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Showing results for metase
Search for metasee instead (1 results)
METase/lncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagy.
Xin L, Zhou Q, Yuan YW, Zhou LQ, Liu L, Li SH, Liu C. Xin L, et al. J Cancer Res Clin Oncol. 2019 Oct;145(10):2507-2517. doi: 10.1007/s00432-019-03015-w. Epub 2019 Sep 4. J Cancer Res Clin Oncol. 2019. PMID: 31485766
The interaction between lncRNA HULC and FoxM1 was confirmed by RNA pull-down and RIP assay. RESULTS: Lentiviral vector carrying METase (LV-METase) suppressed autophagy and CDDP resistance of drug-resistant gastric cancer cells. LncRNA HULC was significantly downregu …
The interaction between lncRNA HULC and FoxM1 was confirmed by RNA pull-down and RIP assay. RESULTS: Lentiviral vector carrying METase
METase promotes cell autophagy via promoting SNHG5 and suppressing miR-20a in gastric cancer.
Xin L, Zhou LQ, Liu L, Yuan YW, Zhang HT, Zeng F. Xin L, et al. Int J Biol Macromol. 2019 Feb 1;122:1046-1052. doi: 10.1016/j.ijbiomac.2018.09.051. Epub 2018 Sep 15. Int J Biol Macromol. 2019. PMID: 30227213
BACKGROUND: Gastric cancer (GC) severely threatens human life, and METase seemed to inhibit tumor growth. However, the potential mechanism underlying it is still unclear. ...CONCLUSION: Overexpressed METase promoted cell apoptosis and autophagy via up-regulating the …
BACKGROUND: Gastric cancer (GC) severely threatens human life, and METase seemed to inhibit tumor growth. However, the potential mech …
Evaluation of METase-pemetrexed-loaded PEG-PLGA nanoparticles modified with anti-CD133-scFV for treatment of gastric carcinoma.
Xin L, Zhang HT, Yang WF, Li YF, Liu C. Xin L, et al. Biosci Rep. 2018 Jan 30;38(1):BSR20171001. doi: 10.1042/BSR20171001. Print 2018 Feb 28. Biosci Rep. 2018. PMID: 29229675 Free PMC article.
The structure characterization and biological functions of METase-pemetrexed-loaded scFV-PEG-PLGA NPs (scFV-METase/pemetrexed-NPs) in vitro were investigated. ...Moreover, METase enhanced the inhibitory effect of pemetrexed on thymidylate synthase (TS) synthe …
The structure characterization and biological functions of METase-pemetrexed-loaded scFV-PEG-PLGA NPs (scFV-METase/pemetrexed- …
Methioninase Gene Therapy.
Hoffman RM, Miki K, Al-Refaie W, Xu M, Tan Y. Hoffman RM, et al. Methods Mol Biol. 2019;1866:173-197. doi: 10.1007/978-1-4939-8796-2_14. Methods Mol Biol. 2019. PMID: 30725416
The combination of rAd-METase and rMETase was synergistic to kill these cells. Normal fibroblasts, on the other hand, appeared relatively resistant to the METase gene in the presence of rMETase. Adenoviral METase-transduced cancer cells were used in combinati …
The combination of rAd-METase and rMETase was synergistic to kill these cells. Normal fibroblasts, on the other hand, appeared relati …
A novel design of HA-coated nanoparticles co-encapsulating plasmid METase and 5-Fu shows enhanced application in targeting gastric cancer stem cells.
Yang W, Zhang H, Xin L. Yang W, et al. Biol Chem. 2018 Feb 23;399(3):293-303. doi: 10.1515/hsz-2017-0208. Biol Chem. 2018. PMID: 29016350
METase supplementation promoted the inhibition effect of 5-Fu on thymidylate synthetase (TS), as well as cell apoptosis. ...It was concluded that HA-coated NPs enhance the target ability, while METase/5-Fu co-encaspulated NPs promote the inhibition effects on tumor
METase supplementation promoted the inhibition effect of 5-Fu on thymidylate synthetase (TS), as well as cell apoptosis. ...It was co
Pharmacokinetics, immunogenicity and anticancer efficiency of Aspergillus flavipes L-methioninase.
El-Sayed AS, Shouman SA, Nassrat HM. El-Sayed AS, et al. Enzyme Microb Technol. 2012 Sep 10;51(4):200-10. doi: 10.1016/j.enzmictec.2012.06.004. Epub 2012 Jun 28. Enzyme Microb Technol. 2012. PMID: 22883554
Thus, the objective of current study was to evaluate the catalytic properties of Af-METase in New Zealand rabbits, exploring its antitumor efficacy. In vivo, Af-METase (40.8 U/ml) have T(1/2) 19.8 h, elimination constant 0.088 U/h and apparent volume distribution 85 …
Thus, the objective of current study was to evaluate the catalytic properties of Af-METase in New Zealand rabbits, exploring its anti …
Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells.
Li YF, Zhang HT, Xin L. Li YF, et al. J Cancer Res Clin Oncol. 2018 Aug;144(8):1463-1473. doi: 10.1007/s00432-018-2678-5. Epub 2018 Jun 1. J Cancer Res Clin Oncol. 2018. PMID: 29858680
Nude mice xenograft models were used to evaluate the effect of HA-PAMAM-Au-METase on GC. RESULTS: The transfection of rMETase carried by HA-G5 PAMAM-Au visibly inhibited the proliferation and tumorsphere formation of GC cells through obviously enhancing METase activ …
Nude mice xenograft models were used to evaluate the effect of HA-PAMAM-Au-METase on GC. RESULTS: The transfection of rMETase carried …
Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells.
Thorpe M, Akula S, Hellman L. Thorpe M, et al. Dev Comp Immunol. 2016 Oct;63:84-95. doi: 10.1016/j.dci.2016.05.013. Epub 2016 May 20. Dev Comp Immunol. 2016. PMID: 27216028
A strict preference for Met in the P1 (cleavage) position, indicating metase specificity was observed. A screening of potential in vivo substrates was performed based on the derived P5-P3' consensus: Arg-Val-Thr-Gly-Met()Ser-Leu-Val. ...
A strict preference for Met in the P1 (cleavage) position, indicating metase specificity was observed. A screening of potential in vi …
91 results