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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1928 1
1931 2
1932 2
1933 1
1934 3
1935 1
1936 2
1938 3
1939 4
1940 4
1941 2
1942 6
1943 4
1944 3
1945 14
1946 57
1947 82
1948 69
1949 63
1950 100
1951 79
1952 86
1953 83
1954 104
1955 94
1956 85
1957 72
1958 84
1959 89
1960 86
1961 93
1962 134
1963 245
1964 414
1965 374
1966 387
1967 477
1968 589
1969 700
1970 702
1971 748
1972 857
1973 846
1974 946
1975 932
1976 897
1977 826
1978 819
1979 889
1980 1062
1981 1152
1982 1364
1983 1551
1984 1662
1985 1726
1986 1859
1987 1824
1988 1837
1989 1857
1990 2068
1991 1961
1992 1975
1993 1878
1994 1816
1995 1738
1996 1687
1997 1636
1998 1533
1999 1501
2000 1572
2001 1531
2002 1538
2003 1551
2004 1641
2005 1644
2006 1748
2007 1745
2008 1753
2009 1679
2010 1794
2011 1806
2012 1831
2013 1906
2014 1823
2015 1705
2016 1778
2017 1810
2018 1829
2019 1987
2020 2080
2021 2101
2022 2142
2023 2003
2024 2025
2025 2260
2026 1593

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90,477 results

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Page 1
Methionine oxidation in bacteria: A reversible post-translational modification.
Vincent MS, Ezraty B. Vincent MS, et al. Mol Microbiol. 2023 Feb;119(2):143-150. doi: 10.1111/mmi.15000. Epub 2022 Nov 22. Mol Microbiol. 2023. PMID: 36350090 Free article. Review.
Although methionine oxidation causes protein damage, it can in some cases activate protein function. Enzymatic systems reducing oxidized methionine have evolved in most bacterial species and methionine oxidation proves to be a reversible post-translational mo …
Although methionine oxidation causes protein damage, it can in some cases activate protein function. Enzymatic systems reducing oxidi …
Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade.
Xue Y, Lu F, Chang Z, Li J, Gao Y, Zhou J, Luo Y, Lai Y, Cao S, Li X, Zhou Y, Li Y, Tan Z, Cheng X, Li X, Chen J, Wang W. Xue Y, et al. Nat Commun. 2023 Aug 8;14(1):4758. doi: 10.1038/s41467-023-40518-0. Nat Commun. 2023. PMID: 37553341 Free PMC article.
Here we show the length of time methionine deprivation affects tumoral ferroptosis differently. Prolonged methionine deprivation prevents glutathione (GSH) depletion from exceeding the death threshold by blocking cation transport regulator homolog 1 (CHAC1) protein …
Here we show the length of time methionine deprivation affects tumoral ferroptosis differently. Prolonged methionine deprivati …
Methionine gamma lyase: Structure-activity relationships and therapeutic applications.
Raboni S, Faggiano S, Bettati S, Mozzarelli A. Raboni S, et al. Biochim Biophys Acta Proteins Proteom. 2024 May 1;1872(3):140991. doi: 10.1016/j.bbapap.2023.140991. Epub 2023 Dec 24. Biochim Biophys Acta Proteins Proteom. 2024. PMID: 38147934 Free article. Review.
Methionine gamma lyase (MGL) is a bacterial and plant enzyme that catalyzes the conversion of methionine in methanthiol, 2-oxobutanoate and ammonia. ...MGL administration to cancer cells leads to methionine starvation, thus decreasing cells viability and incr
Methionine gamma lyase (MGL) is a bacterial and plant enzyme that catalyzes the conversion of methionine in methanthiol, 2-oxo
Methionine deficiency facilitates antitumour immunity by altering m(6)A methylation of immune checkpoint transcripts.
Li T, Tan YT, Chen YX, Zheng XJ, Wang W, Liao K, Mo HY, Lin J, Yang W, Piao HL, Xu RH, Ju HQ. Li T, et al. Gut. 2023 Mar;72(3):501-511. doi: 10.1136/gutjnl-2022-326928. Epub 2022 Jul 8. Gut. 2023. PMID: 35803704 Free PMC article.
DESIGN: The antitumour immunity effect of methionine-restricted diet (MRD) feeding was assessed in murine models. The mechanisms of methionine and YTH domain-containing family protein 1 (YTHDF1) in tumour immune escape were determined in vitro and in vivo. ...Target …
DESIGN: The antitumour immunity effect of methionine-restricted diet (MRD) feeding was assessed in murine models. The mechanisms of …
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2.
