapeutic Potential of Mesenchymal Stem Cells and Their Secretome in the Treatment of Glaucoma.
Harrell CR, Fellabaum C, Arsenijevic A, Markovic BS, Djonov V, Volarevic V. Harrell CR, et al. Stem Cells Int. 2019 Dec 27;2019:7869130. doi: 10.1155/2019/7869130. eCollection 2019. Stem Cells Int. 2019. PMID: 31949441 Free PMC article. Review.
Accordingly, several new therapeutic approaches, including stem cell-based therapy, have been explored for the glaucoma treatment. In this review article, we emphasized current knowledge regarding molecular and cellular mechanisms responsible for beneficial effects of m …
Accordingly, several new therapeutic approaches, including stem cell-based therapy, have been explored for the glaucoma treatment. In …
Human Placenta-Derived Mesenchymal Stem Cells Ameliorate Diabetic Neuropathy via Wnt Signaling Pathway.
Pan S, Hada SS, Liu Y, Hu C, Zhou M, Zheng S, Xu M, Shi C, Yin S, Xie X. Pan S, et al. Stem Cells Int. 2022 Sep 6;2022:6897056. doi: 10.1155/2022/6897056. eCollection 2022. Stem Cells Int. 2022. PMID: 36440182 Free PMC article.
OBJECTIVES: To investigate the effect of placenta-derived mesenchymal stem cells (PMSCs) on diabetic peripheral neuropathy and explore the role of Wnt signaling pathway. ...CONCLUSIONS: PMSCs improved the symptoms of diabetic peripheral neuropathy …
OBJECTIVES: To investigate the effect of placenta-derived mesenchymal stem cells (PMSCs) on diabetic peripheral neur …
The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy.
Wang C, Chi J, Che K, Ma X, Qiu M, Wang Z, Wang Y. Wang C, et al. Exp Ther Med. 2019 May;17(5):3555-3563. doi: 10.3892/etm.2019.7383. Epub 2019 Mar 13. Exp Ther Med. 2019. PMID: 30988737 Free PMC article.
Diabetic neuropathy (DN) is one of the most common diabetic complications that results in an increase in patient discomfort and pain. The present study demonstrated that mesenchymal stem cells (MSCs) or resveratrol (RSV) may improve diabetic hyperglyce …
Diabetic neuropathy (DN) is one of the most common diabetic complications that results in an increase in patient discomfort and pain. …
Nasal administration of mesenchymal stem cells reverses chemotherapy-induced peripheral neuropathy in mice.
Boukelmoune N, Laumet G, Tang Y, Ma J, Mahant I, Singh SK, Nijboer C, Benders M, Kavelaars A, Heijnen CJ. Boukelmoune N, et al. Brain Behav Immun. 2021 Mar;93:43-54. doi: 10.1016/j.bbi.2020.12.011. Epub 2020 Dec 11. Brain Behav Immun. 2021. PMID: 33316379 Free PMC article.
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequently reported adverse effects of cancer treatment. ...We recently demonstrated that nasal administration of mesenchymal stem cells (MSC) reverses the cognitive deficits induced …
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequently reported adverse effects of cancer treatment. ...We r …
256 results