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3,453 results

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Page 1
The role of methionine on metabolism, oxidative stress, and diseases.
Martínez Y, Li X, Liu G, Bin P, Yan W, Más D, Valdivié M, Hu CA, Ren W, Yin Y. Martínez Y, et al. Amino Acids. 2017 Dec;49(12):2091-2098. doi: 10.1007/s00726-017-2494-2. Epub 2017 Sep 19. Amino Acids. 2017. PMID: 28929442 Review.
Recent research has demonstrated that methionine can regulate metabolic processes, the innate immune system, and digestive functioning in mammals. ...This review focuses on the role of methionine in metabolism, oxidative stress, and related diseases... …
Recent research has demonstrated that methionine can regulate metabolic processes, the innate immune system, and digest …
A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation.
Fu L, Zhao J, Huang J, Li N, Dong X, He Y, Wang W, Wang Y, Qiu J, Guo X. Fu L, et al. J Allergy Clin Immunol. 2022 Jun;149(6):2091-2104. doi: 10.1016/j.jaci.2021.12.783. Epub 2021 Dec 30. J Allergy Clin Immunol. 2022. PMID: 34974065
BACKGROUND: Group 2 innate lymphoid cells (ILC2s), the innate counterpart of T(H)2 cells, play a critical role in type 2 immune responses. However, the molecular regulatory mechanisms of ILC2s are still unclear. ...CONCLUSION: The mitochondrial STAT3-methionine meta …
BACKGROUND: Group 2 innate lymphoid cells (ILC2s), the innate counterpart of T(H)2 cells, play a critical role in type 2 immune respo …
Early methionine availability attenuates T cell exhaustion.
Sharma P, Guo A, Poudel S, Boada-Romero E, Verbist KC, Palacios G, Immadisetty K, Chen MJ, Haydar D, Mishra A, Peng J, Babu MM, Krenciute G, Glazer ES, Green DR. Sharma P, et al. Nat Immunol. 2025 Aug;26(8):1384-1396. doi: 10.1038/s41590-025-02223-6. Epub 2025 Jul 23. Nat Immunol. 2025. PMID: 40702340 Free PMC article.
T cell receptor (TCR) activation is regulated in many ways, including niche-specific nutrient availability. Here we investigated how methionine (Met) availability and TCR signaling interplay during the earliest events of T cell activation affect subsequent cell fate. ...
T cell receptor (TCR) activation is regulated in many ways, including niche-specific nutrient availability. Here we investigated how meth …
Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity.
Fang L, Hao Y, Yu H, Gu X, Peng Q, Zhuo H, Li Y, Liu Z, Wang J, Chen Y, Zhang J, Tian H, Gao Y, Gao R, Teng H, Shan Z, Zhu J, Li Z, Liu Y, Zhang Y, Yu F, Lin Z, Hao Y, Ge X, Yuan J, Hu HG, Ma Y, Qin HL, Wang P. Fang L, et al. Cancer Cell. 2023 Jun 12;41(6):1118-1133.e12. doi: 10.1016/j.ccell.2023.05.005. Epub 2023 Jun 1. Cancer Cell. 2023. PMID: 37267951 Free article.
However, it remains unclear whether the cGAS-mediated antitumor activity is affected by nutrient status. Here, our study reports that methionine deprivation enhances cGAS activity by blocking its methylation, which is catalyzed by methyltransferase SUV39H1. ...
However, it remains unclear whether the cGAS-mediated antitumor activity is affected by nutrient status. Here, our study reports that met …
Met1-linked ubiquitination in immune signalling.
Fiil BK, Gyrd-Hansen M. Fiil BK, et al. FEBS J. 2014 Oct;281(19):4337-50. doi: 10.1111/febs.12944. Epub 2014 Aug 12. FEBS J. 2014. PMID: 25060092 Free PMC article. Review.
N-terminal methionine-linked ubiquitin (Met1-Ub), or linear ubiquitin, has emerged as a central post-translational modification in innate immune signalling. ...In this review, we discuss the current data on Met1-Ub function and regulation, and point to some o …
N-terminal methionine-linked ubiquitin (Met1-Ub), or linear ubiquitin, has emerged as a central post-translational modification in in …
Effects of dietary methionine supplementation on growth performance, intestinal morphology, antioxidant capacity and immune function in intra-uterine growth-retarded suckling piglets.
Zhang H, Li Y, Chen Y, Ying Z, Su W, Zhang T, Dong Y, Htoo JK, Zhang L, Wang T. Zhang H, et al. J Anim Physiol Anim Nutr (Berl). 2019 May;103(3):868-881. doi: 10.1111/jpn.13084. Epub 2019 Apr 2. J Anim Physiol Anim Nutr (Berl). 2019. PMID: 30941824
This study investigated the effects of dietary supplementation with (L) -methionine ((L) -Met), (DL) -methionine ((DL) -Met) and calcium salt of the methionine hydroxyl analog (MHA-Ca) on growth performance, intestinal morphology, antioxidant capacity and …
This study investigated the effects of dietary supplementation with (L) -methionine ((L) -Met), (DL) -methionine ((DL) -Met) a …
NLRs guard metabolism to coordinate pattern- and effector-triggered immunity.
Zhai K, Liang D, Li H, Jiao F, Yan B, Liu J, Lei Z, Huang L, Gong X, Wang X, Miao J, Wang Y, Liu JY, Zhang L, Wang E, Deng Y, Wen CK, Guo H, Han B, He Z. Zhai K, et al. Nature. 2022 Jan;601(7892):245-251. doi: 10.1038/s41586-021-04219-2. Epub 2021 Dec 15. Nature. 2022. PMID: 34912119
PICI1 deubiquitinates and stabilizes methionine synthetases to activate methionine-mediated immunity principally through biosynthesis of the phytohormone ethylene. ...Nucleotide-binding domain, leucine-rich-repeat-containing receptors (NLRs) in the plant immune …
PICI1 deubiquitinates and stabilizes methionine synthetases to activate methionine-mediated immunity principally through biosy …
The effect of methionine and aflatoxin on immune function in weanling pigs.
van Heugten E, Spears JW, Coffey MT, Kegley EB, Qureshi MA. van Heugten E, et al. J Anim Sci. 1994 Mar;72(3):658-64. doi: 10.2527/1994.723658x. J Anim Sci. 1994. PMID: 8181982
To investigate the effect of aflatoxin (AF) and dietary methionine (MET) on immune responses of swine, a total of 288 pigs weaned at 21 d of age were allotted to 12 dietary treatments arranged in a 3 x 4 factorial arrangement in a randomized complete block design. D …
To investigate the effect of aflatoxin (AF) and dietary methionine (MET) on immune responses of swine, a total of 288 pigs wea …
Parasites suppress immune-enhancing effect of methionine in nestling great tits.
Wegmann M, Voegeli B, Richner H. Wegmann M, et al. Oecologia. 2015 Jan;177(1):213-21. doi: 10.1007/s00442-014-3138-9. Epub 2014 Nov 14. Oecologia. 2015. PMID: 25395313
To explore this trade-off, we simultaneously exposed nestling great tits (Parus major) to a common ectoparasite, while stimulating immune function. Using a 2 2 experimental design, we first infested half of the nests with hen fleas (Ceratophyllus gallinae) on day …
To explore this trade-off, we simultaneously exposed nestling great tits (Parus major) to a common ectoparasite, while stimulating immune …
3,453 results