Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1996 1
2002 1
2003 2
2004 1
2005 3
2006 3
2007 4
2008 2
2009 3
2010 4
2011 7
2012 3
2013 6
2014 7
2015 3
2016 5
2017 4
2018 4
2019 2
2020 6
2021 6
2022 6
2023 5
2024 6
2025 7
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

91 results

Results by year

Filters applied: . Clear all
Page 1
Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus.
Rezaie A, Buresi M, Lembo A, Lin H, McCallum R, Rao S, Schmulson M, Valdovinos M, Zakko S, Pimentel M. Rezaie A, et al. Am J Gastroenterol. 2017 May;112(5):775-784. doi: 10.1038/ajg.2017.46. Epub 2017 Mar 21. Am J Gastroenterol. 2017. PMID: 28323273 Free PMC article.
OBJECTIVES: Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). ...BT is useful in the diagnosis of carbohydrate maldigestion, methane-associated constipation, and …
OBJECTIVES: Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bac …
Epidemiology of small intestinal bacterial overgrowth.
Efremova I, Maslennikov R, Poluektova E, Vasilieva E, Zharikov Y, Suslov A, Letyagina Y, Kozlov E, Levshina A, Ivashkin V. Efremova I, et al. World J Gastroenterol. 2023 Jun 14;29(22):3400-3421. doi: 10.3748/wjg.v29.i22.3400. World J Gastroenterol. 2023. PMID: 37389240 Free PMC article. Review.
The presence of SIBO is detected in 33.8% of patients with gastroenterological complaints who underwent a breath test, and is significantly associated with smoking, bloating, abdominal pain, and anemia. ...SIBO is significantly associated with functional dyspepsia, …
The presence of SIBO is detected in 33.8% of patients with gastroenterological complaints who underwent a breath test, and is …
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome - An Update.
Takakura W, Pimentel M. Takakura W, et al. Front Psychiatry. 2020 Jul 10;11:664. doi: 10.3389/fpsyt.2020.00664. eCollection 2020. Front Psychiatry. 2020. PMID: 32754068 Free PMC article. Review.
SIBO can be diagnosed either by a small bowel aspirate culture showing 10(3) colony-forming units (CFU) per mL of aspirate, or a positive hydrogen lactulose or glucose breath test. Numerous pathogenic organisms have been shown to be increased in subjects with SIBO …
SIBO can be diagnosed either by a small bowel aspirate culture showing 10(3) colony-forming units (CFU) per mL of aspirate, or a positive h …
Hydrogen Sulfide and Methane on Breath Test Correlate with Human Small Intestinal Hydrogen Sulfide Producers and Methanogens.
Villanueva-Millan MJ, Leite G, Mathur R, Rezaie A, Fajardo CM, de Freitas Germano J, Morales W, Sanchez M, Rivera I, Parodi G, Weitsman S, Rashid M, Hosseini A, Brimberry D, Barlow GM, Pimentel M. Villanueva-Millan MJ, et al. Dig Dis Sci. 2025 Nov;70(11):3846-3856. doi: 10.1007/s10620-025-09156-y. Epub 2025 Jun 26. Dig Dis Sci. 2025. PMID: 40569514 Free PMC article.
BACKGROUND: Evidence indicates that 3 gas breath testing (BT) correlates with stool microbial populations. Breath methane (CH(4)) levels correlate with stool Methanobrevibacter smithii levels and constipation, while hydrogen sulfide (H(2)S) levels corr …
BACKGROUND: Evidence indicates that 3 gas breath testing (BT) correlates with stool microbial populations. Breath methane …
[Small intestine bacterial overgrowth: Myths and realities].
Guardiola-Arévalo A, Mascort Roca J, Noguerol Álvarez M, Carrillo Muñoz R, Mendive Arbeloa JM, Amador Romero J. Guardiola-Arévalo A, et al. Aten Primaria. 2025 Apr;57(4):103201. doi: 10.1016/j.aprim.2024.103201. Epub 2025 Jan 11. Aten Primaria. 2025. PMID: 39799751 Free PMC article. Review. Spanish.
