Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats.
Neurosci Lett. 2002.
PMID: 12384216
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Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion.
Front Cell Neurosci. 2020.
PMID: 32508596
Free PMC article.
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Methylene Blue Preserves Cytochrome Oxidase Activity and Prevents Neurodegeneration and Memory Impairment in Rats With Chronic Cerebral Hypoperfusion.
Front Cell Neurosci. 2020 May 20;14:130. doi: 10.3389/fncel.2020.00130. eCollection 2020.
Front Cell Neurosci. 2020.
PMID: 32508596
Free PMC article.
Methylene blue at low doses stimulates cytochrome oxidase activity and may thus counteract the adverse effects of cerebral hypoperfusion. ...Brain-behavior correlations revealed positive correlations between performance and brain regions in which cy …
Methylene blue at low doses stimulates cytochrome oxidase activity and may thus counteract the adverse effects o …
Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats.
Neurosci Lett. 2002 Oct 31;332(2):83-6. doi: 10.1016/s0304-3940(02)00827-3.
Neurosci Lett. 2002.
PMID: 12384216
Methylene blue, which has been shown to increase oxygen consumption in vitro, was used to restore mitochondrial electron transport in order to facilitate memory consolidation. Administration of 1 mg/kg methylene blue after training …
Methylene blue, which has been shown to increase oxygen consumption in vitro, was used to restore mitochondrial electron …
Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue.
Prog Neurobiol. 2012 Jan;96(1):32-45. doi: 10.1016/j.pneurobio.2011.10.007. Epub 2011 Nov 3.
Prog Neurobiol. 2012.
PMID: 22067440
Free PMC article.
Review.
This paper provides the first review of the memory-enhancing and neuroprotective metabolic mechanisms of action of methylene blue in vivo. ...A major role of the respiratory enzyme cytochrome oxidase on the memory-enhancing effects of …
This paper provides the first review of the memory-enhancing and neuroprotective metabolic mechanisms of action of methylene …
Methylene blue and photobiomodulation recover cognitive impairment in hepatic encephalopathy through different effects on cytochrome c-oxidase.
Behav Brain Res. 2021 Apr 9;403:113164. doi: 10.1016/j.bbr.2021.113164. Epub 2021 Feb 4.
Behav Brain Res. 2021.
PMID: 33549685
Mitochondrial dysfunction plays a central role in hepatic encephalopathy (HE), due to changes in enzyme cytochrome c-oxidase (CCO), causing a decline in brain metabolism. We used an HE animal model and applied intracranial administration of methylene blue …
Mitochondrial dysfunction plays a central role in hepatic encephalopathy (HE), due to changes in enzyme cytochrome c-oxidase ( …
Memory facilitation by methylene blue: dose-dependent effect on behavior and brain oxygen consumption.
Eur J Pharmacol. 2005 Mar 28;511(2-3):151-8. doi: 10.1016/j.ejphar.2005.02.001.
Eur J Pharmacol. 2005.
PMID: 15792783
Methylene blue administered post-training improves memory retention in avoidance and appetitive tasks, and restores spatial memory impaired by an inhibitor of cytochrome oxidase. Methylene blue may improve memory rete …
Methylene blue administered post-training improves memory retention in avoidance and appetitive tasks, and restores spa …
Methylene blue improves streptozotocin-induced memory deficit by restoring mitochondrial function in rats.
Brain Res. 2017 Feb 15;1657:208-214. doi: 10.1016/j.brainres.2016.12.024. Epub 2016 Dec 27.
Brain Res. 2017.
PMID: 28034723
The pathogenesis of Alzheimer's disease (AD) is well documented to involve mitochondrial dysfunction which causes subsequent oxidative stress and energy metabolic failure in hippocampus. Methylene blue (MB) has been implicated to be neuroprotective in a variety of n …
The pathogenesis of Alzheimer's disease (AD) is well documented to involve mitochondrial dysfunction which causes subsequent oxidative stres …
Methylene blue improves brain oxidative metabolism and memory retention in rats.
Pharmacol Biochem Behav. 2004 Jan;77(1):175-81. doi: 10.1016/j.pbb.2003.10.007.
Pharmacol Biochem Behav. 2004.
PMID: 14724055
Methylene blue (MB) increases mitochondrial oxygen consumption and restores memory retention in rats metabolically impaired by inhibition of cytochrome c oxidase. ...Together the findings suggest that low-dose MB enhances spatial memory r …
Methylene blue (MB) increases mitochondrial oxygen consumption and restores memory retention in rats metabolically impa …
Extinction memory improvement by the metabolic enhancer methylene blue.
Learn Mem. 2004 Sep-Oct;11(5):633-40. doi: 10.1101/lm.82404.
Learn Mem. 2004.
PMID: 15466319
Free PMC article.
We investigated whether postextinction administration of methylene blue (MB) could enhance retention of an extinguished conditioned response. MB is a redox compound that at low doses elevates cytochrome oxidase activity, thereby improving brain energy …
We investigated whether postextinction administration of methylene blue (MB) could enhance retention of an extinguished condit …
Effects of post-session administration of methylene blue on fear extinction and contextual memory in adults with claustrophobia.
Am J Psychiatry. 2014 Oct;171(10):1091-8. doi: 10.1176/appi.ajp.2014.13101407.
Am J Psychiatry. 2014.
PMID: 25018057
Free PMC article.
Clinical Trial.
OBJECTIVE: Preclinical studies have shown that low-dose methylene blue increases mitochondrial cytochrome oxidase activity in the brain and improves memory retention after learning tasks, including fear extinction. ...Methylene blue …
OBJECTIVE: Preclinical studies have shown that low-dose methylene blue increases mitochondrial cytochrome oxidase …
Beneficial network effects of methylene blue in an amnestic model.
Neuroimage. 2011 Feb 14;54(4):2623-34. doi: 10.1016/j.neuroimage.2010.11.023. Epub 2010 Nov 16.
Neuroimage. 2011.
PMID: 21087672
Free PMC article.
In rats, PCC hypometabolism induced by mitochondrial dysfunction induces oxidative damage, neurodegeneration and memory deficits. USP methylene blue (MB) is a diaminophenothiazine drug with antioxidant and metabolic-enhancing properties. In rats, MB facilitat …
In rats, PCC hypometabolism induced by mitochondrial dysfunction induces oxidative damage, neurodegeneration and memory deficits. USP …
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