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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 3
1948 1
1949 1
1950 4
1951 9
1952 3
1953 2
1954 5
1955 7
1956 6
1957 4
1958 4
1959 3
1960 4
1961 8
1962 5
1963 12
1964 15
1965 11
1966 7
1967 11
1968 23
1969 20
1970 21
1971 27
1972 33
1973 34
1974 28
1975 44
1976 65
1977 55
1978 41
1979 25
1980 41
1981 39
1982 46
1983 46
1984 65
1985 54
1986 59
1987 56
1988 66
1989 86
1990 88
1991 102
1992 84
1993 76
1994 75
1995 85
1996 123
1997 116
1998 83
1999 106
2000 181
2001 165
2002 198
2003 213
2004 228
2005 201
2006 199
2007 210
2008 241
2009 252
2010 264
2011 295
2012 305
2013 297
2014 268
2015 257
2016 216
2017 262
2018 308
2019 290
2020 308
2021 321
2022 326
2023 337
2024 367
2025 404
2026 29

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8,329 results

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The following term was not found in PubMed: -8-tetradecenoate
Page 1
High-resolution profiling of histone methylations in the human genome.
Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, Wei G, Chepelev I, Zhao K. Barski A, et al. Cell. 2007 May 18;129(4):823-37. doi: 10.1016/j.cell.2007.05.009. Cell. 2007. PMID: 17512414 Free article.
We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the insulator binding protein CTCF across the human genome using the Solexa 1G sequencing …
We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as his …
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.
Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, Wong K, Pathuri S, Briand J, Steidel M, Chapman P, Groy A, Wiseman AK, McHugh CF, Campobasso N, Graves AP, Fairweather E, Werner T, Raoof A, Butlin RJ, Rueda L, Horton JR, Fosbenner DT, Zhang C, Handler JL, Muliaditan M, Mebrahtu M, Jaworski JP, McNulty DE, Burt C, Eberl HC, Taylor AN, Ho T, Merrihew S, Foley SW, Rutkowska A, Li M, Romeril SP, Goldberg K, Zhang X, Kershaw CS, Bantscheff M, Jurewicz AJ, Minthorn E, Grandi P, Patel M, Benowitz AB, Mohammad HP, Gilmartin AG, Prinjha RK, Ogilvie D, Carpenter C, Heerding D, Baylin SB, Jones PA, Cheng X, King BW, Luengo JI, Jordan AM, Waddell I, Kruger RG, McCabe MT. Pappalardi MB, et al. Nat Cancer. 2021 Oct;2(10):1002-1017. Epub 2021 Sep 27. Nat Cancer. 2021. PMID: 34790902 Free PMC article.
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. ...Herein we report the discovery of GSK3685032, a potent first-in-class DNMT1-selective inhibitor that was shown via crystallographic studies to compete with the …
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally dysregulated in cancer. ...Herein we report the …
DNA methylation in mammalian development and disease.
Smith ZD, Hetzel S, Meissner A. Smith ZD, et al. Nat Rev Genet. 2025 Jan;26(1):7-30. doi: 10.1038/s41576-024-00760-8. Epub 2024 Aug 12. Nat Rev Genet. 2025. PMID: 39134824 Review.
The DNA methylation field has matured from a phase of discovery and genomic characterization to one seeking deeper functional understanding of how this modification contributes to development, ageing and disease. ...Here, we summarize the current understanding of the disti …
The DNA methylation field has matured from a phase of discovery and genomic characterization to one seeking deeper functional underst …
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. Cao R, et al. Science. 2002 Nov 1;298(5595):1039-43. doi: 10.1126/science.1076997. Epub 2002 Sep 26. Science. 2002. PMID: 12351676
Here we report the purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex. We demonstrate that the complex specifically methylates nucleosomal histone H3 at lysine 27 (H3-K27). Using chromatin immunoprecipi …
Here we report the purification and characterization of an EED-EZH2 complex, the human counterpart of the Drosophila ESC-E(Z) complex …
Epigenetic analysis of cell-free DNA by fragmentomic profiling.
