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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1948 1
1949 1
1950 5
1951 3
1952 2
1953 3
1954 3
1955 2
1956 1
1957 7
1958 1
1959 2
1960 2
1961 6
1962 9
1963 1
1964 5
1965 8
1966 8
1967 10
1968 21
1969 18
1970 30
1971 47
1972 91
1973 102
1974 111
1975 165
1976 157
1977 127
1978 117
1979 123
1980 167
1981 177
1982 160
1983 196
1984 246
1985 291
1986 323
1987 304
1988 272
1989 350
1990 454
1991 529
1992 625
1993 603
1994 690
1995 745
1996 818
1997 865
1998 1045
1999 1122
2000 1272
2001 1412
2002 1608
2003 1672
2004 1757
2005 1898
2006 2107
2007 2133
2008 2163
2009 2412
2010 2458
2011 2571
2012 2680
2013 2672
2014 2693
2015 2658
2016 2436
2017 2284
2018 2104
2019 2024
2020 1772
2021 1549
2022 1420
2023 1283
2024 1369
2025 1396
2026 774

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57,412 results

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Page 1
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M. Guo X, et al. Nature. 2020 Mar;579(7799):427-432. doi: 10.1038/s41586-020-2078-2. Epub 2020 Mar 4. Nature. 2020. PMID: 32132707 Free PMC article.
In a genome-wide CRISPR interference screen, we identified factors upstream of HRI: OMA1, a mitochondrial stress-activated protease; and DELE1, a little-characterized protein that we found was associated with the inner mitochondrial membrane. Mitochondrial stress stimulate …
In a genome-wide CRISPR interference screen, we identified factors upstream of HRI: OMA1, a mitochondrial stress-activated protease; …
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J, Hu G, Liang Z, Jiang C, Deng L, Wang S, Yang W, Zuo Y, Ma J, Cai R, Chen Y, Fan Q, Dong B, Xue W, Tan H, Qi Y, Gu J, Su B, Eugene Chin Y, Chen G, Wang Q, Wang T, Cheng J. He J, et al. Nat Commun. 2021 Jul 16;12(1):4371. doi: 10.1038/s41467-021-24619-2. Nat Commun. 2021. PMID: 34272364 Free PMC article.
SENP1-Sirt3 signalling augments the deacetylase activity of Sirt3, promoting both OXPHOS and mitochondrial fusion. Mechanistically, SENP1 activates Sirt3 deacetylase activity in T cell mitochondria, leading to reduction of the acetylation of mitochondrial met …
SENP1-Sirt3 signalling augments the deacetylase activity of Sirt3, promoting both OXPHOS and mitochondrial fusion. Mechanistically, S …
Thrombolytic agents.
Collen D, Lijnen HR. Collen D, et al. Thromb Haemost. 2005 Apr;93(4):627-30. doi: 10.1160/TH04-11-0724. Thromb Haemost. 2005. PMID: 15841305 Review.
Thrombolytic agents are plasminogen activators that convert the zymogen plasminogen to the active enzyme plasmin, which degrades fibrin. Elucidation of the molecular mechanism of physiological fibrinolysis opened up a new era of fibrin-specific thrombolysis. Fibrin- …
Thrombolytic agents are plasminogen activators that convert the zymogen plasminogen to the active enzyme plasmin, which degrad …
Translational initiatives in thrombolytic therapy.
Klegerman ME. Klegerman ME. Front Med. 2017 Mar;11(1):1-19. doi: 10.1007/s11684-017-0497-8. Epub 2017 Mar 2. Front Med. 2017. PMID: 28116631 Review.
For the most part, the major clinically used thrombolytics, tissue plasminogen activator, urokinase and streptokinase, as well as the experimentally investigated agent staphylokinase, are the products of recombinant DNA technology, which permits molecular optimization of c …
For the most part, the major clinically used thrombolytics, tissue plasminogen activator, urokinase and streptokinase, as well as the …
Identification of a thermolysin-like metalloendopeptidase in serum: activity in normal subjects and in patients with sarcoidosis.
