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95 results

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Page 1
Inactivation of Japanese encephalitis virus in plasma by methylene blue combined with visible light and in platelet concentrates by ultraviolet C light.
Rustanti L, Hobson-Peters J, Colmant AMG, Hall RA, Young PR, Reichenberg S, Tolksdorf F, Sumian C, Gravemann U, Seltsam A, Marks DC, Faddy HM. Rustanti L, et al. Transfusion. 2020 Nov;60(11):2655-2660. doi: 10.1111/trf.16021. Epub 2020 Aug 23. Transfusion. 2020. PMID: 32830340
JEV is mainly transmitted to humans through the bite of an infected mosquito, but can also be transmitted through blood transfusion. To manage the potential risk of transfusion transmission, pathogen inactivation (PI) technologies, such as THERAFLEX MB-Plasma …
JEV is mainly transmitted to humans through the bite of an infected mosquito, but can also be transmitted through blood transfusion. …
Plasma temperature during methylene blue/light treatment influences virus inactivation capacity and product quality.
Gravemann U, Handke W, Sumian C, Alvarez I, Reichenberg S, Müller TH, Seltsam A. Gravemann U, et al. Vox Sang. 2018 May;113(4):368-377. doi: 10.1111/vox.12643. Epub 2018 Feb 27. Vox Sang. 2018. PMID: 29484670
BACKGROUND: Photodynamic treatment using methylene blue (MB) and visible light is in routine use for pathogen inactivation of human plasma in different countries. Ambient and product temperature conditions for human plasma during production may …
BACKGROUND: Photodynamic treatment using methylene blue (MB) and visible light is in routine use for pathogen inactivation …
Inactivation of yellow fever virus in plasma after treatment with methylene blue and visible light and in platelet concentrates following treatment with ultraviolet C light.
Faddy HM, Fryk JJ, Hall RA, Young PR, Reichenberg S, Tolksdorf F, Sumian C, Gravemann U, Seltsam A, Marks DC. Faddy HM, et al. Transfusion. 2019 Jul;59(7):2223-2227. doi: 10.1111/trf.15332. Epub 2019 May 3. Transfusion. 2019. PMID: 31050821
An approach to manage the potential YFV transfusion transmission risk is the use of pathogen inactivation (PI) technology systems, such as THERAFLEX MB-Plasma and THERAFLEX UV-Platelets (Macopharma). We aimed to investigate the efficacy of these PI technology system …
An approach to manage the potential YFV transfusion transmission risk is the use of pathogen inactivation (PI) technology systems, su …
Methylene blue photochemical treatment as a reliable SARS-CoV-2 plasma virus inactivation method for blood safety and convalescent plasma therapy for COVID-19.
Jin C, Yu B, Zhang J, Wu H, Zhou X, Yao H, Liu F, Lu X, Cheng L, Jiang M, Wu N. Jin C, et al. BMC Infect Dis. 2021 Apr 16;21(1):357. doi: 10.1186/s12879-021-05993-0. BMC Infect Dis. 2021. Retraction in: BMC Infect Dis. 2021 Jul 09;21(1):672. doi: 10.1186/s12879-021-06344-9. PMID: 33863281 Free PMC article. Retracted.
As more asymptomatic infections are identified in COVID-19 cases, blood safety has become particularly important. Methylene blue (MB) photochemical technology has been proven to inactivate lipid-enveloped viruses with high efficiency and safety. The present s …
As more asymptomatic infections are identified in COVID-19 cases, blood safety has become particularly important. Methylene …
Inactivation of three emerging viruses - severe acute respiratory syndrome coronavirus, Crimean-Congo haemorrhagic fever virus and Nipah virus - in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light.
Eickmann M, Gravemann U, Handke W, Tolksdorf F, Reichenberg S, Müller TH, Seltsam A. Eickmann M, et al. Vox Sang. 2020 Apr;115(3):146-151. doi: 10.1111/vox.12888. Epub 2020 Jan 12. Vox Sang. 2020. PMID: 31930543 Free PMC article.
In this study, the ability of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate these viruses in platelet concentrates and plasma, respectively, was investigated. MATERIALS AND METHODS: Blood products were s …
In this study, the ability of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate t …
Hepatitis E virus is effectively inactivated by methylene blue plus light treatment.
Gravemann U, Engelmann M, Kinast V, Burkard T, Behrendt P, Schulze TJ, Todt D, Steinmann E. Gravemann U, et al. Transfusion. 2022 Nov;62(11):2200-2204. doi: 10.1111/trf.17108. Epub 2022 Sep 20. Transfusion. 2022. PMID: 36125237
BACKGROUND AND OBJECTIVES: Photodynamic treatment with methylene blue (MB) and visible light is a well-established pathogen inactivation system for human plasma. ...MB/light treatment was shown to inactivate several transfusion-transmittable viruses, b …
BACKGROUND AND OBJECTIVES: Photodynamic treatment with methylene blue (MB) and visible light is a well-established pathogen …
[The effect of methylene blue/photochemical method for virus inactivation on plasma components].
Zhou XP, Xu JB, Sun P, Yan F, Wang QL, Bu FR. Zhou XP, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003 Jun;11(3):305-7. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003. PMID: 12844419 Chinese.
Virus inactivation of plasma can be achieved by methylene blue/photochemical method. To investigate the effect of this method on immunological properties and biochemical functions of plasma components, the virus-inactivation …
Virus inactivation of plasma can be achieved by methylene blue/photochemical method. To investigate the e …
Virus inactivation in blood components by photoactive phenothiazine dyes.
Wagner SJ. Wagner SJ. Transfus Med Rev. 2002 Jan;16(1):61-6. doi: 10.1053/tmrv.2002.29405. Transfus Med Rev. 2002. PMID: 11788930 Review.
The virucidal properties of photoactive phenothiazine dyes, such as methylene blue, have been known approximately 70 years. The mechanism of virus inactivation involves binding of the dye to nucleic acid, absorption of light, generation of reactive oxy …
The virucidal properties of photoactive phenothiazine dyes, such as methylene blue, have been known approximately 70 years. Th …
Mammalian genotoxicity assessment of methylene blue in plasma: implications for virus inactivation.
Wagner SJ, Cifone MA, Murli H, Dodd RY, Myhr B. Wagner SJ, et al. Transfusion. 1995 May;35(5):407-13. doi: 10.1046/j.1537-2995.1995.35595259151.x. Transfusion. 1995. PMID: 7740612
Previous studies demonstrated that methylene blue, which is currently used in Europe for virus inactivation in fresh-frozen plasma, can elicit mutations in bacterial test systems. ...Considerably more investigation will be required to assess the …
Previous studies demonstrated that methylene blue, which is currently used in Europe for virus inactivation in f …
Inactivation of Zika virus in plasma and derivatives by four different methods.
Wang Y, Ren K, Liao X, Luo G, Kumthip K, Leetrakool N, Li S, Chen L, Yang C, Chen Y. Wang Y, et al. J Med Virol. 2019 Dec;91(12):2059-2065. doi: 10.1002/jmv.25538. Epub 2019 Aug 31. J Med Virol. 2019. PMID: 31389019
In this study, we aimed to study the efficacy of several common pathogen reduction methods in the inactivation of ZIKV. The fresh frozen plasma and derivatives were spiked with a high titer of ZIKV or Sindbis virus (SINV). Viral titers and ZIKV RNA were measu …
In this study, we aimed to study the efficacy of several common pathogen reduction methods in the inactivation of ZIKV. The fresh fro …
95 results