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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1970 1
1975 1
1976 1
1983 2
1984 3
1985 1
1986 3
1987 4
1989 1
1990 6
1991 13
1992 4
1993 6
1994 12
1995 13
1996 16
1997 11
1998 25
1999 32
2000 25
2001 26
2002 42
2003 68
2004 83
2005 112
2006 105
2007 149
2008 136
2009 188
2010 175
2011 187
2012 216
2013 257
2014 270
2015 276
2016 284
2017 277
2018 265
2019 279
2020 274
2021 309
2022 252
2023 229
2024 244
2025 234
2026 61

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4,497 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Metformin: Is it a drug for all reasons and diseases?
Triggle CR, Mohammed I, Bshesh K, Marei I, Ye K, Ding H, MacDonald R, Hollenberg MD, Hill MA. Triggle CR, et al. Metabolism. 2022 Aug;133:155223. doi: 10.1016/j.metabol.2022.155223. Epub 2022 May 29. Metabolism. 2022. PMID: 35640743 Free article. Review.
The objectives for this review are to: 1) evaluate the putative mechanism(s) of action of metformin; 2) analyze the controversial evidence for metformin's effectiveness in the treatment of diseases other than type 2 diabetes; 3) assess the reproducibility of …
The objectives for this review are to: 1) evaluate the putative mechanism(s) of action of metformin; 2) analyze the controversial evi …
Metformin use and preeclampsia risk in women with diabetes: a two-country cohort analysis.
Gordon H, Salim N, Tong S, Walker S, De Silva M, Cluver C, Mehdipour P, Hiscock R, Sutherland L, Doust A, Bergman L, Wikström AK, Lindquist A, Hesselman S, Hastie R. Gordon H, et al. BMC Med. 2024 Sep 27;22(1):418. doi: 10.1186/s12916-024-03628-0. BMC Med. 2024. PMID: 39334302 Free PMC article.
BACKGROUND: Metformin is a hypoglycaemic medication that has been proposed to treat or prevent preeclampsia. ...Of these women, 30.8% (n = 1187) received at least one metformin prescription during pregnancy. For Sweden, 7771 women with gestational diabetes were incl …
BACKGROUND: Metformin is a hypoglycaemic medication that has been proposed to treat or prevent preeclampsia. ...Of these women, 30.8% …
Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.
Tso LO, Costello MF, Albuquerque LET, Andriolo RB, Macedo CR. Tso LO, et al. Cochrane Database Syst Rev. 2020 Dec 21;12(12):CD006105. doi: 10.1002/14651858.CD006105.pub4. Cochrane Database Syst Rev. 2020. PMID: 33347618 Free PMC article.
In a long GnRH-agonist protocol, we are uncertain whether metformin improves live birth rates, but metformin may increase the clinical pregnancy rate. In a short GnRH-antagonist protocol, metformin may reduce live birth rates, although we are uncertain about …
In a long GnRH-agonist protocol, we are uncertain whether metformin improves live birth rates, but metformin may increase the …
Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.
Campbell JM, Bellman SM, Stephenson MD, Lisy K. Campbell JM, et al. Ageing Res Rev. 2017 Nov;40:31-44. doi: 10.1016/j.arr.2017.08.003. Epub 2017 Aug 10. Ageing Res Rev. 2017. PMID: 28802803
Overall, 260 full-texts were reviewed and 53 met the inclusion criteria. Diabetics taking metformin had significantly lower all-cause mortality than non-diabetics (hazard ratio (HR)=0.93, 95%CI 0.88-0.99), as did diabetics taking metformin compared to diabetics rece …
Overall, 260 full-texts were reviewed and 53 met the inclusion criteria. Diabetics taking metformin had significantly lower all-cause …
Metformin versus insulin for the treatment of gestational diabetes.
Rowan JA, Hague WM, Gao W, Battin MR, Moore MP; MiG Trial Investigators. Rowan JA, et al. N Engl J Med. 2008 May 8;358(19):2003-15. doi: 10.1056/NEJMoa0707193. N Engl J Med. 2008. PMID: 18463376 Free article. Clinical Trial.
