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Page 1
Methylene Blue Induces Antioxidant Defense and Reparation of Mitochondrial DNA in a Nrf2-Dependent Manner during Cisplatin-Induced Renal Toxicity.
Samoylova NA, Gureev AP, Popov VN. Samoylova NA, et al. Int J Mol Sci. 2023 Mar 24;24(7):6118. doi: 10.3390/ijms24076118. Int J Mol Sci. 2023. PMID: 37047089 Free PMC article.
Methylene blue, on the contrary, induced mitochondrial H(2)O(2) production. We supposed that methylene blue-induced H(2)O(2) production led to activation of the Nrf2/ARE signaling pathway. ...It is known that the expression of these genes can al …
Methylene blue, on the contrary, induced mitochondrial H(2)O(2) production. We supposed that methylene blue-indu …
Methylene Blue Mitigates Doxorubicin-Induced Cardiotoxicity via KEAP1/NRF2/GPX-4/Caspase3 Modulation.
Ibrahim SG, Abu-Dief AM, Gad AM, Gad ES, Alzahrani AYA, Alraih AM, Barnawi IO, Mansour M, Gadelmawla MHA, Khames A. Ibrahim SG, et al. Int J Mol Sci. 2025 Aug 8;26(16):7680. doi: 10.3390/ijms26167680. Int J Mol Sci. 2025. PMID: 40868998 Free PMC article.
Doxorubicin (Dox) is a potent anthracycline antitumor drug whose clinical utility is significantly restricted by its dose-dependent, cumulative cardiotoxicity, driven by increased oxidative stress, impaired antioxidant defenses, and apoptosis-mediated cardiomyocyte loss. …
Doxorubicin (Dox) is a potent anthracycline antitumor drug whose clinical utility is significantly restricted by its dose-dependent, cumulat …
Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure.
Jaeschke H, Akakpo JY, Umbaugh DS, Ramachandran A. Jaeschke H, et al. Toxicol Sci. 2020 Apr 1;174(2):159-167. doi: 10.1093/toxsci/kfaa002. Toxicol Sci. 2020. PMID: 31926003 Free PMC article. Review.
Other drugs approved for humans such as metformin and methylene blue were shown to be protective in mice at high doses or at human therapeutic doses, respectively. Additional protective strategies such as enhancing antioxidant activities, Nrf2-dependen …
Other drugs approved for humans such as metformin and methylene blue were shown to be protective in mice at high doses or at h …
Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.
Li JW, Wang RL, Xu J, Sun KY, Jiang HM, Sun ZY, Lv ZY, Xu XQ, Wu R, Guo H, Jiang Q, Shi DQ. Li JW, et al. Acta Pharmacol Sin. 2022 Feb;43(2):417-428. doi: 10.1038/s41401-021-00646-z. Epub 2021 Apr 8. Acta Pharmacol Sin. 2022. PMID: 33833406 Free PMC article.
In this study, we investigated the therapeutic effect of methylene blue (MB), a classical and important anti-oxidant with strong neural affinity. ...We demonstrated that these effects of MB resulted from dual targets of important antioxidant enzymes, Nrf2 …
In this study, we investigated the therapeutic effect of methylene blue (MB), a classical and important anti-oxidant with stro …
Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP(+) induced toxicity via ameliorating oxidative stress and mitochondrial dysfunction.
Bhurtel S, Bok E, Katila N, Kim J, Choi DY. Bhurtel S, et al. Biochem Pharmacol. 2021 Oct;192:114719. doi: 10.1016/j.bcp.2021.114719. Epub 2021 Aug 2. Biochem Pharmacol. 2021. PMID: 34352280
In this study, we attempted to determine the neuroprotective effects of methylene blue (MB) against 1-methyl-4-phenylpyridinium (MPP(+))-induced neurotoxicity, and to elucidate its action mechanism. ...Moreover, we demonstrated that MB induced antioxidant mol …
In this study, we attempted to determine the neuroprotective effects of methylene blue (MB) against 1-methyl-4-phenylpyridiniu …
Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity.
