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Year Number of Results
2001 1
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400 results

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Page 1
Metformin and Insulin Resistance: A Review of the Underlying Mechanisms behind Changes in GLUT4-Mediated Glucose Transport.
Herman R, Kravos NA, Jensterle M, Janež A, Dolžan V. Herman R, et al. Int J Mol Sci. 2022 Jan 23;23(3):1264. doi: 10.3390/ijms23031264. Int J Mol Sci. 2022. PMID: 35163187 Free PMC article. Review.
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. ...However, the mechanisms behind this effect and the critical metform …
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such …
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.
Wang Y, An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O'Rourke B, He L. Wang Y, et al. Cell Rep. 2019 Nov 5;29(6):1511-1523.e5. doi: 10.1016/j.celrep.2019.09.070. Cell Rep. 2019. PMID: 31693892 Free PMC article.
Impaired mitochondrial respiratory activity contributes to the development of insulin resistance in type 2 diabetes. Metformin, a first-line antidiabetic drug, functions mainly by improving patients' hyperglycemia and insulin resistance. ...M …
Impaired mitochondrial respiratory activity contributes to the development of insulin resistance in type 2 diabetes. Metfor …
Unveiling Gestational Diabetes: An Overview of Pathophysiology and Management.
Mittal R, Prasad K, Lemos JRN, Arevalo G, Hirani K. Mittal R, et al. Int J Mol Sci. 2025 Mar 5;26(5):2320. doi: 10.3390/ijms26052320. Int J Mol Sci. 2025. PMID: 40076938 Free PMC article. Review.
Additionally, hypoadiponectinemia decreases AMP-activated protein kinase (AMPK) activation in skeletal muscle, impairing GLUT4 translocation. ...Pharmacological interventions, such as insulin or metformin, aim to restore AMPK signa …
Additionally, hypoadiponectinemia decreases AMP-activated protein kinase (AMPK) activation in skeletal muscle, i …
Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis.
Peng Q, Chen X, Liang X, Ouyang J, Wang Q, Ren S, Xie H, Wang C, Sun Y, Wu X, Liu H, Hei C, Sun M, Chang Q, Liu X, Li G, He R. Peng Q, et al. Front Endocrinol (Lausanne). 2023 Jan 23;14:1070264. doi: 10.3389/fendo.2023.1070264. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36755918 Free PMC article.
The body weight, estrous cycle, glucose tolerance test (OGTT)and insulin resistance test (ITT) were monitored. Then, The mice were euthanized to collect serum and ovaries. ...The results of OGTT and ITT showed an improvment of glucose tolerance and insulin …
The body weight, estrous cycle, glucose tolerance test (OGTT)and insulin resistance test (ITT) were monitored. Then, The mice …
Mitochondrial biogenesis: pharmacological approaches.
Valero T. Valero T. Curr Pharm Des. 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. Curr Pharm Des. 2014. PMID: 24606795
Type 2 diabetes is characterized by a peripheral insulin resistance accompanied by an increased secretion of insulin as a compensatory system. ...Thus restoring oxidative capacity by increasing mitochondrial mass appears as a suitable strategy to treat ins …
Type 2 diabetes is characterized by a peripheral insulin resistance accompanied by an increased secretion of insulin as …
Increased hepatic gluconeogenesis and type 2 diabetes mellitus.
Barroso E, Jurado-Aguilar J, Wahli W, Palomer X, Vázquez-Carrera M. Barroso E, et al. Trends Endocrinol Metab. 2024 Dec;35(12):1062-1077. doi: 10.1016/j.tem.2024.05.006. Epub 2024 May 29. Trends Endocrinol Metab. 2024. PMID: 38816269 Review.
Abnormally increased hepatic gluconeogenesis is a significant contributor to hyperglycemia in the fasting state in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance. Metformin, the most prescribed drug for the treatment of T2DM, is belie …
Abnormally increased hepatic gluconeogenesis is a significant contributor to hyperglycemia in the fasting state in patients with type 2 diab …
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M. Li Y, et al. Cell Metab. 2011 Apr 6;13(4):376-388. doi: 10.1016/j.cmet.2011.03.009. Cell Metab. 2011. PMID: 21459323 Free PMC article.
Ser372 phosphorylation of SREBP-1c by AMPK is necessary for inhibition of proteolytic processing and transcriptional activity of SREBP-1c in response to polyphenols and metformin. ...AMPK-dependent phosphorylation of SREBP may offer therapeutic strategies to …
Ser372 phosphorylation of SREBP-1c by AMPK is necessary for inhibition of proteolytic processing and transcriptional activity of SREB …
LncRNAs upregulated in insulin resistance are downregulated by metformin in a liver cell line.
Tello-Flores VA, Eulogio-Metodio Y, Ramírez-Vargas MA, Luciano-Villa CA, Cruz M, Gómez-Zamudio JH, Ramírez M, Alarcón-Romero LDC, Cahua-Pablo JÁ, Flores-Alfaro E. Tello-Flores VA, et al. Cell Mol Biol (Noisy-le-grand). 2025 Apr 15;71(3):57-65. doi: 10.14715/cmb/2025.71.3.7. Cell Mol Biol (Noisy-le-grand). 2025. PMID: 40235331
Insulin resistance (IR) is a key contributor to the development of metabolic diseases, and metformin has been shown to help mitigate IR. ...In conclusion, our findings demonstrate that metformin modulates the expression of key lncRNAs, including HOTAIR …
Insulin resistance (IR) is a key contributor to the development of metabolic diseases, and metformin has been shown to …
Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo.
Jiao Z, Chen Y, Xie Y, Li Y, Li Z. Jiao Z, et al. J Cell Mol Med. 2021 Jul;25(14):6733-6745. doi: 10.1111/jcmm.16677. Epub 2021 May 30. J Cell Mol Med. 2021. PMID: 34053175 Free PMC article.
High uric acid (HUA) is associated with insulin resistance (IR) in cardiomyocytes. We investigated whether metformin protects against HUA-induced IR in cardiomyocytes. ...HUA directly inhibited the phosphorylation of Akt and the translocation of GLUT4 induced …
High uric acid (HUA) is associated with insulin resistance (IR) in cardiomyocytes. We investigated whether metformin pr …
Endothelial Dysfunction in Obesity and Therapeutic Targets.
Engin A. Engin A. Adv Exp Med Biol. 2024;1460:489-538. doi: 10.1007/978-3-031-63657-8_17. Adv Exp Med Biol. 2024. PMID: 39287863 Review.
Besides the adipose tissue inflammation, decreased nitric oxide (NO)-bioavailability, insulin resistance (IR), and oxidized low-density lipoproteins (oxLDLs) are the main factors contributing to endothelial dysfunction in obesity and the development of cardiorenal m …
Besides the adipose tissue inflammation, decreased nitric oxide (NO)-bioavailability, insulin resistance (IR), and oxidized lo …
400 results