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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 3
1965 4
1966 4
1967 2
1968 2
1969 2
1970 4
1971 7
1972 4
1973 3
1974 8
1975 5
1976 13
1977 17
1978 4
1979 9
1980 9
1981 12
1982 9
1983 10
1984 12
1985 11
1986 8
1987 15
1988 7
1989 11
1990 9
1991 14
1992 27
1993 19
1994 13
1995 15
1996 13
1997 24
1998 16
1999 17
2000 11
2001 14
2002 10
2003 12
2004 14
2005 17
2006 10
2007 13
2008 18
2009 16
2010 25
2011 32
2012 18
2013 27
2014 21
2015 37
2016 40
2017 28
2018 29
2019 27
2020 49
2021 33
2022 37
2023 25
2024 28
2025 40
2026 27

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950 results

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Page 1
Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Oki R, Izumi Y, Fujita K, Miyamoto R, Nodera H, Sato Y, Sakaguchi S, Nokihara H, Kanai K, Tsunemi T, Hattori N, Hatanaka Y, Sonoo M, Atsuta N, Sobue G, Shimizu T, Shibuya K, Ikeda K, Kano O, Nishinaka K, Kojima Y, Oda M, Komai K, Kikuchi H, Kohara N, Urushitani M, Nakayama Y, Ito H, Nagai M, Nishiyama K, Kuzume D, Shimohama S, Shimohata T, Abe K, Ishihara T, Onodera O, Isose S, Araki N, Morita M, Noda K, Toda T, Maruyama H, Furuya H, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R; Japan Early-Stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) Collaborators. Oki R, et al. JAMA Neurol. 2022 Jun 1;79(6):575-583. doi: 10.1001/jamaneurol.2022.0901. JAMA Neurol. 2022. PMID: 35532908 Free PMC article. Clinical Trial.
Initial studies have shown ultrahigh-dose methylcobalamin to be a promising agent. OBJECTIVE: To validate the efficacy and safety of ultrahigh-dose methylcobalamin for patients with ALS enrolled within 1 year of onset. ...The target participant number was 64 in both …
Initial studies have shown ultrahigh-dose methylcobalamin to be a promising agent. OBJECTIVE: To validate the efficacy and safety of …
Effect of methylcobalamin on capecitabine induced hand-foot syndrome in patients with HER2 negative early breast cancer: multicentre, double blind, randomised, placebo controlled, phase 3 trial.
Xia Y, Zhu Y, Ling L, Xu F, Yang Y, Ye J, Tan W, Chen Z, Liu Q, Wei W, Zhang J, Zhang A, Zhang L, Song E, Gong C. Xia Y, et al. BMJ. 2025 Sep 11;390:e084290. doi: 10.1136/bmj-2025-084290. BMJ. 2025. PMID: 40935571 Free PMC article. Clinical Trial.
The two groups showed similar incidence of any other adverse events (88 (75.2%) in the methylcobalamin group and 95 (81.2%) in the placebo group). No methylcobalamin specific adverse events were observed. ...The findings support the use of methylcobalamin to …
The two groups showed similar incidence of any other adverse events (88 (75.2%) in the methylcobalamin group and 95 (81.2%) in the pl …
Methylcobalamin.
[No authors listed] [No authors listed] Altern Med Rev. 1998 Dec;3(6):461-3. Altern Med Rev. 1998. PMID: 9855571
Methylcobalamin is one of the two coenzyme forms of vitamin B12. Evidence indicates this form of vitamin B12, in addition to having a theoretical advantage over cyanocobalamin, actually has some metabolic and therapeutic applications not shared by the other forms of …
Methylcobalamin is one of the two coenzyme forms of vitamin B12. Evidence indicates this form of vitamin B12, in addition to having a …
Mecobalamin.
Zhang YF, Ning G. Zhang YF, et al. Expert Opin Investig Drugs. 2008 Jun;17(6):953-64. doi: 10.1517/13543784.17.6.953. Expert Opin Investig Drugs. 2008. PMID: 18491996 Review.
BACKGROUND: Mecobalamin, one of the coenzyme forms of vitamin B(12), acts as an important cofactor in the activities of B(12)-dependent methyltransferases. ...However, there is still lack of a systemic review on the clinical administration of mecoba …
BACKGROUND: Mecobalamin, one of the coenzyme forms of vitamin B(12), acts as an important cofactor in the activi …
Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II/III randomised controlled study.
Kaji R, Imai T, Iwasaki Y, Okamoto K, Nakagawa M, Ohashi Y, Takase T, Hanada T, Shimizu H, Tashiro K, Kuzuhara S. Kaji R, et al. J Neurol Neurosurg Psychiatry. 2019 Apr;90(4):451-457. doi: 10.1136/jnnp-2018-319294. Epub 2019 Jan 13. J Neurol Neurosurg Psychiatry. 2019. PMID: 30636701 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the efficacy and safety of intramuscular ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis (ALS). METHODS: 373 patients with ALS (El Escorial definite or probable; laboratory-supported probable; duration 36 months) were …
OBJECTIVE: To evaluate the efficacy and safety of intramuscular ultra-high-dose methylcobalamin in patients with amyotrophic lateral …
Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial.
Didangelos T, Karlafti E, Kotzakioulafi E, Margariti E, Giannoulaki P, Batanis G, Tesfaye S, Kantartzis K. Didangelos T, et al. Nutrients. 2021 Jan 27;13(2):395. doi: 10.3390/nu13020395. Nutrients. 2021. PMID: 33513879 Free PMC article. Clinical Trial.
AIM: To investigate the effect of normalizing vitamin B12 (B12) levels with oral B12 (methylcobalamin) 1000 mug/day for one year in patients with diabetic neuropathy (DN). PATIENTS AND METHODS: In this prospective, double-blind, placebo-controlled trial, 90 patients with t …
AIM: To investigate the effect of normalizing vitamin B12 (B12) levels with oral B12 (methylcobalamin) 1000 mug/day for one year in p …
Vitamin B(12) in Foods, Food Supplements, and Medicines-A Review of Its Role and Properties with a Focus on Its Stability.
Temova Rakuša Ž, Roškar R, Hickey N, Geremia S. Temova Rakuša Ž, et al. Molecules. 2022 Dec 28;28(1):240. doi: 10.3390/molecules28010240. Molecules. 2022. PMID: 36615431 Free PMC article. Review.
Vitamin B(12), also known as the anti-pernicious anemia factor, is an essential micronutrient totally dependent on dietary sources that is commonly integrated with food supplements. Four vitamin B(12) forms-cyanocobalamin, hydroxoc …
Vitamin B(12), also known as the anti-pernicious anemia factor, is an essential micronutrient totally dependent on diet …
Impact of Cyanocobalamin and Methylcobalamin on Inflammatory Bowel Disease and the Intestinal Microbiota Composition.
Zhu X, Xiang S, Feng X, Wang H, Tian S, Xu Y, Shi L, Yang L, Li M, Shen Y, Chen J, Chen Y, Han J. Zhu X, et al. J Agric Food Chem. 2019 Jan 23;67(3):916-926. doi: 10.1021/acs.jafc.8b05730. Epub 2019 Jan 8. J Agric Food Chem. 2019. PMID: 30572705
Patients with inflammatory bowel disease (IBD) are usually advised to supplement various types of vitamin B(12), because vitamin B(12) is generally absorbed in the colon. Thus, in the current study, the influence of cyanocobalamin …
Patients with inflammatory bowel disease (IBD) are usually advised to supplement various types of vitamin B(12), becaus …
950 results