Zhou Q, Kang G, Jiang P, Qiao R, Lam WKJ, Yu SCY, Ma ML, Ji L, Cheng SH, Gai W, Peng W, Shang H, Chan RWY, Chan SL, Wong GLH, Hiraki LT, Volpi S, Wong VWS, Wong J, Chiu RWK, Chan KCA, Lo YMD. Zhou Q, et al. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2209852119. doi: 10.1073/pnas.2209852119. Epub 2022 Oct 26. Proc Natl Acad Sci U S A. 2022. PMID: 36288287 Free PMC article.
The mean cleavage proportion was twofold higher at the cytosine of methylated CpGs than unmethylated ones in healthy controls. In contrast, the mean cleavage proportion rapidly decreased at the 1-nt position immediately preceding methylated CpGs. ...CGN/NCG motif ra …
The mean cleavage proportion was twofold higher at the cytosine of methylated CpGs than unmethylated ones in healthy controls. In con …
Efficacy of cell-free DNA methylation-based blood test for colorectal cancer screening in high-risk population: a prospective cohort study.
Zhao F, Bai P, Xu J, Li Z, Muhammad S, Li D, Zhang Z, Gao Y, Liu Q. Zhao F, et al. Mol Cancer. 2023 Sep 28;22(1):157. doi: 10.1186/s12943-023-01866-z. Mol Cancer. 2023. PMID: 37770864 Free PMC article.
METHODS: We developed a noninvasive blood-based CRC test, ColonSecure, based on cell-free DNA containing cancer-specific CpG island methylation patterns. We initially screened publicly available datasets for differentially methylated CpG sites in CRC with prediction …
METHODS: We developed a noninvasive blood-based CRC test, ColonSecure, based on cell-free DNA containing cancer-specific CpG island methy …
Stochasticity in gene body methylation.
Goeldel C, Johannes F. Goeldel C, et al. Curr Opin Plant Biol. 2023 Oct;75:102436. doi: 10.1016/j.pbi.2023.102436. Epub 2023 Aug 17. Curr Opin Plant Biol. 2023. PMID: 37597469 Review.
Gene body methylation (gbM) is a widely conserved epigenetic feature of plant genomes. Efforts to delineate the mechanisms by which gbM contributes to transcriptional regulation remain largely inconclusive, and its evolutionary significance continues to be debated. Curious …
Gene body methylation (gbM) is a widely conserved epigenetic feature of plant genomes. Efforts to delineate the mechanisms by which g …
Epigenome-modifying tools in asthma.
Brook PO, Perry MM, Adcock IM, Durham AL. Brook PO, et al. Epigenomics. 2015;7(6):1017-32. doi: 10.2217/epi.15.53. Epub 2015 Oct 7. Epigenomics. 2015. PMID: 26479310 Free PMC article. Review.
The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of noncoding RNA. ...
The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks i …
Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis.
Schellhas L, Monasso GS, Felix JF, Jaddoe VW, Huang P, Fernández-Barrés S, Vrijheid M, Pesce G, Annesi-Maesano I, Page CM, Brantsæter AL, Bekkhus M, Håberg SE, London SJ, Munafò MR, Zuccolo L, Sharp GC. Schellhas L, et al. Epigenomics. 2023 Nov;15(22):1179-1193. doi: 10.2217/epi-2023-0263. Epub 2023 Nov 29. Epigenomics. 2023. PMID: 38018434 Free PMC article. Review.
Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina a …
Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Mat …
Dynamic antagonism between key repressive pathways maintains the placental epigenome.
Weigert R, Hetzel S, Bailly N, Haggerty C, Ilik IA, Yung PYK, Navarro C, Bolondi A, Kumar AS, Anania C, Brändl B, Meierhofer D, Lupiáñez DG, Müller FJ, Aktas T, Elsässer SJ, Kretzmer H, Smith ZD, Meissner A. Weigert R, et al. Nat Cell Biol. 2023 Apr;25(4):579-591. doi: 10.1038/s41556-023-01114-y. Epub 2023 Apr 6. Nat Cell Biol. 2023. PMID: 37024684 Free PMC article.
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartments. In mammals, the majority of the genome is kept in a DNA methylated state, whereas the Polycomb repressive complexes regulate the …
DNA and Histone 3 Lysine 27 methylation typically function as repressive modifications and operate within distinct genomic compartmen …
8,329 results