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Page 1
Methylene blue.
Clifton J 2nd, Leikin JB. Clifton J 2nd, et al. Am J Ther. 2003 Jul-Aug;10(4):289-91. doi: 10.1097/00045391-200307000-00009. Am J Ther. 2003. PMID: 12845393 Review.
Methylene blue finds its major utilization in toxicology in the treatment of methemoglobinemia at a dose of 1 to 2 mg/kg intravenously. By interacting with methemoglobin and the erythrocyte's enzyme systems to reduce back to hemoglobin, methylene bl …
Methylene blue finds its major utilization in toxicology in the treatment of methemoglobinemia at a dose of 1 to 2 mg/k …
Rasburicase-Induced Methemoglobinemia.
Ahmed M, Sanchez T, Norgbe S, Picking CR, Millner PG. Ahmed M, et al. Cureus. 2021 Apr 10;13(4):e14406. doi: 10.7759/cureus.14406. Cureus. 2021. PMID: 33987056 Free PMC article.
Methylene blue, an agent used for treating methemoglobinemia, should be avoided in patients with G6PD deficiency. In patients with G6PD deficiency, methylene blue is inadequately reduced to its active form, which then causes the …
Methylene blue, an agent used for treating methemoglobinemia, should be avoided in patients with G6PD deficiency …
The Potential of Leucomethylene Blue in Methemoglobinemia Treatment: A New Hope for Patients with G6PD?
Emadi E, Alamdari DH, Sahebkar A. Emadi E, et al. Curr Med Chem. 2025;32(6):1033-1039. doi: 10.2174/0929867331666230911113159. Curr Med Chem. 2025. PMID: 37694789 Review.
Methylene blue (MB) has been routinely used to treat methemoglobinemia. In the body, MB is reduced to leucomethylene blue (LMB) by NADPH-dependent methemoglobin (MetHB) reductase, and then LMB reduces Fe(3+) to Fe(2+). ...Therefore, its administration …
Methylene blue (MB) has been routinely used to treat methemoglobinemia. In the body, MB is reduced to leucomethylene …
Methylene blue-induced Hemolysis in a patient with lidocaine-induced Methemoglobinemia: a case report.
Mehmood M, Almarri FJA. Mehmood M, et al. Oxf Med Case Reports. 2025 Dec 26;2025(12):omaf264. doi: 10.1093/omcr/omaf264. eCollection 2025 Dec. Oxf Med Case Reports. 2025. PMID: 41458260 Free PMC article.
Topical anesthetics such as lidocaine can induce methemoglobinemia. Methylene blue (MB) is the first-line antidote, but high doses can oxidize hemoglobin and may precipitate hemolysis even in individuals with normal glucose-6-phosphate dehydrogenase (G6PD …
Topical anesthetics such as lidocaine can induce methemoglobinemia. Methylene blue (MB) is the first-line antidote, but …
Naphthalene Toxicity in Clinical Practice.
Pannu AK, Singla V. Pannu AK, et al. Curr Drug Metab. 2020;21(1):63-66. doi: 10.2174/1389200220666191122110036. Curr Drug Metab. 2020. PMID: 31755382 Review.
The toxicity is more marked in patients with G6PD deficiency and associated with high morbidity and mortality. The management should mainly focus on high-quality supportive care; however, severe methemoglobinemia (>20-30%) requires specific therapy with intraveno …
The toxicity is more marked in patients with G6PD deficiency and associated with high morbidity and mortality. The management should …
Methylene Blue Induced Methemoglobinemia with Acute Kidney Injury in a Glucose-6-Phosphate Dehydrogenase-deficient Patient.
Balwani MR, Bawankule CP, Ramteke V, Tolani P, Vakil S, Yadav R. Balwani MR, et al. Indian J Nephrol. 2017 Nov-Dec;27(6):465-467. doi: 10.4103/ijn.IJN_316_16. Indian J Nephrol. 2017. PMID: 29217886 Free PMC article.
Our case was treated with methylene blue for symptomatic nitrobenzene poisoning. After which he developed methemoglobinemia with acute kidney injury due to hemolysis and on further testing, he was found to be glucose-6-phosphate dehydrogenase (G6PD) en …
Our case was treated with methylene blue for symptomatic nitrobenzene poisoning. After which he developed methemoglobinemia …
Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia.
Liao YP, Hung DZ, Yang DY. Liao YP, et al. Vet Hum Toxicol. 2002 Feb;44(1):19-21. Vet Hum Toxicol. 2002. PMID: 11824767
Methylene blue is utilized as the main treatment of methemoglobinemia conventionally, but it may be ineffective in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. ...Caution should be taken in using methylene blue as …
Methylene blue is utilized as the main treatment of methemoglobinemia conventionally, but it may be ineffective in indi …
Occupational methaemoglobinaemia. Mechanisms of production, features, diagnosis and management including the use of methylene blue.
Bradberry SM. Bradberry SM. Toxicol Rev. 2003;22(1):13-27. doi: 10.2165/00139709-200322010-00003. Toxicol Rev. 2003. PMID: 14579544 Review.
No controlled trial of the efficacy of methylene blue has been performed but clinical experience suggests that methylene blue can increase the rate of methaemoglobin conversion to haemoglobin some 6-fold. ...Exchange transfusion may have a role in the …
No controlled trial of the efficacy of methylene blue has been performed but clinical experience suggests that methylene …
Ascorbic Acid for Methemoglobinemia Treatment: A Case Report and Literature Review.
Keats KR, Robinson R, Patel M, Wallace A, Albrecht S. Keats KR, et al. J Pharm Pract. 2024 Aug;37(4):1015-1020. doi: 10.1177/08971900231188834. Epub 2023 Jul 8. J Pharm Pract. 2024. PMID: 37421600 Review.
Purpose: Ascorbic acid has been proposed as an alternative treatment for methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. However, its efficacy has never been compared to that of methylene blue given the inability …
Purpose: Ascorbic acid has been proposed as an alternative treatment for methemoglobinemia in patients with glucose-6-phosphate dehyd …
64 results