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524 results

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Page 1
Kidney Organoids and Tubuloids.
Yousef Yengej FA, Jansen J, Rookmaaker MB, Verhaar MC, Clevers H. Yousef Yengej FA, et al. Cells. 2020 May 26;9(6):1326. doi: 10.3390/cells9061326. Cells. 2020. PMID: 32466429 Free PMC article. Review.
After differentiation towards the kidney precursor tissues ureteric bud and metanephric mesenchyme, their reciprocal interaction causes self-organization and patterning in vitro to generate nephron structures that resemble the fetal kidney. ...
After differentiation towards the kidney precursor tissues ureteric bud and metanephric mesenchyme, their reciprocal interacti …
Nephron progenitors in the metanephric mesenchyme.
Nishinakamura R, Uchiyama Y, Sakaguchi M, Fujimura S. Nishinakamura R, et al. Pediatr Nephrol. 2011 Sep;26(9):1463-7. doi: 10.1007/s00467-011-1806-0. Epub 2011 Feb 19. Pediatr Nephrol. 2011. PMID: 21336811 Review.
The kidney is formed by a reciprocally inductive interaction between two precursor tissues, the metanephric mesenchyme and the ureteric bud. This interaction can be divided into three processes: attraction of the ureteric bud toward the mesenchyme, maintenance of th …
The kidney is formed by a reciprocally inductive interaction between two precursor tissues, the metanephric mesenchyme and the …
Metanephric mesenchyme-derived Foxd1(+) mesangial precursor cells alleviate mesangial proliferative glomerulonephritis.
Jin M, Yin Z, Wei K, Xie Y, Bai X, Fu B, Feng Z, Li Q, Chen X. Jin M, et al. J Mol Med (Berl). 2019 Apr;97(4):553-561. doi: 10.1007/s00109-019-01749-1. Epub 2019 Feb 27. J Mol Med (Berl). 2019. PMID: 30810761
No effective treatment is currently able to stop or reverse the disease process. Here, we isolated metanephric mesenchyme-derived Foxd1(+) mesangial precursor cells from E13.5 Foxd1(Cre); DTR(flox) double transgenic embryo mice. ...KEY MESSAGES: It is viable to isol …
No effective treatment is currently able to stop or reverse the disease process. Here, we isolated metanephric mesenchyme-deri …
Directed differentiation of ureteric bud and collecting duct organoids from human pluripotent stem cells.
Shi M, Fu P, Bonventre JV, McCracken KW. Shi M, et al. Nat Protoc. 2023 Aug;18(8):2485-2508. doi: 10.1038/s41596-023-00847-2. Epub 2023 Jul 17. Nat Protoc. 2023. PMID: 37460630 Free PMC article. Review.
However, the de novo generation of kidney tissues from human pluripotent stem cells (hPSCs) is challenging owing to the structural and functional complexity of the organ, as well its developmental origin from two distinct embryologic populations: the metanephric mesench …
However, the de novo generation of kidney tissues from human pluripotent stem cells (hPSCs) is challenging owing to the structural and funct …
Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.
Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R. Taguchi A, et al. Cell Stem Cell. 2014 Jan 2;14(1):53-67. doi: 10.1016/j.stem.2013.11.010. Epub 2013 Dec 12. Cell Stem Cell. 2014. PMID: 24332837 Free article.
Here, we define the developmental origins of the metanephric mesenchyme (MM), which generates most kidney components. Unexpectedly, we find that posteriorly located T(+) MM precursors are developmentally distinct from Osr1(+) ureteric bud progenitors during the post …
Here, we define the developmental origins of the metanephric mesenchyme (MM), which generates most kidney components. Unexpect …
Metanephric mesenchyme contains embryonic renal stem cells.
Oliver JA, Barasch J, Yang J, Herzlinger D, Al-Awqati Q. Oliver JA, et al. Am J Physiol Renal Physiol. 2002 Oct;283(4):F799-809. doi: 10.1152/ajprenal.00375.2001. Am J Physiol Renal Physiol. 2002. PMID: 12217872 Free article.
Renal epithelial cells derive from either cells of the metanephric mesenchyme or ureteric bud cells, but the origin of other renal cells is unclear. ...The pluripotency of the 7.1.1 cells is self-renewing. The data suggest that the metanephric mesenchyme …
Renal epithelial cells derive from either cells of the metanephric mesenchyme or ureteric bud cells, but the origin of other r …
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.
Yu CT, Tang K, Suh JM, Jiang R, Tsai SY, Tsai MJ. Yu CT, et al. Development. 2012 Jul;139(13):2330-9. doi: 10.1242/dev.076299. Development. 2012. PMID: 22669823 Free PMC article.
It is believed that Gdnf, produced in the metanephric mesenchyme, activates Ret signaling in the Wolffian duct to initiate the formation of the metanephros. However, the molecular mechanism for induction of Gdnf in the metanephric mesenchyme is not com …
It is believed that Gdnf, produced in the metanephric mesenchyme, activates Ret signaling in the Wolffian duct to initiate the …
524 results