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Page 1
Mitochondrial pharmacology: electron transport chain bypass as strategies to treat mitochondrial dysfunction.
Atamna H, Mackey J, Dhahbi JM. Atamna H, et al. Biofactors. 2012 Mar-Apr;38(2):158-66. doi: 10.1002/biof.197. Epub 2012 Mar 15. Biofactors. 2012. PMID: 22419586 Free PMC article. Review.
This view has been demonstrated by testing the effect of several redox active agents on cellular senescence. Methylene blue (MB, redox potential 10 mV) appears to readily cycle between the oxidized and reduced forms using specific mitochondrial and cytosolic redox …
This view has been demonstrated by testing the effect of several redox active agents on cellular senescence. Methylene blue (M …
Methylene blue does not bypass Complex III antimycin block in mouse brain mitochondria.
Gureev AP, Shaforostova EA, Popov VN, Starkov AA. Gureev AP, et al. FEBS Lett. 2019 Mar;593(5):499-503. doi: 10.1002/1873-3468.13332. Epub 2019 Feb 20. FEBS Lett. 2019. PMID: 30734287 Free PMC article.
Methylene blue (MB) is a promising prodrug to treat mitochondrial dysfunctions that is currently being used in clinical trials for Alzheimer's disease. MB can penetrate the blood brain barrier, accumulating in brain mitochondria where it acts as a redox mediator in …
Methylene blue (MB) is a promising prodrug to treat mitochondrial dysfunctions that is currently being used in clinical trials …
Neuroprotective actions of methylene blue and its derivatives.
Poteet E, Winters A, Yan LJ, Shufelt K, Green KN, Simpkins JW, Wen Y, Yang SH. Poteet E, et al. PLoS One. 2012;7(10):e48279. doi: 10.1371/journal.pone.0048279. Epub 2012 Oct 31. PLoS One. 2012. PMID: 23118969 Free PMC article.
Methylene blue (MB), the first lead chemical structure of phenothiazine and other derivatives, is commonly used in diagnostic procedures and as a treatment for methemoglobinemia. ...MB reduces mitochondrial superoxide production via alternative electron trans …
Methylene blue (MB), the first lead chemical structure of phenothiazine and other derivatives, is commonly used in diagnostic …
Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse hepatocytes.
Lee KK, Boelsterli UA. Lee KK, et al. Redox Biol. 2014;2:599-609. doi: 10.1016/j.redox.2014.03.003. Epub 2014 Mar 13. Redox Biol. 2014. PMID: 25460728 Free PMC article.
The acylamidase inhibitor bis-p-nitrophenyl phosphate prevented cell injury, suggesting that hydrazine greatly contributed to the toxicity. Methylene blue, a redox-active alternative electron acceptor/donor that bypasses complex I/II, effectively prote …
The acylamidase inhibitor bis-p-nitrophenyl phosphate prevented cell injury, suggesting that hydrazine greatly contributed to the toxicity. …
The Effect of Methylene Blue and Its Metabolite-Azure I-on Bioenergetic Parameters of Intact Mouse Brain Mitochondria.
Gureev AP, Samoylova NA, Potanina DV, Popov VN. Gureev AP, et al. Biochem Mosc Suppl B Biomed Chem. 2022;16(2):148-153. doi: 10.1134/S1990750822020044. Epub 2022 May 17. Biochem Mosc Suppl B Biomed Chem. 2022. PMID: 35601460 Free PMC article.
Azure I, an N-dimethylated metabolite of methylene blue, is potentially a more effective compound than methylene blue, but its ability for alternative electron transport has not been studied yet. ...Thus, only methylene blue …
Azure I, an N-dimethylated metabolite of methylene blue, is potentially a more effective compound than methylene blu …
[Effect of methylene blue and its metabolite - azure I - on bioenergetic parameters of intact mice brain mitochondria].
Gureev AP, Samoylova NA, Potanina DV, Popov VN. Gureev AP, et al. Biomed Khim. 2021 Nov;67(6):485-490. doi: 10.18097/PBMC20216706485. Biomed Khim. 2021. PMID: 34964442 Russian.
Azure I, an N-dimethylated metabolite of methylene blue, is potentially a more effective compound than methylene blue, but its ability for alternative electron transport has not been studied. ...As a consequence, only methylene …
Azure I, an N-dimethylated metabolite of methylene blue, is potentially a more effective compound than methylene blu …
Mitochondrial origin of extracelullar transferred electrons in yeast-based biofuel cells.
Hubenova Y, Mitov M. Hubenova Y, et al. Bioelectrochemistry. 2015 Dec;106(Pt A):232-9. doi: 10.1016/j.bioelechem.2014.06.005. Epub 2014 Jun 25. Bioelectrochemistry. 2015. PMID: 24997719
The influence of mitochondrial electron transport chain inhibitors on the electricity outputs of Candida melibiosica yeast-based biofuel cell was investigated. ...It was established that the presence of both inhibitors leads to almost complete mitochondrial d …
The influence of mitochondrial electron transport chain inhibitors on the electricity outputs of Candida melibiosica ye …
The study of the protective effect of mitochondrial uncouplers during acute toxicity of the fungicide difenoconazole in different organs of mice.
Chernyshova EV, Potanina DV, Sadovnikova IS, Krutskikh EP, Volodina DE, Samoylova NA, Gureev AP. Chernyshova EV, et al. Biomed Khim. 2024 Feb;70(1):41-51. doi: 10.18097/PBMC20247001041. Biomed Khim. 2024. PMID: 38450680
Injections of difenoconazole caused cognitive deficits in mice, and the protonophore 2,4-dinitrophenol (2,4-DNP) and Azur I (AzI), a demethylated metabolite of methylene blue (MB), prevented the deterioration of cognitive abilities in mice induced by difenoconazole. …
Injections of difenoconazole caused cognitive deficits in mice, and the protonophore 2,4-dinitrophenol (2,4-DNP) and Azur I (AzI), a demethy …
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.
Wen Y, Li W, Poteet EC, Xie L, Tan C, Yan LJ, Ju X, Liu R, Qian H, Marvin MA, Goldberg MS, She H, Mao Z, Simpkins JW, Yang SH. Wen Y, et al. J Biol Chem. 2011 May 6;286(18):16504-15. doi: 10.1074/jbc.M110.208447. Epub 2011 Mar 18. J Biol Chem. 2011. PMID: 21454572 Free PMC article.
In the current study, we demonstrated that methylene blue (MB) functions as an alternative electron carrier, which accepts electrons from NADH and transfers them to cytochrome c and bypasses complex I/III blockage. ...The present study indicates that r …
In the current study, we demonstrated that methylene blue (MB) functions as an alternative electron carrier, which acce …