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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 1
2000 8
2001 13
2002 43
2003 88
2004 138
2005 211
2006 289
2007 461
2008 697
2009 1164
2010 1437
2011 1804
2012 2396
2013 2674
2014 3454
2015 4051
2016 4866
2017 5479
2018 6401
2019 7870
2020 9508
2021 11411
2022 6325
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62,633 results
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Page 1
Identification of bioactive metabolites using activity metabolomics.
Rinschen MM, Ivanisevic J, Giera M, Siuzdak G. Rinschen MM, et al. Nat Rev Mol Cell Biol. 2019 Jun;20(6):353-367. doi: 10.1038/s41580-019-0108-4. Nat Rev Mol Cell Biol. 2019. PMID: 30814649 Free PMC article. Review.
However, the value of metabolome analysis (metabolomics) has been redefined from a simple biomarker identification tool to a technology for the discovery of active drivers of biological processes. ...In this Review, we focus on recent progress in using metabolomi
However, the value of metabolome analysis (metabolomics) has been redefined from a simple biomarker identification tool to a t …
Untargeted Metabolomics Strategies-Challenges and Emerging Directions.
Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD, McLean JA. Schrimpe-Rutledge AC, et al. J Am Soc Mass Spectrom. 2016 Dec;27(12):1897-1905. doi: 10.1007/s13361-016-1469-y. Epub 2016 Sep 13. J Am Soc Mass Spectrom. 2016. PMID: 27624161 Free PMC article. Review.
These species are involved in enzyme-catalyzed chemical reactions and are essential for cellular function. Upstream biological disruptions result in a series of metabolomic changes and, as such, the metabolome holds a wealth of information that is thought to be most …
These species are involved in enzyme-catalyzed chemical reactions and are essential for cellular function. Upstream biological disruptions r …
Metabolomics for laboratory diagnostics.
Bujak R, Struck-Lewicka W, Markuszewski MJ, Kaliszan R. Bujak R, et al. J Pharm Biomed Anal. 2015 Sep 10;113:108-20. doi: 10.1016/j.jpba.2014.12.017. Epub 2014 Dec 25. J Pharm Biomed Anal. 2015. PMID: 25577715 Review.
Metabolomics is an emerging approach in a systems biology field. Due to continuous development in advanced analytical techniques and in bioinformatics, metabolomics has been extensively applied as a novel, holistic diagnostic tool in clinical and biomedical studies.
Metabolomics is an emerging approach in a systems biology field. Due to continuous development in advanced analytical techniques and
Metabolomics: beyond biomarkers and towards mechanisms.
Johnson CH, Ivanisevic J, Siuzdak G. Johnson CH, et al. Nat Rev Mol Cell Biol. 2016 Jul;17(7):451-9. doi: 10.1038/nrm.2016.25. Epub 2016 Mar 16. Nat Rev Mol Cell Biol. 2016. PMID: 26979502 Free PMC article.
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker dis
Metabolomics study of oral cancers.
Chen X, Yu D. Chen X, et al. Metabolomics. 2019 Feb 8;15(2):22. doi: 10.1007/s11306-019-1483-8. Metabolomics. 2019. PMID: 30830419 Review.
Metabolic reprogramming is an important hallmark of cancer. Metabolomics characterizes all the small molecules in a biological sample, and a complete set of small molecules in such sample is referred as metabolome. ...Metabolomics study of oral cancers in the …
Metabolic reprogramming is an important hallmark of cancer. Metabolomics characterizes all the small molecules in a biological sample …
Mass spectrometric based approaches in urine metabolomics and biomarker discovery.
Khamis MM, Adamko DJ, El-Aneed A. Khamis MM, et al. Mass Spectrom Rev. 2017 Mar;36(2):115-134. doi: 10.1002/mas.21455. Epub 2015 Apr 16. Mass Spectrom Rev. 2017. PMID: 25881008 Review.
Urine metabolomics has recently emerged as a prominent field for the discovery of non-invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific disease or therapeutic intervention. ...In addition to LC-MS, other MS-based technologies have …
Urine metabolomics has recently emerged as a prominent field for the discovery of non-invasive biomarkers that can detect subtle meta …
Mass spectrometry-based metabolomics in microbiome investigations.
Bauermeister A, Mannochio-Russo H, Costa-Lotufo LV, Jarmusch AK, Dorrestein PC. Bauermeister A, et al. Nat Rev Microbiol. 2022 Mar;20(3):143-160. doi: 10.1038/s41579-021-00621-9. Epub 2021 Sep 22. Nat Rev Microbiol. 2022. PMID: 34552265 Review.
Microorganisms affect not only the chemistry of their specific niche, such as the human gut, but also the chemistry of distant environments, such as other parts of the body. Mass spectrometry-based metabolomics is one of the key technologies to detect and identify the smal …
Microorganisms affect not only the chemistry of their specific niche, such as the human gut, but also the chemistry of distant environments, …
Challenges and emergent solutions for LC-MS/MS based untargeted metabolomics in diseases.
Cui L, Lu H, Lee YH. Cui L, et al. Mass Spectrom Rev. 2018 Nov;37(6):772-792. doi: 10.1002/mas.21562. Epub 2018 Feb 27. Mass Spectrom Rev. 2018. PMID: 29486047 Review.
In the past decade, advances in liquid chromatography-mass spectrometry (LC-MS) have revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply, researchers are now primed to uncover key metabolites and their associations with diseases. ...Th …
In the past decade, advances in liquid chromatography-mass spectrometry (LC-MS) have revolutionized untargeted metabolomics analyses. …
NMR metabolomics: A look ahead.
Wishart DS. Wishart DS. J Magn Reson. 2019 Sep;306:155-161. doi: 10.1016/j.jmr.2019.07.013. Epub 2019 Jul 11. J Magn Reson. 2019. PMID: 31377153 Review.
However, a number of other technologies, including mass spectrometry, have appeared in the past few years that are encroaching on NMR's dominance in metabolomics and metabolic studies. In this brief review, some of the current strengths and existing limitations of NMR-base …
However, a number of other technologies, including mass spectrometry, have appeared in the past few years that are encroaching on NMR's domi …
Metabolomics activity screening for identifying metabolites that modulate phenotype.
Guijas C, Montenegro-Burke JR, Warth B, Spilker ME, Siuzdak G. Guijas C, et al. Nat Biotechnol. 2018 Apr 5;36(4):316-320. doi: 10.1038/nbt.4101. Nat Biotechnol. 2018. PMID: 29621222 Free PMC article.
Metabolomics, in which small-molecule metabolites (the metabolome) are identified and quantified, is broadly acknowledged to be the omics discipline that is closest to the phenotype. ...Metabolomics activity screening (MAS) as described here integrates met
Metabolomics, in which small-molecule metabolites (the metabolome) are identified and quantified, is broadly acknowledged to b
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