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Metformin and fibromyalgia pathophysiology: current insights and promising future therapeutic strategies.
AboTaleb HA, Alghamdi BS. AboTaleb HA, et al. Mol Biol Rep. 2024 Dec 18;52(1):60. doi: 10.1007/s11033-024-10159-7. Mol Biol Rep. 2024. PMID: 39692938 Review.
Fibromyalgia (FM) is a complex, chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, and cognitive disturbances. ...Metformin has been shown to mitigate neuroinflammation, protect neural tissues, and modulate key neurotransmitters involve …
Fibromyalgia (FM) is a complex, chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, and cognitive distur …
The Antinociceptive Effects and Sex-Specific Neurotransmitter Modulation of Metformin in a Mouse Model of Fibromyalgia.
AboTaleb HA, Alturkistani HA, Abd El-Aziz GS, Hindi EA, Halawani MM, Al-Thepyani MA, Alghamdi BS. AboTaleb HA, et al. Cells. 2024 Nov 30;13(23):1986. doi: 10.3390/cells13231986. Cells. 2024. PMID: 39682734 Free PMC article.
It has shown promise in alleviating neuropathic and inflammatory pain, suggesting that it could offer a novel approach to managing chronic pain conditions like FM. This study aimed to further explore metformin's analgesic potential by evaluating its effects in an ex …
It has shown promise in alleviating neuropathic and inflammatory pain, suggesting that it could offer a novel approach to managing chronic p …
Metformin: A Prospective Alternative for the Treatment of Chronic Pain.
Baeza-Flores GDC, Guzmán-Priego CG, Parra-Flores LI, Murbartián J, Torres-López JE, Granados-Soto V. Baeza-Flores GDC, et al. Front Pharmacol. 2020 Sep 23;11:558474. doi: 10.3389/fphar.2020.558474. eCollection 2020. Front Pharmacol. 2020. PMID: 33178015 Free PMC article. Review.
Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug has been used for 60 years as a highly effective antihyperglycemic agent. ...Interestingly, metformin is able to reverse some of these consequences of pathological pain in ro …
Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug has been used for 60 years as a highly ef …
Bioinformatics analysis of gene and microRNA targets for fibromyalgia.
Qiu Y, Zhang TJ, Meng LB, Cheng XT, Hua Z. Qiu Y, et al. Clin Exp Rheumatol. 2021 Jan-Feb;39(1):21-31. doi: 10.55563/clinexprheumatol/iitbcp. Epub 2020 Feb 14. Clin Exp Rheumatol. 2021. PMID: 32083545 Free article.
OBJECTIVES: Fibromyalgia (FM) is the most common chronic pain disease in middle-aged women. Patients may also complain of migraine, irritable bowel syndrome and depression, which seriously affect their work and life, causing huge economic losses to society. ...These genes …
OBJECTIVES: Fibromyalgia (FM) is the most common chronic pain disease in middle-aged women. Patients may also complain of migraine, i …
Is insulin resistance the cause of fibromyalgia? A preliminary report.
Pappolla MA, Manchikanti L, Andersen CR, Greig NH, Ahmed F, Fang X, Seffinger MA, Trescot AM. Pappolla MA, et al. PLoS One. 2019 May 6;14(5):e0216079. doi: 10.1371/journal.pone.0216079. eCollection 2019. PLoS One. 2019. Retraction in: PLoS One. 2019 Dec 2;14(12):e0226174. doi: 10.1371/journal.pone.0226174 PMID: 31059525 Free PMC article. Retracted.
Fibromyalgia (FM) is one of the most frequent generalized pain disorders with poorly understood neurobiological mechanisms. ...A subgroup of patients meeting criteria for pre-diabetes or diabetes (patients with HbA1c values of 5.7% or greater) who had undergone treatment w …
Fibromyalgia (FM) is one of the most frequent generalized pain disorders with poorly understood neurobiological mechanisms. ...A subg …
AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome.
Bullón P, Alcocer-Gómez E, Carrión AM, Marín-Aguilar F, Garrido-Maraver J, Román-Malo L, Ruiz-Cabello J, Culic O, Ryffel B, Apetoh L, Ghiringhelli F, Battino M, Sánchez-Alcazar JA, Cordero MD. Bullón P, et al. Antioxid Redox Signal. 2016 Jan 20;24(3):157-70. doi: 10.1089/ars.2014.6120. Epub 2015 Sep 16. Antioxid Redox Signal. 2016. PMID: 26132721 Free PMC article.
This effect was rescued by increasing AMPK phosphorylation via metformin treatment (p<0.001), caloric restriction diet (p<0.001), or NLRP3 inflammasome genetic inactivation using NLRP3 knockout (nlrp3(-/-)) mice (p<0.001). Deficient AMPK activation and overactivat …
This effect was rescued by increasing AMPK phosphorylation via metformin treatment (p<0.001), caloric restriction diet (p<0.001 …
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients.
Alcocer-Gómez E, Garrido-Maraver J, Bullón P, Marín-Aguilar F, Cotán D, Carrión AM, Alvarez-Suarez JM, Giampieri F, Sánchez-Alcazar JA, Battino M, Cordero MD. Alcocer-Gómez E, et al. Biochim Biophys Acta. 2015 Jul;1852(7):1257-67. doi: 10.1016/j.bbadis.2015.03.005. Epub 2015 Mar 14. Biochim Biophys Acta. 2015. PMID: 25779083 Free article.
AMPK activation in FM fibroblast was impaired in response to moderate oxidative stress. In contrast, AMPK activation by metformin or incubation with serum from caloric restricted mice improved the response to moderate oxidative stress and mitochondrial metabolism in FM fib …
AMPK activation in FM fibroblast was impaired in response to moderate oxidative stress. In contrast, AMPK activation by metformin or …
Pregabalin and simvastatin: first report of a case of rhabdomyolysis.
Kaufman MB, Choy M. Kaufman MB, et al. P T. 2012 Oct;37(10):579-95. P T. 2012. PMID: 23115467 Free PMC article.
PATIENT SUMMARY: A 70-year-old man with a history of fibromyalgia, type-2 diabetes, hypercholesterolemia, and chronic back pain presented to the emergency department with altered mental status, limb weakness, twitching, and slurred speech. ...On admission, serum creatinine …
PATIENT SUMMARY: A 70-year-old man with a history of fibromyalgia, type-2 diabetes, hypercholesterolemia, and chronic back pain prese …