Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 2
1999 6
2000 7
2001 8
2002 17
2003 20
2004 26
2005 27
2006 33
2007 18
2008 35
2009 28
2010 28
2011 21
2012 31
2013 28
2014 22
2015 30
2016 16
2017 25
2018 16
2019 15
2020 19
2021 21
2022 30
2023 30
2024 22
2025 28
2026 13

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

562 results

Results by year

Filters applied: . Clear all
Page 1
Metformin use in women with polycystic ovary syndrome (PCOS): Opportunities, benefits, and clinical challenges.
Saadati S, Mason T, Godini R, Vanky E, Teede H, Mousa A. Saadati S, et al. Diabetes Obes Metab. 2025 Jun;27 Suppl 3(Suppl 3):31-47. doi: 10.1111/dom.16422. Epub 2025 May 6. Diabetes Obes Metab. 2025. PMID: 40329601 Free PMC article. Review.
However, the role of metformin in the multifaceted nature of PCOS remains debated. This review synthesises the mechanisms of action of metformin and its effects on metabolic, hormonal, reproductive, and pregnancy-related outcomes in PCOS. ...However, …
However, the role of metformin in the multifaceted nature of PCOS remains debated. This review synthesises the mechanisms of a …
A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS).
Siddiqui S, Mateen S, Ahmad R, Moin S. Siddiqui S, et al. J Assist Reprod Genet. 2022 Nov;39(11):2439-2473. doi: 10.1007/s10815-022-02625-7. Epub 2022 Oct 3. J Assist Reprod Genet. 2022. PMID: 36190593 Free PMC article. Review.
Most symptoms of PCOS arise early during puberty. Since PCOS involves a combination of signs and symptoms, thus it is considered as a heterogeneous disorderliness. ...GDF8 and SERPINE1 expression in PCOS is given in detail....
Most symptoms of PCOS arise early during puberty. Since PCOS involves a combination of signs and symptoms, thus it is consider …
Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial.
Agrawal A, Mahey R, Kachhawa G, Khadgawat R, Vanamail P, Kriplani A. Agrawal A, et al. Gynecol Endocrinol. 2019 Jun;35(6):511-514. doi: 10.1080/09513590.2018.1549656. Epub 2019 Jan 7. Gynecol Endocrinol. 2019. PMID: 30614289 Clinical Trial.
The present study was planned to evaluate the benefit of synergetic effect of Metformin plus Myo-inositol versus Metformin alone in infertile polycystic ovarian syndrome (PCOS) women undergoing ovulation induction. One hundred and twenty infertile P …
The present study was planned to evaluate the benefit of synergetic effect of Metformin plus Myo-inositol versus Metformin alo …
Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility.
Attia GM, Almouteri MM, Alnakhli FT. Attia GM, et al. Cureus. 2023 Aug 31;15(8):e44493. doi: 10.7759/cureus.44493. eCollection 2023 Aug. Cureus. 2023. PMID: 37791160 Free PMC article. Review.
Many studies showed that metformin, when used to treat PCOS, significantly reduced serum androgen levels, improved insulin sensitivity, restored menstrual cyclicity, and was successful in triggering ovulation. As a result, metformin may be useful in tr …
Many studies showed that metformin, when used to treat PCOS, significantly reduced serum androgen levels, improved insulin sen …
Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines.
Fitz V, Graca S, Mahalingaiah S, Liu J, Lai L, Butt A, Armour M, Rao V, Naidoo D, Maunder A, Yang G, Vaddiparthi V, Witchel SF, Pena A, Spritzer PM, Li R, Tay C, Mousa A, Teede H, Ee C. Fitz V, et al. J Clin Endocrinol Metab. 2024 May 17;109(6):1630-1655. doi: 10.1210/clinem/dgad762. J Clin Endocrinol Metab. 2024. PMID: 38163998 Free PMC article.
CONTEXT: Insulin resistance is common in women with polycystic ovary syndrome (PCOS). Inositol may have insulin sensitizing effects; however, its efficacy in the management of PCOS remains indeterminate. ...Myo-inositol likely causes fewer gastrointestinal adverse e …