Almenoff J, Teirstein AS, Thornton JC, Orlowski M. Almenoff J, et al. J Lab Clin Med. 1984 Mar;103(3):420-31. J Lab Clin Med. 1984. PMID: 6366093
Dialysis against EDTA leads to loss of activity, which can be fully restored by zinc and cobalt ions. The serum enzyme closely resembles a membrane-bound metalloendopeptidase (EC 3.4.24.11) abundant in lung, spleen, and kidney in that both enzymes are inhibited by t …
Dialysis against EDTA leads to loss of activity, which can be fully restored by zinc and cobalt ions. The serum enzyme closely resemb …
Metalloendopeptidase activity in urine of rodents.
Beynon RJ, Flannery AV, Macadam GC. Beynon RJ, et al. Biomed Biochim Acta. 1991;50(4-6):795-7. Biomed Biochim Acta. 1991. PMID: 1801757
The role of meprin is unknown, but we have shown that urine from these species contains insulin B chain degrading activity that is due to a phosphoramidon-insensitive metalloendopeptidase. By enzymic and immunological criteria, it is likely that this activity …
The role of meprin is unknown, but we have shown that urine from these species contains insulin B chain degrading activity that is du …
Lactate increases ADAM10 activity and reduces BACE1 activity in mouse brain.
Moberg I, McCarthy SF, Bellaflor S, Finch MS, Hazell TJ, MacPherson REK. Moberg I, et al. J Physiol. 2024 Oct;602(20):5217-5228. doi: 10.1113/JP286962. Epub 2024 Sep 19. J Physiol. 2024. PMID: 39298105 Free article.
Alpha-secretase (ADAM10) cleavage is thought to be neuroprotective while beta-secretase (BACE1) cleavage results in the production of Abeta. Aerobic exercise reduces BACE1 activity, but the mechanisms involved are unknown though several exercise-induced media …
Alpha-secretase (ADAM10) cleavage is thought to be neuroprotective while beta-secretase (BACE1) cleavage results in the production of Abeta. …
Neurolysin: From Initial Detection to Latest Advances.
Checler F, Ferro ES. Checler F, et al. Neurochem Res. 2018 Nov;43(11):2017-2024. doi: 10.1007/s11064-018-2624-6. Epub 2018 Aug 29. Neurochem Res. 2018. PMID: 30159819 Review.
The mechanisms by which peptidergic signals are terminated have been the center of multiple studies leading to the discoveries of novel proteolytic activities. When studying the catabolic fate of neurotensin (NT) in brain and gastrointestinal tract, we detected a novel …
The mechanisms by which peptidergic signals are terminated have been the center of multiple studies leading to the discoveries of novel prot …
Thrombolytic agents in development.
Verstraete M, Lijnen HR, Collen D. Verstraete M, et al. Drugs. 1995 Jul;50(1):29-42. doi: 10.2165/00003495-199550010-00003. Drugs. 1995. PMID: 7588087 Review.
The quest continues for thrombolytic agents with a higher thrombolytic potency, specific thrombolytic activity and/or a better fibrin selectivity. Several lines of research towards improvement of thrombolytic agents are being explored, including the construction of mutants …
The quest continues for thrombolytic agents with a higher thrombolytic potency, specific thrombolytic activity and/or a better fibrin …
Role of the COOH-terminal domains of meprin A in folding, secretion, and activity of the metalloendopeptidase.
Tsukuba T, Bond JS. Tsukuba T, et al. J Biol Chem. 1998 Dec 25;273(52):35260-7. doi: 10.1074/jbc.273.52.35260. J Biol Chem. 1998. PMID: 9857066 Free article.
The DeltaMATH and alpha(1-452) mutants were not activable by limited proteolysis. The alpha(1-528) mutant was as active as wild-type meprin alpha against a bradykinin substrate, but had no activity against azocasein, and it, as all other mutants, was more vul …
The DeltaMATH and alpha(1-452) mutants were not activable by limited proteolysis. The alpha(1-528) mutant was as active as wil …
57,412 results
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