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Page 1
Methylene Blue-Based Combination Therapy with Amodiaquine Prevents Severe Malaria in an Experimental Rodent Model.
Dormoi J, Amalvict R, Gendrot M, Pradines B. Dormoi J, et al. Pharmaceutics. 2022 Sep 24;14(10):2031. doi: 10.3390/pharmaceutics14102031. Pharmaceutics. 2022. PMID: 36297466 Free PMC article.
Given this, it is clear that new chemotherapy must be developed. We contribute new data about using methylene blue (MB) to cure malaria and cerebral malaria in a combined therapy with common antimalarial drugs, including mefloquine (MQ) and amod …
Given this, it is clear that new chemotherapy must be developed. We contribute new data about using methylene blue (MB) to cur …
Efficacy and safety of methylene blue in the treatment of malaria: a systematic review.
Lu G, Nagbanshi M, Goldau N, Mendes Jorge M, Meissner P, Jahn A, Mockenhaupt FP, Müller O. Lu G, et al. BMC Med. 2018 Apr 25;16(1):59. doi: 10.1186/s12916-018-1045-3. BMC Med. 2018. PMID: 29690878 Free PMC article.
BACKGROUND: Methylene blue (MB) was the first synthetic antimalarial to be discovered and was used during the late 19th and early 20th centuries against all types of malaria. ...MB has, thus, been considered a potentially useful partner drug for artemisini …
BACKGROUND: Methylene blue (MB) was the first synthetic antimalarial to be discovered and was used during the late 19th and ea …
Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial.
Coulibaly B, Zoungrana A, Mockenhaupt FP, Schirmer RH, Klose C, Mansmann U, Meissner PE, Müller O. Coulibaly B, et al. PLoS One. 2009;4(5):e5318. doi: 10.1371/journal.pone.0005318. Epub 2009 May 5. PLoS One. 2009. PMID: 19415120 Free PMC article. Clinical Trial.
BACKGROUND: With the availability of new preventive and curative interventions, global malaria control has been strengthened significantly in recent years. Drugs effective in reducing malaria gametocytaemia might contribute to local elimination and possible long-ter …
BACKGROUND: With the availability of new preventive and curative interventions, global malaria control has been strengthened signific …
Efficacy of intravenous methylene blue, intravenous artesunate, and their combination in preclinical models of malaria.
Ohrt C, Li Q, Obaldia N, Im-Erbsin R, Xie L, Berman J. Ohrt C, et al. Malar J. 2014 Oct 21;13:415. doi: 10.1186/1475-2875-13-415. Malar J. 2014. PMID: 25336091 Free PMC article.
Methylene blue (MB) is an approved human agent for IV and oral use, and is already being investigated for oral treatment of uncomplicated malaria. To initiate investigation of IV MB for severe malaria, the efficacy of IV MB was compared to IV AS and to …
Methylene blue (MB) is an approved human agent for IV and oral use, and is already being investigated for oral treatment of un …
Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina Faso.
Coulibaly B, Pritsch M, Bountogo M, Meissner PE, Nebié E, Klose C, Kieser M, Berens-Riha N, Wieser A, Sirima SB, Breitkreutz J, Schirmer RH, Sié A, Mockenhaupt FP, Drakeley C, Bousema T, Müller O. Coulibaly B, et al. J Infect Dis. 2015 Mar 1;211(5):689-97. doi: 10.1093/infdis/jiu540. Epub 2014 Sep 28. J Infect Dis. 2015. PMID: 25267980 Clinical Trial.
BACKGROUND: Methylene blue (MB) has been shown to be safe and effective against falciparum malaria in Africa and to have pronounced gametocytocidal properties. ...Vomiting of the study medication occurred significantly more frequently in the AS-AQ-MB group. C …
BACKGROUND: Methylene blue (MB) has been shown to be safe and effective against falciparum malaria in Africa and to hav …
Efficacy of proveblue (methylene blue) in an experimental cerebral malaria murine model.
