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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1909 1
1916 1
1926 1
1932 1
1933 1
1935 2
1938 1
1945 6
1946 18
1947 25
1948 29
1949 25
1950 27
1951 29
1952 63
1953 65
1954 86
1955 72
1956 75
1957 85
1958 104
1959 83
1960 94
1961 143
1962 104
1963 184
1964 257
1965 299
1966 440
1967 633
1968 741
1969 918
1970 987
1971 1202
1972 1406
1973 1546
1974 1605
1975 2427
1976 2602
1977 2510
1978 2544
1979 2911
1980 3346
1981 3778
1982 4280
1983 5070
1984 5621
1985 6698
1986 7284
1987 8135
1988 9409
1989 11117
1990 12531
1991 13884
1992 15002
1993 16614
1994 18919
1995 21510
1996 23683
1997 25509
1998 27790
1999 30310
2000 33336
2001 36491
2002 40317
2003 44472
2004 49095
2005 54024
2006 59359
2007 63713
2008 67719
2009 70398
2010 75441
2011 81803
2012 87913
2013 91204
2014 92221
2015 93720
2016 92054
2017 91335
2018 91817
2019 95002
2020 95589
2021 92131
2022 82754
2023 74999
2024 97966
2025 119733
2026 36582

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2,080,066 results

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Page 1
Ethical Issues Regarding CRISPR Mediated Genome Editing.
Shinwari ZK, Tanveer F, Khalil AT. Shinwari ZK, et al. Curr Issues Mol Biol. 2018;26:103-110. doi: 10.21775/cimb.026.103. Epub 2017 Sep 7. Curr Issues Mol Biol. 2018. PMID: 28879860 Free article. Review.
The most contentious issues concerning human germline modifications are the challenges to human safety and morality such as risk of unforeseen, undesirable effects in clinical applications particularly to correct or prevent genetic diseases, matter of informed consent and the ris …
The most contentious issues concerning human germline modifications are the challenges to human safety and morality such as risk of unforese …
Telomere attrition: metabolic regulation and signalling function?
Casagrande S, Hau M. Casagrande S, et al. Biol Lett. 2019 Mar 29;15(3):20180885. doi: 10.1098/rsbl.2018.0885. Biol Lett. 2019. PMID: 30890069 Free PMC article.
Based on new biochemical findings, we propose the metabolic telomere attrition hypothesis: during times of substantially increased energy demands, TLs are shortened as part of the transition into an organismal 'emergency state', which prioritizes immediate survival functio …
Based on new biochemical findings, we propose the metabolic telomere attrition hypothesis: during times of substantially increased en …
Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals.
Russak EM, Bednarczyk EM. Russak EM, et al. Ann Pharmacother. 2019 Feb;53(2):211-216. doi: 10.1177/1060028018797110. Epub 2018 Aug 23. Ann Pharmacother. 2019. PMID: 30136594 Review.
Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. Deutetrabenazine (Austedo, Teva Pharmaceutical Industries, Ltd) is the first deuterated drug to receive Food and Drug Administration approval. ...Clinic …
Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. Deutetrabena …
Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date.
Bobo D, Robinson KJ, Islam J, Thurecht KJ, Corrie SR. Bobo D, et al. Pharm Res. 2016 Oct;33(10):2373-87. doi: 10.1007/s11095-016-1958-5. Epub 2016 Jun 14. Pharm Res. 2016. PMID: 27299311 Review.
We define nanomedicines as therapeutic or imaging agents which comprise a nanoparticle in order to control the biodistribution, enhance the efficacy, or otherwise reduce toxicity of a drug or biologic. ...A key challenge for researchers, industry, and regulators is …
We define nanomedicines as therapeutic or imaging agents which comprise a nanoparticle in order to control the biodistribution, enhan …
Effectiveness of school food environment policies on children's dietary behaviors: A systematic review and meta-analysis.
Micha R, Karageorgou D, Bakogianni I, Trichia E, Whitsel LP, Story M, Peñalvo JL, Mozaffarian D. Micha R, et al. PLoS One. 2018 Mar 29;13(3):e0194555. doi: 10.1371/journal.pone.0194555. eCollection 2018. PLoS One. 2018. PMID: 29596440 Free PMC article.
OBJECTIVE: To systematically review and quantify the impact of school food environment policies on dietary habits, adiposity, and metabolic risk in children. METHODS: We systematically searched online databases for randomized or quasi-experimental interventions assessing e …
OBJECTIVE: To systematically review and quantify the impact of school food environment policies on dietary habits, adiposity, and metabol …
Triheptanoin: First Approval.
Shirley M. Shirley M. Drugs. 2020 Oct;80(15):1595-1600. doi: 10.1007/s40265-020-01399-5. Drugs. 2020. PMID: 32897506 Free PMC article. Review.
Triheptanoin (Dojolvi ), a synthetic medium-chain triglyceride, is being developed by Ultragenyx Pharmaceutical as a pharmaceutical-grade anaplerotic compound for use in the treatment of inherited metabolic disorders. In June 2020, triheptanoin received its first regulator …
Triheptanoin (Dojolvi ), a synthetic medium-chain triglyceride, is being developed by Ultragenyx Pharmaceutical as a pharmaceutical-grade an …
Risdiplam: First Approval.
Dhillon S. Dhillon S. Drugs. 2020 Nov;80(17):1853-1858. doi: 10.1007/s40265-020-01410-z. Drugs. 2020. PMID: 33044711 Review.
Adverse food-drug interactions.
de Boer A, van Hunsel F, Bast A. de Boer A, et al. Regul Toxicol Pharmacol. 2015 Dec;73(3):859-65. doi: 10.1016/j.yrtph.2015.10.009. Epub 2015 Oct 19. Regul Toxicol Pharmacol. 2015. PMID: 26482404 Review.
An overview of these suspected interactions is presented and their potential mechanisms of action are described. Mainly during the metabolism of xenobiotics and due to the pharmacodynamics effects interactions seem to occur, which may result in adverse drug reactions. Wher …
An overview of these suspected interactions is presented and their potential mechanisms of action are described. Mainly during the metabo …
[Regulation about generics approval].
Laguna-Goya N, Blázquez-Pérez A, Pozo-Hernández C. Laguna-Goya N, et al. Farm Hosp. 2006 Nov-Dec;30(6):379-84. doi: 10.1016/s1130-6343(06)74010-7. Farm Hosp. 2006. PMID: 17298196 Review. Spanish.
OBJECTIVE: To analyze current legislation referring to generic drugs and to update knowledge concerning these drugs. METHOD: In this paper Spanish and European regulations have been reviewed in relation to the authorisation and procedures that guarantee the quality, …
OBJECTIVE: To analyze current legislation referring to generic drugs and to update knowledge concerning these drugs. METHOD: In this …
2,080,066 results
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