Jiang C, Liu J, He S, Xu W, Huang R, Pan W, Li X, Dai X, Guo J, Zhang T, Inuzuka H, Wang P, Asara JM, Xiao J, Wei W. Jiang C, et al. Cell Metab. 2023 Dec 5;35(12):2183-2199.e7. doi: 10.1016/j.cmet.2023.11.001. Epub 2023 Nov 24. Cell Metab. 2023. PMID: 38006878 Free PMC article.
Methionine is an essential branch of diverse nutrient inputs that dictate mTORC1 activation. In the absence of methionine, SAMTOR binds to GATOR1 and inhibits mTORC1 signaling. However, how mTORC1 is activated upon methionine stimulation remains largely elusi
Methionine is an essential branch of diverse nutrient inputs that dictate mTORC1 activation. In the absence of methionine, SAM
The methionine cycle and its cancer implications.
Tassinari V, Jia W, Chen WL, Candi E, Melino G. Tassinari V, et al. Oncogene. 2024 Nov;43(48):3483-3488. doi: 10.1038/s41388-024-03122-0. Epub 2024 Oct 11. Oncogene. 2024. PMID: 39394448 Review.
The essential amino acid methionine is a crucial regulator of sulfur metabolism in a variety of interconnected biochemical pathways. ...Recent work highlights methionine's critical role in tumor growth and progression, maintaining polyamine synthesis, and pla …
The essential amino acid methionine is a crucial regulator of sulfur metabolism in a variety of interconnected biochemical pathways. …
Methionine secreted by tumor-associated pericytes supports cancer stem cells in clear cell renal carcinoma.
Zhang C, Du Z, Gao Y, Lim KS, Zhou W, Huang H, He H, Xiao J, Xu D, Li Q. Zhang C, et al. Cell Metab. 2024 Apr 2;36(4):778-792.e10. doi: 10.1016/j.cmet.2024.01.018. Epub 2024 Feb 19. Cell Metab. 2024. PMID: 38378000 Free article.
Tumor-cell-derived succinate binds to GPR91 on pericyte to activate autophagy for methionine production. CSCs use methionine to create stabilizing N6-methyladenosine in ATPase-family-AAA-domain-containing 2 (ATAD2) mRNA, and the resulting ATAD2 protein complexes wit …
Tumor-cell-derived succinate binds to GPR91 on pericyte to activate autophagy for methionine production. CSCs use methionine t …
Cysteine and methionine oxidation in thrombotic disorders.
Yang M, Smith BC. Yang M, et al. Curr Opin Chem Biol. 2023 Oct;76:102350. doi: 10.1016/j.cbpa.2023.102350. Epub 2023 Jun 16. Curr Opin Chem Biol. 2023. PMID: 37331217 Free PMC article. Review.
Recent evidence suggests protein cysteine and methionine oxidation as prothrombotic regulators. These oxidative post-translational modifications occur on proteins that participate in the thrombotic process, including Src family kinases, protein disulfide isomerase, beta2 g …
Recent evidence suggests protein cysteine and methionine oxidation as prothrombotic regulators. These oxidative post-translational mo …
Methionine-Restricted Diet: A Feasible Strategy Against Chronic or Aging-Related Diseases.
Wu G, Xu J, Wang Q, Fang Z, Fang Y, Jiang Y, Zhang X, Cheng X, Sun J, Le G. Wu G, et al. J Agric Food Chem. 2023 Jan 11;71(1):5-19. doi: 10.1021/acs.jafc.2c05829. Epub 2022 Dec 26. J Agric Food Chem. 2023. PMID: 36571820 Review.
Dietary methionine restriction (MR) has been associated with multifaceted health-promoting effects. ...
Dietary methionine restriction (MR) has been associated with multifaceted health-promoting effects. ...
Folate-Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review.
Roufael M, Bitar T, Sacre Y, Andres C, Hleihel W. Roufael M, et al. Genes (Basel). 2023 Mar 13;14(3):709. doi: 10.3390/genes14030709. Genes (Basel). 2023. PMID: 36980981 Free PMC article.
Autism Spectrum Disorder (ASD) has become a major public health concern due to its rapidly rising incidence over the past few years. Disturbances in folate or methionine metabolism have been identified in many individuals with ASD, suggesting that the folate-methionine
Autism Spectrum Disorder (ASD) has become a major public health concern due to its rapidly rising incidence over the past few years. Disturb …
90,477 results
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