It causes abdominal pain and distension, bloating, diarrhea, nausea, and weight loss, which can occur in different diseases or with intestinal malabsorption. In IMO there may be constipation. Suggestive analytical data may be iron deficiency, anemia, deficiency of fat-solu …
It causes abdominal pain and distension, bloating, diarrhea, nausea, and weight loss, which can occur in different diseases or with intestin …
Breath Methane Does Not Correlate With Constipation Severity or Bloating in Patients With Constipation.
Singh P, Duehren S, Katon J, Rangan V, Ballou S, Patel R, Iturrino J, Lembo A, Nee J. Singh P, et al. J Clin Gastroenterol. 2020 Apr;54(4):365-369. doi: 10.1097/MCG.0000000000001239. J Clin Gastroenterol. 2020. PMID: 31306344
GOALS: We aimed to study (1) if the breath methane level on glucose breath testing (GBT) was associated with constipation severity and (2) compare methane levels between patients with constipation and diarrhea. BACKGROUND: The breath …
GOALS: We aimed to study (1) if the breath methane level on glucose breath testing (GBT) was associated with constip …
Evaluating breath methane as a diagnostic test for constipation-predominant IBS.
Hwang L, Low K, Khoshini R, Melmed G, Sahakian A, Makhani M, Pokkunuri V, Pimentel M. Hwang L, et al. Dig Dis Sci. 2010 Feb;55(2):398-403. doi: 10.1007/s10620-009-0778-4. Epub 2009 Mar 18. Dig Dis Sci. 2010. PMID: 19294509
In this study, we prospectively evaluated the role of methane as a diagnostic test. Consecutive Rome I positive IBS patients referred for a lactulose breath test were eligible to participate. ...Subjects and physicians were blinded to the results of th …
In this study, we prospectively evaluated the role of methane as a diagnostic test. Consecutive Rome I positive IBS patients r …
Methane on breath testing is associated with constipation: a systematic review and meta-analysis.
Kunkel D, Basseri RJ, Makhani MD, Chong K, Chang C, Pimentel M. Kunkel D, et al. Dig Dis Sci. 2011 Jun;56(6):1612-8. doi: 10.1007/s10620-011-1590-5. Epub 2011 Feb 1. Dig Dis Sci. 2011. PMID: 21286935
Search terms included "methane," "breath test," "constipation," "motility," "transit," "irritable bowel syndrome" and/or "IBS." ...Among these, 1,277 subjects were examined by breath testing (N = 319 methane producers and N = 958 metha …
Search terms included "methane," "breath test," "constipation," "motility," "transit," "irritable bowel syndrome …
Pattern of methane levels with lactulose breath testing; can we shorten the test duration?
Shaker A, Peng B, Soffer E. Shaker A, et al. JGH Open. 2021 Jun 17;5(7):809-812. doi: 10.1002/jgh3.12592. eCollection 2021 Jul. JGH Open. 2021. PMID: 34263076 Free PMC article.
BACKGROUND AND AIM: Methane levels in methane-positive lactulose breath tests are frequently elevated at time zero. ...METHODS: A retrospective study of lactulose breath tests was conducted at an open access motility lab. A methane …
BACKGROUND AND AIM: Methane levels in methane-positive lactulose breath tests are frequently elevated at time ze …
Breath methane in functional constipation: response to treatment with Ispaghula husk.
Vega AB, Perelló A, Martos L, García Bayo I, García M, Andreu V, Abad A, Barenys M. Vega AB, et al. Neurogastroenterol Motil. 2015 Jul;27(7):945-53. doi: 10.1111/nmo.12568. Epub 2015 May 7. Neurogastroenterol Motil. 2015. PMID: 25952409
BACKGROUND: Colonic fermentation produces hydrogen (H2 ), and also produces methane (CH4 ) in subjects with methanogenic flora (M+). Methane production has been associated with chronic constipation (CC) and with changes in gut motility. ...They then underwent …
BACKGROUND: Colonic fermentation produces hydrogen (H2 ), and also produces methane (CH4 ) in subjects with methanogenic flora (M+). …
91 results