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[Small intestine bacterial overgrowth: Myths and realities].
Guardiola-Arévalo A, Mascort Roca J, Noguerol Álvarez M, Carrillo Muñoz R, Mendive Arbeloa JM, Amador Romero J. Guardiola-Arévalo A, et al. Aten Primaria. 2025 Apr;57(4):103201. doi: 10.1016/j.aprim.2024.103201. Epub 2025 Jan 11. Aten Primaria. 2025. PMID: 39799751 Free PMC article. Review. Spanish.
The small intestine bacterial overgrowth (SIBO) is a clinical disorder resulting from colonization of the small intestine by an excessive number of microorganisms or by unusual microorganisms. When they are methane producers it is called intestinal methanogen overgroth ( …
The small intestine bacterial overgrowth (SIBO) is a clinical disorder resulting from colonization of the small intestine by an excessive nu …
Symptom Profile of Patients With Intestinal Methanogen Overgrowth: A Systematic Review and Meta-analysis.
Mehravar S, Takakura W, Wang J, Pimentel M, Nasser J, Rezaie A. Mehravar S, et al. Clin Gastroenterol Hepatol. 2025 Jun;23(7):1111-1122.e9. doi: 10.1016/j.cgh.2024.07.020. Epub 2024 Aug 13. Clin Gastroenterol Hepatol. 2025. PMID: 39147218
Excessive luminal loads of methanogenic archaea (intestinal methanogen overgrowth [IMO]) have been implicated in the pathophysiology of various diseases, including constipation. ...Significant heterogeneity was detected. CONCLUSION: Patients with IMO exhibit …
Excessive luminal loads of methanogenic archaea (intestinal methanogen overgrowth [IMO]) have been implicated in the pathophysiology …
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome - An Update.
Takakura W, Pimentel M. Takakura W, et al. Front Psychiatry. 2020 Jul 10;11:664. doi: 10.3389/fpsyt.2020.00664. eCollection 2020. Front Psychiatry. 2020. PMID: 32754068 Free PMC article. Review.
In addition, Methanobrevibacter smithii, the causal organism in a positive methane breath test, has been linked to constipation predominant irritable bowel syndrome (IBS-C). As M. smithii is an archaeon and can overgrow in areas outside of the small intestine, it wa …
In addition, Methanobrevibacter smithii, the causal organism in a positive methane breath test, has been linked to constipation …
Hydrogen Sulfide and Methane on Breath Test Correlate with Human Small Intestinal Hydrogen Sulfide Producers and Methanogens.
Villanueva-Millan MJ, Leite G, Mathur R, Rezaie A, Fajardo CM, de Freitas Germano J, Morales W, Sanchez M, Rivera I, Parodi G, Weitsman S, Rashid M, Hosseini A, Brimberry D, Barlow GM, Pimentel M. Villanueva-Millan MJ, et al. Dig Dis Sci. 2025 Nov;70(11):3846-3856. doi: 10.1007/s10620-025-09156-y. Epub 2025 Jun 26. Dig Dis Sci. 2025. PMID: 40569514 Free PMC article.
BACKGROUND: Evidence indicates that 3 gas breath testing (BT) correlates with stool microbial populations. Breath methane (CH(4)) levels correlate with stool Methanobrevibacter smithii levels and constipation, while hydrogen sulfide (H(2)S) levels correlate with sto …
BACKGROUND: Evidence indicates that 3 gas breath testing (BT) correlates with stool microbial populations. Breath methane (CH(4)) lev …
Real-world Study of Three-gas Breath Testing Nationwide and the Association With Symptoms.
Pimentel M, Leite G, Joo L, Rezaie A, Mathur R, Brenner D, Nguyen L, Rashid M, Hosseini A, Brimberry D, Mitcho M, Richardson D, Wilfong F. Pimentel M, et al. J Clin Gastroenterol. 2026 May-Jun 01;60(5):406-417. doi: 10.1097/MCG.0000000000002326. Epub 2026 Feb 2. J Clin Gastroenterol. 2026. PMID: 41671534 Free PMC article.
GOALS AND BACKGROUND: Hydrogen (H 2 ) breath testing (BT) is used to diagnose small intestinal bacterial overgrowth (SIBO), and methane (CH 4 ) to diagnose constipation. Recently, a third microbially derived gas, hydrogen sulfide (H 2 S), was added to BT and associa …
GOALS AND BACKGROUND: Hydrogen (H 2 ) breath testing (BT) is used to diagnose small intestinal bacterial overgrowth (SIBO), and methane …
A Single Fasting Exhaled Methane Level Correlates With Fecal Methanogen Load, Clinical Symptoms and Accurately Detects Intestinal Methanogen Overgrowth.
Takakura W, Pimentel M, Rao S, Villanueva-Millan MJ, Chang C, Morales W, Sanchez M, Torosyan J, Rashid M, Hosseini A, Wang J, Leite G, Kowalewski E, Mathur R, Rezaie A. Takakura W, et al. Am J Gastroenterol. 2022 Mar 1;117(3):470-477. doi: 10.14309/ajg.0000000000001607. Am J Gastroenterol. 2022. PMID: 35041624 Clinical Trial.
Therefore, we aimed to assess the reliability of a fasting single methane measurement (SMM) in diagnosing IMO and its utility as a biomarker to monitor treatment response in subjects with IMO. ...DISCUSSION: Fasting SMM 10 ppm seems to accurately diagnose …
Therefore, we aimed to assess the reliability of a fasting single methane measurement (SMM) in diagnosing IMO and its utility …
Can Symptoms and Medical History Predict Outcomes for Hydrogen and Methane Breath Testing?
Haworth JJ, Treadway S, Bloor S, Isaac K, Morrison J, Farmer AD, Hobson AR. Haworth JJ, et al. Am J Gastroenterol. 2025 Aug 1;121(5):1233-40. doi: 10.14309/ajg.0000000000003697. Online ahead of print. Am J Gastroenterol. 2025. PMID: 40788605 Free PMC article.
INTRODUCTION: Hydrogen and methane breath testing (HMBT) is used to diagnose small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO). ...Survey items were statistically interrogated to determine associations with SIBO, IMO, or …
INTRODUCTION: Hydrogen and methane breath testing (HMBT) is used to diagnose small intestinal bacterial overgrowth (SIBO) and intesti …
High prevalence of small intestinal bacterial overgrowth and intestinal methanogen overgrowth in endometriosis patients: A case-control study.
Halfon P, Estrade JP, Penaranda G, Choucroun N, Bouaziz J, Nicolas-Boluda A, Retornaz F, Gurriet B, Plauzolles A. Halfon P, et al. Int J Gynaecol Obstet. 2025 Jul;170(1):284-291. doi: 10.1002/ijgo.70005. Epub 2025 Feb 17. Int J Gynaecol Obstet. 2025. PMID: 39959963
OBJECTIVE: The purpose of this study is to raise awareness of small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO) prevalence among patients with endometriosis to improve global recommendations in the standard of care for endometriosis. . …
OBJECTIVE: The purpose of this study is to raise awareness of small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgro …