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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1870 1
1887 1
1888 1
1889 2
1890 2
1891 1
1896 1
1897 3
1902 2
1903 1
1907 2
1912 2
1914 1
1916 2
1917 1
1918 1
1920 1
1923 1
1924 2
1925 4
1926 3
1927 2
1928 5
1929 2
1930 2
1931 3
1932 7
1933 3
1934 1
1935 4
1936 7
1937 5
1938 3
1939 3
1940 6
1941 5
1942 6
1943 10
1944 8
1945 55
1946 136
1947 214
1948 248
1949 185
1950 179
1951 209
1952 184
1953 192
1954 165
1955 196
1956 224
1957 225
1958 269
1959 245
1960 286
1961 331
1962 399
1963 504
1964 524
1965 538
1966 552
1967 714
1968 812
1969 895
1970 916
1971 1214
1972 1373
1973 1415
1974 1451
1975 2383
1976 2515
1977 2345
1978 2248
1979 2333
1980 2456
1981 2757
1982 2916
1983 3406
1984 3687
1985 4028
1986 4365
1987 4489
1988 4894
1989 5513
1990 6009
1991 6192
1992 6737
1993 7011
1994 7353
1995 7550
1996 7969
1997 7981
1998 8148
1999 8417
2000 9461
2001 9839
2002 10250
2003 11110
2004 11894
2005 13063
2006 14195
2007 14711
2008 15801
2009 16138
2010 17857
2011 19030
2012 20098
2013 20770
2014 21013
2015 21181
2016 20433
2017 20468
2018 20865
2019 21212
2020 22690
2021 23111
2022 22845
2023 21754
2024 9160

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521,117 results

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Page 1
Methyl DNA immunoprecipitation.
Magdalena J, Goval JJ. Magdalena J, et al. Methods Mol Biol. 2009;567:237-47. doi: 10.1007/978-1-60327-414-2_15. Methods Mol Biol. 2009. PMID: 19588096 Review.
The first is described in Chapter 2 and the second is shown here. At Diagenode, a novel METHYL kit has been designed to immunoprecipitate methylated DNA (Methyl DNA IP). ...This brand new Methyl DNA IP method provides methylated DNA (meDNA) and …
The first is described in Chapter 2 and the second is shown here. At Diagenode, a novel METHYL kit has been designed to immunoprecipi …
Writing, erasing and reading histone lysine methylations.
Hyun K, Jeon J, Park K, Kim J. Hyun K, et al. Exp Mol Med. 2017 Apr 28;49(4):e324. doi: 10.1038/emm.2017.11. Exp Mol Med. 2017. PMID: 28450737 Free PMC article. Review.
In addition, distinct effector proteins ('readers') recognize specific methyl-lysines in a manner that depends on the neighboring amino-acid sequence and methylation state. ...This review summarizes enzymes responsible for histone lysine methylation and demet …
In addition, distinct effector proteins ('readers') recognize specific methyl-lysines in a manner that depends on the neighboring ami …
Methylation multiplicity and its clinical values in cancer.
Dai X, Ren T, Zhang Y, Nan N. Dai X, et al. Expert Rev Mol Med. 2021 Mar 31;23:e2. doi: 10.1017/erm.2021.4. Expert Rev Mol Med. 2021. PMID: 33787478 Free PMC article. Review.
To aid in the diagnostic and therapeutic design for cancer treatment utilising methylation, this review provides a boutique yet comprehensive overview on methylation at different levels including the mechanisms, cross-talking and clinical implications with a particu …
To aid in the diagnostic and therapeutic design for cancer treatment utilising methylation, this review provides a boutique yet compr …
Biological functions of methyl-CpG-binding proteins.
Defossez PA, Stancheva I. Defossez PA, et al. Prog Mol Biol Transl Sci. 2011;101:377-98. doi: 10.1016/B978-0-12-387685-0.00012-3. Prog Mol Biol Transl Sci. 2011. PMID: 21507359 Review.
Biological effects of DNA methylation are, at least in part, mediated by proteins that preferentially bind to methylated DNA. It is now recognized that several structurally unrelated protein folds have the ability to recognize methylated CpGs in vitro and in …
Biological effects of DNA methylation are, at least in part, mediated by proteins that preferentially bind to methylated DNA. …
ProMetheusDB: An In-Depth Analysis of the High-Quality Human Methyl-proteome.
