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Year Number of Results
1979 1
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2004 1
2005 2
2006 2
2007 3
2008 4
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2011 4
2012 2
2014 5
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2016 5
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62 results

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Page 1
tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state.
Gupta R, Laxman S. Gupta R, et al. Curr Genet. 2020 Jun;66(3):475-480. doi: 10.1007/s00294-019-01045-y. Epub 2019 Nov 22. Curr Genet. 2020. PMID: 31758251 Review.
This mini-review considers the idea that conserved chemical modifications of wobble (U34) position tRNA uridines enable cells to sense nutrients and regulate their metabolic state. tRNA wobble uridines are chemically modified at the 2- and 5- positions, with a thiol …
This mini-review considers the idea that conserved chemical modifications of wobble (U34) position tRNA uridines enable cells to sens …
Ribonucleosides from tRNA in hyperglycemic mammalian cells and diabetic murine cardiac models.
Dodson TA, Nieuwoudt S, Morse CN, Pierre V, Liu C, Senyo SE, Prestwich EG. Dodson TA, et al. Life Sci. 2023 Apr 1;318:121462. doi: 10.1016/j.lfs.2023.121462. Epub 2023 Feb 2. Life Sci. 2023. PMID: 36736767 Free PMC article.
AIMS: Cardiomyopathy is a diabetic comorbidity with few molecular targets. To address this, we evaluated transfer RNA (tRNA) modifications in the diabetic heart because tRNA modifications have been implicated in diabetic etiologies. ...Specific tRNA
AIMS: Cardiomyopathy is a diabetic comorbidity with few molecular targets. To address this, we evaluated transfer RNA (tRNA
Urm1: A Non-Canonical UBL.
Termathe M, Leidel SA. Termathe M, et al. Biomolecules. 2021 Jan 22;11(2):139. doi: 10.3390/biom11020139. Biomolecules. 2021. PMID: 33499055 Free PMC article. Review.
This sulfurtransferase domain catalyzes the formation of a C-terminal thiocarboxylate on Urm1. Thiocarboxylated Urm1 is the sulfur donor for 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U), a chemical nucleotide modification at the wobble position in tRNA. ...Th …
This sulfurtransferase domain catalyzes the formation of a C-terminal thiocarboxylate on Urm1. Thiocarboxylated Urm1 is the sulfur donor for …
Substrate recognition mechanism of tRNA-targeting ribonuclease, colicin D, and an insight into tRNA cleavage-mediated translation impairment.
Ogawa T, Takahashi K, Ishida W, Aono T, Hidaka M, Terada T, Masaki H. Ogawa T, et al. RNA Biol. 2021 Aug;18(8):1193-1205. doi: 10.1080/15476286.2020.1838782. Epub 2020 Nov 19. RNA Biol. 2021. PMID: 33211605 Free PMC article.
How colicin D selects tRNA(Arg)s from the tRNA pool of sensitive E. coli cells is therefore intriguing. ...The strategy should also be applicable to other tRNA-targeting RNases, as they, too, recognize anticodon-loops.Abbreviations: mnm(5)U: 5-methylaminometh …
How colicin D selects tRNA(Arg)s from the tRNA pool of sensitive E. coli cells is therefore intriguing. ...The strategy should …
Elongator-a tRNA modifying complex that promotes efficient translational decoding.
Johansson MJO, Xu F, Byström AS. Johansson MJO, et al. Biochim Biophys Acta Gene Regul Mech. 2018 Apr;1861(4):401-408. doi: 10.1016/j.bbagrm.2017.11.006. Epub 2017 Nov 21. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 29170010 Review.
Uridines present at the wobble position in eukaryotic cytoplasmic tRNAs often contain a 5-carbamoylmethyl (ncm(5)) or 5-methoxycarbonylmethyl (mcm(5)) side-chain and sometimes also a 2-thio or 2'-O-methyl group. ...This article is part of a Special Issue entitled: SI: Regu …
Uridines present at the wobble position in eukaryotic cytoplasmic tRNAs often contain a 5-carbamoylmethyl (ncm(5)) or 5-methoxycarbonylme
Genome recoding by tRNA modifications.
Tuorto F, Lyko F. Tuorto F, et al. Open Biol. 2016 Dec;6(12):160287. doi: 10.1098/rsob.160287. Open Biol. 2016. PMID: 27974624 Free PMC article. Review.
RNA modifications are emerging as an additional regulatory layer on top of the primary RNA sequence. ...Recent studies have provided novel insights into how these modifications orchestrate the speed and fidelity of translation to ensure proper protein homeostasis. T
RNA modifications are emerging as an additional regulatory layer on top of the primary RNA sequence. ...Recent studies have pr
SSD1 modifies phenotypes of Elongator mutants.
Xu F, Byström AS, Johansson MJO. Xu F, et al. Curr Genet. 2020 Jun;66(3):481-485. doi: 10.1007/s00294-019-01048-9. Epub 2019 Nov 27. Curr Genet. 2020. PMID: 31776648 Free PMC article. Review.
The Elongator complex promotes the first step in the formation of 5-methoxycarbonylmethyl (mcm(5)), 5-methoxycarbonylhydroxymethyl (mchm(5)), and 5-carbamoylmethyl (ncm(5)) groups on wobble uridine residues in eukaryotic cytosolic tRNAs. Elongator mutants in yeast, worms, …
The Elongator complex promotes the first step in the formation of 5-methoxycarbonylmethyl (mcm(5)), 5-methoxycarbonylhydroxymethyl (m …
Combined tRNA modification defects impair protein homeostasis and synthesis of the yeast prion protein Rnq1.
Schaffrath R, Klassen R. Schaffrath R, et al. Prion. 2017 Jan 2;11(1):48-53. doi: 10.1080/19336896.2017.1284734. Prion. 2017. PMID: 28281930 Free PMC article.
In Saccharomyces cerevisiae, the simultaneous presence of mcm(5)s(2)U and psi38 in tRNA(Gln)(UUG) was shown to mediate efficient synthesis of the Q/N rich [PIN(+)] prion forming protein Rnq1. (1) In the absence of these two tRNA modifications, higher than normal lev …
In Saccharomyces cerevisiae, the simultaneous presence of mcm(5)s(2)U and psi38 in tRNA(Gln)(UUG) was shown to mediate efficient synt …
Aspergillus fumigatus Elongator complex subunit 3 affects hyphal growth, adhesion and virulence through wobble uridine tRNA modification.
Zhang Y, Wang Y, Fan J, Zhu G, Lu L. Zhang Y, et al. PLoS Pathog. 2022 Nov 14;18(11):e1010976. doi: 10.1371/journal.ppat.1010976. eCollection 2022 Nov. PLoS Pathog. 2022. PMID: 36374932 Free PMC article.
LC-MS/MS chromatograms revealed that loss of Elp3 abolished the 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification of tRNA wobble uridine (U34), and the overexpression of tRNAGlnUUG and tRNAGluUUC, which normally harbor mcm5s2U modifications, mainly rescue …
LC-MS/MS chromatograms revealed that loss of Elp3 abolished the 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) modification of tR
62 results