Stack C, Jainuddin S, Elipenahli C, Gerges M, Starkova N, Starkov AA, Jové M, Portero-Otin M, Launay N, Pujol A, Kaidery NA, Thomas B, Tampellini D, Beal MF, Dumont M. Stack C, et al. Hum Mol Genet. 2014 Jul 15;23(14):3716-32. doi: 10.1093/hmg/ddu080. Epub 2014 Feb 20. Hum Mol Genet. 2014. PMID: 24556215 Free PMC article.
Methylene blue (MB, methylthioninium chloride) is a phenothiazine that crosses the blood brain barrier and acts as a redox cycler. ...These beneficial effects were associated with increased expression of genes regulated by NF-E2-related factor 2 (Nrf2)/ant …
Methylene blue (MB, methylthioninium chloride) is a phenothiazine that crosses the blood brain barrier and acts as a redox cyc …
Methylene blue mitigates lung injury in HCA rats by regulating macrophage pyroptosis via Nrf2/HO-1 and NLRP3 pathways.
Ding F, Wang H, Qiao G, Zhang Z. Ding F, et al. Biomol Biomed. 2025 Aug 5;25(9):2020-2034. doi: 10.17305/bb.2025.11851. Biomol Biomed. 2025. PMID: 39957615 Free PMC article.
Methylene blue (MB) has antioxidant properties, yet its role in acute lung injury (ALI) induced by hypothermic circulatory arrest (HCA) remains unexplored. ...MB also lowered proinflammatory cytokine levels, increased SOD and GSH-Px activity, promoted AM pola …
Methylene blue (MB) has antioxidant properties, yet its role in acute lung injury (ALI) induced by hypothermic circulat …
Brain Protection by Methylene Blue and Its Derivative, Azur B, via Activation of the Nrf2/ARE Pathway in Cisplatin-Induced Cognitive Impairment.
Krutskikh EP, Potanina DV, Samoylova NA, Gryaznova MV, Sadovnikova IS, Gureev AP, Popov VN. Krutskikh EP, et al. Pharmaceuticals (Basel). 2022 Jun 30;15(7):815. doi: 10.3390/ph15070815. Pharmaceuticals (Basel). 2022. PMID: 35890114 Free PMC article.
The aim of our work was to study neuroprotectors capable of preventing cisplatin-induced neurotoxicity. Methylene blue (MB) and AzurB (AzB) are able to neutralize the neurotoxicity caused by cisplatin by protecting nerve cells as a result of the activation of the Nt …
The aim of our work was to study neuroprotectors capable of preventing cisplatin-induced neurotoxicity. Methylene blue (MB) an …
The hormetic dose-response mechanism: Nrf2 activation.
Calabrese EJ, Kozumbo WJ. Calabrese EJ, et al. Pharmacol Res. 2021 May;167:105526. doi: 10.1016/j.phrs.2021.105526. Epub 2021 Mar 2. Pharmacol Res. 2021. PMID: 33667690 Review.
Nrf2 conducts crosstalk with other TFs to further integrate and enhance the effectiveness of adaptive metabolic strategies that produce acquired resilience. This adaptive mechanism of Nrf2 accounts for the generality and ubiquity of hormetic dose responses and suppo …
Nrf2 conducts crosstalk with other TFs to further integrate and enhance the effectiveness of adaptive metabolic strategies that produ …
Intravitreally Injected Methylene Blue Protects Retina against Acute Ocular Hypertension in Rats.
Ye Z, Li X, Zheng D, Pei S, Cheng P, Zhang L, Zhu L. Ye Z, et al. Curr Eye Res. 2022 Jan;47(1):91-101. doi: 10.1080/02713683.2021.1948062. Epub 2021 Jul 26. Curr Eye Res. 2022. PMID: 34165383
PURPOSE: To assess the neuroprotective effects of methylene blue (MB) in a rat model of acute ocular hypertension (AOH) and explore its possible mechanisms. ...CONCLUSIONS: MB can protect the retina from AOH injury and the possible mechanism might involve the inhibi …
PURPOSE: To assess the neuroprotective effects of methylene blue (MB) in a rat model of acute ocular hypertension (AOH) and ex …
25 results