Massignani E, Giambruno R, Maniaci M, Nicosia L, Yadav A, Cuomo A, Raimondi F, Bonaldi T. Massignani E, et al. Mol Cell Proteomics. 2022 Jul;21(7):100243. doi: 10.1016/j.mcpro.2022.100243. Epub 2022 May 14. Mol Cell Proteomics. 2022. PMID: 35577067 Free PMC article.
Upon intersecting our R-methyl-sites dataset with the PhosphoSitePlus phosphorylation dataset, we observed that R methylation correlates differently with S/T-Y phosphorylation in response to various stimuli. Finally, we explored the application of heavy methyl
Upon intersecting our R-methyl-sites dataset with the PhosphoSitePlus phosphorylation dataset, we observed that R methylation
The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA.
Liu Y, Liu Z, Tang H, Shen Y, Gong Z, Xie N, Zhang X, Wang W, Kong W, Zhou Y, Fu Y. Liu Y, et al. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C762-C775. doi: 10.1152/ajpcell.00212.2019. Epub 2019 Jul 31. Am J Physiol Cell Physiol. 2019. PMID: 31365297 Free article.
Conversely, its overexpression via plasmid transfection greatly facilitated M1, but attenuated M2, macrophage polarization. Further methylated RNA immunoprecipitation and in vitro m(6)A methylation assays suggested that METTL3 directly methylates mRNA encodin …
Conversely, its overexpression via plasmid transfection greatly facilitated M1, but attenuated M2, macrophage polarization. Further methy
Methyl-Analyzer--whole genome DNA methylation profiling.
Xin Y, Ge Y, Haghighi FG. Xin Y, et al. Bioinformatics. 2011 Aug 15;27(16):2296-7. doi: 10.1093/bioinformatics/btr356. Epub 2011 Jun 17. Bioinformatics. 2011. PMID: 21685051 Free PMC article.
SUMMARY: Methyl-Analyzer is a python package that analyzes genome-wide DNA methylation data produced by the Methyl-MAPS (methylation mapping analysis by paired-end sequencing) method. ...It combines enzymatic-based approaches with high-throughput next- …
SUMMARY: Methyl-Analyzer is a python package that analyzes genome-wide DNA methylation data produced by the Methyl-MAPS …
A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in Its Interactions with alpha7 and alpha4beta2 Nicotinic Acetylcholine Receptors.
Xing H, Andrud KW, Soti F, Rouchaud A, Jahn SC, Lu Z, Cho YH, Habibi S, Corsino P, Slavov S, Rocca JR, Lindstrom JM, Lukas RJ, Kem WR. Xing H, et al. Mol Pharmacol. 2020 Aug;98(2):168-180. doi: 10.1124/mol.119.118786. Epub 2020 May 30. Mol Pharmacol. 2020. PMID: 32474444 Free PMC article.
Replacing the 1'-N-methyl with an ethyl group or adding a second 1'-N-methyl group significantly reduced interaction with alpha4beta2 but not alpha7 receptors. ...Although 3'- and 5'-trans-methylations were much better tolerated by alpha7 receptors than alpha …
Replacing the 1'-N-methyl with an ethyl group or adding a second 1'-N-methyl group significantly reduced interaction with alph …
Blocker-dUThiophene poly tailing-based method for assessing methyl transferase activity.
Alom KM, Seo YJ. Alom KM, et al. Anal Bioanal Chem. 2023 Aug;415(19):4631-4638. doi: 10.1007/s00216-023-04793-6. Epub 2023 Jun 8. Anal Bioanal Chem. 2023. PMID: 37289210
The short dsDNA probe is designed with C3 spacers at both 3' ends to prevent any type of tailing reaction. However, the probe contains a methyl transferase recognition sequence that can methylate adenosines in the palindromic part of both strands. ...The unblocked p …
The short dsDNA probe is designed with C3 spacers at both 3' ends to prevent any type of tailing reaction. However, the probe contains a …
Epigenetics: Methylating patterns.
Dart A. Dart A. Nat Rev Cancer. 2018 Apr;18(4):206. doi: 10.1038/nrc.2018.21. Epub 2018 Mar 9. Nat Rev Cancer. 2018. PMID: 29520088 No abstract available.
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