RESULTS: Of the 363 women assigned to metformin, 92.6% continued to receive metformin until delivery and 46.3% received supplemental insulin. ...There were no serious adverse events associated with the use of metformin. CONCLUSIONS: In women with gestational …
RESULTS: Of the 363 women assigned to metformin, 92.6% continued to receive metformin until delivery and 46.3% received supple …
Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis.
Zhao H, Xing C, Zhang J, He B. Zhao H, et al. Reprod Health. 2021 Aug 18;18(1):171. doi: 10.1186/s12978-021-01207-7. Reprod Health. 2021. PMID: 34407851 Free PMC article.
Myo-inositol combined with D-chiro-inositol is particularly efficacious in menstrual recovery. Thiazolidinediones and metformin combined with thiazolidinediones improve lipid metabolism better than metformin alone. ...Myo-inositol combined with D-chiro-inositol is p …
Myo-inositol combined with D-chiro-inositol is particularly efficacious in menstrual recovery. Thiazolidinediones and metformin combi …
Initial Combination of Empagliflozin and Metformin in Patients With Type 2 Diabetes.
Hadjadj S, Rosenstock J, Meinicke T, Woerle HJ, Broedl UC. Hadjadj S, et al. Diabetes Care. 2016 Oct;39(10):1718-28. doi: 10.2337/dc16-0522. Epub 2016 Aug 4. Diabetes Care. 2016. PMID: 27493136 Clinical Trial.
OBJECTIVE: This study compared the efficacy and safety of initial combinations of empagliflozin + metformin with empagliflozin and metformin monotherapy in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: The study randomized 1,364 drug-naive patients (Hb …
OBJECTIVE: This study compared the efficacy and safety of initial combinations of empagliflozin + metformin with empagliflozin and …
Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial.
Mueller NT, Differding MK, Zhang M, Maruthur NM, Juraschek SP, Miller ER 3rd, Appel LJ, Yeh HC. Mueller NT, et al. Diabetes Care. 2021 Jul;44(7):1462-1471. doi: 10.2337/dc20-2257. Epub 2021 May 18. Diabetes Care. 2021. PMID: 34006565 Free PMC article. Clinical Trial.
Effects were similar in comparison of the metformin group with the behavioral weight loss group. Metformin versus control also increased butyrate, acetate, and valerate at 6 months (but not at 12 months). ...Future research is needed to elucidate whether the gut mic …
Effects were similar in comparison of the metformin group with the behavioral weight loss group. Metformin versus control also …
Effects of combined treatment of probiotics and metformin in management of type 2 diabetes: A systematic review and meta-analysis.
Memon H, Abdulla F, Reljic T, Alnuaimi S, Serdarevic F, Asimi ZV, Kumar A, Semiz S. Memon H, et al. Diabetes Res Clin Pract. 2023 Aug;202:110806. doi: 10.1016/j.diabres.2023.110806. Epub 2023 Jun 25. Diabetes Res Clin Pract. 2023. PMID: 37369280 Free article.
This systematic review and meta-analysis aim to assess the efficacy of metformin plus probiotics versus metformin alone on outcomes in patients with T2DM. METHODS: We searched MEDLINE and EMBASE from inception to February 2023 to identify all randomized controlled t …
This systematic review and meta-analysis aim to assess the efficacy of metformin plus probiotics versus metformin alone on out …
Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome.
Fraison E, Kostova E, Moran LJ, Bilal S, Ee CC, Venetis C, Costello MF. Fraison E, et al. Cochrane Database Syst Rev. 2020 Aug 13;8(8):CD005552. doi: 10.1002/14651858.CD005552.pub3. Cochrane Database Syst Rev. 2020. PMID: 32794179 Free PMC article.
In adolescents, we are uncertain whether there is a difference between Metformin and the OCP, on hirsutism and adverse events. Metformin versus metformin combined with the OCP In adult women, metformin may be less effective in improving hirsutism compa …
In adolescents, we are uncertain whether there is a difference between Metformin and the OCP, on hirsutism and adverse events. Met …
4,497 results