Dormoi J, Briolant S, Desgrouas C, Pradines B. Dormoi J, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3412-4. doi: 10.1128/AAC.02381-12. Epub 2013 Apr 22. Antimicrob Agents Chemother. 2013. PMID: 23612202 Free PMC article.
Although 100% of untreated mice infected with Plasmodium berghei died with specific signs of cerebral malaria and 100% of mice treated with 3 mg/kg dihydroartemisinin, the active metabolite of artesunate, which is used as the first-line treatment for severe malaria, …
Although 100% of untreated mice infected with Plasmodium berghei died with specific signs of cerebral malaria and 100% of mice treate …
Transmission-blocking activities of artesunate, chloroquine, and methylene blue on Plasmodium vivax gametocytes.
Chaumeau V, Wasisakun P, Watson JA, Oo T, Aryalamloed S, Sue MP, Htoo GN, Tha NM, Archusuksan L, Sawasdichai S, Gornsawun G, Mehra S, White NJ, Nosten FH. Chaumeau V, et al. Antimicrob Agents Chemother. 2024 Sep 4;68(9):e0085324. doi: 10.1128/aac.00853-24. Epub 2024 Jul 26. Antimicrob Agents Chemother. 2024. PMID: 39058023 Free PMC article.
The transmission-blocking effects of chloroquine, artesunate, and methylene blue on P. vivax gametocytes were assessed. Blood specimens were collected from patients presenting with vivax malaria, incubated with or without the tested drugs, and then fed to mos …
The transmission-blocking effects of chloroquine, artesunate, and methylene blue on P. vivax gametocytes were assessed. Blood …
Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.
Zoungrana A, Coulibaly B, Sié A, Walter-Sack I, Mockenhaupt FP, Kouyaté B, Schirmer RH, Klose C, Mansmann U, Meissner P, Müller O. Zoungrana A, et al. PLoS One. 2008 Feb 20;3(2):e1630. doi: 10.1371/journal.pone.0001630. PLoS One. 2008. PMID: 18286187 Free PMC article. Clinical Trial.
BACKGROUND: Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever u …
BACKGROUND: Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combi …
Safety and efficacy of artesunate-amodiaquine combined with either methylene blue or primaquine in children with falciparum malaria in Burkina Faso: A randomized controlled trial.
Mendes Jorge M, Ouermi L, Meissner P, Compaoré G, Coulibaly B, Nebie E, Krisam J, Klose C, Kieser M, Jahn A, Lu G, D Alessandro U, Sié A, Mockenhaupt FP, Müller O. Mendes Jorge M, et al. PLoS One. 2019 Oct 10;14(10):e0222993. doi: 10.1371/journal.pone.0222993. eCollection 2019. PLoS One. 2019. PMID: 31600221 Free PMC article. Clinical Trial.
Artemisinin resistance is threatening global efforts for malaria control and elimination. Primaquine (PQ) and methylene blue (MB) are gametocytocidal drugs that can be combined with artemisinin-based combination therapy (ACT) to re …
Artemisinin resistance is threatening global efforts for malaria control and elimination. Primaquine (PQ) and methylene …
Alternatives to currently used antimalarial drugs: in search of a magic bullet.
Bhagavathula AS, Elnour AA, Shehab A. Bhagavathula AS, et al. Infect Dis Poverty. 2016 Nov 4;5(1):103. doi: 10.1186/s40249-016-0196-8. Infect Dis Poverty. 2016. PMID: 27809883 Free PMC article. Review.
Malaria is a major cause of morbidity and mortality in many African countries and parts of Asia and South America. ...Tafenoquine, the only new anti-relapse scaffold for patients with a glucose-6-phosphate dehydrogenase deficiency, has raised significant concerns due to it …
Malaria is a major cause of morbidity and mortality in many African countries and parts of Asia and South America. ...Tafenoquine, th …
25 results