Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1968 1
1977 1
1982 1
1987 2
1988 1
1990 2
1991 1
1992 2
1993 5
1994 4
1995 4
1996 6
1997 10
1998 15
1999 12
2000 13
2001 16
2002 27
2003 38
2004 45
2005 56
2006 66
2007 55
2008 80
2009 66
2010 67
2011 78
2012 118
2013 111
2014 138
2015 112
2016 113
2017 96
2018 111
2019 105
2020 116
2021 139
2022 104
2023 109
2024 88

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,916 results

Results by year

Filters applied: . Clear all
Page 1
Metformin: Mechanisms in Human Obesity and Weight Loss.
Yerevanian A, Soukas AA. Yerevanian A, et al. Curr Obes Rep. 2019 Jun;8(2):156-164. doi: 10.1007/s13679-019-00335-3. Curr Obes Rep. 2019. PMID: 30874963 Free PMC article. Review.
RECENT FINDINGS: Metformin is a first-line therapy for type 2 diabetes. Large cohort studies have shown weight loss benefits associated with metformin therapy. ...Multiple mechanisms underlie the weight loss-inducing and health-promoting …
RECENT FINDINGS: Metformin is a first-line therapy for type 2 diabetes. Large cohort studies have shown weight loss ben …
Effectiveness of metformin on weight loss in non-diabetic individuals with obesity.
Seifarth C, Schehler B, Schneider HJ. Seifarth C, et al. Exp Clin Endocrinol Diabetes. 2013 Jan;121(1):27-31. doi: 10.1055/s-0032-1327734. Epub 2012 Nov 12. Exp Clin Endocrinol Diabetes. 2013. PMID: 23147210
RESULTS: The mean weight loss in the metformin treated group was 5.87.0 kg (5.66.5%). Untreated controls gained 0.83.5 kg (0.83.7%) on average. Patients with severe insulin resistance lost significantly more weight as compared to insulin sensitive pati …
RESULTS: The mean weight loss in the metformin treated group was 5.87.0 kg (5.66.5%). Untreated controls gained 0.83.5 …
Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.
Apolzan JW, Venditti EM, Edelstein SL, Knowler WC, Dabelea D, Boyko EJ, Pi-Sunyer X, Kalyani RR, Franks PW, Srikanthan P, Gadde KM; Diabetes Prevention Program Research Group. Apolzan JW, et al. Ann Intern Med. 2019 May 21;170(10):682-690. doi: 10.7326/M18-1605. Epub 2019 Apr 23. Ann Intern Med. 2019. PMID: 31009939 Free PMC article. Clinical Trial.
BACKGROUND: Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management. OBJECTIVE: To identify some predictors of LTWL. ...LIMITATION: Post hoc analysis; examination of nonrandomized subsets of randomized groups a …
BACKGROUND: Identifying reliable predictors of long-term weight loss (LTWL) could lead to improved weight management. O …
Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.
Day EA, Ford RJ, Smith BK, Mohammadi-Shemirani P, Morrow MR, Gutgesell RM, Lu R, Raphenya AR, Kabiri M, McArthur AG, McInnes N, Hess S, Paré G, Gerstein HC, Steinberg GR. Day EA, et al. Nat Metab. 2019 Dec;1(12):1202-1208. doi: 10.1038/s42255-019-0146-4. Epub 2019 Dec 9. Nat Metab. 2019. PMID: 32694673
Given the high concentration of metformin in the liver and its many beneficial effects beyond glycemic control, we reasoned that metformin may increase the secretion of a hepatocyte-derived endocrine factor that communicates with the central nervous system(4). ...An …
Given the high concentration of metformin in the liver and its many beneficial effects beyond glycemic control, we reasoned that m …
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM; Diabetes Prevention Program Research Group. Knowler WC, et al. N Engl J Med. 2002 Feb 7;346(6):393-403. doi: 10.1056/NEJMoa012512. N Engl J Med. 2002. PMID: 11832527 Free PMC article. Clinical Trial.
We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes. METHODS: We randomly assigned 3234 nondiabetic persons with elevated fasting and post-load plasma gluco …
We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent o …
GDF15 mediates the effects of metformin on body weight and energy balance.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S. Coll AP, et al. Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25. Nature. 2020. PMID: 31875646 Free PMC article. Clinical Trial.
More than 60% of this effect is attributable to the ability of metformin to lower body weight in a sustained manner(3). The molecular mechanisms by which metformin lowers body weight are unknown. ...Metformin prevented weight gain in resp …
More than 60% of this effect is attributable to the ability of metformin to lower body weight in a sustained manner(3). The mo …
Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.
Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, Liu B, Cui X, Brown K; SURPASS-2 Investigators. Frías JP, et al. N Engl J Med. 2021 Aug 5;385(6):503-515. doi: 10.1056/NEJMoa2107519. Epub 2021 Jun 25. N Engl J Med. 2021. PMID: 34170647 Clinical Trial.
At baseline, the mean glycated hemoglobin level was 8.28%, the mean age 56.6 years, and the mean weight 93.7 kg. The primary end point was the change in the glycated hemoglobin level from baseline to 40 weeks. ...Tirzepatide at all doses was noninferior and superior to sem …
At baseline, the mean glycated hemoglobin level was 8.28%, the mean age 56.6 years, and the mean weight 93.7 kg. The primary end poin …
Metformin-induced weight loss in patients with or without type 2 diabetes/prediabetes: A retrospective cohort study.
Chukir T, Mandel L, Tchang BG, Al-Mulla NA, Igel LI, Kumar RB, Waitman J, Aronne LJ, Shukla AP. Chukir T, et al. Obes Res Clin Pract. 2021 Jan-Feb;15(1):64-68. doi: 10.1016/j.orcp.2020.12.005. Epub 2020 Dec 30. Obes Res Clin Pract. 2021. PMID: 33386253
It is unknown whether weight loss outcomes differ with metformin monotherapy in patients with obesity with or without type 2 diabetes (T2DM)/prediabetes (PreDM). In this retrospective study, 6- or 12-month weight loss outcomes were compared in 2 …
It is unknown whether weight loss outcomes differ with metformin monotherapy in patients with obesity with or without t …
Effects of metformin on weight loss: potential mechanisms.
Malin SK, Kashyap SR. Malin SK, et al. Curr Opin Endocrinol Diabetes Obes. 2014 Oct;21(5):323-9. doi: 10.1097/MED.0000000000000095. Curr Opin Endocrinol Diabetes Obes. 2014. PMID: 25105996 Review.
RECENT FINDINGS: Many individuals struggle to maintain clinically relevant weight loss from lifestyle and bariatric surgery interventions. Long-term follow-up from the Diabetes Prevention Program demonstrates that metformin produces durable weight l …
RECENT FINDINGS: Many individuals struggle to maintain clinically relevant weight loss from lifestyle and bariatric surgery in …
Postpartum Use of Weight Loss and Metformin for the Prevention of Type 2 Diabetes Mellitus: a Review of the Evidence.
Whelan AR, Ayala NK, Werner EF. Whelan AR, et al. Curr Diab Rep. 2021 Sep 8;21(10):37. doi: 10.1007/s11892-021-01410-7. Curr Diab Rep. 2021. PMID: 34495405 Review.
Similarly, intervening with lifestyle modification postpartum has not resulted in significant diabetes risk reduction in prospective studies. Metformin is known to decrease insulin resistance and is also associated with weight loss. Data from large prospectiv …
Similarly, intervening with lifestyle modification postpartum has not resulted in significant diabetes risk reduction in prospective studies …
1,916 results

Searches related to "metformin weight loss"