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2006 3
2007 1
2009 5
2010 2
2011 3
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2014 9
2015 7
2016 16
2017 18
2018 38
2019 60
2020 72
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tRNA Misacylation with Methionine in the Mouse Gut Microbiome in Situ.
Schwartz MH, Pan T. Schwartz MH, et al. Microb Ecol. 2017 Jul;74(1):10-14. doi: 10.1007/s00248-016-0928-0. Epub 2017 Jan 9. Microb Ecol. 2017. PMID: 28070678 Free PMC article.
In all instances, methionine mistranslation occurs through a regulated process where low-fidelity forms of methionyl-tRNA synthetase are conditionally induced to mischarge non-methionyl-tRNAs with methionine followed by the utilization of the misacylated tRNAs in tr …
In all instances, methionine mistranslation occurs through a regulated process where low-fidelity forms of methionyl-tRNA synthetase …
Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.
Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene ND, Gems D. Cabreiro F, et al. Cell. 2013 Mar 28;153(1):228-39. doi: 10.1016/j.cell.2013.02.035. Cell. 2013. PMID: 23540700 Free PMC article.
We report that metformin increases lifespan by altering microbial folate and methionine metabolism. Alterations in metformin-induced longevity by mutation of worm methionine synthase (metr-1) and S-adenosylmethionine synthase (sams-1) imply metformin-induced …
We report that metformin increases lifespan by altering microbial folate and methionine metabolism. Alterations in metformin-induced …
Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis.
Ye JZ, Li YT, Wu WR, Shi D, Fang DQ, Yang LY, Bian XY, Wu JJ, Wang Q, Jiang XW, Peng CG, Ye WC, Xia PC, Li LJ. Ye JZ, et al. World J Gastroenterol. 2018 Jun 21;24(23):2468-2481. doi: 10.3748/wjg.v24.i23.2468. World J Gastroenterol. 2018. PMID: 29930468 Free PMC article.
AIM: To investigate changes in gut microbiota and metabolism during nonalcoholic steatohepatitis (NASH) development in mice fed a methionine-choline-deficient (MCD) diet. ...CONCLUSION: The MCD diet induced persistent alterations in the gut microbiota and met …
AIM: To investigate changes in gut microbiota and metabolism during nonalcoholic steatohepatitis (NASH) development in mice fed a …
D-methionine alleviates cisplatin-induced mucositis by restoring the gut microbiota structure and improving intestinal inflammation.
Wu CH, Ko JL, Liao JM, Huang SS, Lin MY, Lee LH, Chang LY, Ou CC. Wu CH, et al. Ther Adv Med Oncol. 2019 Feb 12;11:1758835918821021. doi: 10.1177/1758835918821021. eCollection 2019. Ther Adv Med Oncol. 2019. PMID: 30792823 Free PMC article.
Cisplatin administration resulted in high relative abundances of Deferribacteres and Proteobacteria and a low diversity of the microbiota when compared with control groups, D-methionine only and cisplatin plus D-methionine. ...By enhancing growth of beneficia …
Cisplatin administration resulted in high relative abundances of Deferribacteres and Proteobacteria and a low diversity of the microbiota …
Dietary methionine restriction improves the gut microbiota and reduces intestinal permeability and inflammation in high-fat-fed mice.
Yang Y, Zhang Y, Xu Y, Luo T, Ge Y, Jiang Y, Shi Y, Sun J, Le G. Yang Y, et al. Food Funct. 2019 Sep 1;10(9):5952-5968. doi: 10.1039/c9fo00766k. Epub 2019 Sep 2. Food Funct. 2019. PMID: 31475718
We hypothesized that intestinal microbiota changes may mediate these effects, and this study aims to prove this hypothesis. Mice were fed a normal diet (ND, 0.86% methionine + 4% fat), a HF diet (HFD, 0.86% methionine + 20% fat), or a MRD (0.17% methionine …
We hypothesized that intestinal microbiota changes may mediate these effects, and this study aims to prove this hypothesis. Mice were …
Butyrate Protects Mice Against Methionine-Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels.
Ye J, Lv L, Wu W, Li Y, Shi D, Fang D, Guo F, Jiang H, Yan R, Ye W, Li L. Ye J, et al. Front Microbiol. 2018 Aug 21;9:1967. doi: 10.3389/fmicb.2018.01967. eCollection 2018. Front Microbiol. 2018. PMID: 30186272 Free PMC article.
We aimed to investigate the role of butyrate-induced gut microbiota and metabolism in NASH development. Sixty-five C57BL/6J mice were divided into four groups (n = 15-17 per group) and were fed either a methionine-choline-sufficient (MCS) diet or methionine-c …
We aimed to investigate the role of butyrate-induced gut microbiota and metabolism in NASH development. Sixty-five C57BL/6J mice were …
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease.
Hertel J, Harms AC, Heinken A, Baldini F, Thinnes CC, Glaab E, Vasco DA, Pietzner M, Stewart ID, Wareham NJ, Langenberg C, Trenkwalder C, Krüger R, Hankemeier T, Fleming RMT, Mollenhauer B, Thiele I. Hertel J, et al. Cell Rep. 2019 Nov 12;29(7):1767-1777.e8. doi: 10.1016/j.celrep.2019.10.035. Cell Rep. 2019. PMID: 31722195 Free PMC article. Clinical Trial.
Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched controls with constraint-based modeling of …
Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, …
Intestinal Microbiota Protects against MCD Diet-Induced Steatohepatitis.
Schneider KM, Mohs A, Kilic K, Candels LS, Elfers C, Bennek E, Schneider LB, Heymann F, Gassler N, Penders J, Trautwein C. Schneider KM, et al. Int J Mol Sci. 2019 Jan 14;20(2):308. doi: 10.3390/ijms20020308. Int J Mol Sci. 2019. PMID: 30646522 Free PMC article.
However, its functional implications in the methionine-choline dietary model, remain incompletely understood. Here, we investigated the physiological relevance of gut microbiota in methionine-choline deficient (MCD) diet induced NASH. ...Our data demonstrated …
However, its functional implications in the methionine-choline dietary model, remain incompletely understood. Here, we investigated t …
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. Henao-Mejia J, et al. Nature. 2012 Feb 1;482(7384):179-85. doi: 10.1038/nature10809. Nature. 2012. PMID: 22297845 Free PMC article.
Here, we show that the NLRP6 and NLRP3 inflammasomes and the effector protein IL-18 negatively regulate NAFLD/NASH progression, as well as multiple aspects of metabolic syndrome via modulation of the gut microbiota. ...Thus, altered interactions between the gut microbio …
Here, we show that the NLRP6 and NLRP3 inflammasomes and the effector protein IL-18 negatively regulate NAFLD/NASH progression, as well as m …
Fructo-oligosaccharides and intestinal barrier function in a methionine-choline-deficient mouse model of nonalcoholic steatohepatitis.
Matsumoto K, Ichimura M, Tsuneyama K, Moritoki Y, Tsunashima H, Omagari K, Hara M, Yasuda I, Miyakawa H, Kikuchi K. Matsumoto K, et al. PLoS One. 2017 Jun 20;12(6):e0175406. doi: 10.1371/journal.pone.0175406. eCollection 2017. PLoS One. 2017. PMID: 28632732 Free PMC article.
Prebiotic fructo-oligosaccharides restore balance in the gastrointestinal microbiome. This study was conducted to determine the effects of dietary fructo-oligosaccharides on intestinal barrier function and steatohepatitis in methionine-choline-deficient mice. ...The …
Prebiotic fructo-oligosaccharides restore balance in the gastrointestinal microbiome. This study was conducted to determine the effec …
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