CONTEXT: Insulin resistance is common in women with polycystic ovary syndrome (PCOS). Inositol may have insulin sensitizing effects; …
Comparative efficacy of combined myo-inositol and D-chiro inositol versus metformin across PCOS Phenotypes: enhancing ovarian function, ovulation, and stress response in a prospective clinical trial.
Gul M, Khan H, Rauf B, Bukhari SMS, Ehtesham E, Malik MO, Shah FA, Alanazi FE, Shah M. Gul M, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul;398(7):8761-8772. doi: 10.1007/s00210-025-03813-9. Epub 2025 Jan 23. Naunyn Schmiedebergs Arch Pharmacol. 2025. PMID: 39847053 Clinical Trial.
This study aimed to evaluate the comparative efficacy of Myo-inositol (MI) and D-chiro-inositol (DCI) with metformin in enhancing ovarian function, promoting ovulation, and reducing perceived stress in patients with polycystic ovary syndrome (PCOS). ...Our fi …
This study aimed to evaluate the comparative efficacy of Myo-inositol (MI) and D-chiro-inositol (DCI) with metformin in enhancing ova …
Polycystic ovarian syndrome-current pharmacotherapy and clinical implications.
Rashid R, Mir SA, Kareem O, Ali T, Ara R, Malik A, Amin F, Bader GN. Rashid R, et al. Taiwan J Obstet Gynecol. 2022 Jan;61(1):40-50. doi: 10.1016/j.tjog.2021.11.009. Taiwan J Obstet Gynecol. 2022. PMID: 35181044 Free article. Review.
The treatment in PCOS is mainly symptomatic and involves lifestyle interventions and medications such as Metformin, Oral contraceptives and Antiandrogens. However, the management of PCOS is challenging and current interventions are not able to deal with outco …
The treatment in PCOS is mainly symptomatic and involves lifestyle interventions and medications such as Metformin, Oral contr …
Twenty years of ovulation induction with metformin for PCOS; what is the best available evidence?
Abu Hashim H. Abu Hashim H. Reprod Biomed Online. 2016 Jan;32(1):44-53. doi: 10.1016/j.rbmo.2015.09.015. Epub 2015 Oct 19. Reprod Biomed Online. 2016. PMID: 26656973 Review.
Evidence is insufficient to favour the use of metformin or metformin plus clomiphene citrate instead of clomiphene citrate for ovulation induction in women with newly diagnosed PCOS. Evidence is also insufficient to recommend metformin as a prim …
Evidence is insufficient to favour the use of metformin or metformin plus clomiphene citrate instead of clomiphene citrate for …
Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation.
Zhang KH, Zhang FF, Zhang ZL, Fang KF, Sun WX, Kong N, Wu M, Liu HO, Liu Y, Li Z, Cai QQ, Wang Y, Wei QW, Lin PC, Lin Y, Xu W, Xu CJ, Yuan YY, Zhao SM. Zhang KH, et al. Protein Cell. 2024 Jul 1;15(7):512-529. doi: 10.1093/procel/pwad065. Protein Cell. 2024. PMID: 38167949 Free PMC article.
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility. Inadequate understanding of the ovulation drivers hinders PCOS intervention. ...Glutamine removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS …
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility. Inadequate understanding of the ovulation dr …
The pathogenesis and treatment of polycystic ovary syndrome: What's new?
Bednarska S, Siejka A. Bednarska S, et al. Adv Clin Exp Med. 2017 Mar-Apr;26(2):359-367. doi: 10.17219/acem/59380. Adv Clin Exp Med. 2017. PMID: 28791858 Free article. Review.
Polycystic ovary syndrome (PCOS) is currently the leading cause of menstrual complications in women. It is characterized by clinical and/or biochemical hyperandrogenism, ovulation abnormalities and the presence of enlarged and/or polycystic ovaries in ultrasound ima …
Polycystic ovary syndrome (PCOS) is currently the leading cause of menstrual complications in women. It is characterized by clinical …
562 results