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Metaxalone.
[No authors listed] [No authors listed] 2014 Feb 12. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2014 Feb 12. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644145 Free Books & Documents. Review.
Metaxalone is a centrally acting skeletal muscle relaxant that has been in use for more than 40 years. Metaxalone has not been associated with serum aminotransferase elevations during therapy or with clinically apparent hepatic injury....
Metaxalone is a centrally acting skeletal muscle relaxant that has been in use for more than 40 years. Metaxalone has not been
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain.
Friedman BW, Irizarry E, Solorzano C, Zias E, Pearlman S, Wollowitz A, Jones MP, Shah PD, Gallagher EJ. Friedman BW, et al. Ann Emerg Med. 2019 Oct;74(4):512-520. doi: 10.1016/j.annemergmed.2019.02.017. Epub 2019 Apr 5. Ann Emerg Med. 2019. PMID: 30955985 Free PMC article. Clinical Trial.
At 1-week follow-up, 30% of placebo patients (95% CI 21% to 41%) reported moderate to severe low back pain versus 33% of baclofen patients (95% CI 24% to 44%), 37% of metaxalone patients (95% CI 27% to 48%), and 33% of tizanidine patients (95% CI 23% to 44%). CONCLUSION: A …
At 1-week follow-up, 30% of placebo patients (95% CI 21% to 41%) reported moderate to severe low back pain versus 33% of baclofen patients ( …
Monoamine oxidase A inhibition by toxic concentrations of metaxalone.
Cherrington B, Englich U, Niruntari S, Grant W, Hodgman M. Cherrington B, et al. Clin Toxicol (Phila). 2020 May;58(5):383-387. doi: 10.1080/15563650.2019.1648815. Epub 2019 Aug 2. Clin Toxicol (Phila). 2020. PMID: 31373522
Monoamine oxidase A (MAO-A) inhibition by metaxalone has been proposed as the etiology of this toxicity. Metaxalone concentrations reported with cases of serotonin toxicity range from 31 to 61 mcg/ml (140-276 M). We investigated the effect of metaxalone on MA …
Monoamine oxidase A (MAO-A) inhibition by metaxalone has been proposed as the etiology of this toxicity. Metaxalone concentrat …
Metaxalone Suppresses Production of Inflammatory Cytokines Associated with Painful Conditions in Mouse Macrophages RAW264.7 Cells in Vitro: Synergistic Effect with beta-caryophyllene.
Yamaguchi M, Levy RM. Yamaguchi M, et al. Curr Mol Med. 2020;20(8):643-652. doi: 10.2174/1566524020666200217102508. Curr Mol Med. 2020. PMID: 32065089
Inflammatory cytokines with painful conditions are well known as biomarkers in human muscle pain, and they are produced by macrophages. Metaxalone is used as a skeletal muscle relaxant, but the mechanism by which metaxalone acts is unknown. ...CONCLUSION: Metaxal
Inflammatory cytokines with painful conditions are well known as biomarkers in human muscle pain, and they are produced by macrophages. M
Metaxalone (Skelaxin)-related death.
Poklis JL, Ropero-Miller JD, Garside D, Winecker RE. Poklis JL, et al. J Anal Toxicol. 2004 Sep;28(6):537-41. doi: 10.1093/jat/28.6.537. J Anal Toxicol. 2004. PMID: 15516312
Four additional cases in which metaxalone was present were analyzed for comparison. Two cases were probable drug-related deaths and had metaxalone aorta blood concentrations of 18 and 11 mg/L. The other two cases had therapeutic metaxalone concentrations in t …
Four additional cases in which metaxalone was present were analyzed for comparison. Two cases were probable drug-related deaths and h …
Choosing a skeletal muscle relaxant.
See S, Ginzburg R. See S, et al. Am Fam Physician. 2008 Aug 1;78(3):365-70. Am Fam Physician. 2008. PMID: 18711953 Free article. Review.
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. ...
The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol a …
Postmortem Metaxalone (Skelaxin) Data from North Carolina.
Bishop-Freeman SC, Miller A, Hensel EM, Winecker RE. Bishop-Freeman SC, et al. J Anal Toxicol. 2015 Oct;39(8):629-36. doi: 10.1093/jat/bkv066. J Anal Toxicol. 2015. PMID: 26378137
The mean metaxalone concentration for the additive deaths was 14.2 mg/L with a median value of 11 mg/L (n = 18) and a mean metaxalone concentration of 36.7 mg/L with a median value of 32 mg/L (n = 9) for primary deaths. For unattributed metaxalone concentrati …
The mean metaxalone concentration for the additive deaths was 14.2 mg/L with a median value of 11 mg/L (n = 18) and a mean metaxal
Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic review.
Chou R, Peterson K, Helfand M. Chou R, et al. J Pain Symptom Manage. 2004 Aug;28(2):140-75. doi: 10.1016/j.jpainsymman.2004.05.002. J Pain Symptom Manage. 2004. PMID: 15276195 Free article. Review.
There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dantrolene compared to placebo in patients with musculoskeletal conditions. There is insufficient evidence to determine the relative efficacy or …
There is very limited or inconsistent data regarding the effectiveness of metaxalone, methocarbamol, chlorzoxazone, baclofen, or dant …
Metaxalone estimation in biological matrix using high-throughput LC-MS/MS bioanalytical method.
Goswami D, Saha A, Gurule S, Khuroo A, Monif T, Vats P. Goswami D, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 1;902:132-6. doi: 10.1016/j.jchromb.2012.05.034. Epub 2012 Jun 4. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22766230
Metaxalone is a skeletal muscle relaxant, an approved drug for pain relief. ...An accurate, precise, high-throughput tandem mass spectroscopic method has been developed and validated. Following solid phase extraction (SPE), metaxalone and the internal standard me
Metaxalone is a skeletal muscle relaxant, an approved drug for pain relief. ...An accurate, precise, high-throughput tandem mass spec
Development of a Clinically Relevant Dissolution Method for Metaxalone Immediate Release Formulations Based on an IVIVC Model.
Vuletić L, Khan MZI, Špoljarić D, Radić M, Cetina-Čižmek B, Filipović-Grčić J. Vuletić L, et al. Pharm Res. 2018 Jun 22;35(8):163. doi: 10.1007/s11095-018-2434-1. Pharm Res. 2018. PMID: 29934663
PURPOSE: The aim of the present work was to classify metaxalone according to the Biopharmaceutics Classification System (BCS), to develop a clinically relevant dissolution method that can be used to predict the oral absorption of metaxalone and to establish an in vi …
PURPOSE: The aim of the present work was to classify metaxalone according to the Biopharmaceutics Classification System (BCS), to dev …
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